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Laura A. T. Cleghorn · SciRah

Researcher profile · Semantic Scholar

Laura A. T. Cleghorn

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Laura A. T. Cleghorn — researcher profile on SciRah

h-index: 16
Works: 37
Citations: 1,123

Most-cited papers

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness
J. Frearson, S. Brand, S. McElroy, Laura A. T. Cleghorn +22 more
2010Nature312 citations Open access
Semantic Scholar
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
S. Brand, Laura A. T. Cleghorn, S. McElroy, D. A. Robinson +16 more
2011Journal of Medicinal Chemistry123 citations Open access
Semantic Scholar
Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis
Kriti Arora, Bernardo Ochoa-Montaño, P. Tsang, T. Blundell +11 more
2014Antimicrobial Agents and Chemotherapy116 citations Open access
Semantic Scholar
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis
Yumi Park, A. Pacitto, Tracy Bayliss, Laura A. T. Cleghorn +51 more
2016ACS Infectious Diseases85 citations Open access
Semantic Scholar
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei
D. Spinks, Emma Shanks, Laura A. T. Cleghorn, S. McElroy +6 more
2009ChemMedChem52 citations Open access
Semantic Scholar
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB
Laura A. T. Cleghorn, Peter C. Ray, J. Odingo, Anuradha Kumar +22 more
2018Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3
Laura A. T. Cleghorn, Andrew Woodland, I. Collie, L. S. Torrie +9 more
2011ChemMedChem50 citations Open access
Semantic Scholar
Configurations of metallocyclams and relevance to anti-HIV activity.
Tina M. Hunter, S. Paisey, Hye-seo Park, Laura A. T. Cleghorn +3 more
2004Journal of Inorganic Biochemistry44 citations
Semantic Scholar
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, M. De Rycker, M. Ajakane, S. Albrecht +48 more
2018Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules
Andrew Woodland, Raffaella Grimaldi, Torsten Luksch, Laura A. T. Cleghorn +6 more
2013ChemMedChem33 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
S. Green, S. Davis, S. Damerow, Curtis A. Engelhart +41 more
2022Nature Communications30 citations Open access
Semantic Scholar
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
Peter C. Ray, M. Huggett, Penelope A. Turner, Malcolm Taylor +33 more
2021ACS Omega30 citations Open access
Semantic Scholar
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei
Laura A. T. Cleghorn, S. Albrecht, L. Stojanovski, F. Simeons +10 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Bimetallic catalytic synthesis of annelated benzazepines.
Laura A. T. Cleghorn, R. Grigg, C. Kilner, William S. MacLachlan +1 more
2005Chemical Communications19 citations
Semantic Scholar
Additive effects in palladium–indium mediated Barbier type allylations
Laura A. T. Cleghorn, Ian R. Cooper, R. Grigg, William S. MacLachlan +1 more
200319 citations
Semantic Scholar
Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality: Part 1. Scope and Class 1 examples with aldehydes and ketones
Laura A. T. Cleghorn, Ian R. Cooper, C. Fishwick, R. Grigg +3 more
200317 citations
Semantic Scholar
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
Andrew Woodland, S. Thompson, Laura A. T. Cleghorn, N. Norcross +13 more
2015ChemMedChem16 citations Open access
Semantic Scholar
Reactive organoallyl species generated from aryl halides and allene: allylation of α,β-unsaturated aldehydes and cyclic ketones employing Pd/In transmetallation processes
Laura A. T. Cleghorn, R. Grigg, V. Savić, M. Simić
200811 citations Open access
Semantic Scholar
Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis
F. Tomasi, Jessica T. P. Schweber, S. Kimura, Junhao Zhu +5 more
2022bioRxiv10 citations Open access
Semantic Scholar
Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488
V. Smith, Laura A. T. Cleghorn, Andrew Woodland, D. Spinks +10 more
2011ChemMedChem9 citations Open access
Semantic Scholar
Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors
Lauren Ames, Renée Allen, H. Boshoff, Laura A. T. Cleghorn +3 more
2025ACS Infectious Diseases8 citations Open access
Semantic Scholar
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Laura A. T. Cleghorn, Richard J. Wall, S. Albrecht, S. MacGowan +18 more
2023Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis
Simon R. Green, J. Harrison, S. Thompson, Dinakaran Murugesan +19 more
2025ACS Infectious Diseases4 citations Open access
Semantic Scholar
Correction for Arora et al., “Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis”
Kriti Arora, Bernardo Ochoa-Montaño, P. Tsang, T. Blundell +11 more
2017Antimicrobial Agents and Chemotherapy3 citations Open access
Semantic Scholar
Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis
S. Davis, M. Mathieson, K. Buchanan, Alice Dawson +24 more
2025bioRxiv2 citations Open access
Semantic Scholar
Navigating the Landscape of Academic Drug Discovery: An 18-Year Journey.
B. Baragaña, Laura A. T. Cleghorn
2025Journal of Medicinal Chemistry1 citations
Semantic Scholar
Common biological features of Mycobacterium tuberculosis MmpL3 inhibitors
Lauren Ames, Renée Allen, H. Boshoff, Laura A. T. Cleghorn +3 more
2025bioRxiv1 citations Open access
Semantic Scholar
Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis
Claire Naylor, G. A. Prosser, Tracy Bayliss, Lila Berle +15 more
2026bioRxiv0 citations Open access
Semantic Scholar
Integrating chemical, genetic, and feasibility assessments for anti-tubercular target validation
Dirk Schnappinger, S. Berthel, H. Boshoff, Inna V. Krieger +19 more
2026EMBO Molecular Medicine0 citations Open access
Semantic Scholar
Identification and Evaluation of Dibasic Piperidines as Cell Wall Inhibitors against Mycobacterium tuberculosis
Claire Naylor, G. Prosser, Tracy Bayliss, Lila Berle +15 more
2026ACS Infectious Diseases0 citations Open access
Semantic Scholar
University of Dundee Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors Brand
Stephen Brand, Laura A. T. Cleghorn, Stuart P. McElroy, D. A. Robinson +16 more
20170 citations
Semantic Scholar
Back Cover: From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013)
Andrew Woodland, Raffaella Grimaldi, Torsten Luksch, Laura A. T. Cleghorn +6 more
20130 citations
Semantic Scholar
Hit to lead and lead optimization of novel small molecules for the treatment of human African trypanosomiasis
C. FreemanJennifer, Joe B. Perales, Andrew Woodland, C. Bacchi +15 more
20090 citations
Semantic Scholar
Inhibitors N-myristoyl transferase
S. Brand, P. Wyatt, S. Thompson, J. Harrison +6 more
20090 citations
Semantic Scholar
Bimetallic Catalytic Synthesis of Anellated Benzazepines.
Laura A. T. Cleghorn, R. Grigg, C. Kilner, William S. MacLachlan +1 more
20050 citations
Semantic Scholar
Additive Effects in Palladium—Indium Mediated Barbier-type Allylations.
Laura A. T. Cleghorn, Ian R. Cooper, R. Grigg, William S. MacLachlan +1 more
20040 citations
Semantic Scholar
Three-Component Bimetallic (Pd/In) Mediated Cascade Allylation of C=X Functionality. Part 1. Scope and Class 1 Examples with Aldehydes and Ketones.
Laura A. T. Cleghorn, Ian R. Cooper, C. Fishwick, R. Grigg +3 more
20040 citations
Semantic Scholar

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