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E. Domingo · SciRah

Researcher profile · Semantic Scholar

E. Domingo

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E. Domingo — researcher profile on SciRah

h-index: 47
Works: 105
Citations: 11K

Most-cited papers

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
C. Palles, J. Cazier, K. Howarth, E. Domingo +33 more
2012Nature Genetics948 citations Open access
Semantic Scholar
Replication stress links structural and numerical cancer chromosomal instability
R. Burrell, S. McClelland, D. Endesfelder, P. Groth +17 more
2013Nature850 citations
Semantic Scholar
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
R. Houlston, E. Webb, P. Broderick, A. Pittman +46 more
2008Nature Genetics606 citations Open access
Semantic Scholar
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
I. Tomlinson, E. Webb, L. Carvajal-Carmona, P. Broderick +71 more
2008Nature Genetics586 citations
Semantic Scholar
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
P. Broderick, L. Carvajal-Carmona, A. Pittman, E. Webb +27 more
2007Nature Genetics540 citations
Semantic Scholar
Deep learning for prediction of colorectal cancer outcome: a discovery and validation study.
O. Skrede, S. de Raedt, A. Kleppe, T. Hveem +16 more
2020The Lancet512 citations Open access
Semantic Scholar
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
R. Houlston, J. Cheadle, S. Dobbins, A. Tenesa +41 more
2010Nature Genetics405 citations Open access
Semantic Scholar
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing
E. Domingo, P. Laiho, M. Ollikainen, Mafalda Pinto +15 more
2004Journal of Medical Genetics359 citations Open access
Semantic Scholar
DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
D. Church, S. Briggs, C. Palles, E. Domingo +9 more
2013Human Molecular Genetics336 citations Open access
Semantic Scholar
The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial.
A. Huijbers, R. Tollenaar, G. W. V. Pelt, E. Zeestraten +9 more
2013Annals of Oncology332 citations
Semantic Scholar
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
E. Jaeger, E. Webb, K. Howarth, L. Carvajal-Carmona +30 more
2008Nature Genetics328 citations
Semantic Scholar
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.
E. Domingo, L. Freeman-Mills, E. Rayner, M. Glaire +31 more
2016The Lancet Gastroenterology and Hepatology284 citations Open access
Semantic Scholar
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
M. Dunlop, S. Dobbins, S. Farrington, A. Jones +60 more
2012Nature Genetics249 citations Open access
Semantic Scholar
Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Dan Rosmarin, C. Palles, D. Church, E. Domingo +40 more
2014Journal of Clinical Oncology233 citations Open access
Semantic Scholar
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning
K. Sirinukunwattana, E. Domingo, S. Richman, K. Redmond +20 more
2020Gut232 citations Open access
Semantic Scholar
KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer
J. Tie, L. Lipton, J. Desai, P. Gibbs +20 more
2011Clinical Cancer Research217 citations Open access
Semantic Scholar
Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.
E. Domingo, D. Church, O. Sieber, R. Ramamoorthy +6 more
2013Journal of Clinical Oncology200 citations Open access
Semantic Scholar
BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes
E. Domingo, R. Niessen, Carla Oliveira, P. Alhopuro +11 more
2005Oncogene187 citations Open access
Semantic Scholar
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression
C. Oliveira, S. Velho, C. Moutinho, A. Ferreira +9 more
2007Oncogene184 citations Open access
Semantic Scholar
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
C. Thirlwell, O. Will, E. Domingo, T. Graham +12 more
2010Gastroenterology154 citations
Semantic Scholar
Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial.
R. Kerr, S. Love, E. Segelov, E. Johnstone +11 more
2016The Lancet Oncology151 citations Open access
Semantic Scholar
An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance
Ning-Ning Li, R. Babaei‐Jadidi, F. Lorenzi, B. Spencer-Dene +11 more
2019Oncogenesis141 citations Open access
Semantic Scholar
The evolutionary landscape of colorectal tumorigenesis
W. Cross, M. Kováč, V. Mustonen, D. Temko +29 more
2018Nature Ecology & Evolution141 citations Open access
Semantic Scholar
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations
D. Mouradov, E. Domingo, P. Gibbs, R. Jorissen +18 more
2013American Journal of Gastroenterology141 citations Open access
Semantic Scholar
A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS
Dan Rosmarin, C. Palles, A. Pagnamenta, K. Kaur +21 more
2014Gut106 citations Open access
Semantic Scholar
A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment
Amélie Viratham Pulsawatdi, Stephanie G. Craig, V. Bingham, Kris D. McCombe +9 more
2020Molecular Oncology102 citations Open access
Semantic Scholar
Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
H. Alazzouzi, V. Davalos, A. Kokko, E. Domingo +13 more
2005Cancer Research98 citations Open access
Semantic Scholar
TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
J. Fielden, K. Wiseman, Ignacio Torrecilla, Shudong Li +13 more
2020Nature Communications93 citations Open access
Semantic Scholar
Use of multivariate analysis to suggest a new molecular classification of colorectal cancer
E. Domingo, R. Ramamoorthy, D. Oukrif, Dan Rosmarin +17 more
2013Journal of Pathology92 citations Open access
Semantic Scholar
Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring
J. Seligmann, D. Fisher, L. Brown, R. Adams +18 more
2021Journal of Clinical Oncology91 citations Open access
Semantic Scholar
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer
C. López-García, Laurent Sansregret, E. Domingo, N. Mcgranahan +19 more
2017Cancer Cell91 citations Open access
Semantic Scholar
Alternative splicing of TIA‐1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance
M. A. Hamdollah Zadeh, Elianna M Amin, C. Hoareau-Aveilla, E. Domingo +15 more
2014Molecular Oncology78 citations Open access
Semantic Scholar
Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.
A. Pittman, E. Webb, L. Carvajal-Carmona, K. Howarth +60 more
2008Human Molecular Genetics74 citations Open access
Semantic Scholar
APC and the three-hit hypothesis
S. Segditsas, A. Rowan, K. Howarth, A. Jones +9 more
2009Oncogene73 citations
Semantic Scholar
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
A. Baker, Wei-Ni Huang, Xiaoming Wang, M. Jansen +17 more
2017Nature Communications70 citations Open access
Semantic Scholar
Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series
E. Domingo, C. Camps, P. Kaisaki, Marie J Parsons +25 more
2018The Lancet Gastroenterology and Hepatology68 citations Open access
Semantic Scholar
The clinical features of polymerase proof-reading associated polyposis (PPAP) and recommendations for patient management
C. Palles, Lynn Martin, E. Domingo, L. Chegwidden +9 more
2021Familial Cancer67 citations Open access
Semantic Scholar
Prognostic markers for colorectal cancer: estimating ploidy and stroma
H. Danielsen, T. S. Hveem, E. Domingo, M. Pradhan +14 more
2017Annals of Oncology67 citations Open access
Semantic Scholar
Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN
A. Beggs, E. Domingo, Megan J. Mcgregor, Mikael Presz +10 more
2012OncoTarget66 citations Open access
Semantic Scholar
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
C. Palles, J. Cazier, K. Howarth, E. Domingo +33 more
2013Nature Genetics62 citations Open access
Semantic Scholar
Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia
Stephanie G. Craig, M. Humphries, M. Alderdice, V. Bingham +20 more
2020British Journal of Cancer60 citations Open access
Semantic Scholar
Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer
C. Oliveira, S. Velho, E. Domingo, A. Preto +5 more
2005Oncogene60 citations
Semantic Scholar
Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
M. Glaire, E. Domingo, A. Sveen, J. Bruun +12 more
2019British Journal of Cancer51 citations Open access
Semantic Scholar
Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis.
H. Alazzouzi, E. Domingo, S. González, I. Blanco +5 more
2005Human Molecular Genetics48 citations
Semantic Scholar
Pharmacoproteomic characterisation of human colon and rectal cancer
Martin Frejno, Riccardo Zenezini Chiozzi, M. Wilhelm, Heiner M. Koch +16 more
2017Molecular Systems Biology44 citations Open access
Semantic Scholar
'Toxgnostics': an unmet need in cancer medicine
D. Church, R. Kerr, E. Domingo, Dan Rosmarin +4 more
2014Nature Reviews. Cancer32 citations
Semantic Scholar
A study of genomic instability in early preneoplastic colonic lesions
A. Beggs, E. Domingo, M. Abulafi, Shirley Hodgson +1 more
2012Oncogene32 citations Open access
Semantic Scholar
Guidelines for using sigQC for systematic evaluation of gene signatures
A. Dhawan, A. Barberis, Wei-Chen Cheng, E. Domingo +5 more
2019Nature Protocols31 citations
Semantic Scholar
Integrated Clinical-Molecular Classification of Colorectal Liver Metastases: A Biomarker Analysis of the Phase 3 New EPOC Randomized Clinical Trial.
R. Katipally, C. Martinez, S. Pugh, J. Bridgewater +7 more
2023JAMA Oncology28 citations Open access
Semantic Scholar
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer
Sarah McCuaig, D. Barras, E. Mann, M. Friedrich +10 more
2020Clinical Cancer Research26 citations Open access
Semantic Scholar

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