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I. Gilbert · SciRah

Researcher profile · Semantic Scholar

I. Gilbert

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I. Gilbert — researcher profile on SciRah

h-index: 55
Works: 265
Citations: 11K

Most-cited papers

Towards the sustainable discovery and development of new antibiotics
M. Miethke, M. Pieroni, T. Weber, M. Brönstrup +50 more
2021Nature Reviews Chemistry944 citations Open access
Semantic Scholar
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B. Baragaña, I. Hallyburton, Marcus C. S. Lee, N. Norcross +60 more
2015Nature417 citations Open access
Semantic Scholar
Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2017Nature Reviews Microbiology367 citations Open access
Semantic Scholar
Challenges and recent progress in tropical disease drug discovery
M. De Rycker, B. Baragaña, S. Duce, I. Gilbert
2018Nature182 citations Open access
Semantic Scholar
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
S. Wyllie, S. Brand, M. Thomas, M. De Rycker +45 more
2019Proceedings of the National Academy of Sciences of the United States of America149 citations Open access
Semantic Scholar
Anti-trypanosomatid drug discovery: progress and challenges
M. De Rycker, S. Wyllie, D. Horn, K. Read +1 more
2022Nature Reviews Microbiology142 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B. Baragaña, B. Forte, Ryan Choi, Stephen Nakazawa-Hewitt +73 more
2019Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
S. Wyllie, M. Thomas, Stephen Patterson, Sabrinia D Crouch +28 more
2018Nature119 citations Open access
Semantic Scholar
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3
Richard J. Wall, Eva Rico, Iva Lukac, Fabio Zuccotto +7 more
2018Proceedings of the National Academy of Sciences of the United States of America109 citations Open access
Semantic Scholar
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
B. Baragaña, N. Norcross, Caroline Wilson, Achim Porzelle +23 more
2016Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities
L. Arendse, S. Wyllie, K. Chibale, I. Gilbert
2021ACS Infectious Diseases80 citations Open access
Semantic Scholar
MalDA, Accelerating Malaria Drug Discovery
Tuo Yang, Sabine Ottilie, E. Istvan, Karla P. Godinez-Macias +19 more
2021Trends in Parasitology79 citations Open access
Semantic Scholar
Prioritization of Molecular Targets for Antimalarial Drug Discovery
B. Forte, Sabine Ottilie, A. Plater, B. Campo +17 more
2021ACS Infectious Diseases69 citations Open access
Semantic Scholar
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
Victoriano Corpas-Lopez, S. Moniz, M. Thomas, Richard J. Wall +17 more
2018ACS Infectious Diseases69 citations Open access
Semantic Scholar
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
C. Mowbray, S. Braillard, P. Glossop, G. Whitlock +18 more
2021Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Small-Molecule Antibiotic Drug Development: Need and Challenges
M. Bergkessel, Barbara Forte, I. Gilbert
2023ACS Infectious Diseases63 citations Open access
Semantic Scholar
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
R. Summers, C. Pasaje, J. P. Pisco, Josefine Striepen +30 more
2021Cell Chemical Biology55 citations Open access
Semantic Scholar
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
J. Harrison, S. Brand, V. Smith, D. A. Robinson +15 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022
Nicola Caldwell, R. Afshar, B. Baragaña, A. Bustinduy +17 more
2023ACS Infectious Diseases43 citations Open access
Semantic Scholar
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, M. De Rycker, M. Ajakane, S. Albrecht +48 more
2018Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
W. Fang, D. A. Robinson, O. Raimi, D. Blair +7 more
2015ACS Chemical Biology41 citations Open access
Semantic Scholar
Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease
I. Gilbert, S. Vinayak, B. Striepen, U. Manjunatha +2 more
2023BMJ Global Health39 citations Open access
Semantic Scholar
Application of RNAi to Genomic Drug Target Validation in Schistosomes
A. Guidi, Nuha R Mansour, R. Paveley, Ian M. Carruthers +4 more
2015PLoS Neglected Tropical Diseases37 citations Open access
Semantic Scholar
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
S. Brand, E. Ko, Elisabet Viayna, S. Thompson +32 more
2017Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, S. Brand, M. De Rycker, Fabio Zuccotto +20 more
2021Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
Richard J. Wall, S. Carvalho, R. Milne, Juan A. Bueren-Calabuig +18 more
2020ACS Infectious Diseases32 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
S. Green, S. Davis, S. Damerow, Curtis A. Engelhart +41 more
2022Nature Communications30 citations Open access
Semantic Scholar
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani
L. S. Torrie, S. Brand, D. A. Robinson, E. Ko +15 more
2017ACS Infectious Diseases28 citations Open access
Semantic Scholar
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei
Laura A. T. Cleghorn, S. Albrecht, L. Stojanovski, F. Simeons +10 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
In Vitro Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing Enterobacterales Collected in India
Y. Bakthavatchalam, Divyaa Elangovan, Subha Vajjiravelu Jaganathan, Nivedhana Subburaju +18 more
2023Microbiology spectrum27 citations Open access
Semantic Scholar
Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.
Peter C. Ray, Michael Kiczun, M. Huggett, Andrew S. T. Lim +3 more
2017Drug Discovery Today27 citations Open access
Semantic Scholar
Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi
Linda J. Herrera, S. Brand, Andrés Santos, L. Nohara +9 more
2016PLoS Neglected Tropical Diseases27 citations Open access
Semantic Scholar
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
Luciana S. Paradela, Richard J. Wall, S. Carvalho, Giulia Chemi +11 more
2021Cell Chemical Biology26 citations Open access
Semantic Scholar
Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
Richard J. Wall, S. Moniz, M. Thomas, S. Norval +7 more
2018Antimicrobial Agents and Chemotherapy25 citations Open access
Semantic Scholar
Setting Our Sights on Infectious Diseases
M. De Rycker, D. Horn, B. Aldridge, R. Amewu +33 more
2019ACS Infectious Diseases23 citations Open access
Semantic Scholar
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
Tracy Bayliss, D. A. Robinson, V. Smith, S. Brand +10 more
2017Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
M. Thomas, Kate McGonagle, P. Rowland, D. A. Robinson +37 more
2023Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Screening a protein kinase inhibitor library against Plasmodium falciparum
I. Hallyburton, Raffaella Grimaldi, Andrew Woodland, B. Baragaña +9 more
2017Malaria Journal19 citations Open access
Semantic Scholar
Discovery and optimisation studies of antimalarial phenotypic hits
Alka Mital, Dinakaran Murugesan, M. Kaiser, C. Yeates +1 more
2015European journal of medicinal chemistry18 citations Open access
Semantic Scholar
SophosQM: Accurate Binding Affinity Prediction in Compound Optimization
R. Guareschi, Iva Lukac, I. Gilbert, Fabio Zuccotto
2023ACS Omega17 citations Open access
Semantic Scholar
Clinical and Genomic Evolution of Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections over Two Time Periods at a Tertiary Care Hospital in South India: A Prospective Cohort Study
A. Manesh, C. Shankar, M. George, D. S. Jasrotia +21 more
2023Infectious Disease and Therapy16 citations Open access
Semantic Scholar
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Simon R. Green, Caroline Wilson, T. Eadsforth, A. Punekar +19 more
2023Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
R. Milne, N. Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan +13 more
2022ACS Infectious Diseases16 citations Open access
Semantic Scholar
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
L. S. Torrie, D. A. Robinson, M. Thomas, J. Hobrath +11 more
2020ACS Infectious Diseases16 citations Open access
Semantic Scholar
Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2018Nature Reviews Microbiology16 citations Open access
Semantic Scholar
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
Nicola Caldwell, Caroline Peet, Peter J. Miller, Beatrice L Colon +29 more
2024Science Translational Medicine15 citations Open access
Semantic Scholar
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
S. Wyllie, M. Thomas, Stephen Patterson, Sabrinia D Crouch +28 more
2023Nature15 citations Open access
Semantic Scholar
High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria
F. Tamaki, F. Fisher, R. Milne, F. S. Terán +8 more
2022Antimicrobial Agents and Chemotherapy15 citations Open access
Semantic Scholar
Accurate prediction of dynamic protein–ligand binding using P‐score ranking
Peter E. G. F. Ibrahim, Fabio Zuccotto, Ulrich Zachariae, I. Gilbert +1 more
2024Journal of Computational Chemistry14 citations Open access
Semantic Scholar
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Alasdair R C Smith, Richard J. Wall, Stephen Patterson, Timothy J. Rowan +25 more
2022Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar

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