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A. Tramutola · SciRah

Researcher profile · Semantic Scholar

A. Tramutola

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A. Tramutola — researcher profile on SciRah

h-index: 35
Works: 112
Citations: 3,449

Most-cited papers

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre‐clinical AD, amnestic mild cognitive impairment and late‐stage AD
A. Tramutola, Judy C. Triplett, F. Di Domenico, Dana M. Niedowicz +4 more
2015Journal of Neurochemistry327 citations
Semantic Scholar
Oxidative stress, protein modification and Alzheimer disease.
A. Tramutola, Chiara Lanzillotta, M. Perluigi, D. Butterfield
2017Brain Research Bulletin279 citations
Semantic Scholar
Role of 4‐hydroxy‐2‐nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age‐related neurodegenerative disorders
F. Di Domenico, A. Tramutola, Allan D. Butterfield
2017Free Radical Biology & Medicine252 citations
Semantic Scholar
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
Annika Höhn, A. Tramutola, R. Cascella
2020Oxidative Medicine and Cellular Longevity166 citations Open access
Semantic Scholar
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease
A. Tramutola, F. Di Domenico, E. Barone, M. Perluigi +1 more
2016Oxidative Medicine and Cellular Longevity103 citations Open access
Semantic Scholar
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.
E. Barone, F. Di Domenico, T. Cassano, A. Arena +5 more
2016Free Radical Biology & Medicine102 citations
Semantic Scholar
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
A. Tramutola, Chiara Lanzillotta, E. Barone, A. Arena +6 more
2018Translational Neurodegeneration96 citations Open access
Semantic Scholar
Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients.
F. Di Domenico, Gilda Pupo, E. Giraldo, M. Badia +9 more
2015Free Radical Biology & Medicine88 citations
Semantic Scholar
Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease
E. Barone, A. Tramutola, Francesca Triani, Silvio Calcagnini +7 more
2018Molecular Neurobiology85 citations
Semantic Scholar
mTOR in Down Syndrome: Role in Aβ and Tau Neuropathology and Transition to Alzheimer Disease-Like Dementia
F. Di Domenico, A. Tramutola, C. Foppoli, Elizabeth Head +2 more
2017Free Radical Biology & Medicine80 citations Open access
Semantic Scholar
Age-related Changes in the Proteostasis Network in the Brain of the Naked Mole-Rat: Implications Promoting Healthy Longevity
Judy C. Triplett, A. Tramutola, Aaron M. Swomley, Jessime M. Kirk +9 more
2015Biochimica et Biophysica Acta69 citations Open access
Semantic Scholar
Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome.
A. Tramutola, Chiara Lanzillotta, F. Di Domenico, Elizabeth Head +3 more
2020Neurobiology of Disease67 citations Open access
Semantic Scholar
Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies
A. Tramutola, Chiara Lanzillotta, F. Di Domenico
2017Expert Review of Neurotherapeutics65 citations
Semantic Scholar
Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
F. Di Domenico, A. Tramutola, E. Barone, Chiara Lanzillotta +9 more
2019Redox Biology64 citations Open access
Semantic Scholar
Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.
Nidhi Sharma, A. Tramutola, Chiara Lanzillotta, A. Arena +6 more
2019Neurobiology of Disease57 citations Open access
Semantic Scholar
Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder
A. Romano, M. V. Micioni Di Bonaventura, Cristina Anna Gallelli, Justyna Barbara Koczwara +14 more
2020Neuropsychopharmacology53 citations Open access
Semantic Scholar
Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.
Francesca Triani, A. Tramutola, F. Di Domenico, Nidhi Sharma +4 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease52 citations Open access
Semantic Scholar
Cathepsin D as a therapeutic target in Alzheimer’s disease
F. Di Domenico, A. Tramutola, M. Perluigi
2016Expert opinion on therapeutic targets49 citations Open access
Semantic Scholar
Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in Down syndrome.
Chiara Lanzillotta, A. Tramutola, Graziella Di Giacomo, F. Marini +4 more
2021Free Radical Biology & Medicine47 citations
Semantic Scholar
Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology
A. Tramutola, F. Di Domenico, E. Barone, A. Arena +7 more
2017Antioxidants and Redox Signaling47 citations Open access
Semantic Scholar
Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2
B. Buttari, A. Tramutola, A. I. Rojo, N. Chondrogianni +9 more
2025Biomolecules44 citations Open access
Semantic Scholar
Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome
A. Tramutola, Chiara Lanzillotta, A. Arena, E. Barone +2 more
2015Neurodegenerative Diseases44 citations
Semantic Scholar
The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia
M. Perluigi, A. Tramutola, Sara Pagnotta, E. Barone +1 more
2020Antioxidants42 citations Open access
Semantic Scholar
Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease.
A. Tramutola, Nidhi Sharma, E. Barone, Chiara Lanzillotta +9 more
2018Biochimica et Biophysica Acta - Molecular Basis of Disease40 citations Open access
Semantic Scholar
Aeration and supplementation with heme and menaquinone affect survival to stresses and antioxidant capability of Lactobacillus casei strains
R. Ianniello, A. Ricciardi, E. Parente, A. Tramutola +2 more
201539 citations Open access
Semantic Scholar
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention.
Chiara Lanzillotta, Ilaria Zuliani, A. Tramutola, E. Barone +11 more
2020Progress in neurobiology37 citations Open access
Semantic Scholar
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
F. A. Cimini, A. Arena, I. Barchetta, A. Tramutola +14 more
2019Biochimica et Biophysica Acta - Molecular Basis of Disease37 citations Open access
Semantic Scholar
Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
I. Barchetta, V. Ceccarelli, F. A. Cimini, E. Barone +10 more
2020Journal of Endocrinological Investigation36 citations Open access
Semantic Scholar
Poly-ubiquitin profile in Alzheimer disease brain.
A. Tramutola, Francesca Triani, F. Di Domenico, E. Barone +4 more
2018Neurobiology of Disease36 citations Open access
Semantic Scholar
ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE
A. Tramutola, Gilda Pupo, F. Di Domenico, E. Barone +7 more
2016Journal of Alzheimer's Disease36 citations Open access
Semantic Scholar
Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer’s Disease Progression
V. Protto, A. Tramutola, M. Fabiani, M. E. Marcocci +8 more
2020Microorganisms35 citations Open access
Semantic Scholar
Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
A. Tramutola, A. Arena, C. Cini, D. Butterfield +1 more
2017Expert Review of Neurotherapeutics35 citations
Semantic Scholar
Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles
M. Perluigi, A. Picca, E. Montanari, R. Calvani +11 more
2021Alzheimer's & Dementia32 citations Open access
Semantic Scholar
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
Ilaria Zuliani, Chiara Lanzillotta, A. Tramutola, A. Francioso +4 more
2020Neurotherapeutics28 citations Open access
Semantic Scholar
High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures
Ilaria Zuliani, Chiara Lanzillotta, A. Tramutola, E. Barone +10 more
2021International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β
Chiara Lanzillotta, A. Tramutola, Simona Lanzillotta, Viviana Greco +17 more
2024Redox Biology26 citations Open access
Semantic Scholar
Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection
A. Tramutola, G. Abate, Chiara Lanzillotta, Francesca Triani +11 more
2018Free Radical Biology & Medicine23 citations Open access
Semantic Scholar
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome.
Sara Pagnotta, A. Tramutola, E. Barone, F. Di Domenico +8 more
2022Free Radical Biology & Medicine22 citations
Semantic Scholar
Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus.
I. Barchetta, G. Ciccarelli, E. Barone, F. A. Cimini +9 more
2019NMCD. Nutrition Metabolism and Cardiovascular Diseases22 citations
Semantic Scholar
Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models
Chiara Lanzillotta, A. Tramutola, Shelby E. Meier, Frederick Schmitt +4 more
2018Journal of Alzheimer's Disease22 citations Open access
Semantic Scholar
Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer’s Disease-like Neuropathology in a Mouse Model for Down Syndrome
A. Tramutola, Simona Lanzillotta, Giuseppe Aceto, Sara Pagnotta +9 more
2023Antioxidants21 citations Open access
Semantic Scholar
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity
Amani Bouzidi, M. Magnifico, A. Paiardini, A. Macone +14 more
2020Cell Death and Disease20 citations Open access
Semantic Scholar
Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies
F. Di Domenico, Chiara Lanzillotta, A. Tramutola
2018Expert Review of Neurotherapeutics19 citations
Semantic Scholar
Rapid detection assay for oxygen consumption in the Lactobacillus casei group
A. Ricciardi, R. Ianniello, A. Tramutola, E. Parente +1 more
2014Annals of Microbiology19 citations Open access
Semantic Scholar
Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model.
Chiara Lanzillotta, Monika Rataj Baniowska, F. Prestia, Chiara Sette +7 more
2024Neurobiology of Disease18 citations Open access
Semantic Scholar
Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression
A. Tramutola, Susanna Falcucci, Umberto Brocco, Francesca Triani +10 more
2020Cancers18 citations Open access
Semantic Scholar
Engineering memory with an extrinsically disordered kinase
C. Ripoli, Onur Dagliyan, P. Renna, F. Pastore +12 more
2023Science Advances16 citations Open access
Semantic Scholar
GLUT-1 changes in paediatric Huntington disease brain cortex and fibroblasts: an observational case-control study
A. Tramutola, Hannah S. Bakels, Federica Perrone, M. Di Nottia +9 more
2023EBioMedicine16 citations Open access
Semantic Scholar
Podium Presentations
D. Datta, Y. Morozov, C. Paspalas, A. Arnsten +5 more
201716 citations
Semantic Scholar
Altered Mitochondrial Unfolded Protein Response and Protein Quality Control promote oxidative distress in Down Syndrome brain.
Simona Lanzillotta, D. Esteve, Chiara Lanzillotta, A. Tramutola +7 more
2024Free Radical Biology & Medicine14 citations Open access
Semantic Scholar

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M. Perluigi — researcher profile on SciRah
F. Di Domenico×37
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E. Barone×27
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Chiara Lanzillotta

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