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F. Aprile · SciRah

Researcher profile · Semantic Scholar

F. Aprile

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F. Aprile — researcher profile on SciRah

h-index: 27
Works: 72
Citations: 4,580

Most-cited papers

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
N. Cremades, Samuel I. A. Cohen, E. Deas, A. Abramov +11 more
2012Cell905 citations Open access
Semantic Scholar
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Serene W. Chen, S. Drakulić, E. Deas, Myriam M. Ouberai +15 more
2015Proceedings of the National Academy of Sciences of the United States of America505 citations Open access
Semantic Scholar
The CamSol method of rational design of protein mutants with enhanced solubility.
Pietro Sormanni, F. Aprile, M. Vendruscolo
2015Journal of Molecular Biology485 citations
Semantic Scholar
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America268 citations Open access
Semantic Scholar
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S. De, David C Wirthensohn, Patrick Flagmeier, Craig D. Hughes +13 more
2019Nature Communications220 citations Open access
Semantic Scholar
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Gabriella T. Heller, F. Aprile, T. Michaels, Ryan Limbocker +12 more
2019Science Advances147 citations Open access
Semantic Scholar
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
Pietro Sormanni, F. Aprile, M. Vendruscolo
2015Proceedings of the National Academy of Sciences of the United States of America141 citations Open access
Semantic Scholar
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
S. Giorgetti, C. Greco, P. Tortora, F. Aprile
2018International Journal of Molecular Sciences132 citations Open access
Semantic Scholar
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.
P. Arosio, Thomas Müller, L. Rajah, Emma V. Yates +10 more
2016ACS Nano131 citations
Semantic Scholar
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
F. Aprile, Pietro Sormanni, Michele Perni, P. Arosio +4 more
2017Science Advances128 citations Open access
Semantic Scholar
Third generation antibody discovery methods: in silico rational design.
Pietro Sormanni, F. Aprile, M. Vendruscolo
2018Chemical Society Reviews111 citations
Semantic Scholar
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
F. Aprile, Emma Källstig, Galina Limorenko, M. Vendruscolo +2 more
2017Scientific Reports105 citations Open access
Semantic Scholar
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
Tim Guilliams, Farah El-Turk, A. Buell, E. O'Day +11 more
2013Journal of Molecular Biology104 citations Open access
Semantic Scholar
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Michele Perni, Patrick Flagmeier, Ryan Limbocker, R. Cascella +19 more
2018ACS Chemical Biology103 citations Open access
Semantic Scholar
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S. De, Daniel R. Whiten, F. Ruggeri, Craig D. Hughes +13 more
2019Acta Neuropathologica Communications89 citations Open access
Semantic Scholar
Hsp70 Oligomerization Is Mediated by an Interaction between the Interdomain Linker and the Substrate-Binding Domain
F. Aprile, Anne Dhulesia, F. Stengel, C. Roodveldt +6 more
2013PLoS ONE78 citations Open access
Semantic Scholar
SUPPORTING INFORMATION Rational design of a conformation-specific antibody for the quantification of Ab oligomers
F. Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur +14 more
202066 citations
Semantic Scholar
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.
Gabriella T. Heller, F. Aprile, Massimiliano Bonomi, C. Camilloni +2 more
2017Journal of Molecular Biology62 citations Open access
Semantic Scholar
Structure of a low-population binding intermediate in protein-RNA recognition
Aditi N. Borkar, M. F. Bardaro, C. Camilloni, F. Aprile +2 more
2016Proceedings of the National Academy of Sciences of the United States of America60 citations Open access
Semantic Scholar
Methods of probing the interactions between small molecules and disordered proteins
Gabriella T. Heller, F. Aprile, M. Vendruscolo
2017Cellular and Molecular Life Sciences58 citations Open access
Semantic Scholar
Cell surface localised Hsp70 is a cancer specific regulator of clathrin‐independent endocytosis
Benedikt Nimmervoll, Lilia A. Chtcheglova, Kata Juhász, N. Cremades +6 more
2015FEBS Letters53 citations Open access
Semantic Scholar
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
F. Aprile, P. Arosio, Giuliana Fusco, Serene W. Chen +7 more
2017Biochemistry47 citations Open access
Semantic Scholar
α-Synuclein Aggregation Is Triggered by Oligomeric Amyloid-β 42 via Heterogeneous Primary Nucleation
Devkee M. Vadukul, Marcell Papp, Rebecca J. Thrush, Jie-Lei Wang +3 more
2023Journal of the American Chemical Society42 citations Open access
Semantic Scholar
Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
Juan García-Revilla, A. Boza-Serrano, Yi-Yun Jin, Devkee M. Vadukul +9 more
2023Acta Neuropathologica35 citations Open access
Semantic Scholar
Structure of a low-population intermediate state in the release of an enzyme product
A. De Simone, F. Aprile, Anne Dhulesia, C. Dobson +1 more
2015eLife35 citations Open access
Semantic Scholar
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P. Arosio, Kevin C. Hu, F. Aprile, Thomas Müller +1 more
2016Analytical Chemistry28 citations
Semantic Scholar
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate.
F. Aprile, Pietro Sormanni, M. Vendruscolo
2015Biochemistry28 citations
Semantic Scholar
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
Michele Perni, A. T. van der Goot, Ryan Limbocker, T. V. van Ham +25 more
2021Frontiers in Cell and Developmental Biology24 citations Open access
Semantic Scholar
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation
A. Pras, Bert Houben, F. Aprile, Renée I. Seinstra +16 more
2020bioRxiv23 citations Open access
Semantic Scholar
The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli
Gaetano Invernizzi, F. Aprile, A. Natalello, A. Ghisleni +5 more
2012PLoS ONE23 citations Open access
Semantic Scholar
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T. Scheidt, J. Carozza, C. Kolbe, F. Aprile +12 more
2021Proceedings of the National Academy of Sciences of the United States of America21 citations Open access
Semantic Scholar
Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood–brain barrier using focused ultrasound
Tiffany G. Chan, Carmen L. Ruehl, S. Morse, M. Simon +5 more
2021Chemical Science20 citations Open access
Semantic Scholar
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease
Tatsuya Ikenoue, F. Aprile, Pietro Sormanni, F. Ruggeri +10 more
2020Scientific Reports20 citations Open access
Semantic Scholar
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
Michele Perni, F. Aprile, Sam Casford, B. Mannini +3 more
2017Scientific Reports20 citations Open access
Semantic Scholar
A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
Jean B. Bertoldo, T. Rodrigues, Lavinia Dunsmore, F. Aprile +8 more
2017Chem20 citations Open access
Semantic Scholar
Supporting Information Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
P. R. Lindstedt, F. Aprile, M. Matos, Michele Perni +11 more
201919 citations
Semantic Scholar
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells
Marie N. Bongiovanni, F. Aprile, Pietro Sormanni, M. Vendruscolo
2018International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates
Maya A. Wright, F. Aprile, P. Arosio, M. Vendruscolo +2 more
2015Chemical Communications19 citations Open access
Semantic Scholar
Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers
Ryan Limbocker, B. Mannini, Rodrigo Cataldi, Shianne Chhangur +12 more
2020International Journal of Molecular Sciences17 citations Open access
Semantic Scholar
Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis
P. R. Lindstedt, F. Aprile, Pietro Sormanni, R. Rakoto +3 more
2020Cell Chemical Biology15 citations Open access
Semantic Scholar
Structure and Dynamics of the Integrin LFA-1 I-Domain in the Inactive State Underlie its Inside-Out/Outside-In Signaling and Allosteric Mechanisms
P. Kukic, Hoi Tik Alvin Leung, Francesco Bemporad, F. Aprile +4 more
2015Structure15 citations Open access
Semantic Scholar
The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris
Marcella Bonanomi, Valentina Roffia, A. de Palma, A. Lombardi +5 more
2017Scientific Reports14 citations Open access
Semantic Scholar
Cooperative Assembly of Hsp70 Subdomain Clusters
Maya A. Wright, F. Aprile, Mathias M. J. Bellaiche, T. Michaels +5 more
2018Biochemistry13 citations Open access
Semantic Scholar
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis
G. Faravelli, S. Raimondi, L. Marchese, F. Partridge +11 more
2019Scientific Reports12 citations Open access
Semantic Scholar
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients
K. Kulenkampff, D. Emin, Roxine Staats, Yu P. Zhang +9 more
2022Chemical Science10 citations Open access
Semantic Scholar
University of Groningen Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation
O. Sin, Tristan V. de Jong, Alejandro Mata-Cabana, Michelle M. Kudron +15 more
10 citations
Semantic Scholar
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
F. Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur +14 more
2020Proceedings of the National Academy of Sciences of the United States of America9 citations Open access
Semantic Scholar
The Diagnostic Potential of Amyloidogenic Proteins
Yi-Yun Jin, Devkee M. Vadukul, Dimitra Gialama, Ying Ge +3 more
2021International Journal of Molecular Sciences8 citations Open access
Semantic Scholar
Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures
Tatsuya Ikenoue, F. Aprile, Pietro Sormanni, M. Vendruscolo
2021Frontiers in Neuroscience8 citations Open access
Semantic Scholar

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