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J. Bronson · SciRah

Researcher profile · Semantic Scholar

J. Bronson

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J. Bronson — researcher profile on SciRah

h-index: 30
Works: 152
Citations: 3,105

Most-cited papers

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
K. Gillman, J. Starrett, Michael F. Parker, Kai Xie +18 more
2010ACS Medicinal Chemistry Letters174 citations Open access
Semantic Scholar
Antimicrobial Evaluation of Nocathiacins, a Thiazole Peptide Class of Antibiotics
M. Pucci, J. Bronson, J. Barrett, Kenneth L. Denbleyker +3 more
2004Antimicrobial Agents and Chemotherapy89 citations Open access
Semantic Scholar
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
W. Kostich, Brian D. Hamman, Yu-wen Li, Sreenivasulu Naidu +51 more
2016Journal of Pharmacology and Experimental Therapeutics86 citations Open access
Semantic Scholar
Discovery of the first antibacterial small molecule inhibitors of MurB.
J. Bronson, Kenneth L. Denbleyker, P. Falk, Robert A. Mate +3 more
2003Bioorganic & Medicinal Chemistry Letters76 citations
Semantic Scholar
The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression*
C. Burton, J. Meredith, D. Barten, M. Goldstein +28 more
2008Journal of Biological Chemistry65 citations Open access
Semantic Scholar
Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
C. Albright, R. Dockens, J. Meredith, R. Olson +29 more
2013Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: synthesis and biological properties.
Yasutsugu Ueda, J. Matiskella, J. Golik, T. Connolly +18 more
2003Bioorganic & Medicinal Chemistry Letters51 citations
Semantic Scholar
A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Richard A. Hartz, Vijay T. Ahuja, X. Zhuo, R. Mattson +20 more
2009Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Progress in the discovery of BACE inhibitors.
L. Thompson, J. Bronson, F. Zusi
2005Current pharmaceutical design47 citations
Semantic Scholar
Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics.
B. Naidu, Margaret E. Sorenson, Yun-Hui Zhang, O. Kim +9 more
2004Bioorganic & Medicinal Chemistry Letters46 citations Open access
Semantic Scholar
Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts.
B. Naidu, Margaret E. Sorenson, J. Bronson, M. Pucci +2 more
2005Bioorganic & Medicinal Chemistry Letters45 citations
Semantic Scholar
Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid.
S. D'Andrea, Z. Zheng, Kenneth L. Denbleyker, J. Fung-Tomc +4 more
2005Bioorganic & Medicinal Chemistry Letters45 citations
Semantic Scholar
Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4)
Darren W. Engers, A. L. Blobaum, R. Gogliotti, Y. Cheung +14 more
2016ACS Chemical Neuroscience41 citations Open access
Semantic Scholar
Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.
L. Snyder, Zhaoxing Meng, Robert A. Mate, S. D'Andrea +9 more
2004Bioorganic & Medicinal Chemistry Letters41 citations
Semantic Scholar
Synthesis and antibacterial activity of nocathiacin I analogues.
B. Naidu, Margaret E. Sorenson, J. Matiskella, Wenying Li +8 more
2006Bioorganic & Medicinal Chemistry Letters40 citations
Semantic Scholar
Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity
Martin A. Lewis, L. Hunihan, J. Watson, R. Gentles +17 more
2015Journal of Pharmacology and Experimental Therapeutics36 citations Open access
Semantic Scholar
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Lawrence R. Marcin, Mendi A. Higgins, F. Zusi, Yun-Hui Zhang +19 more
2011Bioorganic & Medicinal Chemistry Letters33 citations
Semantic Scholar
Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Richard A. Hartz, Vijay T. Ahuja, A. Arvanitis, M. Rafalski +26 more
2009Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Novel semi-synthetic nocathiacin antibiotics: synthesis and antibacterial activity of bis- and mono-O-alkylated derivatives.
Alicia Regueiro-Ren, B. Naidu, Xiao-Fan Zheng, T. Hudyma +9 more
2004Bioorganic & Medicinal Chemistry Letters32 citations
Semantic Scholar
In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Richard A. Hartz, Vijay T. Ahuja, M. Rafalski, W. Schmitz +20 more
2009Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Organic reactions in frozen water: Michael addition of amines and thiols to the dehydroalanine side chain of nocathiacins
B. Naidu, Wenying Li, Margaret E. Sorenson, T. Connolly +7 more
200430 citations
Semantic Scholar
In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter ‐1 (SLC7A10)
J. M. Brown, L. Hunihan, M. Prack, D. Harden +7 more
2014Journal of Neurochemistry29 citations
Semantic Scholar
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
Guang-Lin Luo, Ling Chen, W. Kostich, Brian D. Hamman +55 more
2022Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Synthesis and activity of a C-8 keto pleuromutilin derivative.
Dane M. Springer, Margaret E. Sorenson, Stella Huang, T. Connolly +6 more
2003Bioorganic & Medicinal Chemistry Letters28 citations
Semantic Scholar
Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease.
Joseph D. Panarese, Darren W. Engers, Yong-Jin Wu, J. Bronson +16 more
2018ACS Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
Carolyn D. Dzierba, Ying-Zhi Bi, Bireshwar Dasgupta, Richard A. Hartz +29 more
2015Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.
Hong Huang, A. P. Degnan, Anand Balakrishnan, Amy E. Easton +15 more
2016Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
Ying-Zhi Bi, Carolyn D. Dzierba, Cynthia A. Fink, Yudith Garcia +18 more
2015Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.
Fu-Kang Yang, L. Snyder, Anand Balakrishnan, J. M. Brown +21 more
2016ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.
Yong-Jin Wu, Huan He, R. Bertekap, R. Westphal +7 more
2013Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives.
B. Naidu, Margaret E. Sorenson, T. Hudyma, Xiao-Fan Zheng +5 more
2004Bioorganic & Medicinal Chemistry Letters23 citations
Semantic Scholar
Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.
M. D. Hill, Haiquan Fang, J. M. Brown, T. Molski +15 more
2016ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
S. Sheriff, Brett R. Beno, W. Zhai, W. Kostich +16 more
2011Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Chapter 1 Recent Advances in Corticotropin-Releasing Factor Receptor Antagonists
Carolyn D. Dzierba, Richard A. Hartz, J. Bronson
200822 citations
Semantic Scholar
To Market, To Market—2011
J. Bronson, M. Dhar, W. Ewing, N. Lonberg
201221 citations
Semantic Scholar
Synthesis and structure-activity relationships of N3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Richard A. Hartz, Vijay T. Ahuja, W. Schmitz, T. Molski +4 more
2010Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
COMPARATIVE BIOTRANSFORMATION OF PYRAZINONE-CONTAINING CORTICOTROPIN-RELEASING FACTOR RECEPTOR-1 (CRF-R1) ANTAGONISTS: MINIMIZING THE REACTIVE METABOLITE FORMATION
X. Zhuo, Richard A. Hartz, J. Bronson, Harvey +7 more
200921 citations
Semantic Scholar
Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.
Yu-wen Li, Matthew A. Seager, T. Wojcik, K. Heman +15 more
2016Neuropharmacology20 citations
Semantic Scholar
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).
Kenneth M. Boy, J. Guernon, Jianliang Shi, J. Toyn +14 more
2011Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Biaryl isoxazolinone antibacterial agents.
C. Quesnelle, P. Gill, Stéphan Roy, M. Dodier +21 more
2005Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives.
Dane M. Springer, B. Luh, J. Goodrich, J. Bronson
2003Bioorganic & Medicinal Chemistry19 citations
Semantic Scholar
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Guang-Lin Luo, Ling Chen, W. Kostich, Brian D. Hamman +39 more
2022Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Yong-Jin Wu, J. Guernon, Andrea Mcclure, Guang-Lin Luo +21 more
2017Bioorganic & Medicinal Chemistry18 citations Open access
Semantic Scholar
Potential CRF1R PET imaging agents: N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines.
Dmitry Zuev, R. Mattson, Hong Huang, Gail K. Mattson +9 more
2011Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.
W. Schmitz, Allison B Brenner, J. Bronson, Jonathan L. Ditta +7 more
2010Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
L. Marcin, J. Warrier, Srinivasan Thangathirupathy, Jianliang Shi +44 more
2018ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
L. Bristow, Jyoti Gulia, M. Weed, B. Srikumar +40 more
2017Journal of Pharmacology and Experimental Therapeutics16 citations Open access
Semantic Scholar
Chemical conversion of nocathiacin I to nocathiacin II and a lactone analogue of glycothiohexide alpha.
T. Connolly, Alicia Regueiro-Ren, J. Leet, Dane M. Springer +6 more
2005Journal of Natural Products16 citations
Semantic Scholar
Cyclopentanone ring-cleaved pleuromutilin derivatives.
Dane M. Springer, A. Bunker, B. Luh, Margaret E. Sorenson +5 more
2007European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Synthesis and Evaluation of Candidate PET Radioligands for Corticotropin-Releasing Factor Type-1 Receptors
N. Lodge, Yu-wen Li, Frederick T. Chin, D. Dischino +13 more
2014Nuclear Medicine and Biology14 citations Open access
Semantic Scholar

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