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K. Read · SciRah

Researcher profile · Semantic Scholar

K. Read

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K. Read — researcher profile on SciRah

h-index: 43
Works: 141
Citations: 6,693

Most-cited papers

A novel multiple-stage antimalarial agent that inhibits protein synthesis
B. Baragaña, I. Hallyburton, Marcus C. S. Lee, N. Norcross +60 more
2015Nature417 citations Open access
Semantic Scholar
Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2017Nature Reviews Microbiology367 citations Open access
Semantic Scholar
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
Julianty Frost, C. Galdeano, P. Soares, M. Gadd +10 more
2016Nature Communications210 citations Open access
Semantic Scholar
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
S. Wyllie, S. Brand, M. Thomas, M. De Rycker +45 more
2019Proceedings of the National Academy of Sciences of the United States of America149 citations Open access
Semantic Scholar
Anti-trypanosomatid drug discovery: progress and challenges
M. De Rycker, S. Wyllie, D. Horn, K. Read +1 more
2022Nature Reviews Microbiology142 citations Open access
Semantic Scholar
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrroli
P. Soares, M. Gadd, Julianty Frost, C. Galdeano +5 more
2017Journal of Medicinal Chemistry131 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B. Baragaña, B. Forte, Ryan Choi, Stephen Nakazawa-Hewitt +73 more
2019Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
S. Wyllie, M. Thomas, Stephen Patterson, Sabrinia D Crouch +28 more
2018Nature119 citations Open access
Semantic Scholar
Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania
S. Wyllie, A. Roberts, S. Norval, Stephen Patterson +4 more
2016PLoS Pathogens90 citations Open access
Semantic Scholar
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
B. Baragaña, N. Norcross, Caroline Wilson, Achim Porzelle +23 more
2016Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis
Yumi Park, A. Pacitto, Tracy Bayliss, Laura A. T. Cleghorn +51 more
2016ACS Infectious Diseases85 citations Open access
Semantic Scholar
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
Stephen Patterson, S. Wyllie, S. Norval, L. Stojanovski +5 more
2016eLife75 citations Open access
Semantic Scholar
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
Victoriano Corpas-Lopez, S. Moniz, M. Thomas, Richard J. Wall +17 more
2018ACS Infectious Diseases69 citations Open access
Semantic Scholar
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
S. Brand, N. Norcross, S. Thompson, J. Harrison +17 more
2014Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure–Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization
Dinakaran Murugesan, Peter C. Ray, Tracy Bayliss, G. A. Prosser +27 more
2018ACS Infectious Diseases64 citations Open access
Semantic Scholar
Targeting N-myristoylation for therapy of B-cell lymphomas
Erwan Beauchamp, Megan C. Yap, A. Iyer, M. Perinpanayagam +14 more
2020Nature Communications62 citations Open access
Semantic Scholar
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1
E. Barini, Ageo Miccoli, Federico Tinarelli, K. Mulholland +8 more
2018ChemBioChem58 citations Open access
Semantic Scholar
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites
Shao-Wei Zhang, M. Sakuma, G. S. Deora, C. Levy +14 more
2019Communications Biology56 citations Open access
Semantic Scholar
Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease
Jennifer Riley, S. Brand, Michael W. Voice, Iván Caballero +2 more
2015PLoS Neglected Tropical Diseases54 citations Open access
Semantic Scholar
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
S. N. Hewitt, David M. Dranow, B. G. Horst, Jan Abendroth +22 more
2016ACS Infectious Diseases51 citations Open access
Semantic Scholar
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB
Laura A. T. Cleghorn, Peter C. Ray, J. Odingo, Anuradha Kumar +22 more
2018Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
J. Harrison, S. Brand, V. Smith, D. A. Robinson +15 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
C-reactive protein is essential for innate resistance to pneumococcal infection
J. Simons, Jutta M. Loeffler, R. Al-Shawi, S. Ellmerich +8 more
2014Immunology45 citations Open access
Semantic Scholar
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022
Nicola Caldwell, R. Afshar, B. Baragaña, A. Bustinduy +17 more
2023ACS Infectious Diseases43 citations Open access
Semantic Scholar
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, M. De Rycker, M. Ajakane, S. Albrecht +48 more
2018Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target
Caroline Wilson, Peter C. Ray, Fabio Zuccotto, Jorge Hernández +36 more
2021Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides.
S. Russell, Raphaël Rahmani, Amy J. Jones, Harriet L. Newson +22 more
2016Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
S. Brand, E. Ko, Elisabet Viayna, S. Thompson +32 more
2017Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, S. Brand, M. De Rycker, Fabio Zuccotto +20 more
2021Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future
Paul W. Smith, Fabio Zuccotto, Robert H. Bates, María S. Martínez-Martínez +3 more
2018ACS Infectious Diseases34 citations Open access
Semantic Scholar
Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition
A. C. Runcie, M. Zengerle, Kwok-Ho Chan, A. Testa +8 more
2018Chemical Science32 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs
S. Green, S. Davis, S. Damerow, Curtis A. Engelhart +41 more
2022Nature Communications30 citations Open access
Semantic Scholar
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth
Peter C. Ray, M. Huggett, Penelope A. Turner, Malcolm Taylor +33 more
2021ACS Omega30 citations Open access
Semantic Scholar
Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users
C. McKenzie, Oliver B. Sutcliffe, K. Read, P. Scullion +9 more
2018Forensic Toxicology30 citations Open access
Semantic Scholar
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Ning Zhang, M. Zoltner, K. Leung, P. Scullion +11 more
2018PLoS Pathogens30 citations Open access
Semantic Scholar
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism
A. MacLeod, kevin-Sebastien Coquelin, L. Huertas, F. Simeons +14 more
2024Proceedings of the National Academy of Sciences of the United States of America29 citations Open access
Semantic Scholar
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
Federica Giordani, Daniel Paape, Isabel M. Vincent, Andrew W. Pountain +15 more
2020PLoS Pathogens29 citations Open access
Semantic Scholar
Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
D. Stoessel, C. Nowell, Amy J. Jones, Lori Ferrins +8 more
2016Metabolomics29 citations Open access
Semantic Scholar
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani
L. S. Torrie, S. Brand, D. A. Robinson, E. Ko +15 more
2017ACS Infectious Diseases28 citations Open access
Semantic Scholar
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei
Laura A. T. Cleghorn, S. Albrecht, L. Stojanovski, F. Simeons +10 more
2015Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Short-course combination treatment for experimental chronic Chagas disease
Silvia González, Richard J. Wall, John Thomas, S. Braillard +26 more
2023Science Translational Medicine24 citations Open access
Semantic Scholar
A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market
Andrew M Brandon, Lysbeth H. Antonides, Jennifer Riley, O. Epemolu +3 more
2021Molecules24 citations Open access
Semantic Scholar
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1
M. Bell, David W. Foley, C. Naylor, C. Robinson +9 more
2018Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage
A. Francisco, Shiromani Jayawardhana, M. Lewis, K. White +8 more
2016Scientific Reports24 citations Open access
Semantic Scholar
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more
2015ChemMedChem24 citations Open access
Semantic Scholar
Setting Our Sights on Infectious Diseases
M. De Rycker, D. Horn, B. Aldridge, R. Amewu +33 more
2019ACS Infectious Diseases23 citations Open access
Semantic Scholar
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
Tracy Bayliss, D. A. Robinson, V. Smith, S. Brand +10 more
2017Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening
Andreas Holmqvist, N. Kocaturk, Christina Duncan, Jennifer Riley +10 more
2025Nature Communications22 citations Open access
Semantic Scholar
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors
M. Thomas, Kate McGonagle, P. Rowland, D. A. Robinson +37 more
2023Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice
Villő Muha, R. Williamson, R. Hills, A. McNeilly +10 more
2019Open Biology18 citations Open access
Semantic Scholar

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