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Amy E. Easton · SciRah

Researcher profile · Semantic Scholar

Amy E. Easton

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Amy E. Easton — researcher profile on SciRah

h-index: 16
Works: 26
Citations: 635

Most-cited papers

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease
P. Wes, Amy E. Easton, John P. Corradi, D. Barten +16 more
2014PLoS ONE106 citations Open access
Semantic Scholar
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
W. Kostich, Brian D. Hamman, Yu-wen Li, Sreenivasulu Naidu +51 more
2016Journal of Pharmacology and Experimental Therapeutics86 citations Open access
Semantic Scholar
Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features
P. Hagedorn, J. M. Brown, Amy E. Easton, M. Pierdomenico +9 more
2022Nucleic Acid Therapeutics57 citations Open access
Semantic Scholar
Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer’s disease
Amy E. Easton, S. Sankaranarayanan, Tang-He An, D. Terwel +6 more
2013Psychopharmacology37 citations
Semantic Scholar
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
Yong-Jin Wu, J. Guernon, Jianliang Shi, Jonathan L. Ditta +20 more
2017Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats
Kelli M. Jones, Ivar M. Mcdonald, C. Bourin, R. Olson +2 more
2014Psychopharmacology33 citations
Semantic Scholar
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia
L. Bristow, Amy E. Easton, Yu-wen Li, D. V. Sivarao +19 more
2016PLoS ONE30 citations Open access
Semantic Scholar
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
Guang-Lin Luo, Ling Chen, W. Kostich, Brian D. Hamman +55 more
2022Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.
Hong Huang, A. P. Degnan, Anand Balakrishnan, Amy E. Easton +15 more
2016Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5.
Fu-Kang Yang, L. Snyder, Anand Balakrishnan, J. M. Brown +21 more
2016ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
Guang-Lin Luo, Ling Chen, Amy E. Easton, Amy E. Newton +18 more
2018Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators.
M. D. Hill, Haiquan Fang, J. M. Brown, T. Molski +15 more
2016ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Effects of BMS‐902483, an &agr;7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents
R. Pieschl, Regina Miller, Kelli M. Jones, D. Post‐Munson +17 more
2017European Journal of Pharmacology20 citations
Semantic Scholar
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Guang-Lin Luo, Ling Chen, W. Kostich, Brian D. Hamman +39 more
2022Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Yong-Jin Wu, J. Guernon, Andrea Mcclure, Guang-Lin Luo +21 more
2017Bioorganic & Medicinal Chemistry18 citations Open access
Semantic Scholar
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.
J. Cook, F. Zusi, Ivar M. Mcdonald, D. King +32 more
2016Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.
D. King, Christiana I. Iwuagwu, J. Cook, Ivar M. Mcdonald +24 more
2017ACS Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
Richard A. Hartz, Vijay T. Ahuja, S. Nara, C. M. Vijaya Kumar +22 more
2021Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Mendi A. Higgins, L. Marcin, F. Zusi, R. Gentles +18 more
2017Bioorganic & Medicinal Chemistry13 citations Open access
Semantic Scholar
Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists.
M. D. Hill, Haiquan Fang, H. King, Christiana I. Iwuagwu +18 more
2017ACS Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
Guang-Lin Luo, Ling Chen, Amy E. Easton, Amy E. Newton +18 more
2019Journal of Medicinal Chemistry4 citations
Semantic Scholar
Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer’s disease
Amy E. Easton, S. Sankaranarayanan, Tang-He An, D. Terwel +6 more
2013Psychopharmacology3 citations
Semantic Scholar
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain
Carolyn D. Dzierba, Bireshwar Dasgupta, George N Karageorge, W. Kostich +27 more
2023Medicinal Chemistry Research1 citations Open access
Semantic Scholar
Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.
A. P. Degnan, D. Maxwell, Anand Balakrishnan, J. M. Brown +14 more
2016Bioorganic & Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats
Kelli M. Jones, Ivar M. Mcdonald, C. Bourin, R. Olson +2 more
2013Psychopharmacology0 citations
Semantic Scholar
Identiﬁcation and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies
Amy E. Easton, Marianne L. Jensen, Congwei Wang, P. H. Hagedorn +34 more
0 citations
Semantic Scholar

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L. Bristow×19
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L. Bristow — researcher profile on SciRah
J. Macor×16
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C. Bourin×14
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Michael Gulianello×9

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R. Pieschl — researcher profile on SciRah

Carolyn D. Dzierba×9

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Carolyn D. Dzierba — researcher profile on SciRah

Regina Miller×9

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Regina Miller — researcher profile on SciRah

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Kelli M. Jones×8

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Kelli M. Jones — researcher profile on SciRah