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J. Frearson · SciRah

Researcher profile · Semantic Scholar

J. Frearson

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J. Frearson — researcher profile on SciRah

h-index: 30
Works: 75
Citations: 3,539

Most-cited papers

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases
R. Brenk, A. Schipani, D. James, A. Krasowski +3 more
2007ChemMedChem674 citations Open access
Semantic Scholar
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B. Baragaña, I. Hallyburton, Marcus C. S. Lee, N. Norcross +60 more
2015Nature417 citations Open access
Semantic Scholar
N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness
J. Frearson, S. Brand, S. McElroy, Laura A. T. Cleghorn +22 more
2010Nature312 citations Open access
Semantic Scholar
Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay
M. De Rycker, I. Hallyburton, John Thomas, Lorna Campbell +8 more
2013Antimicrobial Agents and Chemotherapy141 citations Open access
Semantic Scholar
Target assessment for antiparasitic drug discovery
J. Frearson, P. Wyatt, I. Gilbert, A. Fairlamb
2007Trends in Parasitology137 citations Open access
Semantic Scholar
Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
Stephen Patterson, M. Alphey, Deuan C. Jones, Emma Shanks +5 more
2011Journal of Medicinal Chemistry132 citations Open access
Semantic Scholar
The Phosphotyrosine Phosphatase SHP-2 Participates in a Multimeric Signaling Complex and Regulates T Cell Receptor (TCR) coupling to the Ras/Mitogen-activated Protein Kinase (MAPK) Pathway in Jurkat T Cells
J. Frearson, D. Alexander
1998Journal of Experimental Medicine132 citations Open access
Semantic Scholar
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
S. Brand, Laura A. T. Cleghorn, S. McElroy, D. A. Robinson +16 more
2011Journal of Medicinal Chemistry123 citations Open access
Semantic Scholar
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening
C. Mpamhanga, D. Spinks, L. Tulloch, Emma Shanks +8 more
2009Journal of Medicinal Chemistry101 citations Open access
Semantic Scholar
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
B. Baragaña, N. Norcross, Caroline Wilson, Achim Porzelle +23 more
2016Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
HTS and hit finding in academia – from chemical genomics to drug discovery
J. Frearson, I. Collie
2009Drug Discovery Today80 citations Open access
Semantic Scholar
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis
Deuan C. Jones, I. Hallyburton, L. Stojanovski, K. Read +2 more
2010Biochemical Pharmacology69 citations Open access
Semantic Scholar
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
S. Brand, N. Norcross, S. Thompson, J. Harrison +17 more
2014Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei
M. Urbaniak, Toby Mathieson, M. Bantscheff, Dirk Eberhard +6 more
2012ACS Chemical Biology61 citations Open access
Semantic Scholar
Chemical Validation of Trypanothione Synthetase
L. S. Torrie, S. Wyllie, D. Spinks, Sandra L. Oza +6 more
2009Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Drug Discovery in Academia- the third way?
J. Frearson, P. Wyatt
2010Expert Opinion on Drug Discovery53 citations Open access
Semantic Scholar
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei
D. Spinks, Emma Shanks, Laura A. T. Cleghorn, S. McElroy +6 more
2009ChemMedChem52 citations Open access
Semantic Scholar
Acetazolamide-based fungal chitinase inhibitors
A. W. Schüttelkopf, L. Gros, D. Blair, J. Frearson +2 more
2010Bioorganic & Medicinal Chemistry51 citations Open access
Semantic Scholar
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1
D. Spinks, Ong B. Han, C. Mpamhanga, Emma Shanks +8 more
2010ChemMedChem51 citations Open access
Semantic Scholar
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3
Laura A. T. Cleghorn, Andrew Woodland, I. Collie, L. S. Torrie +9 more
2011ChemMedChem50 citations Open access
Semantic Scholar
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
J. Harrison, S. Brand, V. Smith, D. A. Robinson +15 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase
Stephen Patterson, Deuan C. Jones, Emma Shanks, J. Frearson +3 more
2009ChemMedChem47 citations Open access
Semantic Scholar
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
D. Spinks, L. S. Torrie, S. Thompson, J. Harrison +5 more
2011ChemMedChem44 citations Open access
Semantic Scholar
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.
P. D. Andrews, M. Becroft, A. Aspegren, J. Gilmour +12 more
2010Biochemical Journal44 citations Open access
Semantic Scholar
Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei
Jiang-Tao Ma, Corinna Benz, Raffaella Grimaldi, C. Stockdale +3 more
2010Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.
Tomomi Kosugi, D. R. Mitchell, A. Fujino, M. Imai +25 more
2012Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules
Andrew Woodland, Raffaella Grimaldi, Torsten Luksch, Laura A. T. Cleghorn +6 more
2013ChemMedChem33 citations Open access
Semantic Scholar
The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis
R. Urich, Raffaella Grimaldi, Torsten Luksch, J. Frearson +2 more
2014Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Finding new hits in neglected disease projects: target or phenotypic based screening?
I. Gilbert, D. Leroy, J. Frearson
2011Current Topics in Medicinal Chemistry32 citations
Semantic Scholar
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
Emma Shanks, Ong B. Han, D. A. Robinson, S. Thompson +3 more
2010Analytical Biochemistry31 citations Open access
Semantic Scholar
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei
Laura A. T. Cleghorn, S. Albrecht, L. Stojanovski, F. Simeons +10 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei
M. Urbaniak, I. Collie, W. Fang, Tonia Aristotelous +7 more
2013ACS Chemical Biology26 citations Open access
Semantic Scholar
IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening
N. Tidten-Luksch, Raffaella Grimaldi, L. S. Torrie, J. Frearson +2 more
2012PLoS ONE25 citations Open access
Semantic Scholar
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more
2015ChemMedChem24 citations Open access
Semantic Scholar
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
Tracy Bayliss, D. A. Robinson, V. Smith, S. Brand +10 more
2017Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Assessment of Pseudomonas aeruginosa N 5,N 10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target
T. Eadsforth, M. Gardiner, F. Maluf, S. McElroy +4 more
2012PLoS ONE21 citations Open access
Semantic Scholar
Screening a protein kinase inhibitor library against Plasmodium falciparum
I. Hallyburton, Raffaella Grimaldi, Andrew Woodland, B. Baragaña +9 more
2017Malaria Journal19 citations Open access
Semantic Scholar
Adapting compassion focused therapy for an adult with a learning disability—A case study
Rosalind Cooper, J. Frearson
201719 citations Open access
Semantic Scholar
Quinol derivatives as potential trypanocidal agents
Amy S. Capes, Stephen Patterson, S. Wyllie, I. Hallyburton +7 more
2012Bioorganic & Medicinal Chemistry19 citations Open access
Semantic Scholar
Differential regulation of von Willebrand factor exocytosis and prostacyclin synthesis in electropermeabilized endothelial cell monolayers.
J. Frearson, Paul L. Harrison, Michael C. Scrutton, Jeremy D. Pearson
1995Biochemical Journal17 citations Open access
Semantic Scholar
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
Andrew Woodland, S. Thompson, Laura A. T. Cleghorn, N. Norcross +13 more
2015ChemMedChem16 citations Open access
Semantic Scholar
Drug Design and Discovery in Alzheimer’s Disease
Atta-ur-rahman, M. Choudhary, A. Crider, A. Adem +66 more
201413 citations
Semantic Scholar
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis
B. Baragaña, I. Hallyburton, Marcus C. S. Lee, N. Norcross +60 more
2016Nature12 citations Open access
Semantic Scholar
Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials
N. Norcross, B. Baragaña, Caroline Wilson, I. Hallyburton +26 more
2016Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488
V. Smith, Laura A. T. Cleghorn, Andrew Woodland, D. Spinks +10 more
2011ChemMedChem9 citations Open access
Semantic Scholar
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
N. Norcross, Caroline Wilson, B. Baragaña, I. Hallyburton +24 more
2019ChemMedChem8 citations Open access
Semantic Scholar
Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay
M. De Rycker, I. Hallyburton, John Thomas, Lorna Campbell +8 more
2014Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Laura A. T. Cleghorn, Richard J. Wall, S. Albrecht, S. MacGowan +18 more
2023Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Tyrosine phosphatases in T-cell development and signalling.
L. A. Conroy, J. Stone, J. Frearson, K. Byth +3 more
1997Biochemical Society Transactions5 citations
Semantic Scholar
Towards Small Molecules as Therapies for Alzheimer’s Disease and Other Neurodegenerative Disorders
O. Aziz, R. Bürli, D. Fischer, J. Frearson +1 more
20144 citations
Semantic Scholar

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