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Stephen Patterson · SciRah

Researcher profile · Semantic Scholar

Stephen Patterson

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Stephen Patterson — researcher profile on SciRah

h-index: 22
Works: 49
Citations: 1,881

Most-cited papers

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects
Stephen Patterson, S. Wyllie
2014Trends in Parasitology299 citations Open access
Semantic Scholar
The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis
S. Wyllie, Stephen Patterson, L. Stojanovski, F. Simeons +4 more
2012Science Translational Medicine170 citations Open access
Semantic Scholar
Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
Stephen Patterson, M. Alphey, Deuan C. Jones, Emma Shanks +5 more
2011Journal of Medicinal Chemistry132 citations Open access
Semantic Scholar
Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis
A. Y. Sokolova, S. Wyllie, Stephen Patterson, Sandra L. Oza +2 more
2010Antimicrobial Agents and Chemotherapy129 citations Open access
Semantic Scholar
Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
S. Wyllie, M. Thomas, Stephen Patterson, Sabrinia D Crouch +28 more
2018Nature119 citations Open access
Semantic Scholar
Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania
S. Wyllie, A. Roberts, S. Norval, Stephen Patterson +4 more
2016PLoS Pathogens90 citations Open access
Semantic Scholar
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
S. Wyllie, Sandra L. Oza, Stephen Patterson, D. Spinks +2 more
2009Molecular Microbiology80 citations Open access
Semantic Scholar
A comparative study of methylglyoxal metabolism in trypanosomatids
N. Greig, S. Wyllie, Stephen Patterson, A. Fairlamb
2009The FEBS Journal76 citations Open access
Semantic Scholar
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
Stephen Patterson, S. Wyllie, S. Norval, L. Stojanovski +5 more
2016eLife75 citations Open access
Semantic Scholar
The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis
Stephen Patterson, S. Wyllie, L. Stojanovski, M. Perry +6 more
2013Antimicrobial Agents and Chemotherapy69 citations Open access
Semantic Scholar
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
C. Mowbray, S. Braillard, P. Glossop, G. Whitlock +18 more
2021Journal of Medicinal Chemistry66 citations Open access
Semantic Scholar
Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation
S. Wyllie, Stephen Patterson, A. Fairlamb
2012Antimicrobial Agents and Chemotherapy60 citations Open access
Semantic Scholar
Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis.
A. Fairlamb, Stephen Patterson
2019Current Medicinal Chemistry54 citations Open access
Semantic Scholar
Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase
Stephen Patterson, Deuan C. Jones, Emma Shanks, J. Frearson +3 more
2009ChemMedChem47 citations Open access
Semantic Scholar
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis
M. Thomas, M. De Rycker, M. Ajakane, S. Albrecht +48 more
2018Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin
Cristina Lucas‐Lopez, Stephen Patterson, T. Blum, A. Straight +5 more
200539 citations
Semantic Scholar
Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome
Deuan C. Jones, Bernardo J. Foth, M. Urbaniak, Stephen Patterson +3 more
2015PLoS Neglected Tropical Diseases37 citations Open access
Semantic Scholar
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
Richard J. Wall, S. Carvalho, R. Milne, Juan A. Bueren-Calabuig +18 more
2020ACS Infectious Diseases32 citations Open access
Semantic Scholar
Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process.
Stephen Patterson, D. O'Hagan
2002Phytochemistry27 citations
Semantic Scholar
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
Luciana S. Paradela, Richard J. Wall, S. Carvalho, Giulia Chemi +11 more
2021Cell Chemical Biology26 citations Open access
Semantic Scholar
Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei
Ong B. Han, Wai S. Lee, Stephen Patterson, S. Wyllie +1 more
2014Molecular Microbiology24 citations Open access
Semantic Scholar
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy
Ong B. Han, N. Sienkiewicz, S. Wyllie, Stephen Patterson +1 more
2013Molecular Microbiology24 citations Open access
Semantic Scholar
Quinol derivatives as potential trypanocidal agents
Amy S. Capes, Stephen Patterson, S. Wyllie, I. Hallyburton +7 more
2012Bioorganic & Medicinal Chemistry19 citations Open access
Semantic Scholar
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase
R. Milne, N. Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan +13 more
2022ACS Infectious Diseases16 citations Open access
Semantic Scholar
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
S. Wyllie, M. Thomas, Stephen Patterson, Sabrinia D Crouch +28 more
2023Nature15 citations Open access
Semantic Scholar
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Alasdair R C Smith, Richard J. Wall, Stephen Patterson, Timothy J. Rowan +25 more
2022Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Snapshot Profiling of the Antileishmanial Potency of Lead Compounds and Drug Candidates against Intracellular Leishmania donovani Amastigotes, with a Focus on Human-Derived Host Cells
Markela Koniordou, Stephen Patterson, S. Wyllie, Karin Seifert
2017Antimicrobial Agents and Chemotherapy13 citations Open access
Semantic Scholar
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity
M. Thomas, M. De Rycker, Richard J. Wall, D. Spinks +18 more
2020Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Asymmetric catalytic oxidative cleavage of polycyclic systems: the synthesis of atropisomeric diazonanes and diazecanes.
A. M. Jones, Gu Liu, M. Lorion, Stephen Patterson +3 more
2011Chemistry11 citations Open access
Semantic Scholar
Synthesis and biological evaluation of functionalised tetrahydro-β-carboline analogues as inhibitors of Toxoplasma gondii invasion.
J. Walton, Stephen Patterson, Liu Gu, Jeralyn D. Haraldsen +4 more
200911 citations
Semantic Scholar
Parallel synthesis and spectroscopic analysis of a collection of heterocycles based on the diazabenz[e]aceanthrylene core structure
A. M. Jones, T. Lebl, Stephen Patterson, T. van Mourik +4 more
200911 citations
Semantic Scholar
Targeting invasion and egress: from tools to drugs?
R. E. Morgan, K. M. Evans, Stephen Patterson, Federica Catti +2 more
2007Current Drug Targets11 citations
Semantic Scholar
Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates
Robert J. Smith, R. Milne, Victoriano Corpas López, N. Wiedemar +4 more
2023STAR Protocols7 citations Open access
Semantic Scholar
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static–Cidal Screening of Analogues
Laura A. T. Cleghorn, Richard J. Wall, S. Albrecht, S. MacGowan +18 more
2023Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Rapid Access to a Pentacyclic Library Core Structure: A Microwave Assisted Approach
Stephen Patterson, Christian Lorenz, A. Slawin, N. Westwood
20046 citations
Semantic Scholar
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas’ Disease
M. Lima, Lindsay B Tulloch, Victoriano Corpas-Lopez, Sandra Carvalho +12 more
2021Antimicrobial Agents and Chemotherapy4 citations Open access
Semantic Scholar
A core switching strategy to pyrrolo[2,3-b]quinolines and diazocino[1,2-a]indolinones.
A. M. Jones, Stephen Patterson, M. Lorion, A. Slawin +1 more
2016Organic and biomolecular chemistry4 citations Open access
Semantic Scholar
SELECTIVE CHEMICAL INTERVENTION IN BIOLOGICAL SYSTEMS : THE SMALL MOLECULE TOOL , ( S )-(-)-BLEBBISTATIN
Stephen Patterson, Christina Lucas, López, Nicholas +2 more
20033 citations
Semantic Scholar
Isotopically labelled tropane alkaloids. the synthesis of (RS)-[3', 3'-2H2]- and (RS)-[1'-13C, 3', 3'-2H2]- hyoscyamines for metabolism studies in plants
Stephen Patterson, D. O'Hagan
20023 citations
Semantic Scholar
Author response: The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
Stephen Patterson, S. Wyllie, S. Norval, L. Stojanovski +5 more
20161 citations Open access
Semantic Scholar
University of Dundee Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity
M. De Rycker, Richard J. Wall, D. Spinks, O. Epemolu +17 more
20200 citations
Semantic Scholar
Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00071494)
M. Alphey, Stephen Patterson, A. Fairlamb
20100 citations
Semantic Scholar
Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00065414)
M. Alphey, Stephen Patterson, A. Fairlamb
20100 citations
Semantic Scholar
Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073357)
M. Alphey, Stephen Patterson, A. Fairlamb
20100 citations
Semantic Scholar
Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00085762)
M. Alphey, Stephen Patterson, A. Fairlamb
20100 citations
Semantic Scholar
Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073359)
M. Alphey, Stephen Patterson, A. Fairlamb
20100 citations
Semantic Scholar
Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1‐(1‐(Benzo[b]thiophen‐2‐yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)
John L. Richardson, Isabelle R. E. Nett, Deuan C. Jones, M. H. Abdille +6 more
20090 citations Open access
Semantic Scholar
Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (-)-Blebbistatin.
Cristina Lucas‐Lopez, Stephen Patterson, T. Blum, A. Straight +5 more
20050 citations
Semantic Scholar
Biosynthetic Studies on the Tropane Alkaloid Hyoscyamine in Datura stramonium; Hyoscyamine Is Stable to in vivo Oxidation and Is Not Derived from Littorine via a Vicinal Interchage Process.
Stephen Patterson, D. O'Hagan
20030 citations
Semantic Scholar

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