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Yu-wen Li · SciRah

Researcher profile · Semantic Scholar

Yu-wen Li

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Yu-wen Li — researcher profile on SciRah

h-index: 22
Works: 53
Citations: 1,225

Most-cited papers

40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors
D. V. Sivarao, Ping Chen, A. Senapati, Yi-Li Yang +5 more
2016Neuropsychopharmacology120 citations Open access
Semantic Scholar
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
W. Kostich, Brian D. Hamman, Yu-wen Li, Sreenivasulu Naidu +51 more
2016Journal of Pharmacology and Experimental Therapeutics86 citations Open access
Semantic Scholar
Receptor Occupancy of Nonpeptide Corticotropin-Releasing Factor 1 Antagonist DMP696: Correlation with Drug Exposure and Anxiolytic Efficacy
Yu-wen Li, Geraldine Hill, H. Wong, Natasha Kelly +9 more
2003Journal of Pharmacology and Experimental Therapeutics59 citations
Semantic Scholar
The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists.
Yu-wen Li, L. Fitzgerald, H. Wong, S. Lelas +7 more
2006CNS drug reviews57 citations Open access
Semantic Scholar
Anxiolytic-Like Effects of the Corticotropin-Releasing Factor1 (CRF1) Antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats
S. Lelas, H. Wong, Yu-wen Li, K. Heman +16 more
2004Journal of Pharmacology and Experimental Therapeutics53 citations
Semantic Scholar
Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus.
J. Graef, K. Newberry, Amy E. Newton, R. Pieschl +8 more
2015Brain Research49 citations
Semantic Scholar
A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Richard A. Hartz, Vijay T. Ahuja, X. Zhuo, R. Mattson +20 more
2009Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Binding Sites of γ-Secretase Inhibitors in Rodent Brain: Distribution, Postnatal Development, and Effect of Deafferentation
Xiao-Xin Yan, Tong Li, Cynthia M. Rominger, S. Prakash +4 more
2004Journal of Neuroscience44 citations Open access
Semantic Scholar
Corticotropin-releasing factor antagonists: recent advances and exciting prospects for the treatment of human diseases.
P. Gilligan, Yu-wen Li
2004Current opinion in drug discovery & development43 citations
Semantic Scholar
Ex vivo assessment of binding site occupancy of monoamine reuptake inhibitors: methodology and biological significance.
K. Lengyel, R. Pieschl, Todd Strong, T. Molski +3 more
2008Neuropharmacology40 citations
Semantic Scholar
6-Hydroxybuspirone Is a Major Active Metabolite of Buspirone: Assessment of Pharmacokinetics and 5-Hydroxytryptamine1A Receptor Occupancy in Rats
H. Wong, R. Dockens, L. Pajor, S. Yeola +6 more
2007Drug Metabolism And Disposition35 citations
Semantic Scholar
Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Richard A. Hartz, Vijay T. Ahuja, A. Arvanitis, M. Rafalski +26 more
2009Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
P. Gilligan, Liqi He, Todd Clarke, P. Tivitmahaisoon +19 more
2009Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Ion channels as potential targets for the treatment of depression.
N. Lodge, Yu-wen Li
2008Current opinion in drug discovery & development32 citations
Semantic Scholar
In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists.
Richard A. Hartz, Vijay T. Ahuja, M. Rafalski, W. Schmitz +20 more
2009Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia
L. Bristow, Amy E. Easton, Yu-wen Li, D. V. Sivarao +19 more
2016PLoS ONE30 citations Open access
Semantic Scholar
NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats
D. V. Sivarao, Ping Chen, Yi-Li Yang, Yu-wen Li +2 more
2014Frontiers in Psychiatry30 citations Open access
Semantic Scholar
Pharmacological Characterization of a Novel Nonpeptide Antagonist Radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for Corticotropin-Releasing Factor1 Receptors
Ge Zhang, Ning Huang, Yu-wen Li, Xiaoping Qi +9 more
2003Journal of Pharmacology and Experimental Therapeutics30 citations Open access
Semantic Scholar
Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice.
K. V. Kumar, A. Rudra, M. V. Sreedhara, T. Subramani +10 more
2014Brain, behavior, and immunity29 citations
Semantic Scholar
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
Guang-Lin Luo, Ling Chen, W. Kostich, Brian D. Hamman +55 more
2022Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.
Fu-Kang Yang, L. Snyder, Anand Balakrishnan, J. M. Brown +21 more
2016ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Characterization of the adrenocorticotrophic hormone ‐ induced mouse model of resistance to antidepressant drug treatment
B. Srikumar, M. Paschapur, N. Kalidindi, Bharath Adepu +12 more
2017Pharmacology, Biochemistry and Behavior22 citations
Semantic Scholar
Effects of BMS‐902483, an &agr;7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents
R. Pieschl, Regina Miller, Kelli M. Jones, D. Post‐Munson +17 more
2017European Journal of Pharmacology20 citations
Semantic Scholar
Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy.
Yu-wen Li, Matthew A. Seager, T. Wojcik, K. Heman +15 more
2016Neuropharmacology20 citations
Semantic Scholar
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Guang-Lin Luo, Ling Chen, W. Kostich, Brian D. Hamman +39 more
2022Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists.
W. Schmitz, Allison B Brenner, J. Bronson, Jonathan L. Ditta +7 more
2010Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
L. Bristow, Jyoti Gulia, M. Weed, B. Srikumar +40 more
2017Journal of Pharmacology and Experimental Therapeutics16 citations Open access
Semantic Scholar
Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice.
A. Fernandes, T. Wojcik, Praveena Baireddy, R. Pieschl +5 more
2015European Journal of Pharmacology16 citations
Semantic Scholar
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
Shuang Liu, Congxiang Zha, K. Nacro, Min Hu +37 more
2014ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Synthesis and Evaluation of Candidate PET Radioligands for Corticotropin-Releasing Factor Type-1 Receptors
N. Lodge, Yu-wen Li, Frederick T. Chin, D. Dischino +13 more
2014Nuclear Medicine and Biology14 citations Open access
Semantic Scholar
Focused microwave irradiation-assisted immunohistochemistry to study effects of ketamine on phospho-ERK expression in the mouse brain.
A. Fernandes, Yu-wen Li
2017Brain Research13 citations
Semantic Scholar
Mapping the central effects of (±)-ketamine and traxoprodil using pharmacological magnetic resonance imaging in awake rats
Hai-Ying Tang, D. Kukral, Yu-wen Li, M. Fronheiser +9 more
2018Journal of Psychopharmacology11 citations
Semantic Scholar
Ex Vivo Occupancy of γ-Secretase Inhibitors Correlates with Brain β-Amyloid Peptide Reduction in Tg2576 Mice
M. Goldstein, Yang Cao, Tracey Fiedler, J. Toyn +9 more
2007Journal of Pharmacology and Experimental Therapeutics11 citations
Semantic Scholar
Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats.
Yu-wen Li, Shaun Langdon, R. Pieschl, Todd Strong +4 more
2014European Journal of Pharmacology10 citations
Semantic Scholar
Synthesis, structure-activity relationships, and in vivo properties of 3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-ones as corticotropin-releasing factor-1 receptor antagonists.
Carolyn D. Dzierba, Amy G Takvorian, M. Rafalski, Padmaja Kasireddy-Polam +12 more
2004Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Target Engagement of a Phosphodiesterase 2A Inhibitor Affecting Long-Term Memory in the Rat
G. Gu, Trevor Scott, Y. Yan, Noelle Warren +11 more
2019Journal of Pharmacology and Experimental Therapeutics9 citations Open access
Semantic Scholar
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.
Michael G. Yang, Zi-Li Xiao, T. G. Murali Dhar, Hai-Yun Xiao +27 more
2016Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.
K. Gillman, Michael F. Parker, Mark V. Silva, A. P. Degnan +14 more
2013Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
[3H]BMT‐046091 a potent and selective radioligand to determine AAK1 distribution and target engagement
J. Louis, Yi-Feng Lu, R. Pieschl, Yun Tian +12 more
2017Neuropharmacology7 citations
Semantic Scholar
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.
J. Deskus, D. Dischino, R. Mattson, Jonathan L. Ditta +23 more
2012Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors.
A. P. Degnan, George O. Tora, Ying Han, R. Rajamani +15 more
2015Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test.
S. Lelas, Yu-wen Li, Tanya L. Wallace-Boone, M. Taber +10 more
2013Neuropharmacology6 citations
Semantic Scholar
Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.
M. Goldstein, Yang Cao, Tracey Fiedler, J. Toyn +9 more
2007Journal of Pharmacology and Experimental Therapeutics6 citations
Semantic Scholar
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.
A. P. Degnan, George O. Tora, Hong Huang, David A. Conlon +20 more
2016ACS Chemical Neuroscience4 citations
Semantic Scholar
Anxiolytic-Like Effects of the Corticotropin-Releasing Factor 1 ( CRF 1 ) Antagonist DMP 904 [ 4-( 3-pentylamino )-2 , 7-dimethyl-8-( 2-methyl-4-methoxyphenyl )-pyrazolo-[ 1 , 5-a ]-pyrimidine ] Administered Acutely or Chronically at Doses Occupying Central CRF 1 Receptors in Rats
S. Lelas, H. Wong, Yu-wen Li, K. Heman +16 more
20043 citations
Semantic Scholar
Receptor Occupancy of Non-Peptide CRF 1 Antagonist DMP 696 : Correlation with Drug Exposure and Anxiolytic Efficacy
Yu-wen Li, Geraldine Hill, H. Wong, Natasha Kelly +9 more
20023 citations
Semantic Scholar
Pharmacological and behavioral characterization of the novel CRF1 antagonist BMS-763534.
N. Lodge, S. Lelas, Yu-wen Li, T. Molski +8 more
2013Neuropharmacology2 citations
Semantic Scholar
Corrections to In Vitro Intrinsic Clearance-Based Optimization of N3-Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonists
Richard A. Hartz, Vijay T. Ahuja, M. Rafalski, W. Schmitz +20 more
20092 citations
Semantic Scholar
Anxiolytic-like Effects of the CRF1 Antagonist DMP904 Administered Acutely or Chronically at Doses Occupying Central CRF1 Receptors in Rats
S. Lelas, H. Wong, Yu-wen Li, K. Heman +19 more
20032 citations
Semantic Scholar
Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus
B. N. Srikumar, P. S. Naidu, N. Kalidindi, M. Paschapur +15 more
2018Journal of Psychopharmacology1 citations Open access
Semantic Scholar

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