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A. De Simone · SciRah

Researcher profile · Semantic Scholar

A. De Simone

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A. De Simone — researcher profile on SciRah

h-index: 46
Works: 201
Citations: 8,628

Most-cited papers

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Giuliana Fusco, Serene W. Chen, P. Williamson, R. Cascella +9 more
2017Science637 citations Open access
Semantic Scholar
Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis
P. Nguyen, A. Ramamoorthy, Bikash R. Sahoo, Jie Zheng +30 more
2021Chemical Reviews564 citations Open access
Semantic Scholar
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
J. Lautenschläger, A. Stephens, Giuliana Fusco, Florian Ströhl +16 more
2018Nature Communications304 citations Open access
Semantic Scholar
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
A. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco +9 more
2020Nature Communications148 citations Open access
Semantic Scholar
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Gabriella T. Heller, F. Aprile, T. Michaels, Ryan Limbocker +12 more
2019Science Advances147 citations Open access
Semantic Scholar
Structural basis of synaptic vesicle assembly promoted by α-synuclein
Giuliana Fusco, Tillmann Pape, A. Stephens, Pierre Mahou +7 more
2016Nature Communications124 citations Open access
Semantic Scholar
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
Wing K. Man, Bogachan Tahirbegi, Michail D. Vrettas, Swapan Preet +4 more
2021Nature Communications103 citations Open access
Semantic Scholar
Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein
Giuliana Fusco, Tillmann Pape, A. Stephens, Pierre Mahou +7 more
2017Nature Communications101 citations Open access
Semantic Scholar
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
M. Runfola, A. De Simone, M. Vendruscolo, C. Dobson +1 more
2020Scientific Reports69 citations Open access
Semantic Scholar
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide.
Gabriella T. Heller, F. Aprile, Massimiliano Bonomi, C. Camilloni +2 more
2017Journal of Molecular Biology62 citations Open access
Semantic Scholar
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
Jonathan D. Taylor, William J. Hawthorne, Joanne C. Lo, A. Dear +20 more
2016Scientific Reports62 citations Open access
Semantic Scholar
Order and disorder in the physiological membrane binding of α-synuclein.
Giuliana Fusco, Máximo Sanz-Hernández, A. De Simone
2018Current Opinion in Structural Biology60 citations
Semantic Scholar
Cavitation energies can outperform dispersion interactions
Suhang He, Frank Biedermann, N. Vankova, Lyuben Zhechkov +5 more
2018Nature Chemistry60 citations
Semantic Scholar
Membrane Interactions and Toxicity by Misfolded Protein Oligomers
M. Gonzalez-Garcia, Giuliana Fusco, A. De Simone
2021Frontiers in Cell and Developmental Biology56 citations Open access
Semantic Scholar
Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates
Serene W. Chen, J. Barritt, R. Cascella, A. Bigi +8 more
2024Journal of the American Chemical Society51 citations Open access
Semantic Scholar
The toxicity of misfolded protein oligomers is independent of their secondary structure.
Mirella Vivoli Vega, R. Cascella, Serene W. Chen, Giuliana Fusco +4 more
2019ACS Chemical Biology47 citations
Semantic Scholar
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
C. Olivieri, Geoffrey C. Li, Yingjie Wang, Manu V. S. +8 more
2022Science Advances46 citations Open access
Semantic Scholar
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
R. Cascella, Michele Perni, Serene W. Chen, Giuliana Fusco +5 more
2019ACS Chemical Biology45 citations Open access
Semantic Scholar
A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles
Wing K. Man, A. De Simone, J. Barritt, M. Vendruscolo +2 more
2020Frontiers in Neuroscience37 citations Open access
Semantic Scholar
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
Giuliana Fusco, Máximo Sanz-Hernández, F. Ruggeri, M. Vendruscolo +2 more
2018Biopolymers35 citations Open access
Semantic Scholar
A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics
F. Squeglia, A. Ruggiero, A. De Simone, R. Berisio
2018Protein Science35 citations Open access
Semantic Scholar
Mechanism of misfolding of the human prion protein revealed by a pathological mutation
Máximo Sanz-Hernández, J. Barritt, J. Sobek, S. Hornemann +2 more
2021Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters.
M. Romano, Giuliana Fusco, H. Choudhury, S. Mehmood +8 more
2018ACS Chemical Biology34 citations Open access
Semantic Scholar
Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers
L. Boi, A. Pisanu, Maria Francesca Palmas, Giuliana Fusco +12 more
2020International Journal of Molecular Sciences31 citations Open access
Semantic Scholar
Structural basis for allosteric control of the SERCA-Phospholamban membrane complex by Ca2+ and phosphorylation
Daniel K. Weber, Máximo Sanz-Hernández, U. V. Reddy, Songlin Wang +7 more
2020bioRxiv29 citations Open access
Semantic Scholar
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
Michele Perni, A. T. van der Goot, Ryan Limbocker, T. V. van Ham +25 more
2021Frontiers in Cell and Developmental Biology24 citations Open access
Semantic Scholar
Structural differences between toxic and nontoxic HypF-N oligomers.
C. Capitini, Jayneil R. Patel, A. Natalello, C. D'Andrea +9 more
2018Chemical Communications23 citations
Semantic Scholar
Desolvation of the substrate-binding protein TauA dictates ligand specificity for the alkanesulfonate ABC importer TauABC
F. Qu, K. El-Omari, A. Wagner, A. De Simone +1 more
2019Biochemical Journal18 citations Open access
Semantic Scholar
A Kink in DWORF Helical Structure Controls the Activation of the Sarcoplasmic Reticulum Ca2+-ATPase
U. V. Reddy, Daniel K. Weber, Songlin Wang, Erik K Larsen +4 more
2021bioRxiv16 citations Open access
Semantic Scholar
Repurposing Pomalidomide as a Neuroprotective Drug: Efficacy in an Alpha-Synuclein-Based Model of Parkinson’s Disease
Maria Francesca Palmas, A. Ena, Chiara Burgaletto, M. Casu +15 more
2022Neurotherapeutics14 citations Open access
Semantic Scholar
Immune responses to oligomeric α-synuclein in Parkinson’s disease peripheral blood mononuclear cells
A. F. Vega-Benedetti, Clara Porcedda, Tommaso Ercoli, Giuliana Fusco +12 more
2024Journal of Neurology13 citations Open access
Semantic Scholar
The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex
Maria Francesca Palmas, Michela Etzi, A. Pisanu, C. Camoglio +15 more
2022Cells13 citations Open access
Semantic Scholar
The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes
Giuliana Fusco, Francesco Bemporad, F. Chiti, C. Dobson +1 more
2022Frontiers in Molecular Biosciences12 citations Open access
Semantic Scholar
Biochemical and biophysical comparison of human and mouse beta‐2 microglobulin reveals the molecular determinants of low amyloid propensity
A. Achour, L. Broggini, Xiao Han, R. Sun +12 more
2019The FEBS Journal12 citations Open access
Semantic Scholar
The PROSECCO server for chemical shift predictions in ordered and disordered proteins
Máximo Sanz-Hernández, A. De Simone
2017Journal of Biomolecular NMR12 citations Open access
Semantic Scholar
Metal interactions of α-synuclein probed by NMR amide-proton exchange
M. Gonzalez-Garcia, Giuliana Fusco, A. De Simone
2023Frontiers in Chemistry11 citations Open access
Semantic Scholar
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat
F. Malagrinò, Giuliana Fusco, V. Pennacchietti, A. Toto +4 more
2022Protein Science11 citations Open access
Semantic Scholar
Probing the dynamic stalk region of the ribosome using solution NMR
Xiaolin Wang, J. Kirkpatrick, H. Launay, A. De Simone +6 more
2019Scientific Reports11 citations Open access
Semantic Scholar
Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein
M. Zacharopoulou, Neeleema Seetaloo, James F Ross, A. Stephens +10 more
2025Journal of the American Chemical Society10 citations Open access
Semantic Scholar
α-Synuclein and biological membranes: the danger of loving too much
Silvia Mansueto, Giuliana Fusco, A. De Simone
2023Chemical Communications10 citations Open access
Semantic Scholar
Plasticity of Membrane Binding by the Central Region of α-Synuclein
Carlos Navarro-Paya, Máximo Sanz-Hernández, A. De Simone
2022Frontiers in Molecular Biosciences10 citations Open access
Semantic Scholar
The identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism
Irene Cipollone, Vittoria Monaco, J. Britto-Júnior, A. Lima +19 more
2025Frontiers in Pharmacology9 citations Open access
Semantic Scholar
Stimuli-Responsive Hydrogels from Liquid–Liquid Phase Separations of FUS-Derived Peptides
Elisabetta Rosa, Mariantonietta Pizzella, Luca Cimmino, V. Castelletto +4 more
2025ACS Applied Materials and Interfaces9 citations
Semantic Scholar
Local ionic conditions modulate the aggregation propensity and influence the structural polymorphism of alpha-synuclein
Maria Zacharopoulou, Neeleema Seetaloo, James F Ross, A. Stephens +10 more
2024bioRxiv9 citations Open access
Semantic Scholar
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation
L. Reimer, Hjalte Gram, N. M. Jensen, C. Betzer +10 more
2022PNAS Nexus9 citations Open access
Semantic Scholar
Enhancing Biomolecular Simulations with Hybrid Potentials Incorporating NMR Data
Guowei Qi, Michail D. Vrettas, Carmen Biancaniello, Máximo Sanz-Hernández +5 more
2022Journal of Chemical Theory and Computation9 citations Open access
Semantic Scholar
α-Synuclein and Mitochondria: Probing the Dynamics of Disordered Membrane-protein Regions Using Solid-State Nuclear Magnetic Resonance
Angelo Gallo, Silvia Mansueto, Alessandro Emendato, Giuliana Fusco +1 more
2024JACS Au8 citations Open access
Semantic Scholar
Region-specific changes in gene expression are associated with cognitive deficits in the alpha-synuclein-induced model of Parkinson's disease: A transcriptomic profiling study.
M. F. Manchinu, Mauro Pala, Maria Francesca Palmas, Maria Antonietta Diana +10 more
2023Experimental Neurology8 citations Open access
Semantic Scholar
Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2.
A. Toto, Daniela Bonetti, A. De Simone, S. Gianni
2017OncoTarget8 citations Open access
Semantic Scholar
Under the Influence of Water: Molecular Recognition of Organic Hydrophilic Molecules in Water with a Prismarene Host Driven by Hydration Effects.
Rocco del Regno, P. Della Sala, Giuseppina D. G. Santonoceta, P. Neri +5 more
2024Chemistry7 citations
Semantic Scholar

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Giuliana Fusco×29
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M. Vendruscolo×14
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Serene W. Chen×5

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