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M. Horrocks · SciRah

Researcher profile · Semantic Scholar

M. Horrocks

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M. Horrocks — researcher profile on SciRah

h-index: 31
Works: 98
Citations: 4,506

Most-cited papers

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
M. H. Ludtmann, Plamena R. Angelova, M. Horrocks, Minee L. Choi +19 more
2018Nature Communications460 citations Open access
Semantic Scholar
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
E. Deas, N. Cremades, Plamena R. Angelova, M. H. Ludtmann +12 more
2016Antioxidants and Redox Signaling351 citations Open access
Semantic Scholar
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Plamena R. Angelova, Minee L. Choi, A. Berezhnov, M. Horrocks +15 more
2020Cell Death and Differentiation270 citations Open access
Semantic Scholar
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, B. P. Singh, Catherine Maclachlan +26 more
2022Nature Neuroscience223 citations Open access
Semantic Scholar
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Marija Iljina, Gonzalo A. Garcia, M. Horrocks, Laura Tosatto +9 more
2016Proceedings of the National Academy of Sciences of the United States of America221 citations Open access
Semantic Scholar
Ubiquitin chain conformation regulates recognition and activity of interacting proteins
Yu Ye, Georg Blaser, M. Horrocks, M. Ruedas-Rama +6 more
2012Nature199 citations Open access
Semantic Scholar
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
Amy K. Reeve, M. H. Ludtmann, Plamena R. Angelova, E. Simcox +5 more
2015Cell Death and Disease195 citations Open access
Semantic Scholar
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
Sarah L. Shammas, Gonzalo A. Garcia, Satish Kumar, M. Kjaergaard +6 more
2015Nature Communications184 citations Open access
Semantic Scholar
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping
Marie N. Bongiovanni, J. Godet, M. Horrocks, Laura Tosatto +9 more
2016Nature Communications183 citations Open access
Semantic Scholar
Synaptic oligomeric tau in Alzheimer's disease - a potential culprit in the spread of tau pathology through the brain
Martí Colom‐Cadena, C. Davies, S. Sirisi, Ji-Eun Lee +17 more
2023medRxiv182 citations Open access
Semantic Scholar
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
Plamena R. Angelova, M. H. Ludtmann, M. Horrocks, A. Negoda +7 more
2016Journal of Cell Science161 citations Open access
Semantic Scholar
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits
M. Broadhead, M. Horrocks, Fei Zhu, Leila Mureşan +9 more
2016Scientific Reports140 citations Open access
Semantic Scholar
Lipid peroxidation is essential for α-synuclein-induced cell death
Plamena R. Angelova, M. Horrocks, D. Klenerman, S. Gandhi +2 more
2015Journal of Neurochemistry138 citations Open access
Semantic Scholar
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
M. Horrocks, Steven F. Lee, S. Gandhi, Nadia K. Magdalinou +11 more
2016ACS Chemical Neuroscience113 citations Open access
Semantic Scholar
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
D. Cox, Daniel R. Whiten, James W. P. Brown, M. Horrocks +5 more
2018Journal of Biological Chemistry111 citations Open access
Semantic Scholar
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
Laura Tosatto, M. Horrocks, A. Dear, T. Knowles +4 more
2015Scientific Reports110 citations Open access
Semantic Scholar
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
Franziska Kundel, S. De, Patrick Flagmeier, M. Horrocks +5 more
2018ACS Chemical Biology104 citations Open access
Semantic Scholar
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
Ji-Eun Lee, Jason C. Sang, M. Rodrigues, A. Carr +8 more
2018Nano letters (Print)96 citations Open access
Semantic Scholar
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
M. Horrocks, Laura Tosatto, A. Dear, Gonzalo A. Garcia +6 more
2015Analytical Chemistry93 citations Open access
Semantic Scholar
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
Daniel R. Whiten, D. Cox, M. Horrocks, Christopher G. Taylor +8 more
2018Cell Reports68 citations Open access
Semantic Scholar
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
Marija Iljina, Liu Hong, M. Horrocks, M. H. Ludtmann +14 more
2017BMC Biology66 citations Open access
Semantic Scholar
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions
P. Jönsson, J. Southcombe, A. M. Santos, J. Huo +19 more
2016Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
Daniel R. Whiten, Yukun Zuo, L. Calo’, Minee L. Choi +13 more
2018ChemBioChem51 citations Open access
Semantic Scholar
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Z. Yao +22 more
2022npj Parkinson's Disease50 citations Open access
Semantic Scholar
Probing TDP-43 condensation using an in silico designed aptamer
E. Zacco, Owen Kantelberg, E. Milanetti, Alexandros Armaos +10 more
2022Nature Communications50 citations Open access
Semantic Scholar
LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions
C. Oi, Zoe Gidden, Louise V. Holyoake, Owen Kantelberg +3 more
2020Communications Biology48 citations Open access
Semantic Scholar
Coaggregation of κ-Casein and β-Lactoglobulin Produces Morphologically Distinct Amyloid Fibrils.
J. Raynes, L. Day, Pauline Crepin, M. Horrocks +1 more
2017Small42 citations Open access
Semantic Scholar
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
H. Spence, Fergal M. Waldron, Rebecca S. Saleeb, Anna-Leigh Brown +14 more
2023bioRxiv41 citations Open access
Semantic Scholar
Single molecule fluorescence under conditions of fast flow.
M. Horrocks, Hai-Tao Li, Jung-uk Shim, Rohan T. Ranasinghe +4 more
2012Analytical Chemistry37 citations Open access
Semantic Scholar
Detecting RNA base methylations in single cells by in situ hybridization
Rohan T. Ranasinghe, M. R. Challand, Kristina A. Ganzinger, Benjamin W. Lewis +7 more
2018Nature Communications35 citations Open access
Semantic Scholar
Small Fluorogenic Amino Acids for Peptide‐Guided Background‐Free Imaging
F. de Moliner, Zuzanna Konieczna, Lorena Mendive-Tapia, Rebecca S. Saleeb +6 more
2022Angewandte Chemie31 citations Open access
Semantic Scholar
Single-Molecule Measurements of Transient Biomolecular Complexes through Microfluidic Dilution
M. Horrocks, L. Rajah, P. Jönsson, M. Kjaergaard +3 more
2013Analytical Chemistry31 citations Open access
Semantic Scholar
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models
Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi +9 more
2023Nature Machine Intelligence28 citations Open access
Semantic Scholar
pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data
Samuel B. Pattle, Judi O’Shaughnessy, Owen Kantelberg, O. Rifai +7 more
2022The Journal of Pathology: Clinical Research28 citations Open access
Semantic Scholar
Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution
Christopher G. Taylor, G. Meisl, M. Horrocks, H. Zetterberg +2 more
2018Analytical Chemistry24 citations Open access
Semantic Scholar
The changing point-spread function: single-molecule-based super-resolution imaging
M. Horrocks, Matthieu Palayret, D. Klenerman, Steven F. Lee
2014Histochemistry and Cell Biology23 citations
Semantic Scholar
PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations.
A. Janeczek, Edoardo Scarpa, M. Horrocks, R. Tare +6 more
2017Nanomedicine22 citations Open access
Semantic Scholar
α-Synuclein–Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation
Irene Pérez-Pi, David Evans, M. Horrocks, N. Phạm +4 more
2019Analytical Chemistry15 citations Open access
Semantic Scholar
Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates
Franziska Kundel, Laura Tosatto, Daniel R. Whiten, David C. Wirthensohn +2 more
2018The FEBS Journal15 citations Open access
Semantic Scholar
PAINT using proteins: A new brush for super‐resolution artists
C. Oi, S. Mochrie, M. Horrocks, L. Regan
2020Protein Science14 citations Open access
Semantic Scholar
A sticky situation: Aberrant protein-protein interactions in Parkinson's disease.
James W. P. Brown, M. Horrocks
2020Seminars in Cell and Developmental Biology13 citations Open access
Semantic Scholar
Lipid‐induced polymorphic amyloid fibril formation by α‐synuclein
B. P. Singh, R. J. Morris, T. Kunath, C. MacPhee +1 more
2023Protein Science12 citations Open access
Semantic Scholar
Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry
Kiani Jeacock, Alexandre Chappard, Kelly J. Gallagher, C. Mackay +4 more
2023Journal of the American Society for Mass Spectrometry12 citations Open access
Semantic Scholar
Single‐Molecule Two‐Color Coincidence Detection of Unlabeled alpha‐Synuclein Aggregates
Alexandre Chappard, C. Leighton, Rebecca S. Saleeb, Kiani Jeacock +11 more
2023Angewandte Chemie12 citations Open access
Semantic Scholar
Bayesian inference of accurate population sizes and FRET efficiencies from single diffusing biomolecules.
R. R. Murphy, G. Danezis, M. Horrocks, S. Jackson +1 more
2014Analytical Chemistry11 citations Open access
Semantic Scholar
Synaptic expression of TAR-DNA-binding protein 43 in the mouse spinal cord determined using super-resolution microscopy
M. Broadhead, Ani Ayvazian-Hancock, Katherine G. Doucet, Owen Kantelberg +5 more
2023Frontiers in Molecular Neuroscience9 citations Open access
Semantic Scholar
Live‐cell super‐resolution imaging of actin using LifeAct‐14 with a PAINT‐based approach
Haresh Bhaskar, D. Kleinjan, C. Oi, Zoe Gidden +3 more
2022bioRxiv9 citations Open access
Semantic Scholar
A case of adenomyosis in a pigtailed monkey diagnosed by magnetic resonance imaging and treated with the novel pure antiestrogen, ICI 182,780.
J. Waterton, S. Breen, Michael Dukes, M. Horrocks +1 more
1993Laboratory animal science9 citations
Semantic Scholar
Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy
N. Vijiaratnam, C. Girges, Martin Wiegand, Claudia Ismail +26 more
2025Annals of Neurology8 citations Open access
Semantic Scholar
GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression
D. Athauda, James R. Evans, Laura Mahoney-Sánchez, Gurvir S. Virdi +24 more
2024bioRxiv8 citations Open access
Semantic Scholar

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