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Michele Perni · SciRah

Researcher profile · Semantic Scholar

Michele Perni

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Michele Perni — researcher profile on SciRah

h-index: 20
Works: 50
Citations: 2,669

Most-cited papers

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Giuliana Fusco, Serene W. Chen, P. Williamson, R. Cascella +9 more
2017Science637 citations Open access
Semantic Scholar
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America268 citations Open access
Semantic Scholar
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J. Habchi, Sean Chia, Ryan Limbocker, B. Mannini +11 more
2016Proceedings of the National Academy of Sciences of the United States of America215 citations Open access
Semantic Scholar
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J. Habchi, P. Arosio, Michele Perni, A. R. Costa +10 more
2016Science Advances190 citations Open access
Semantic Scholar
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Gabriella T. Heller, F. Aprile, T. Michaels, Ryan Limbocker +12 more
2019Science Advances147 citations Open access
Semantic Scholar
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Ryan Limbocker, Sean Chia, F. Ruggeri, Michele Perni +21 more
2019Nature Communications139 citations Open access
Semantic Scholar
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
F. Aprile, Pietro Sormanni, Michele Perni, P. Arosio +4 more
2017Science Advances128 citations Open access
Semantic Scholar
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Michele Perni, Patrick Flagmeier, Ryan Limbocker, R. Cascella +19 more
2018ACS Chemical Biology103 citations Open access
Semantic Scholar
TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells
C. Capitini, S. Conti, Michele Perni, Francesca Guidi +6 more
2014PLoS ONE86 citations Open access
Semantic Scholar
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
U. Nowicka, P. Chrościcki, K. Stroobants, Maria Sladowska +8 more
2021bioRxiv83 citations Open access
Semantic Scholar
SUPPORTING INFORMATION Rational design of a conformation-specific antibody for the quantification of Ab oligomers
F. Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur +14 more
202066 citations
Semantic Scholar
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
Michele Perni, P. Challa, J. B. Kirkegaard, Ryan Limbocker +14 more
2018Journal of Neuroscience Methods61 citations Open access
Semantic Scholar
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
B. Mannini, J. Habchi, Sean Chia, F. Ruggeri +4 more
2018ACS Chemical Neuroscience56 citations Open access
Semantic Scholar
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Ryan Limbocker, B. Mannini, F. Ruggeri, R. Cascella +18 more
2020Communications Biology55 citations Open access
Semantic Scholar
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
Ryan Limbocker, Roxine Staats, Sean Chia, F. Ruggeri +26 more
2021Frontiers in Neuroscience53 citations Open access
Semantic Scholar
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
M. Koopman, Q. Peter, Renée I. Seinstra, Michele Perni +4 more
2020Nature Protocols49 citations Open access
Semantic Scholar
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
R. Cascella, Michele Perni, Serene W. Chen, Giuliana Fusco +5 more
2019ACS Chemical Biology45 citations Open access
Semantic Scholar
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Rodrigo Cataldi, Sean Chia, Katarina Pisani, F. Ruggeri +12 more
2021Communications Biology44 citations Open access
Semantic Scholar
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans
R. Laine, T. Sinnige, K. Ma, A. Haack +9 more
2018bioRxiv35 citations Open access
Semantic Scholar
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
Michele Perni, A. T. van der Goot, Ryan Limbocker, T. V. van Ham +25 more
2021Frontiers in Cell and Developmental Biology24 citations Open access
Semantic Scholar
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease
Tatsuya Ikenoue, F. Aprile, Pietro Sormanni, F. Ruggeri +10 more
2020Scientific Reports20 citations Open access
Semantic Scholar
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation
D. C. Delivoria, Sean Chia, J. Habchi, Michele Perni +7 more
2019Science Advances20 citations Open access
Semantic Scholar
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
Michele Perni, F. Aprile, Sam Casford, B. Mannini +3 more
2017Scientific Reports20 citations Open access
Semantic Scholar
Supporting Information Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
P. R. Lindstedt, F. Aprile, M. Matos, Michele Perni +11 more
201919 citations
Semantic Scholar
Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
Priyanka Joshi, Michele Perni, Ryan Limbocker, B. Mannini +6 more
2021Communications Biology15 citations Open access
Semantic Scholar
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer’s Disease
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese +15 more
2021Pharmaceuticals12 citations Open access
Semantic Scholar
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
Michele Perni, B. Mannini, Catherine K. Xu, J. Kumita +3 more
2021Scientific Reports12 citations Open access
Semantic Scholar
C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis
G. Faravelli, S. Raimondi, L. Marchese, F. Partridge +11 more
2019Scientific Reports12 citations Open access
Semantic Scholar
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
F. Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur +14 more
2020Proceedings of the National Academy of Sciences of the United States of America9 citations Open access
Semantic Scholar
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform.
Michele Perni, Sam Casford, F. Aprile, E. Nollen +3 more
2018Journal of Visualized Experiments8 citations Open access
Semantic Scholar
Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni +5 more
2023ACS Chemical Neuroscience7 citations Open access
Semantic Scholar
Targeting Protein Aggregation in ALS
Michele Perni, B. Mannini
2024Biomolecules4 citations
Semantic Scholar
Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni +2 more
2021bioRxiv3 citations Open access
Semantic Scholar
Anti-aging properties of the aminosterols of the dogfish shark
Denise Barbut, Michele Perni, Michael A. Zasloff
2024npj Aging2 citations
Semantic Scholar
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
Sean Chia, J. Habchi, Ryan Limbocker, B. Mannini +11 more
20182 citations Open access
Semantic Scholar
Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compounds
William R. Smisko, W. Haury, Michele Perni, Rebecca Kalik +7 more
2026bioRxiv1 citations Open access
Semantic Scholar
Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions across development
Amanda E. Friedman, Michele Perni, Josephine Millard, Damjan Karanfilovski +2 more
2026bioRxiv1 citations Open access
Semantic Scholar
Unique and overlapping behavioral effects of isoform-specific NRXN1 deletions
Amanda E. Friedman, Michele Perni, Josephine Millard, Damjan Karanfilovski +2 more
2026Disease Models & Mechanisms1 citations Open access
Semantic Scholar
Publisher Correction: A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Rodrigo Cataldi, Sean Chia, Katarina Pisani, F. Ruggeri +12 more
2021Communications Biology1 citations Open access
Semantic Scholar
SG-2: A promising lipolytic and pro-autophagic hit-compound to treat Alzheimer’s disease
Massimiliano Runfola, Michele Perni, S. Sestito, G. Chiellini +2 more
20201 citations Open access
Semantic Scholar
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
Ryan Limbocker, B. Mannini, Sean Chia, F. Ruggeri +9 more
20181 citations Open access
Semantic Scholar
Attenuating the Toxicity of Amyloid-Beta Aggregation with Specific Species
Ryan Limbocker, B. Mannini, Michele Perni, Sean Chia +9 more
20171 citations Open access
Semantic Scholar
Counteraction of amyloid-β aggregation by vitamin A and E metabolites in a crowded environment
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni +2 more
2022Biophysical Journal0 citations Open access
Semantic Scholar
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response
Priyanka Joshi, Michele Perni, Ryan Limbocker, B. Mannini +6 more
2021Communications Biology0 citations Open access
Semantic Scholar
Multistep Inhibition of a-synuclein aggregation and toxicity in vitro 1 and in vivo by trodusquemine 2 3
Michele Perni, Patrick Flagmeier, Ryan Limbocker, R. Cascella +20 more
20190 citations
Semantic Scholar
Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
F. Aprile, Pietro Sormanni, Michele Perni, P. Arosio +4 more
2019Biophysical Journal0 citations Open access
Semantic Scholar
Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans
T. Sinnige, R. Laine, K. Ma, A. Haack +8 more
20180 citations Open access
Semantic Scholar
Establishing C. elegans as a high-throughput system for the identification of novel therapeutic strategies for Parkinson’s disease
Michele Perni
20170 citations
Semantic Scholar
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
Michele Perni, F. Aprile, Sam Casford, B. Mannini +3 more
2017Scientific Reports0 citations Open access
Semantic Scholar

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