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J. Starrett · SciRah

Researcher profile · Semantic Scholar

J. Starrett

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J. Starrett — researcher profile on SciRah

h-index: 22
Works: 48
Citations: 1,857

Most-cited papers

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
K. Gillman, J. Starrett, Michael F. Parker, Kai Xie +18 more
2010ACS Medicinal Chemistry Letters174 citations Open access
Semantic Scholar
Effects of channel modulators on cloned large-conductance calcium-activated potassium channels.
V. K. Gribkoff, J. T. Lum-Ragan, C. G. Boissard, D. J. Post-Munson +8 more
1996Molecular Pharmacology170 citations
Semantic Scholar
Maxi-K Potassium Channels: Form, Function, and Modulation of a Class of Endogenous Regulators of Intracellular Calcium
V. Gribkoff, J. Starrett, S. Dworetzky
2001The Neuroscientist126 citations
Semantic Scholar
The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.
P. Hewawasam, V. Gribkoff, Yadagiri Pendri, S. Dworetzky +11 more
2002Bioorganic & Medicinal Chemistry Letters116 citations
Semantic Scholar
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
J. Starrett, D. Tortolani, Michael J. M. Hitchcock, John C. Martin +1 more
1992Antiviral Research107 citations
Semantic Scholar
An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning
M. Lindner, D. Hodges, J. Hogan, Anitra F. Orie +8 more
2003Journal of Pharmacology and Experimental Therapeutics96 citations
Semantic Scholar
The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.
P. Hewawasam, Wen-Hong Fan, J. Knipe, S. Moon +3 more
2002Bioorganic & Medicinal Chemistry Letters84 citations
Semantic Scholar
The pharmacology and molecular biology of large-conductance calcium-activated (BK) potassium channels.
V. Gribkoff, J. Starrett, S. Dworetzky
1997Advances in Pharmacology82 citations
Semantic Scholar
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.
P. Hewawasam, Wen-Hong Fan, Min Ding, Kim Flint +8 more
2003Journal of Medicinal Chemistry81 citations
Semantic Scholar
Synthesis and biological activity of 3-substituted imidazo[1,2-a]pyridines as antiulcer agents.
J. Starrett, T. A. Montzka, A. R. Crosswell, R. Cavanagh
1989Journal of Medicinal Chemistry77 citations
Semantic Scholar
The Maxi-K Channel Opener BMS-204352 Attenuates Regional Cerebral Edema and Neurologic Motor Impairment after Experimental Brain Injury
Jessica A. Cheney, J. D. Weisser, F. Bareyre, H. Laurer +5 more
2001Journal of Cerebral Blood Flow and Metabolism74 citations
Semantic Scholar
Cognition-enhancing drugs increase stimulated hippocampal theta rhythm amplitude in the urethane-anesthetized rat.
Gene G. Kinney, P. Patino, Yvan Mermet-Bouvier, J. Starrett +1 more
1999Journal of Pharmacology and Experimental Therapeutics63 citations
Semantic Scholar
Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
C. Albright, R. Dockens, J. Meredith, R. Olson +29 more
2013Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
Yong-Jin Wu, C. Boissard, C. Greco, V. Gribkoff +19 more
2003Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Serine 232 and Methionine 272 Define the Ligand Binding Pocket in Retinoic Acid Receptor Subtypes*
J. Ostrowski, T. Roalsvig, L. Hammer, A. Marinier +3 more
1998Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Structural studies of the anti-HIV agent 2',3'-didehydro-2',3'-dideoxythymidine (D4T).
William E. Harte, J. Starrett, J. Martin, M. Mansuri
1991Biochemical and Biophysical Research Communications - BBRC39 citations
Semantic Scholar
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.
Kenneth M. Boy, J. Guernon, Sing-Yuen Sit, Kai Xie +7 more
2004Bioorganic & Medicinal Chemistry Letters38 citations
Semantic Scholar
Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound
K. Fitzgerald, S. Tertyshnikova, Lisa A. Moore, Lynn Bjerke +23 more
2006PLoS Genetics37 citations Open access
Semantic Scholar
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.
P. Hewawasam, M. Erway, G. Thalody, H. Weiner +5 more
2002Bioorganic & Medicinal Chemistry Letters37 citations
Semantic Scholar
Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers
Yong-Jin Wu, Huan He, Li-Qiang Sun, Alexandre L’Heureux +7 more
200435 citations
Semantic Scholar
4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels.
J. Romine, Scott W. Martin, V. Gribkoff, C. Boissard +6 more
2002Journal of Medicinal Chemistry32 citations
Semantic Scholar
4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle.
P. Hewawasam, Wen-Hong Fan, D. Cook, K. Newberry +4 more
2004Bioorganic & Medicinal Chemistry Letters28 citations
Semantic Scholar
(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.
Yong-Jin Wu, C. Boissard, Jie Chen, W. Fitzpatrick +13 more
2004Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.
P. Hewawasam, Min Ding, Nathan Chen, D. King +5 more
2003Bioorganic & Medicinal Chemistry Letters20 citations
Semantic Scholar
The discovery of novel openers of Ca2+-dependent large-conductance potassium channels: Pharmacophore search and physiological evaluation of flavonoids
Yi Li, J. Starrett, N. Meanwell, G. Johnson +4 more
199720 citations
Semantic Scholar
The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.
P. Hewawasam, Nathan Chen, Min Ding, Joanne Natale +5 more
2004Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.
Yong-Jin Wu, Li-Qiang Sun, Huan He, Jie Chen +15 more
2004Bioorganic & Medicinal Chemistry Letters16 citations
Semantic Scholar
Modulators of Large-Conductance Calcium-Activated Potassium (BK) Channels as Potential Therapeutic Targets
J. Starrett, S. Dworetzky, V. Gribkoff
1996Current pharmaceutical design16 citations
Semantic Scholar
Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection.
John W. Russell, Diana Marrero, Valerie J. Whiterock, Lewis J. Klunk +1 more
1991Journal of Chromatography A16 citations
Semantic Scholar
Atropisomeric 3-(beta-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K potassium channel openers.
V. M. Vrudhula, Bireshwar Dasgupta, J. Qian-Cutrone, E. Kozlowski +7 more
2007Journal of Medicinal Chemistry13 citations
Semantic Scholar
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Yong-Jin Wu, Charles M. Conway, Li-Qiang Sun, F. Machet +18 more
2013Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.
Alexandre L’Heureux, A. Martel, Huan He, Jie Chen +9 more
2005Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Synthesis of 3H and 14C labeled (S)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one, maxipost™. An agent for post-stroke neuroprotection
Douglas D. Dischino, Valentin K. Gribkoff, P. Hewawasam, G. M. Luke +3 more
20038 citations
Semantic Scholar
Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes.
V. M. Vrudhula, Bireshwar Dasgupta, C. Boissard, V. Gribkoff +4 more
2005Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
An assessment of the present and future roles of non-ligand gated ion channel modulators as CNS therapeutics.
Valentin K. Gribkoff, J. Starrett
1999Expert Opinion on Pharmacotherapy7 citations
Semantic Scholar
In‐vivo Activity of Retinoid Esters in Skin is Related to In‐vitro Hydrolysis Rate
Simon Chen, Inger M. Darling, Kuo-Long Yu, J. Starrett +3 more
1995The Journal of pharmacy and pharmacology5 citations
Semantic Scholar
Chapter 24. Advances in technologies for the discovery and characterization of ion channel modulators: Focus on potassium channels
V. Gribkoff, J. Starrett
20024 citations
Semantic Scholar
An Assessment of the Effects of 5-HT6 Receptor Antagonists in Rodent Models of Learning
M. Lindner, D. Hodges, J. Hogan, Anitra F. Orie +8 more
20033 citations
Semantic Scholar
Synthesis and Biological Activity of 3-Substituted Imidazo(1,2-a)pyridines as Antiulcer Agents.
J. Starrett, T. A. Montzka, A. R. Crosswell, R. Cavanagh
19902 citations
Semantic Scholar
Small‐Molecule Modulators of Large‐Conductance, Calcium‐Activated (BK) Channels
J. Starrett
20081 citations
Semantic Scholar
4‐Aryl‐3‐(mercapto)quinolin‐2‐ones: Novel Maxi‐K Channel Opening Relaxants of Corporal Smooth Muscle.
P. Hewawasam, Wen-Hong Fan, D. Cook, K. Newberry +4 more
20041 citations
Semantic Scholar
Composés tricycliques utilisés en tant qu'agents anticancéreux
Derek J. Norris, Wayne Vaccaro, Mikkel V. Debenedetto, Andrew P. Degnan +8 more
20160 citations
Semantic Scholar
JPET # 199356 3 Recommended section assignment to guide listing in table of contents : Neuropharmacology
C. Albright, R. Dockens, J. Meredith, R. Olson +29 more
20120 citations
Semantic Scholar
The Discovery of Novel Openers of Ca2+-Dependent Large-Conductance Potassium Channels: Pharmacophore Search and Physiological Evaluation of Flavonoids.
Yi Li, J. Starrett, N. Meanwell, G. Johnson +4 more
20100 citations
Semantic Scholar
Editorial [Hot Topic: Alzheimerss Disease, Dementia and Cognitive Decline (Executive Editors: J.E. Starrett, Jr. and G.S. Poindexter)]
J. Starrett, G. Poindexter
20050 citations
Semantic Scholar
Promedicaments phosphates de fluorooxindoles
K. Gillman, P. Hewawasam, W. Schmitz, Omar D. Lopez +2 more
20030 citations
Semantic Scholar
The Synthesis and Structure—Activity Relationships of 1,3‐Diaryl 1,2,4‐(4H)‐Triazol‐5‐ones: A New Class of Calcium‐Dependent, Large Conductance, Potassium (Maxi‐K) Channel Opener Targeted for Urge Urinary Incontinence.
P. Hewawasam, M. Erway, G. Thalody, H. Weiner +5 more
20020 citations
Semantic Scholar
Derives benzoate de 1,3,4-oxadiazolone
P. Hewawasam, Min Ding, J. Starrett
19990 citations
Semantic Scholar

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