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N. Cremades · SciRah

Researcher profile · Semantic Scholar

N. Cremades

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N. Cremades — researcher profile on SciRah

h-index: 39
Works: 77
Citations: 6,530

Most-cited papers

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
N. Cremades, Samuel I. A. Cohen, E. Deas, A. Abramov +11 more
2012Cell905 citations Open access
Semantic Scholar
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Giuliana Fusco, Serene W. Chen, P. Williamson, R. Cascella +9 more
2017Science637 citations Open access
Semantic Scholar
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Serene W. Chen, S. Drakulić, E. Deas, Myriam M. Ouberai +15 more
2015Proceedings of the National Academy of Sciences of the United States of America505 citations Open access
Semantic Scholar
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
E. Deas, N. Cremades, Plamena R. Angelova, M. H. Ludtmann +12 more
2016Antioxidants and Redox Signaling351 citations Open access
Semantic Scholar
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America268 citations Open access
Semantic Scholar
Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected Anaerobic Bacteria and Parasites, and Campylobacter jejuni
P. Hoffman, G. Sisson, Matthew A. Croxen, K. Welch +3 more
2006Antimicrobial Agents and Chemotherapy245 citations Open access
Semantic Scholar
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Marija Iljina, Gonzalo A. Garcia, M. Horrocks, Laura Tosatto +9 more
2016Proceedings of the National Academy of Sciences of the United States of America221 citations Open access
Semantic Scholar
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents
N. Polinski, L. Volpicelli-Daley, C. Sortwell, Kelvin C. Luk +7 more
2018Journal of Parkinson's Disease220 citations Open access
Semantic Scholar
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
R. Cascella, Serene W. Chen, A. Bigi, José D. Camino +5 more
2021Nature Communications201 citations Open access
Semantic Scholar
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
E. De Genst, Tim Guilliams, Joke Wellens, E. O'Day +11 more
2010Journal of Molecular Biology182 citations Open access
Semantic Scholar
Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria.
A. L. Pey, Ming Ying, N. Cremades, A. Velázquez-Campoy +4 more
2008Journal of Clinical Investigation175 citations Open access
Semantic Scholar
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Plamena R. Angelova, M. H. Ludtmann, M. Horrocks, A. Negoda +7 more
2016Journal of Cell Science161 citations Open access
Semantic Scholar
Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease
G. Tóth, S. Gardai, W. Zago, C. Bertoncini +22 more
2014PLoS ONE142 citations Open access
Semantic Scholar
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice
Jessica M. Froula, Marta Castellana-Cruz, Nadia M Anabtawi, José D. Camino +9 more
2019Journal of Biological Chemistry118 citations Open access
Semantic Scholar
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
M. Horrocks, Steven F. Lee, S. Gandhi, Nadia K. Magdalinou +11 more
2016ACS Chemical Neuroscience113 citations Open access
Semantic Scholar
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
Laura Tosatto, M. Horrocks, A. Dear, T. Knowles +4 more
2015Scientific Reports110 citations Open access
Semantic Scholar
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
Tim Guilliams, Farah El-Turk, A. Buell, E. O'Day +11 more
2013Journal of Molecular Biology104 citations Open access
Semantic Scholar
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Michele Perni, Patrick Flagmeier, Ryan Limbocker, R. Cascella +19 more
2018ACS Chemical Biology103 citations Open access
Semantic Scholar
On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid.
Christofer Lendel, C. Bertoncini, N. Cremades, C. Waudby +5 more
2009Biochemistry103 citations
Semantic Scholar
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
R. Cascella, A. Bigi, N. Cremades, C. Cecchi
2022Cellular and Molecular Life Sciences101 citations Open access
Semantic Scholar
Structural Characteristics of α-Synuclein Oligomers.
N. Cremades, Serene W. Chen, C. Dobson
2017International Review of Cell and Molecular Biology98 citations
Semantic Scholar
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
M. Horrocks, Laura Tosatto, A. Dear, Gonzalo A. Garcia +6 more
2015Analytical Chemistry93 citations Open access
Semantic Scholar
Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau
P. Gracia, David Polanco, Jorge Tarancón-Díez, Ilenia Serra +5 more
2022Nature Communications84 citations Open access
Semantic Scholar
Population of non-native states of lysozyme variants drives amyloid fibril formation
A. Buell, Anne Dhulesia, M. F. Mossuto, N. Cremades +6 more
2011Journal of the American Chemical Society79 citations Open access
Semantic Scholar
Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
F. Aprile, Anne Dhulesia, F. Stengel, C. Roodveldt +6 more
2013PLoS ONE78 citations Open access
Semantic Scholar
Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing
J. T. Pedersen, Serene W. Chen, Christian B. Borg, Samuel Ness +6 more
2016Journal of the American Chemical Society77 citations Open access
Semantic Scholar
The role of water in the primary nucleation of protein amyloid aggregation.
José D. Camino, P. Gracia, N. Cremades
2020Biophysical Chemistry74 citations Open access
Semantic Scholar
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.
N. Cremades, C. Dobson
2018Neurobiology of Disease69 citations Open access
Semantic Scholar
Flavodoxin:Quinone Reductase (FqrB): a Redox Partner of Pyruvate:Ferredoxin Oxidoreductase That Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni
M. St. Maurice, N. Cremades, Matthew A. Croxen, G. Sisson +2 more
2007Journal of Bacteriology68 citations Open access
Semantic Scholar
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity
Jaime Santos, P. Gracia, Susanna Navarro, Samuel Peña-Díaz +4 more
2021Nature Communications61 citations Open access
Semantic Scholar
Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution
Anne Dhulesia, N. Cremades, J. Kumita, S. Hsu +6 more
2010Journal of the American Chemical Society60 citations Open access
Semantic Scholar
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Ryan Limbocker, B. Mannini, F. Ruggeri, R. Cascella +18 more
2020Communications Biology55 citations Open access
Semantic Scholar
Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.
N. Cremades, A. Velázquez-Campoy, M. Martínez-Júlvez, J. Neira +6 more
2009ACS Chemical Biology54 citations
Semantic Scholar
Cell surface localised Hsp70 is a cancer specific regulator of clathrin‐independent endocytosis
Benedikt Nimmervoll, Lilia A. Chtcheglova, Kata Juhász, N. Cremades +6 more
2015FEBS Letters53 citations Open access
Semantic Scholar
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in Disease
P. Gracia, José D. Camino, L. Volpicelli-Daley, N. Cremades
2020International Journal of Molecular Sciences52 citations Open access
Semantic Scholar
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
F. Aprile, P. Arosio, Giuliana Fusco, Serene W. Chen +7 more
2017Biochemistry47 citations Open access
Semantic Scholar
Towards a new therapeutic target: Helicobacter pylori flavodoxin.
N. Cremades, Marta Bueno, Miguel Toja, J. Sancho
2005Biophysical Chemistry47 citations Open access
Semantic Scholar
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
Ryan Limbocker, N. Cremades, R. Cascella, Peter M. Tessier +2 more
2023Accounts of Chemical Research42 citations Open access
Semantic Scholar
Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme.
Barbara Zambelli, N. Cremades, P. Neyroz, P. Turano +2 more
2012Molecular Biosystems40 citations
Semantic Scholar
The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates
José D. Camino, P. Gracia, Serene W. Chen, J. Sot +6 more
2020bioRxiv38 citations Open access
Semantic Scholar
All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species
Aitor Franco, P. Gracia, A. Colom, José D. Camino +8 more
2021Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.
N. Cremades, A. Velázquez-Campoy, E. Freire, J. Sancho
2008Biochemistry32 citations Open access
Semantic Scholar
Filling small, empty protein cavities: structural and energetic consequences.
Marta Bueno, N. Cremades, J. Neira, J. Sancho
2006Journal of Molecular Biology32 citations
Semantic Scholar
Common conformational changes in flavodoxins induced by FMN and anion binding: The structure of Helicobacter pylori apoflavodoxin
M. Martínez-Júlvez, N. Cremades, Marta Bueno, I. Pérez-Dorado +6 more
2007Proteins: Structure, Function, and Bioinformatics28 citations
Semantic Scholar
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
G. Tóth, T. Neumann, Amandine Berthet, E. Masliah +26 more
2019Scientific Reports26 citations Open access
Semantic Scholar
Structure and Properties of a Complex of alpha-Synuclein and a Single-Domain Camelid Antibody
E. De Genst, Tim Guilliams, Joke Wellens, E. O'Day +9 more
201026 citations
Semantic Scholar
The native-state ensemble of proteins provides clues for folding, misfolding and function.
N. Cremades, J. Sancho, E. Freire
2006TIBS -Trends in Biochemical Sciences. Regular ed25 citations
Semantic Scholar
Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Z. Du +8 more
2022Molecules15 citations Open access
Semantic Scholar
Preparation of α-Synuclein Amyloid Assemblies for Toxicity Experiments.
Serene W. Chen, N. Cremades
2018Methods in molecular biology13 citations
Semantic Scholar

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