A. Dear

Most-cited papers

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide
T. Michaels, A. Šarić, Samo Curk, K. Bernfur +8 more
2020bioRxiv302 citations Open access
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Kinetic diversity of amyloid oligomers
A. Dear, T. Michaels, G. Meisl, D. Klenerman +5 more
2020Proceedings of the National Academy of Sciences of the United States of America158 citations Open access
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Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
Laura Tosatto, M. Horrocks, A. Dear, T. Knowles +4 more
2015Scientific Reports110 citations Open access
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Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.
M. Horrocks, Laura Tosatto, A. Dear, Gonzalo A. Garcia +6 more
2015Analytical Chemistry93 citations Open access
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Identification of on- and off-pathway oligomers in amyloid fibril formation
A. Dear, G. Meisl, A. Šarić, T. Michaels +3 more
2020Chemical Science66 citations Open access
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Oligomer Diversity during the Aggregation of the Repeat Region of Tau
M. Kjaergaard, A. Dear, Franziska Kundel, S. Qamar +3 more
2018ACS Chemical Neuroscience64 citations Open access
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Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
Jonathan D. Taylor, William J. Hawthorne, Joanne C. Lo, A. Dear +20 more
2016Scientific Reports62 citations Open access
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α-Synuclein oligomers form by secondary nucleation
Catherine K. Xu, G. Meisl, E. Andrzejewska, G. Krainer +11 more
2024bioRxiv61 citations Open access
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Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
Marija Iljina, Gonzalo A. Garcia, A. Dear, Jennie Flint +6 more
2016Scientific Reports59 citations Open access
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Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
Patrick Flagmeier, S. De, T. Michaels, Xiaoting Yang +7 more
2020Nature Structural & Molecular Biology53 citations
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Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2
Jie Yang, A. Dear, T. Michaels, C. Dobson +3 more
2018Journal of the American Chemical Society50 citations Open access
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Quantifying Co-Oligomer Formation by α-Synuclein
Marija Iljina, A. Dear, Gonzalo A. Garcia, S. De +8 more
2018ACS Nano48 citations Open access
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Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation
Gabriel A. Braun, A. Dear, Kalyani Sanagavarapu, H. Zetterberg +1 more
2022Chemical Science42 citations Open access
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On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide.
Gabriel A. Braun, Beatrice Ary, A. Dear, M. Rohn +7 more
2020Biomacromolecules40 citations
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The catalytic nature of protein aggregation
A. Dear, G. Meisl, T. Michaels, Manuela R Zimmermann +2 more
2020Journal of Chemical Physics40 citations Open access
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Fluctuations in the Kinetics of Linear Protein Self-Assembly.
T. Michaels, A. Dear, J. B. Kirkegaard, K. Saar +2 more
2016Physical Review Letters34 citations Open access
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The role of shear forces in primary and secondary nucleation of amyloid fibrils
Emil Axell, Jing Hu, Max Lindberg, A. Dear +7 more
2024Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
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Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
Xizhou Liu, Z. Toprakcioglu, A. Dear, A. Levin +8 more
2019Macromolecular rapid communications31 citations Open access
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Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers.
T. Michaels, A. Dear, Samuel I. A. Cohen, M. Vendruscolo +1 more
2022Journal of Chemical Physics24 citations Open access
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Stochastic calculus of protein filament formation under spatial confinement
T. Michaels, A. Dear, T. Knowles
201823 citations Open access
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Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
Jason C. Sang, Ji-Eun Lee, A. Dear, S. De +5 more
2019Chemical Science21 citations Open access
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Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
A. Dear, Xiang-Yu Teng, Sarah R. Ball, Josh Lewin +13 more
2023bioRxiv18 citations Open access
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In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers
E. Zurlo, Pravin Kumar, G. Meisl, A. Dear +4 more
2021PLoS ONE18 citations Open access
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Kinetics of Amyloid Oligomer Formation.
Jia-Peng Wei, G. Meisl, A. Dear, Thomas C. T. Michaels +1 more
2025Annual Review of Biophysics17 citations Open access
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Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces
A. Dear, D. Thacker, Stefan Wennmalm, L. Ortigosa-Pascual +4 more
2024ACS Chemical Neuroscience15 citations Open access
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Geometric localization in supported elastic struts
T. Michaels, R. Kusters, A. Dear, C. Storm +2 more
2019Proceedings of the Royal Society A14 citations Open access
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Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils.
Jie Yang, A. Dear, Qiong-Qiong Yao, Zhenyan Liu +4 more
2020Nanoscale13 citations Open access
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Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation
D. Thacker, Amanda Willas, A. Dear, S. Linse
2022ACS Chemical Neuroscience11 citations Open access
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Statistical Mechanics of Globular Oligomer Formation by Protein Molecules.
A. Dear, A. Šarić, T. Michaels, C. Dobson +1 more
2018Journal of Physical Chemistry B10 citations Open access
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Scaling and dimensionality in the chemical kinetics of protein filament formation
T. Michaels, A. Dear, T. Knowles
201610 citations
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Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
T. Michaels, A. Šarić, Samo Curk, K. Bernfur +8 more
2020Nature Chemistry9 citations Open access
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Structural defects in amyloid-β fibrils drive secondary nucleation
Jing Hu, T. Scheidt, D. Thacker, Emil Axell +15 more
2025bioRxiv8 citations Open access
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Maximum entropy determination of mammalian proteome dynamics
A. Dear, Gonzalo A. Garcia, G. Meisl, G. A. Collins +2 more
2024Proceedings of the National Academy of Sciences of the United States of America6 citations Open access
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Mechanism, scaling and rates of protein aggregation from in vivo measurements
G. Meisl, A. Dear, T. Michaels, T. Knowles
20205 citations
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Supporting information for: Quantifying Co-Oligomer Formation by Alpha-Synuclein
Marija Iljina, A. Dear, Gonzalo A. Garcia, S. De +8 more
20185 citations
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Effect of disorder on condensation in the lattice gas model on a random graph.
T. P. Handford, A. Dear, F. Pérez-Reche, S. Taraskin
2013Physical review. E, Statistical, nonlinear, and soft matter physics5 citations Open access
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Kinetics of seeded protein aggregation: Theory and application.
A. Dear, G. Meisl, Jing Hu, T. Knowles +1 more
2025Journal of Chemical Physics4 citations Open access
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Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
Alisdair Stevenson, Roxine Staats, A. Dear, D. Voderholzer +8 more
2025Proceedings of the National Academy of Sciences of the United States of America4 citations Open access
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Feedback control of protein aggregation.
A. Dear, T. Michaels, T. Knowles, L. Mahadevan
2021Journal of Chemical Physics4 citations
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Universality of filamentous aggregation phenomena.
T. Michaels, A. Dear, T. Knowles
2019Physical Review E4 citations Open access
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Dynamics of heteromolecular filament formation.
A. Dear, T. Michaels, T. Knowles
2016Journal of Chemical Physics4 citations
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Kinetic models reveal the interplay of protein production and aggregation
Jia-Peng Wei, G. Meisl, A. Dear, Matthijs Oosterhuis +4 more
2024Chemical Science3 citations Open access
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Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
Alisdair Stevenson, Roxine Staats, A. Dear, D. Voderholzer +7 more
2024bioRxiv3 citations Open access
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Surface effects on functional amyloid formation.
A. Dear, G. Meisl, Christopher G. Taylor, U. C. Palmiero +6 more
2024Nanoscale3 citations
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Spontaneous enrichment of client molecules at phase boundaries of biomolecular condensates.
Vitus I Getzinger, Marco Curschellas, A. Dear, Thomas C. T. Michaels
2026Journal of Chemical Physics2 citations Open access
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An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates
Lucas B. Fallot, Johnathan R. Pinc, Joseph E Buselmeier, Julia C. Palchak +26 more
2025Proceedings of the National Academy of Sciences of the United States of America2 citations Open access
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Endogenous flow and dialytaxis govern aging of Adenosine 5’-triphosphate (ATP) condensates
Fei-Peng Chen, A. Dear, Parrik Dang Kow, Yuchao Wang +2 more
2025bioRxiv2 citations Open access
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Approximate Lie symmetries and singular perturbation theory
A. Dear, L. Mahadevan
2023Proceedings of the Royal Society A2 citations Open access
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Amyloid-b peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-b 42 aggregation †
Gabriel A. Braun, A. Dear, Kalyani Sanagavarapu, H. Zetterberg +1 more
1 citations
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Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
Karolina Matulewska-Sobczuk, K. Bernfur, D. Thacker, Johan Wallerstein +10 more
2026bioRxiv0 citations Open access
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