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L. S. Torrie · SciRah

Researcher profile · Semantic Scholar

L. S. Torrie

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L. S. Torrie — researcher profile on SciRah

h-index: 21
Works: 47
Citations: 2,098

Most-cited papers

Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2017Nature Reviews Microbiology367 citations Open access
Semantic Scholar
N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness
J. Frearson, S. Brand, S. McElroy, Laura A. T. Cleghorn +22 more
2010Nature312 citations Open access
Semantic Scholar
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research
S. Rihn, A. Merits, Siddharth Bakshi, Matthew L. Turnbull +78 more
2021PLoS Biology206 citations Open access
Semantic Scholar
Resolution of the insect ouabain paradox.
L. S. Torrie, Jonathan C. Radford, Tony D. Southall, Laura Kean +3 more
2004Proceedings of the National Academy of Sciences of the United States of America147 citations Open access
Semantic Scholar
A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays
S. McElroy, T. Nomura, L. S. Torrie, E. Warbrick +3 more
2013PLoS Biology134 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B. Baragaña, B. Forte, Ryan Choi, Stephen Nakazawa-Hewitt +73 more
2019Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
S. Brand, Laura A. T. Cleghorn, S. McElroy, D. A. Robinson +16 more
2011Journal of Medicinal Chemistry123 citations Open access
Semantic Scholar
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
Victoriano Corpas-Lopez, S. Moniz, M. Thomas, Richard J. Wall +17 more
2018ACS Infectious Diseases69 citations Open access
Semantic Scholar
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis
S. Brand, N. Norcross, S. Thompson, J. Harrison +17 more
2014Journal of Medicinal Chemistry68 citations Open access
Semantic Scholar
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
M. Alphey, Lisa Pirrie, L. S. Torrie, Wassila Abdelli Boulkeroua +13 more
2013ACS Chemical Biology56 citations Open access
Semantic Scholar
Chemical Validation of Trypanothione Synthetase
L. S. Torrie, S. Wyllie, D. Spinks, Sandra L. Oza +6 more
2009Journal of Biological Chemistry55 citations Open access
Semantic Scholar
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3
Laura A. T. Cleghorn, Andrew Woodland, I. Collie, L. S. Torrie +9 more
2011ChemMedChem50 citations Open access
Semantic Scholar
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors
J. Harrison, S. Brand, V. Smith, D. A. Robinson +15 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors
D. Spinks, L. S. Torrie, S. Thompson, J. Harrison +5 more
2011ChemMedChem44 citations Open access
Semantic Scholar
N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus
W. Fang, D. A. Robinson, O. Raimi, D. Blair +7 more
2015ACS Chemical Biology41 citations Open access
Semantic Scholar
Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase
A. Roberts, L. S. Torrie, S. Wyllie, A. Fairlamb
2014Biochemical Journal33 citations Open access
Semantic Scholar
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani
L. S. Torrie, S. Brand, D. A. Robinson, E. Ko +15 more
2017ACS Infectious Diseases28 citations Open access
Semantic Scholar
IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening
N. Tidten-Luksch, Raffaella Grimaldi, L. S. Torrie, J. Frearson +2 more
2012PLoS ONE25 citations Open access
Semantic Scholar
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more
2015ChemMedChem24 citations Open access
Semantic Scholar
Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay
Filip Zmuda, L. Sastry, S. Shepherd, Deuan C. Jones +6 more
2019Antimicrobial Agents and Chemotherapy23 citations Open access
Semantic Scholar
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
Tracy Bayliss, D. A. Robinson, V. Smith, S. Brand +10 more
2017Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
R. Milne, N. Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan +13 more
2022ACS Infectious Diseases16 citations Open access
Semantic Scholar
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
L. S. Torrie, D. A. Robinson, M. Thomas, J. Hobrath +11 more
2020ACS Infectious Diseases16 citations Open access
Semantic Scholar
Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, D. Horn, A. Fairlamb, M. Ferguson +7 more
2018Nature Reviews Microbiology16 citations Open access
Semantic Scholar
Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase
L. S. Torrie, Fabio Zuccotto, D. A. Robinson, D. Gray +2 more
2019PLoS ONE10 citations Open access
Semantic Scholar
Burkholderia pseudomallei d‐alanine‐d‐alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target
L. Díaz-Sáez, L. S. Torrie, S. McElroy, D. Gray +1 more
2019The FEBS Journal8 citations Open access
Semantic Scholar
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Thomas C. Eadsforth, L. S. Torrie, P. Rowland, Emma V. Edgar +9 more
2024Journal of Biological Chemistry7 citations Open access
Semantic Scholar
Anti-trypanosomal quinazolines targeting lysyl-tRNA synthetases show partial efficacy in a mouse model of acute Chagas disease
Lindsay B Tulloch, Hugh Tawell, Annie E. Taylor, M. Lima +23 more
2025Science Translational Medicine6 citations Open access
Semantic Scholar
Vector-borne diseases series Antitrypanosomatid drug discovery: an ongoing challenge and a continuing need
A. Fairlamb, M. Ferguson, D. Gray, K. Read +3 more
20176 citations
Semantic Scholar
Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment
Filip Zmuda, S. Shepherd, M. Ferguson, D. Gray +2 more
2019Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease
M. Lima, Lindsay B Tulloch, Victoriano Corpas-Lopez, Sandra Carvalho +12 more
2021Antimicrobial Agents and Chemotherapy4 citations Open access
Semantic Scholar
Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors
N. Norcross, S. Thompson, J. Harrison, V. Smith +16 more
20143 citations
Semantic Scholar
Structure-activity relationships of 1,5-dihydro-2H-benzo[b][1,4]diazepine-2,4(3H)-diones as inhibitors of Trypanosoma cruzi
M. Thomas, Joanne Dunne, P. Dodd, E. D'Oria +13 more
2025RSC Medicinal Chemistry0 citations Open access
Semantic Scholar
Leishmania major methionyl-tRNA synthetase in complex with an allosteric inhibitor
D. A. Robinson, L. S. Torrie, S. Shepherd, M. De Rycker +2 more
20200 citations
Semantic Scholar
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand
D. A. Robinson, J. Harrison, S. Brand, V. Smith +15 more
20180 citations
Semantic Scholar
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and an Azepanyl Phenyl Benzylsulphonamide Ligand
D. A. Robinson, J. Harrison, S. Brand, V. Smith +15 more
20180 citations
Semantic Scholar
Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a Quionlinyl aryl sulphonamide ligand
D. A. Robinson, J. Harrison, S. Brand, V. Smith +15 more
20180 citations
Semantic Scholar
University of Dundee Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors Brand
Stephen Brand, Laura A. T. Cleghorn, Stuart P. McElroy, D. A. Robinson +16 more
20170 citations
Semantic Scholar
Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor
D. A. Robinson, T. Eadsforth, S. Shepherd, L. S. Torrie +2 more
20170 citations
Semantic Scholar
University of Dundee Chemical Validation of Methionyl tRNA Synthetase ( MetRS ) as a Druggable Target in Leishmania donovani
L. S. Torrie, S. Brand, D. A. Robinson, E. Ko +15 more
20170 citations
Semantic Scholar
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND
D. A. Robinson, D. Spinks, V. Smith, S. Thompson +9 more
20150 citations
Semantic Scholar
Cover Picture: Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015)
D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more
20150 citations
Semantic Scholar
Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a benzofuran ligand R0-09-4879
D. A. Robinson, W. Fang, O. Raimi, D. Blair +7 more
20140 citations
Semantic Scholar
Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand
D. A. Robinson, S. Brand, N. Norcross, S. Thompson +15 more
20140 citations
Semantic Scholar
Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor
M. Alphey, Lisa Pirrie, L. S. Torrie, M. Gardiner +5 more
20120 citations
Semantic Scholar
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
D. A. Robinson, S. Brand, L. A. T. Cleghorn, S. McElroy +15 more
20110 citations
Semantic Scholar
DISCOVERY OF INHIBITORS OF TRYPANOSOMA BRUCEI TRYPANOTHIONE SYNTHETASE
L. S. Torrie, S. Wyllie, D. Spinks, Sandra L. Oza +7 more
20090 citations
Semantic Scholar

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