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P. Hoffman · SciRah

Researcher profile · Semantic Scholar

P. Hoffman

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P. Hoffman — researcher profile on SciRah

h-index: 47
Works: 123
Citations: 6,218

Most-cited papers

Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen‐insensitive NADPH nitroreductase
A. Goodwin, D. Kersulyte, G. Sisson, S. V. van Zanten +2 more
1998Molecular Microbiology389 citations Open access
Semantic Scholar
Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected Anaerobic Bacteria and Parasites, and Campylobacter jejuni
P. Hoffman, G. Sisson, Matthew A. Croxen, K. Welch +3 more
2006Antimicrobial Agents and Chemotherapy245 citations Open access
Semantic Scholar
Surface-Associated Hsp60 Chaperonin of Legionella pneumophila Mediates Invasion in a HeLa Cell Model
R. Garduño, E. Garduño, P. Hoffman
1998Infection and Immunity232 citations Open access
Semantic Scholar
The Helicobacter pylori Chemotaxis Receptor TlpB (HP0103) Is Required for pH Taxis and for Colonization of the Gastric Mucosa
Matthew A. Croxen, G. Sisson, R. Melano, P. Hoffman
2006Journal of Bacteriology184 citations Open access
Semantic Scholar
Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori: Genetic and Kinetic Characterization
L. Baker, A. Raudonikiene, P. Hoffman, L. Poole
2001Journal of Bacteriology182 citations Open access
Semantic Scholar
Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori
G. Sisson, A. Goodwin, A. Raudonikiene, Nicky J. Hughes +3 more
2002Antimicrobial Agents and Chemotherapy171 citations Open access
Semantic Scholar
Treatment of intestinal parasitic infections: a review of nitazoxanide.
H. Gilles, P. Hoffman
2002Trends in Parasitology166 citations
Semantic Scholar
Systematic Identification of Selective Essential Genes in Helicobacter pylori by Genome Prioritization and Allelic Replacement Mutagenesis
A. F. Chalker, H. Minehart, Nicky J. Hughes, K. Koretke +7 more
2001Journal of Bacteriology162 citations Open access
Semantic Scholar
Newer Antibacterial Drugs for a New Century
Gina Devasahayam, W. Scheld, P. Hoffman
2010Expert Opinion on Investigational Drugs161 citations Open access
Semantic Scholar
Intracellular Growth of Legionella pneumophila Gives Rise to a Differentiated Form Dissimilar to Stationary-Phase Forms
R. Garduño, E. Garduño, Margot F Hiltz, P. Hoffman
2002Infection and Immunity161 citations Open access
Semantic Scholar
Sequential Inactivation of rdxA (HP0954) and frxA (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in Helicobacter pylori
J. Jeong, A. Mukhopadhyay, D. Dailidiene, Yipeng Wang +19 more
2000Journal of Bacteriology138 citations Open access
Semantic Scholar
Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in Helicobacter pylori and inEscherichia coli Containing a Cloned H. pylori rdxA+ (Nitroreductase) Gene
G. Sisson, J. Jeong, A. Goodwin, L. Bryden +5 more
2000Journal of Bacteriology136 citations Open access
Semantic Scholar
Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.
Y. Qu, J. R. Olsen, Xing Yuan, P. Cheng +7 more
2018Nature Chemical Biology134 citations
Semantic Scholar
Metabolic activities of metronidazole-sensitive and -resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance
P. Hoffman, A. Goodwin, J. Johnsen, K. Magee +1 more
1996Journal of Bacteriology124 citations Open access
Semantic Scholar
Persistent G. lamblia impairs growth in a murine malnutrition model.
L. Bartelt, J. Roche, G. Kolling, David T. Bolick +6 more
2013Journal of Clinical Investigation110 citations Open access
Semantic Scholar
Germination and Amplification of Anthrax Spores by Soil-Dwelling Amoebas
R. Dey, P. Hoffman, I. Glomski
2012Applied and Environmental Microbiology102 citations Open access
Semantic Scholar
Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells
P. Hoffman, L. Houston, C. A. Butler
1990Infection and Immunity97 citations Open access
Semantic Scholar
Antibacterial Discovery: 21st Century Challenges
P. Hoffman
2020Antibiotics96 citations Open access
Semantic Scholar
Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence
R. Fernandez, S. Logan, Spencer H. S. Lee, P. Hoffman
1996Infection and Immunity93 citations Open access
Semantic Scholar
Roles of FrxA and RdxA Nitroreductases ofHelicobacter pylori in Susceptibility and Resistance to Metronidazole
J. Jeong, A. Mukhopadhyay, J. Akada, D. Dailidiene +2 more
2001Journal of Bacteriology92 citations Open access
Semantic Scholar
Cloning and temperature-dependent expression in Escherichia coli of a Legionella pneumophila gene coding for a genus-common 60-kilodalton antigen
P. Hoffman, C. A. Butler, F. D. Quinn
1989Infection and Immunity92 citations Open access
Semantic Scholar
Immunolocalization of Hsp60 inLegionella pneumophila
R. Garduño, G. Faulkner, M. Trevors, N. Vats +1 more
1998Journal of Bacteriology85 citations Open access
Semantic Scholar
Insertion of Mini-IS605 and Deletion of Adjacent Sequences in the Nitroreductase (rdxA) Gene Cause Metronidazole Resistance in Helicobacter pyloriNCTC11637
Y. Debets-Ossenkopp, R. Pot, D. V. van Westerloo, A. Goodwin +4 more
1999Antimicrobial Agents and Chemotherapy79 citations Open access
Semantic Scholar
Microaerophily and Oxygen Toxicity
N. Krieg, P. Hoffman
198677 citations
Semantic Scholar
CRYPTOSPORIDIUM-MALNUTRITION INTERACTIONS: MUCOSAL DISRUPTION, CYTOKINES, AND TLR SIGNALING IN A WEANED MURINE MODEL
L. Costa, Eric A JohnBull, J. Reeves, J. Sevilleja +7 more
2011Journal of Parasitology76 citations Open access
Semantic Scholar
Characterization of a Legionella pneumophila extracellular protease exhibiting hemolytic and cytotoxic activities
M. Keen, P. Hoffman
1989Infection and Immunity74 citations Open access
Semantic Scholar
The i genome sequence: G genome sequence: Genetic factors for long life in the gastric mucosa
D. Berg, P. Hoffman, B. Appelmelk, J. Kusters
199773 citations
Semantic Scholar
Flavodoxin:Quinone Reductase (FqrB): a Redox Partner of Pyruvate:Ferredoxin Oxidoreductase That Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni
M. St. Maurice, N. Cremades, Matthew A. Croxen, G. Sisson +2 more
2007Journal of Bacteriology68 citations Open access
Semantic Scholar
A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila
A. Brassinga, Margot F Hiltz, G. Sisson, Michael G. Morash +5 more
2003Journal of Bacteriology60 citations Open access
Semantic Scholar
Compensatory Functions of Two Alkyl Hydroperoxide Reductases in the Oxidative Defense System of Legionella pneumophila
J. LeBlanc, R. Davidson, P. Hoffman
2006Journal of Bacteriology58 citations Open access
Semantic Scholar
Vancomycin Treatment's Association with Delayed Intestinal Tissue Injury, Clostridial Overgrowth, and Recurrence of Clostridium difficile Infection in Mice
C. Warren, E. Van Opstal, Mary S. Riggins, Yuesheng Li +4 more
2012Antimicrobial Agents and Chemotherapy57 citations Open access
Semantic Scholar
Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection.
N. Cremades, A. Velázquez-Campoy, M. Martínez-Júlvez, J. Neira +6 more
2009ACS Chemical Biology54 citations
Semantic Scholar
An inducible tellurite-resistance operon in Proteus mirabilis.
Anna Toptchieva, G. Sisson, L. Bryden, Diane E. Taylor +1 more
2003Microbiology54 citations Open access
Semantic Scholar
Identification of differentially regulated proteins in metronidozole resistant Helicobacter pylori by proteome techniques
C. Patrick McAtee, P. Hoffman, D. Berg
2001Proteomics54 citations
Semantic Scholar
Surface-associated heat shock proteins of Legionella pneumophila and Helicobacter pylori: roles in pathogenesis and immunity.
P. Hoffman, R. Garduño
1999Infectious Diseases in Obstetrics and Gynecology54 citations Open access
Semantic Scholar
Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn4401 Deletion
Anita Cheruvanky, N. Stoesser, A. Sheppard, D. Crook +8 more
2017Antimicrobial Agents and Chemotherapy53 citations Open access
Semantic Scholar
Cysteine Metabolism in Legionella pneumophila: Characterization of an l-Cystine-Utilizing Mutant
F. Ewann, P. Hoffman
2006Applied and Environmental Microbiology53 citations
Semantic Scholar
Nitazoxanide Inhibits Biofilm Production and Hemagglutination by Enteroaggregative Escherichia coli Strains by Blocking Assembly of AafA Fimbriae
E. Shamir, Michelle D. Warthan, Sareena P Brown, J. Nataro +2 more
2010Antimicrobial Agents and Chemotherapy48 citations Open access
Semantic Scholar
CARB-9, a Carbenicillinase Encoded in the VCR Region of Vibrio cholerae Non-O1, Non-O139 Belongs to a Family of Cassette-Encoded β-Lactamases
A. Petroni, R. Melano, H. A. Saka, Alicia Garutti +8 more
2004Antimicrobial Agents and Chemotherapy48 citations Open access
Semantic Scholar
Development of an Interleukin-12-Deficient Mouse Model That Is Permissive for Colonization by a Motile KE26695 Strain of Helicobacter pylori
P. Hoffman, N. Vats, D. Hutchison, Jared J. Butler +5 more
2003Infection and Immunity47 citations Open access
Semantic Scholar
Response to Metronidazole and Oxidative Stress Is Mediated through Homeostatic Regulator HsrA (HP1043) in Helicobacter pylori
I. Olekhnovich, Serhiy Vitko, Meaghan A. Valliere, P. Hoffman
2013Journal of Bacteriology41 citations Open access
Semantic Scholar
Reciprocal Expression of Integration Host Factor and HU in the Developmental Cycle and Infectivity of Legionella pneumophila
Michael G. Morash, A. Brassinga, Michelle D. Warthan, Poornima Gourabathini +3 more
2009Applied and Environmental Microbiology39 citations Open access
Semantic Scholar
The Largest Subunits of RNA Polymerase from Gastric Helicobacters Are Tethered*
N. Zakharova, P. Hoffman, D. Berg, K. Severinov
1998Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Role of keto acids and reduced-oxygen-scavenging enzymes in the growth of Legionella species
L. Pine, P. Hoffman, G. Malcolm, R. Benson +1 more
1986Journal of Clinical Microbiology37 citations Open access
Semantic Scholar
Antisense RNA Modulation of Alkyl Hydroperoxide Reductase Levels in Helicobacter pylori Correlates with Organic Peroxide Toxicity but Not Infectivity
Matthew A. Croxen, P. Ernst, P. Hoffman
2007Journal of Bacteriology33 citations Open access
Semantic Scholar
Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane
Peter Chahales, P. Hoffman, D. Thanassi
2016Antimicrobial Agents and Chemotherapy32 citations Open access
Semantic Scholar
An Ortholog of OxyR in Legionella pneumophila Is Expressed Postexponentially and Negatively Regulates the Alkyl Hydroperoxide Reductase (ahpC2D) Operon
J. LeBlanc, A. Brassinga, F. Ewann, R. Davidson +1 more
2008Journal of Bacteriology32 citations Open access
Semantic Scholar
Ability of laboratory methods to predict in-use efficacy of antimicrobial preservatives in an experimental cosmetic
J. Farrington, E. Martz, S. J. Wells, C. Ennis +6 more
1994Applied and Environmental Microbiology32 citations Open access
Semantic Scholar
Improved flavodoxin inhibitors with potential therapeutic effects against Helicobacter pylori infection.
Juan J. Galano, M. Alías, Reyes Pérez, A. Velázquez-Campoy +2 more
2013Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Efficacy of antiamebic drugs in a mouse model.
Stephen M. Becker, P. Hoffman, E. Houpt
2011American Journal of Tropical Medicine and Hygiene31 citations Open access
Semantic Scholar

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A. Goodwin×6
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Matthew A. Croxen

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