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T. Blundell · SciRah

Researcher profile · Semantic Scholar

T. Blundell

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T. Blundell — researcher profile on SciRah

h-index: 101
Works: 859
Citations: 56K

Most-cited papers

Structure-based drug design with equivariant diffusion models
Arne Schneuing, Charles Harris, Yuanqi Du, Kieran Didi +9 more
2022Nature Computational Science529 citations Open access
Semantic Scholar
Utilizing graph machine learning within drug discovery and development
Thomas Gaudelet, Ben Day, Arian Jamasb, Jyothish Soman +10 more
2021Briefings Bioinform.332 citations Open access
Semantic Scholar
Stepwise pathogenic evolution of Mycobacterium abscessus
J. Bryant, Karen P. Brown, Sophie Burbaud, Isobel Everall +21 more
2021Science140 citations Open access
Semantic Scholar
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
A. K. Chaplin, S. Hardwick, A. K. Stavridi, C. Buehl +8 more
2021Molecules and Cells98 citations Open access
Semantic Scholar
Dimers of DNA-PK create a stage for DNA double-strand break repair
A. K. Chaplin, S. Hardwick, Shikang Liang, Antonia Kefala Stavridi +5 more
2020Nature Structural & Molecular Biology98 citations Open access
Semantic Scholar
Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs
Shikang Liang, S. E. Thomas, A. K. Chaplin, S. Hardwick +2 more
2022Nature73 citations Open access
Semantic Scholar
PDBe-KB: collaboratively defining the biological context of structural data
M. Váradi, S. Anyango, David R. Armstrong, J. Berrisford +67 more
2021Nucleic Acids Res.70 citations Open access
Semantic Scholar
Benchmarking Generated Poses: How Rational is Structure-based Drug Design with Generative Models?
Charles Harris, Kieran Didi, A. Jamasb, Chaitanya K. Joshi +3 more
202369 citations
Semantic Scholar
Mycobacterium abscessus pathogenesis identified by phenogenomic analyses
L. Boeck, Sophie Burbaud, Marcin J. Skwark, W. Pearson +13 more
2022Nature Microbiology43 citations Open access
Semantic Scholar
PAXX binding to the NHEJ machinery explains functional redundancy with XLF
Murielle Seif-El-Dahan, Antonia Kefala-Stavridi, P. Frit, S. Hardwick +13 more
2023Science Advances42 citations Open access
Semantic Scholar
Two distinct long-range synaptic complexes promote different aspects of end-processing prior to repair of DNA breaks by non-homologous end joining
C. Buehl, Noah J. Goff, S. Hardwick, M. Gellert +4 more
2023Molecules and Cells39 citations Open access
Semantic Scholar
SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets
Ali F. Alsulami, S. E. Thomas, Arian Jamasb, Christopher A. Beaudoin +6 more
2021Briefings Bioinform.35 citations Open access
Semantic Scholar
Three Simple Properties Explain Protein Stability Change upon Mutation
Octav Caldararu, T. Blundell, K. P. Kepp
2021Journal of Chemical Information and Modeling34 citations Open access
Semantic Scholar
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses
Christopher A. Beaudoin, Arian Jamasb, Ali F. Alsulami, Liviu Copoiu +7 more
2021bioRxiv34 citations Open access
Semantic Scholar
Human DNA-dependent protein kinase activation mechanism
Shikang Liang, T. Blundell
2023Nature Structural & Molecular Biology33 citations Open access
Semantic Scholar
Graphein - a Python Library for Geometric Deep Learning and Network Analysis on Biomolecular Structures and Interaction Networks
A. Jamasb, Ramón Viñas Torné, Eric Ma, Yuanqi Du +5 more
2022Neural Information Processing Systems29 citations
Semantic Scholar
A base measure of precision for protein stability predictors: structural sensitivity
Octav Caldararu, T. Blundell, K. P. Kepp
2021BMC Bioinformatics29 citations Open access
Semantic Scholar
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis
Pooja Gupta, S. E. Thomas, Shaymaa A. Zaidan, M. A. Pasillas +11 more
2021bioRxiv26 citations Open access
Semantic Scholar
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents
S. Stockwell, D. Scott, G. Fischer, Estrella Guarino +21 more
2024bioRxiv23 citations Open access
Semantic Scholar
Catalytically inactive DNA ligase IV promotes DNA repair in living cells
Noah J. Goff, Manon Brenière, C. Buehl, A. J. de Melo +7 more
2022Nucleic Acids Research22 citations Open access
Semantic Scholar
Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?
Christopher A. Beaudoin, S. Hamaia, C. Huang, T. Blundell +1 more
2021Frontiers in Cellular and Infection Microbiology22 citations Open access
Semantic Scholar
Deep Learning for Protein-Protein Interaction Site Prediction.
Arian Jamasb, Ben Day, Cătălina Cangea, Pietro Liò +1 more
2021Methods in molecular biology21 citations Open access
Semantic Scholar
Searching for New Z-DNA/Z-RNA Binding Proteins Based on Structural Similarity to Experimentally Validated Zα Domain
M. Bartas, Kristyna Slychko, V. Brázda, J. Červeň +3 more
2022International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
In silico analysis of mutations near S1/S2 cleavage site in SARS‐CoV‐2 spike protein reveals increased propensity of glycosylation in Omicron strain
Christopher A. Beaudoin, A. Pandurangan, So Yeon Kim, S. Hamaia +4 more
2022Journal of Medical Virology20 citations Open access
Semantic Scholar
The Resolution Revolution in X-ray Diffraction, Cryo-EM and other Technologies.
T. Blundell, A. K. Chaplin
2021Progress in Biophysics and Molecular Biology19 citations
Semantic Scholar
Are There Hidden Genes in DNA/RNA Vaccines?
Christopher A. Beaudoin, M. Bartas, A. Volná, P. Pečinka +1 more
2022Frontiers in Immunology16 citations Open access
Semantic Scholar
Strategies for drug target identification in Mycobacterium leprae.
Marta Acebrón-García-de-Eulate, T. Blundell, Sundeep Chaitanya Vedithi
2021Drug Discovery Today15 citations Open access
Semantic Scholar
COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets
Ali F. Alsulami, P. Torres, Ismail Moghul, S. Arif +3 more
2021Briefings Bioinform.14 citations Open access
Semantic Scholar
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach
S. Charoensutthivarakul, S. E. Thomas, A. Curran, Karen P. Brown +11 more
2022ACS Infectious Diseases13 citations Open access
Semantic Scholar
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19
Bridget P. Bannerman, J. Júlvez, Alexandru Oarga, T. Blundell +2 more
2021Life Science Alliance12 citations Open access
Semantic Scholar
Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis
S. Arif, R. A. Floto, T. Blundell
2022Frontiers in Molecular Biosciences10 citations Open access
Semantic Scholar
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site
Vítor Mendes, S. Green, Joanna C. Evans, Jeannine Hess +22 more
2021Nature Communications10 citations Open access
Semantic Scholar
Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance
A. Munir, S. Vedithi, A. K. Chaplin, T. Blundell
2020Frontiers in Genetics10 citations Open access
Semantic Scholar
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
Marta Acebrón-García-de-Eulate, Joan Mayol-Llinàs, Matthew T. O. Holland, So Yeon Kim +9 more
2022Journal of Medicinal Chemistry9 citations Open access
Semantic Scholar
The first resolution revolution in protein structure analysis: X-ray diffraction of polypeptide conformations and globular protein folds in 1950s and 1960s.
T. Blundell
2021Progress in Biophysics and Molecular Biology9 citations
Semantic Scholar
Decoding Surface Fingerprints for Protein-Ligand Interactions
Ilia Igashov, A. Jamasb, A. Sadek, Freyr Sverrisson +5 more
2022bioRxiv8 citations Open access
Semantic Scholar
Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA
M. Bartas, A. Volná, Christopher A. Beaudoin, E. Poulsen +5 more
2022Briefings Bioinform.8 citations Open access
Semantic Scholar
In silico analyses of isoniazid and streptomycin resistance-associated mutations in Mycobacterium tuberculosis
Rushikesh Singh Dasoondi, T. Blundell, A. Pandurangan
2023Computational and Structural Biotechnology Journal7 citations Open access
Semantic Scholar
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ.
S. Hardwick, A. K. Stavridi, D. Chirgadze, T. D. de Oliveira +5 more
2023Structure6 citations Open access
Semantic Scholar
Mutational spectra analysis reveals bacterial niche and transmission routes
Christopher Ruis, Aaron Weimann, G. Tonkin-Hill, A. Pandurangan +6 more
2022bioRxiv6 citations Open access
Semantic Scholar
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4′-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity
Joanna C. Evans, Dinakaran Murugesan, John Post, Vítor Mendes +16 more
2021ACS Infectious Diseases6 citations Open access
Semantic Scholar
Structural landscapes of PPI interfaces
Carlos H. M. Rodrigues, Douglas E. V. Pires, T. Blundell, D. Ascher
2022Briefings Bioinform.5 citations Open access
Semantic Scholar
Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design
S. E. Thomas, W. J. McCarthy, Jamal El Bakali, Karen P. Brown +7 more
2022Frontiers in Molecular Biosciences5 citations Open access
Semantic Scholar
ProtCHOIR: a tool for proteome-scale generation of homo-oligomers
P. Torres, A. D. Rossi, T. Blundell
2021Briefings Bioinform.5 citations Open access
Semantic Scholar
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools
V. Sebastián-Pérez, Alfonso García‐Rubia, S. S. Seif el-Din, Abdel-Nasser A. Sabra +8 more
2020Journal of Enzyme Inhibition and Medicinal Chemistry5 citations Open access
Semantic Scholar
SARS-CoV-2 Omicron subvariant spike N405 unlikely to rapidly deamidate
Christopher A. Beaudoin, Emmanouela Petsolari, S. Hamaia, S. Hala +6 more
2023Biochemical and Biophysical Research Communications - BBRC4 citations Open access
Semantic Scholar
Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae
S. Vedithi, Sony Malhotra, Marta Acebrón-García-de-Eulate, Modestas Matusevicius +2 more
2021Frontiers in Molecular Biosciences4 citations Open access
Semantic Scholar
Ionic control of porin permeability in bacteria
Santiago E. Caño Muñiz, A. Hagting, Ieuan E. Evans, Ali F. Alsulami +3 more
2022bioRxiv2 citations Open access
Semantic Scholar
Slipknot or Crystallographic Error: A Computational Analysis of the Plasmodium falciparum DHFR Structural Folds
R. Tata, Ali F. Alsulami, Olivier Sheik Amamuddy, T. Blundell +1 more
2022International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Structural-guided fragment-based drug discovery applied to antitoxin, MAB3862 opens a new possibility of exploring the Toxin and Antitoxin for antibiotics
So Yeon Kim, Hyun-Jong Eun, Joo-bok Lee, W. Lee +6 more
2022bioRxiv2 citations Open access
Semantic Scholar

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