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R. Cascella · SciRah

Researcher profile · Semantic Scholar

R. Cascella

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R. Cascella — researcher profile on SciRah

h-index: 37
Works: 80
Citations: 4,799

Most-cited papers

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Giuliana Fusco, Serene W. Chen, P. Williamson, R. Cascella +9 more
2017Science637 citations Open access
Semantic Scholar
Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View
Giovanna Cenini, A. Lloret, R. Cascella
2019Oxidative Medicine and Cellular Longevity428 citations Open access
Semantic Scholar
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America268 citations Open access
Semantic Scholar
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
R. Cascella, Serene W. Chen, A. Bigi, José D. Camino +5 more
2021Nature Communications201 citations Open access
Semantic Scholar
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.
B. Mannini, Estefania Mulvihill, C. Sgromo, R. Cascella +5 more
2014ACS Chemical Biology192 citations
Semantic Scholar
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
Annika Höhn, A. Tramutola, R. Cascella
2020Oxidative Medicine and Cellular Longevity166 citations Open access
Semantic Scholar
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
B. Mannini, R. Cascella, M. Zampagni, Maria van Waarde-Verhagen +11 more
2012Proceedings of the National Academy of Sciences of the United States of America159 citations Open access
Semantic Scholar
Calcium Dyshomeostasis in Alzheimer’s Disease Pathogenesis
R. Cascella, C. Cecchi
2021International Journal of Molecular Sciences156 citations Open access
Semantic Scholar
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Ryan Limbocker, Sean Chia, F. Ruggeri, Michele Perni +21 more
2019Nature Communications139 citations Open access
Semantic Scholar
Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
S. Rigacci, C. Miceli, C. Nediani, A. Berti +6 more
2015OncoTarget132 citations Open access
Semantic Scholar
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
E. Evangelisti, R. Cascella, M. Becatti, G. Marrazza +4 more
2016Scientific Reports109 citations Open access
Semantic Scholar
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Michele Perni, Patrick Flagmeier, Ryan Limbocker, R. Cascella +19 more
2018ACS Chemical Biology103 citations Open access
Semantic Scholar
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
R. Cascella, A. Bigi, N. Cremades, C. Cecchi
2022Cellular and Molecular Life Sciences101 citations Open access
Semantic Scholar
Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.
J. J. V. Branca, G. Morucci, M. Maresca, Barbara Tenci +6 more
2018Toxicology in Vitro89 citations Open access
Semantic Scholar
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors
Giulia Fani, B. Mannini, Giulia Vecchi, R. Cascella +4 more
2021ACS Chemical Neuroscience86 citations Open access
Semantic Scholar
TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells
C. Capitini, S. Conti, Michele Perni, Francesca Guidi +6 more
2014PLoS ONE86 citations Open access
Semantic Scholar
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers
E. Evangelisti, C. Cecchi, R. Cascella, C. Sgromo +4 more
2012Journal of Cell Science86 citations Open access
Semantic Scholar
Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies *
R. Cascella, C. Capitini, Giulia Fani, C. Dobson +2 more
2016Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro.
R. Cascella, S. Conti, B. Mannini, Xin-Yi Li +4 more
2013Biochimica et Biophysica Acta80 citations Open access
Semantic Scholar
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers
Seyyed Abolghasem Ghadami, Sean Chia, F. Ruggeri, G. Meisl +7 more
2020Biomacromolecules74 citations Open access
Semantic Scholar
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.
R. Cascella, S. Conti, F. Tatini, E. Evangelisti +5 more
2013Biochimica et Biophysica Acta70 citations Open access
Semantic Scholar
Allele specific Taqman-based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients.
P. Pinzani, F. Salvianti, R. Cascella, D. Massi +3 more
2010Clinica chimica acta; international journal of clinical chemistry68 citations
Semantic Scholar
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
M. Zampagni, R. Cascella, F. Casamenti, C. Grossi +8 more
2011Journal of Cellular and Molecular Medicine67 citations Open access
Semantic Scholar
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions
C. Di Natale, P. Scognamiglio, R. Cascella, C. Cecchi +9 more
2015The FASEB Journal60 citations Open access
Semantic Scholar
Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models.
M. Zampagni, D. Wright, R. Cascella, Giampiero D’Adamio +8 more
2012Free Radical Biology & Medicine56 citations
Semantic Scholar
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Ryan Limbocker, B. Mannini, F. Ruggeri, R. Cascella +18 more
2020Communications Biology55 citations Open access
Semantic Scholar
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
Ryan Limbocker, Roxine Staats, Sean Chia, F. Ruggeri +26 more
2021Frontiers in Neuroscience53 citations Open access
Semantic Scholar
Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates
Serene W. Chen, J. Barritt, R. Cascella, A. Bigi +8 more
2024Journal of the American Chemical Society51 citations Open access
Semantic Scholar
Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease.
E. Evangelisti, D. Wright, M. Zampagni, R. Cascella +8 more
2013Current Alzheimer Research50 citations Open access
Semantic Scholar
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
A. Bigi, R. Cascella, F. Chiti, C. Cecchi
2022Bioessays49 citations Open access
Semantic Scholar
The toxicity of misfolded protein oligomers is independent of their secondary structure.
Mirella Vivoli Vega, R. Cascella, Serene W. Chen, Giuliana Fusco +4 more
2019ACS Chemical Biology47 citations
Semantic Scholar
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
R. Cascella, Michele Perni, Serene W. Chen, Giuliana Fusco +5 more
2019ACS Chemical Biology45 citations Open access
Semantic Scholar
Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane
M. Zampagni, E. Evangelisti, R. Cascella, G. Liguri +9 more
2010Journal of molecular medicine45 citations
Semantic Scholar
Oxidative Stress and Mitochondrial Damage in Neurodegenerative Diseases: From Molecular Mechanisms to Targeted Therapies
Giovanna Cenini, A. Lloret, R. Cascella
2020Oxidative Medicine and Cellular Longevity44 citations Open access
Semantic Scholar
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
Ryan Limbocker, N. Cremades, R. Cascella, Peter M. Tessier +2 more
2023Accounts of Chemical Research42 citations Open access
Semantic Scholar
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia
P. Scognamiglio, C. Di Natale, M. Leone, R. Cascella +8 more
2016OncoTarget42 citations Open access
Semantic Scholar
Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload
R. Cascella, E. Evangelisti, A. Bigi, M. Becatti +4 more
2017Journal of Alzheimer's Disease41 citations Open access
Semantic Scholar
α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
A. Bigi, R. Cascella, C. Cecchi
2023Neural Regeneration Research36 citations Open access
Semantic Scholar
Quantitative assessment of the degradation of aggregated TDP‐43 mediated by the ubiquitin proteasome system and macroautophagy
R. Cascella, Giulia Fani, C. Capitini, P. Rusmini +3 more
2017The FASEB Journal36 citations Open access
Semantic Scholar
Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
J. Mehla, G. Malloci, R. Mansbach, C. López +18 more
2021mBio33 citations Open access
Semantic Scholar
Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
A. Bigi, Emilio Ermini, Serene W. Chen, R. Cascella +1 more
2021Life28 citations Open access
Semantic Scholar
Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy
R. Oropesa-Nuñez, Silvia Seghezza, S. Dante, A. Diaspro +5 more
2016OncoTarget28 citations Open access
Semantic Scholar
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species
Giulia Fani, Chiara Ester La Torre, R. Cascella, C. Cecchi +2 more
2022Cellular and Molecular Life Sciences27 citations Open access
Semantic Scholar
Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.
M. Calamai, E. Evangelisti, R. Cascella, Niccoló Parenti +3 more
2016Biochimica et Biophysica Acta26 citations Open access
Semantic Scholar
Light-responsive nanocomposite sponges for on demand chemical release with high spatial and dosage control.
P. Matteini, M. Martina, G. Giambastiani, F. Tatini +6 more
2013Journal of materials chemistry. B26 citations
Semantic Scholar
The acute myeloid leukemia‐associated Nucleophosmin 1 gene mutations dictate amyloidogenicity of the C‐terminal domain
S. La Manna, P. Scognamiglio, V. Roviello, F. Borbone +9 more
2019The FEBS Journal25 citations Open access
Semantic Scholar
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
R. Cascella, A. Bigi, Dylan Giorgino Riffert, M. Gagliani +5 more
2022Science Advances24 citations Open access
Semantic Scholar
Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases
R. Cascella, Giulia Fani, A. Bigi, F. Chiti +1 more
2019International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans.
R. Cascella, E. Evangelisti, M. Zampagni, M. Becatti +5 more
2014Free Radical Biology & Medicine23 citations
Semantic Scholar
Plasma Membrane Injury Depends on Bilayer Lipid Composition in Alzheimer's Disease
E. Evangelisti, M. Zampagni, R. Cascella, M. Becatti +5 more
2014Journal of Alzheimer's Disease22 citations
Semantic Scholar

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C. Cecchi×41
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C. Cecchi — researcher profile on SciRah
F. Chiti×30
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C. Dobson×16
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C. Dobson — researcher profile on SciRah
A. Bigi×12
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×11

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M. Vendruscolo — researcher profile on SciRah

E. Evangelisti×11

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E. Evangelisti — researcher profile on SciRah

Serene W. Chen×9

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Serene W. Chen — researcher profile on SciRah

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B. Mannini — researcher profile on SciRah

Michele Perni×8

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Michele Perni — researcher profile on SciRah

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N. Cremades — researcher profile on SciRah

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M. Zampagni — researcher profile on SciRah

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M. Becatti — researcher profile on SciRah