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C. Cecchi · SciRah

Researcher profile · Semantic Scholar

C. Cecchi

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C. Cecchi — researcher profile on SciRah

h-index: 42
Works: 129
Citations: 5,946

Most-cited papers

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Giuliana Fusco, Serene W. Chen, P. Williamson, R. Cascella +9 more
2017Science637 citations Open access
Semantic Scholar
A causative link between the structure of aberrant protein oligomers and their toxicity.
Silvia Campioni, B. Mannini, M. Zampagni, Anna Pensalfini +7 more
2010Nature Chemical Biology559 citations
Semantic Scholar
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni, Céline Galvagnion, Alexander S. Maltsev, G. Meisl +20 more
2017Proceedings of the National Academy of Sciences of the United States of America268 citations Open access
Semantic Scholar
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
R. Cascella, Serene W. Chen, A. Bigi, José D. Camino +5 more
2021Nature Communications201 citations Open access
Semantic Scholar
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.
B. Mannini, Estefania Mulvihill, C. Sgromo, R. Cascella +5 more
2014ACS Chemical Biology192 citations
Semantic Scholar
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
B. Mannini, R. Cascella, M. Zampagni, Maria van Waarde-Verhagen +11 more
2012Proceedings of the National Academy of Sciences of the United States of America159 citations Open access
Semantic Scholar
Calcium Dyshomeostasis in Alzheimer’s Disease Pathogenesis
R. Cascella, C. Cecchi
2021International Journal of Molecular Sciences156 citations Open access
Semantic Scholar
SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
M. Becatti, N. Taddei, C. Cecchi, N. Nassi +2 more
2012Cellular and Molecular Life Sciences142 citations Open access
Semantic Scholar
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Ryan Limbocker, Sean Chia, F. Ruggeri, Michele Perni +21 more
2019Nature Communications139 citations Open access
Semantic Scholar
The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity.
C. Cecchi, M. Stefani
2013Biophysical Chemistry113 citations
Semantic Scholar
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
E. Evangelisti, R. Cascella, M. Becatti, G. Marrazza +4 more
2016Scientific Reports109 citations Open access
Semantic Scholar
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
Michele Perni, Patrick Flagmeier, Ryan Limbocker, R. Cascella +19 more
2018ACS Chemical Biology103 citations Open access
Semantic Scholar
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
R. Cascella, A. Bigi, N. Cremades, C. Cecchi
2022Cellular and Molecular Life Sciences101 citations Open access
Semantic Scholar
Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways.
C. Fiorillo, M. Becatti, Anna Pensalfini, C. Cecchi +6 more
2008Free Radical Biology & Medicine89 citations Open access
Semantic Scholar
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors
Giulia Fani, B. Mannini, Giulia Vecchi, R. Cascella +4 more
2021ACS Chemical Neuroscience86 citations Open access
Semantic Scholar
TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells
C. Capitini, S. Conti, Michele Perni, Francesca Guidi +6 more
2014PLoS ONE86 citations Open access
Semantic Scholar
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers
E. Evangelisti, C. Cecchi, R. Cascella, C. Sgromo +4 more
2012Journal of Cell Science86 citations Open access
Semantic Scholar
Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies *
R. Cascella, C. Capitini, Giulia Fani, C. Dobson +2 more
2016Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro.
R. Cascella, S. Conti, B. Mannini, Xin-Yi Li +4 more
2013Biochimica et Biophysica Acta80 citations Open access
Semantic Scholar
Immune-related Adverse Events of Pembrolizumab in a Large Real-world Cohort of Patients With NSCLC With a PD-L1 Expression ≥ 50% and Their Relationship With Clinical Outcomes.
A. Cortellini, A. Friedlaender, G. Banna, G. Porzio +67 more
2020Clinical Lung Cancer79 citations Open access
Semantic Scholar
A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cells.
C. Cecchi, Daniela Nichino, M. Zampagni, C. Bernacchioni +6 more
2009Biochimica et Biophysica Acta76 citations Open access
Semantic Scholar
SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival
M. Becatti, C. Fiorillo, V. Barygina, C. Cecchi +5 more
2014Journal of Cellular and Molecular Medicine71 citations Open access
Semantic Scholar
Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
C. Cecchi, Fabiana Rosati, Anna Pensalfini, L. Formigli +9 more
2008Journal of Cellular and Molecular Medicine71 citations Open access
Semantic Scholar
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.
R. Cascella, S. Conti, F. Tatini, E. Evangelisti +5 more
2013Biochimica et Biophysica Acta70 citations Open access
Semantic Scholar
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
M. Zampagni, R. Cascella, F. Casamenti, C. Grossi +8 more
2011Journal of Cellular and Molecular Medicine67 citations Open access
Semantic Scholar
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions
C. Di Natale, P. Scognamiglio, R. Cascella, C. Cecchi +9 more
2015The FASEB Journal60 citations Open access
Semantic Scholar
Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models.
M. Zampagni, D. Wright, R. Cascella, Giampiero D’Adamio +8 more
2012Free Radical Biology & Medicine56 citations
Semantic Scholar
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism
Ryan Limbocker, B. Mannini, F. Ruggeri, R. Cascella +18 more
2020Communications Biology55 citations Open access
Semantic Scholar
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
Ryan Limbocker, Roxine Staats, Sean Chia, F. Ruggeri +26 more
2021Frontiers in Neuroscience53 citations Open access
Semantic Scholar
Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates
Serene W. Chen, J. Barritt, R. Cascella, A. Bigi +8 more
2024Journal of the American Chemical Society51 citations Open access
Semantic Scholar
Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease.
E. Evangelisti, D. Wright, M. Zampagni, R. Cascella +8 more
2013Current Alzheimer Research50 citations Open access
Semantic Scholar
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
A. Bigi, R. Cascella, F. Chiti, C. Cecchi
2022Bioessays49 citations Open access
Semantic Scholar
The toxicity of misfolded protein oligomers is independent of their secondary structure.
Mirella Vivoli Vega, R. Cascella, Serene W. Chen, Giuliana Fusco +4 more
2019ACS Chemical Biology47 citations
Semantic Scholar
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
R. Cascella, Michele Perni, Serene W. Chen, Giuliana Fusco +5 more
2019ACS Chemical Biology45 citations Open access
Semantic Scholar
Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblasts.
Anna Pensalfini, M. Zampagni, G. Liguri, M. Becatti +7 more
2011Neurobiology of Aging45 citations Open access
Semantic Scholar
Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane
M. Zampagni, E. Evangelisti, R. Cascella, G. Liguri +9 more
2010Journal of molecular medicine45 citations
Semantic Scholar
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia
P. Scognamiglio, C. Di Natale, M. Leone, R. Cascella +8 more
2016OncoTarget42 citations Open access
Semantic Scholar
Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload
R. Cascella, E. Evangelisti, A. Bigi, M. Becatti +4 more
2017Journal of Alzheimer's Disease41 citations Open access
Semantic Scholar
α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
A. Bigi, R. Cascella, C. Cecchi
2023Neural Regeneration Research36 citations Open access
Semantic Scholar
Quantitative assessment of the degradation of aggregated TDP‐43 mediated by the ubiquitin proteasome system and macroautophagy
R. Cascella, Giulia Fani, C. Capitini, P. Rusmini +3 more
2017The FASEB Journal36 citations Open access
Semantic Scholar
Differentiation Increases the Resistance of Neuronal Cells to Amyloid Toxicity
C. Cecchi, Anna Pensalfini, G. Liguri, S. Baglioni +6 more
2008Neurochemical Research35 citations
Semantic Scholar
Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress.
Anna Pensalfini, C. Cecchi, M. Zampagni, M. Becatti +7 more
2008Free Radical Biology & Medicine35 citations
Semantic Scholar
Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways
Giovanna Cenini, C. Cecchi, Anna Pensalfini, S. Bonini +4 more
2009Amino Acids34 citations Open access
Semantic Scholar
Biophysical characterization of full‐length TAR DNA‐binding protein (TDP‐43) phase separation
Tommaso Staderini, A. Bigi, Daniele Mongiello, C. Cecchi +1 more
2022Protein Science33 citations Open access
Semantic Scholar
Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
A. Bigi, Emilio Ermini, Serene W. Chen, R. Cascella +1 more
2021Life28 citations Open access
Semantic Scholar
Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy
R. Oropesa-Nuñez, Silvia Seghezza, S. Dante, A. Diaspro +5 more
2016OncoTarget28 citations Open access
Semantic Scholar
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species
Giulia Fani, Chiara Ester La Torre, R. Cascella, C. Cecchi +2 more
2022Cellular and Molecular Life Sciences27 citations Open access
Semantic Scholar
Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.
M. Calamai, E. Evangelisti, R. Cascella, Niccoló Parenti +3 more
2016Biochimica et Biophysica Acta26 citations Open access
Semantic Scholar
Light-responsive nanocomposite sponges for on demand chemical release with high spatial and dosage control.
P. Matteini, M. Martina, G. Giambastiani, F. Tatini +6 more
2013Journal of materials chemistry. B26 citations
Semantic Scholar
The acute myeloid leukemia‐associated Nucleophosmin 1 gene mutations dictate amyloidogenicity of the C‐terminal domain
S. La Manna, P. Scognamiglio, V. Roviello, F. Borbone +9 more
2019The FEBS Journal25 citations Open access
Semantic Scholar

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R. Cascella×37
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F. Chiti×28
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C. Dobson×16
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E. Evangelisti×12
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A. Bigi — researcher profile on SciRah

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B. Mannini — researcher profile on SciRah

M. Zampagni×10

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M. Zampagni — researcher profile on SciRah

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M. Stefani — researcher profile on SciRah

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M. Becatti — researcher profile on SciRah

Serene W. Chen×9

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Serene W. Chen — researcher profile on SciRah

M. Vendruscolo×9

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Anna Pensalfini — researcher profile on SciRah