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W. Ewing · SciRah

Researcher profile · Semantic Scholar

W. Ewing

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W. Ewing — researcher profile on SciRah

h-index: 29
Works: 88
Citations: 3,169

Most-cited papers

Control of angiogenesis with synthetic heparin substitutes.
J. Folkman, Paul B. Weisz, M. Joullié, William W. Li +1 more
1989Science292 citations
Semantic Scholar
Decarboxylative Alkylation: An Approach to Site-Selective Bioconjugation of Native Proteins via Oxidation Potentials
S. Bloom, Chun Liu, Dominik K. Kölmel, Jennifer X. Qiao +4 more
2017Nature Chemistry277 citations Open access
Semantic Scholar
Overcoming the Limitations of γ, and δ-C–H Arylation of Amines through Ligand Development
Yan-Qiao Chen, Zhen Wang, Yong-Wei Wu, S. Wisniewski +4 more
2018Journal of the American Chemical Society145 citations
Semantic Scholar
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).
R. Sulsky, D. Magnin, Yan-Ting Huang, L. Simpkins +16 more
2007Bioorganic & Medicinal Chemistry Letters139 citations Open access
Semantic Scholar
Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis.
E. Webb, John Park, Erin L. Cole, D. Donnelly +3 more
2020Journal of the American Chemical Society119 citations Open access
Semantic Scholar
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation
Beryl X. Li, Daniel K Kim, S. Bloom, Richard Y.-C. Huang +5 more
2021Nature Chemistry117 citations Open access
Semantic Scholar
Crystal structures of human factor Xa complexed with potent inhibitors.
S. Maignan, J. Guilloteau, Stéphanie Pouzieux, Y. M. Choi-Sledeski +6 more
2000Journal of Medicinal Chemistry116 citations Open access
Semantic Scholar
A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen
Zhen Li, Zhen Wang, Nikita Chekshin, Shaoqun Qian +5 more
2021Science103 citations Open access
Semantic Scholar
Molecular structures of human factor Xa complexed with ketopiperazine inhibitors: preference for a neutral group in the S1 pocket.
S. Maignan, J. Guilloteau, Y. M. Choi-Sledeski, M. Becker +4 more
2003Journal of Medicinal Chemistry96 citations Open access
Semantic Scholar
Total synthesis and structural investigations of didemnins A, B, and C
Wen-Ren Li, W. Ewing, B. D. Harris, M. Joullié
199096 citations
Semantic Scholar
Site-Selective Functionalization of Methionine Residues via Photoredox Catalysis
Junyong Kim, Beryl X. Li, Richard Y.-C. Huang, Jennifer X. Qiao +2 more
2020Journal of the American Chemical Society95 citations Open access
Semantic Scholar
Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines
David C. Miller, J. M. Ganley, Andrew J. Musacchio, Trevor C. Sherwood +2 more
2019Journal of the American Chemical Society91 citations Open access
Semantic Scholar
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
Andrew K. Dilger, Kumar B. Pabbisetty, J. R. Corte, Indawati De Lucca +28 more
2021Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
Ni-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination
Christoph Heinz, J. P. Lutz, E. Simmons, Michael M. Miller +2 more
2018Journal of the American Chemical Society80 citations Open access
Semantic Scholar
Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
C. Mapelli, S. Natarajan, Jean-Philippe Meyer, M. Bastos +25 more
2009Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.
Gang Li, Andrew K. Dilger, Peter T. W. Cheng, W. Ewing +1 more
2018Angewandte Chemie69 citations
Semantic Scholar
Pd(II)-Catalyzed Enantioselective C(sp3)−H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group
Li-Jun Xiao, K. Hong, Fan Luo, Liang Hu +3 more
2020Angewandte Chemie67 citations Open access
Semantic Scholar
Milvexian, an orally bioavailable, small‐molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits
P. Wong, Earl J. Crain, J. Bozarth, Yiming Wu +5 more
2021Journal of Thrombosis and Haemostasis58 citations Open access
Semantic Scholar
meta C–H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity
Luo-Yan Liu, Jennifer X. Qiao, Kap-Sun Yeung, W. Ewing +1 more
2019Journal of the American Chemical Society53 citations Open access
Semantic Scholar
Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
D. Pinto, Michael J. Orwat, Leon M. Smith, Mi-Mi L. Quan +25 more
2017Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
Factor XIa Inhibitors as New Anticoagulants.
Mi-Mi L. Quan, D. Pinto, J. Smallheer, W. Ewing +4 more
2018Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
meta-Selective C–H Arylation of Fluoroarenes and Simple Arenes
Luo-Yan Liu, Jennifer X. Qiao, Kap-Sun Yeung, W. Ewing +1 more
2020Angewandte Chemie46 citations Open access
Semantic Scholar
Hemilabile Benzyl Ether Enables γ-C(sp3)–H Carbonylation and Olefination of Alcohols
Keita Tanaka, W. Ewing, Jin-Quan Yu
2019Journal of the American Chemical Society43 citations Open access
Semantic Scholar
Ligand-Enabled Pd(II)-Catalyzed C(sp3)–H Lactonization using Molecular oxygen as oxidant
Shaoqun Qian, Zi-Qi Li, Min-Yan Li, S. Wisniewski +6 more
2020Organic Letters40 citations Open access
Semantic Scholar
PROGRESS IN THE DESIGN OF INHIBITORS OF COAGULATION FACTOR XA
W. Ewing, H. Pauls, P. SpadaAlfred
199939 citations
Semantic Scholar
Discovery of a potent and novel motilin agonist.
James J. Li, H. Chao, Haixia Wang, J. Tino +16 more
2004Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Affinity of fibroblast growth factors for β-cyclodextrin tetradecasulfate
Yuen W. Shing, J. Folkman, P. B. Weisz, M. Joullié +1 more
199037 citations
Semantic Scholar
Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.
B. Ellsworth, Ying Wang, Yeheng Zhu, A. Pendri +14 more
2007Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Manganese-Catalyzed Desaturation of N-Acyl Amines and Ethers
Gang Li, Patrick A. Kates, Andrew K. Dilger, Peter T. W. Cheng +2 more
2019ACS Catalysis29 citations
Semantic Scholar
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer
Hyun Min Lee, Nefertiti Muhammad, Elizabeth L. Lieu, F. Cai +19 more
2024Nature Metabolism27 citations
Semantic Scholar
Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)─H Lactamization of Native Amides
Shuang Liu, Zhe Zhuang, Jennifer X. Qiao, Kap-Sun Yeung +6 more
2021Journal of the American Chemical Society26 citations Open access
Semantic Scholar
Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer
Kuo Zhao, Kenji Yamashita, Joseph Carpenter, Trevor C. Sherwood +3 more
2019Journal of the American Chemical Society26 citations Open access
Semantic Scholar
Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).
Jun Li, Stephanie Y. Chen, James J. Li, Haixia Wang +28 more
2007Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Synthetic studies of the detoxin complex. I. total synthesis of (-) detoxinine
W. Ewing, B. D. Harris, K. L. Bhat, M. Joullié
198626 citations
Semantic Scholar
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.
Elizabeth A. Jurica, Xi-Mao Wu, Kristin N Williams, Andrés S. Hernández +34 more
2017Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
A Short, Stereocontrolled Synthesis of (—)-Detoxinine
M. Joullié, W. Ewing
198822 citations Open access
Semantic Scholar
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
Jun Shi, Zheng-Xiang Gu, Elizabeth A. Jurica, Xi-Mao Wu +35 more
2018Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
To Market, To Market—2011
J. Bronson, M. Dhar, W. Ewing, N. Lonberg
201221 citations
Semantic Scholar
Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
J. R. Corte, D. Pinto, Tianan Fang, Honey Osuna +26 more
2019Journal of Medicinal Chemistry20 citations
Semantic Scholar
The Design of Competitive, Small-molecule Inhibitors of Coagulation Factor Xa
H. Pauls, W. Ewing, Y. M. Choi-Sledeski
200120 citations
Semantic Scholar
Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.
Y. M. Choi-Sledeski, M. Becker, D. Green, R. Davis +14 more
1999Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
Wu Yang, Yufeng Wang, A. Lai, C. Clark +26 more
2020Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
J. R. Corte, Wu Yang, Tianan Fang, Yufeng Wang +16 more
2017Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Synthetic studies of didemnins. i. revision of the stereochemistry of the hydroxyisovalerylpropionyl (hip) unit.
W. Ewing, K. L. Bhat, Madeleine M. Joullie
198619 citations Open access
Semantic Scholar
Identification of potent 11mer glucagon-like peptide-1 receptor agonist peptides with novel C-terminal amino acids: Homohomophenylalanine analogs.
T. Haque, V. Lee, D. Riexinger, M. Lei +8 more
2010Peptides17 citations
Semantic Scholar
Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
T. Haque, Ningning Liang, R. Golla, R. Seethala +6 more
2009Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Pharmacodynamic activity and antithrombotic efficacy of RPR120844, a novel inhibitor of coagulation factor Xa.
R. Leadley, Suzanne R. Morgan, Ross G. Bentley, J. Bostwick +10 more
1999Journal of Cardiovascular Pharmacology17 citations Open access
Semantic Scholar
Design and synthesis of tetrazole-based growth hormone secretagogue: the SAR studies of the O-benzyl serine side chain.
Jun Li, Stephanie Y. Chen, Shiwei Tao, Haixia Wang +20 more
2008Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Synthesis of bicyclic pyrimidine derivatives as ATP analogues.
G. Makara, W. Ewing, Yao Ma, E. Wintner
2001Journal of Organic Chemistry15 citations
Semantic Scholar
To Market, To Market—2010
J. Bronson, M. Dhar, W. Ewing, N. Lonberg
201114 citations
Semantic Scholar

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