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P. Wyatt · SciRah

Researcher profile · Semantic Scholar

P. Wyatt

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P. Wyatt — researcher profile on SciRah

h-index: 44
Works: 221
Citations: 7,120

Most-cited papers

A novel multiple-stage antimalarial agent that inhibits protein synthesis
B. Baragaña, I. Hallyburton, Marcus C. S. Lee, N. Norcross +60 more
2015Nature417 citations Open access
Semantic Scholar
Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2017Nature Reviews Microbiology367 citations Open access
Semantic Scholar
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research
S. Rihn, A. Merits, Siddharth Bakshi, Matthew L. Turnbull +78 more
2021PLoS Biology206 citations Open access
Semantic Scholar
The role of phthiocerol dimycoserosate and the PE/PPE protein family in outer cell wall permeability in Mycobacterium tuberculosis
Qinglan Wang, H. Boshoff, J. Harrison, Peter C. Ray +3 more
2020Science176 citations Open access
Semantic Scholar
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
S. Wyllie, S. Brand, M. Thomas, M. De Rycker +45 more
2019Proceedings of the National Academy of Sciences of the United States of America149 citations Open access
Semantic Scholar
Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay
M. De Rycker, I. Hallyburton, John Thomas, Lorna Campbell +8 more
2013Antimicrobial Agents and Chemotherapy141 citations Open access
Semantic Scholar
Prediction of Drug Penetration in Tuberculosis Lesions
J. Sarathy, Fabio Zuccotto, Hsin-Pin Ho, L. Sandberg +6 more
2016ACS Infectious Diseases138 citations Open access
Semantic Scholar
Fragment-based hit identification: thinking in 3D.
A. Morley, A. Pugliese, K. Birchall, J. Bower +12 more
2013Drug Discovery Today132 citations
Semantic Scholar
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B. Baragaña, B. Forte, Ryan Choi, Stephen Nakazawa-Hewitt +73 more
2019Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
S. Wyllie, M. Thomas, Stephen Patterson, Sabrinia D Crouch +28 more
2018Nature119 citations Open access
Semantic Scholar
Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis
Kriti Arora, Bernardo Ochoa-Montaño, P. Tsang, T. Blundell +11 more
2014Antimicrobial Agents and Chemotherapy116 citations Open access
Semantic Scholar
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
B. Baragaña, N. Norcross, Caroline Wilson, Achim Porzelle +23 more
2016Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis
Yumi Park, A. Pacitto, Tracy Bayliss, Laura A. T. Cleghorn +51 more
2016ACS Infectious Diseases85 citations Open access
Semantic Scholar
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Lee A. Armstrong, S. Lange, Virginia Dee Cesare, S. Matthews +14 more
2021PLoS ONE71 citations Open access
Semantic Scholar
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
Victoriano Corpas-Lopez, S. Moniz, M. Thomas, Richard J. Wall +17 more
2018ACS Infectious Diseases69 citations Open access
Semantic Scholar
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
S. Brand, N. Norcross, S. Thompson, J. Harrison +17 more
2014Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization
Dinakaran Murugesan, Peter C. Ray, Tracy Bayliss, G. A. Prosser +27 more
2018ACS Infectious Diseases64 citations Open access
Semantic Scholar
Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity
S. Tardif, Oladipo A. Madamidola, Sean G Brown, Lorna Frame +4 more
2014Human Reproduction63 citations Open access
Semantic Scholar
Targeting N-myristoylation for therapy of B-cell lymphomas
Erwan Beauchamp, Megan C. Yap, A. Iyer, M. Perinpanayagam +14 more
2020Nature Communications62 citations Open access
Semantic Scholar
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB
Laura A. T. Cleghorn, Peter C. Ray, J. Odingo, Anuradha Kumar +22 more
2018Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
The TB Drug Accelerator at Year Ten: What Have We Learned?
B. Aldridge, David Barros-Aguirre, C. Barry, Robert H. Bates +33 more
2021Nature Medicine48 citations Open access
Semantic Scholar
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
J. Harrison, S. Brand, V. Smith, D. A. Robinson +15 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, M. De Rycker, M. Ajakane, S. Albrecht +48 more
2018Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
W. Fang, D. A. Robinson, O. Raimi, D. Blair +7 more
2015ACS Chemical Biology41 citations Open access
Semantic Scholar
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target
Caroline Wilson, Peter C. Ray, Fabio Zuccotto, Jorge Hernández +36 more
2021Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
A. Czarna, Jacek Plewka, Leanid Kresik, A. Matsuda +11 more
2022bioRxiv35 citations Open access
Semantic Scholar
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
S. Brand, E. Ko, Elisabet Viayna, S. Thompson +32 more
2017Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, S. Brand, M. De Rycker, Fabio Zuccotto +20 more
2021Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents
Dinakaran Murugesan, M. Kaiser, K. White, S. Norval +6 more
2013ChemMedChem34 citations Open access
Semantic Scholar
From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules
Andrew Woodland, Raffaella Grimaldi, Torsten Luksch, Laura A. T. Cleghorn +6 more
2013ChemMedChem33 citations Open access
Semantic Scholar
The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis
R. Urich, Raffaella Grimaldi, Torsten Luksch, J. Frearson +2 more
2014Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
S. Green, S. Davis, S. Damerow, Curtis A. Engelhart +41 more
2022Nature Communications30 citations Open access
Semantic Scholar
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
Peter C. Ray, M. Huggett, Penelope A. Turner, Malcolm Taylor +33 more
2021ACS Omega30 citations Open access
Semantic Scholar
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei
Laura A. T. Cleghorn, S. Albrecht, L. Stojanovski, F. Simeons +10 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Fragment library design, synthesis and expansion: nurturing a synthesis and training platform.
Peter C. Ray, Michael Kiczun, M. Huggett, Andrew S. T. Lim +3 more
2017Drug Discovery Today27 citations Open access
Semantic Scholar
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1
M. Bell, David W. Foley, C. Naylor, C. Robinson +9 more
2018Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more
2015ChemMedChem24 citations Open access
Semantic Scholar
Setting Our Sights on Infectious Diseases
M. De Rycker, D. Horn, B. Aldridge, R. Amewu +33 more
2019ACS Infectious Diseases23 citations Open access
Semantic Scholar
Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem
S. J. Martins da Silva, Sean G Brown, Keith A. Sutton, Louise King +6 more
2017Human Reproduction23 citations Open access
Semantic Scholar
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
Tracy Bayliss, D. A. Robinson, V. Smith, S. Brand +10 more
2017Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes
B. Galvin, Zhiru Li, Estelle Villemaine, Catherine B. Poole +4 more
2014PLoS Neglected Tropical Diseases23 citations Open access
Semantic Scholar
Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B. Simelane +22 more
2021Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Screening a protein kinase inhibitor library against Plasmodium falciparum
I. Hallyburton, Raffaella Grimaldi, Andrew Woodland, B. Baragaña +9 more
2017Malaria Journal19 citations Open access
Semantic Scholar
Inhibition of CorA-Dependent Magnesium Homeostasis Is Cidal in Mycobacterium tuberculosis
Yumi Park, Yong-Mo Ahn, S. Jonnala, Sangmi Oh +10 more
2019Antimicrobial Agents and Chemotherapy18 citations Open access
Semantic Scholar
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA
Federica Prati, Fabio Zuccotto, Daniel Fletcher, M. Convery +13 more
2018ChemMedChem17 citations Open access
Semantic Scholar
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Simon R. Green, Caroline Wilson, T. Eadsforth, A. Punekar +19 more
2023Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis
M. D. Libardo, C. Duncombe, S. Green, P. Wyatt +7 more
2021Cell Chemical Biology16 citations Open access
Semantic Scholar
Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2018Nature Reviews Microbiology16 citations Open access
Semantic Scholar
Generation of Polar Semi-Saturated Bicyclic Pyrazoles for Fragment-Based Drug-Discovery Campaigns.
Nicola Luise, P. Wyatt
2018Chemistry16 citations Open access
Semantic Scholar
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
Andrew Woodland, S. Thompson, Laura A. T. Cleghorn, N. Norcross +13 more
2015ChemMedChem16 citations Open access
Semantic Scholar

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