V. Smith

Most-cited papers

1. Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

   S. Brand, Laura A. T. Cleghorn, S. McElroy, D. A. Robinson +16 more

   2011Journal of Medicinal Chemistry123 citations Open access

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2. Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

   S. Brand, N. Norcross, S. Thompson, J. Harrison +17 more

   2014Journal of Medicinal Chemistry68 citations Open access

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3. A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

   J. Harrison, S. Brand, V. Smith, D. A. Robinson +15 more

   2018Journal of Medicinal Chemistry47 citations Open access

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4. Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

   M. Thomas, M. De Rycker, M. Ajakane, S. Albrecht +48 more

   2018Journal of Medicinal Chemistry43 citations Open access

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5. Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

   S. Brand, E. Ko, Elisabet Viayna, S. Thompson +32 more

   2017Journal of Medicinal Chemistry35 citations Open access

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6. Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi

   Linda J. Herrera, S. Brand, Andrés Santos, L. Nohara +9 more

   2016PLoS Neglected Tropical Diseases27 citations Open access

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7. Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode

   D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more

   2015ChemMedChem24 citations Open access

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8. Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors

   Tracy Bayliss, D. A. Robinson, V. Smith, S. Brand +10 more

   2017Journal of Medicinal Chemistry23 citations Open access

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9. Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

   V. Smith, Laura A. T. Cleghorn, Andrew Woodland, D. Spinks +10 more

   2011ChemMedChem9 citations Open access

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10. Lead optimization of a pyrazole sulfonamide series of trypanosoma brucei N myristoyltransferase inhibitors

    N. Norcross, S. Thompson, J. Harrison, V. Smith +16 more

    20143 citations

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11. Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand

    D. A. Robinson, J. Harrison, S. Brand, V. Smith +15 more

    20180 citations

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12. Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and an Azepanyl Phenyl Benzylsulphonamide Ligand

    D. A. Robinson, J. Harrison, S. Brand, V. Smith +15 more

    20180 citations

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13. Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a Quionlinyl aryl sulphonamide ligand

    D. A. Robinson, J. Harrison, S. Brand, V. Smith +15 more

    20180 citations

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14. University of Dundee Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors Brand

    Stephen Brand, Laura A. T. Cleghorn, Stuart P. McElroy, D. A. Robinson +16 more

    20170 citations

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15. CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A THIAZOLIDINONE LIGAND

    D. A. Robinson, D. Spinks, V. Smith, S. Thompson +9 more

    20150 citations

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16. Cover Picture: Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015)

    D. Spinks, V. Smith, S. Thompson, D. A. Robinson +15 more

    20150 citations

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17. Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand

    D. A. Robinson, S. Brand, N. Norcross, S. Thompson +15 more

    20140 citations

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18. CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

    D. A. Robinson, S. Brand, L. A. T. Cleghorn, S. McElroy +15 more

    20110 citations

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19. Inhibitors N-myristoyl transferase

    S. Brand, P. Wyatt, S. Thompson, J. Harrison +6 more

    20090 citations

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