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D. Church · SciRah

Researcher profile · Semantic Scholar

D. Church

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D. Church — researcher profile on SciRah

h-index: 34
Works: 104
Citations: 6,742

Most-cited papers

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study.
O. Skrede, S. de Raedt, A. Kleppe, T. Hveem +16 more
2020The Lancet512 citations Open access
Semantic Scholar
Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a TransPORTEC initiative
E. Stelloo, T. Bosse, R. Nout, H. Mackay +11 more
2015Modern Pathology455 citations Open access
Semantic Scholar
Clinicopathological and molecular characterisation of ‘multiple‐classifier’ endometrial carcinomas
A. Léon-Castillo, Ester Gilvazquez, R. Nout, V. Smit +15 more
2019Journal of Pathology391 citations Open access
Semantic Scholar
Interpretation of somatic POLE mutations in endometrial carcinoma
A. Léon-Castillo, Heidi Britton, M. McConechy, J. McAlpine +9 more
2019Journal of Pathology389 citations Open access
Semantic Scholar
A panoply of errors: polymerase proofreading domain mutations in cancer
E. Rayner, I. C. Van Gool, C. Palles, S. Kearsey +3 more
2016Nature Reviews. Cancer347 citations
Semantic Scholar
DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
D. Church, S. Briggs, C. Palles, E. Domingo +9 more
2013Human Molecular Genetics336 citations Open access
Semantic Scholar
Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer
D. Church, E. Stelloo, R. Nout, N. Valtcheva +12 more
2014Journal of the National Cancer Institute326 citations Open access
Semantic Scholar
POLE proofreading mutations elicit an anti-tumor immune response in endometrial cancer
I. C. Van Gool, F. Eggink, L. Freeman-Mills, E. Stelloo +13 more
2015Clinical Cancer Research291 citations Open access
Semantic Scholar
Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study.
E. Domingo, L. Freeman-Mills, E. Rayner, M. Glaire +31 more
2016The Lancet Gastroenterology and Hepatology284 citations Open access
Semantic Scholar
Practical guidance for mismatch repair-deficiency testing in endometrial cancer
E. Stelloo, A. M. Jansen, E. M. Osse, R. Nout +7 more
2016Annals of Oncology259 citations Open access
Semantic Scholar
Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
Dan Rosmarin, C. Palles, D. Church, E. Domingo +40 more
2014Journal of Clinical Oncology233 citations Open access
Semantic Scholar
A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer
H. Workel, J. Lübbers, R. Arnold, Thalina M. Prins +15 more
2019Cancer immunology research215 citations Open access
Semantic Scholar
Promises and challenges of adoptive T-cell therapies for solid tumours
M. Morotti, A. Albukhari, Abdulkhaliq Alsaadi, Mara Artibani +17 more
2021British Journal of Cancer205 citations Open access
Semantic Scholar
Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer.
E. Domingo, D. Church, O. Sieber, R. Ramamoorthy +6 more
2013Journal of Clinical Oncology200 citations Open access
Semantic Scholar
p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
L. Vermij, A. Léon-Castillo, Naveena Singh, M. Powell +33 more
2022Modern Pathology165 citations Open access
Semantic Scholar
Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial.
R. Kerr, S. Love, E. Segelov, E. Johnstone +11 more
2016The Lancet Oncology151 citations Open access
Semantic Scholar
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas
M. D. de Jonge, A. Auguste, L. M. van Wijk, P. Schouten +14 more
2018Clinical Cancer Research148 citations
Semantic Scholar
Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
N. Horeweg, H. Workel, Dominik Loiero, D. Church +17 more
2022Nature Communications131 citations Open access
Semantic Scholar
Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition
F. Eggink, I. C. Van Gool, A. Leary, P. Pollock +10 more
2016Oncoimmunology125 citations Open access
Semantic Scholar
Survivin in Solid Tumors: Rationale for Development of Inhibitors
D. Church, D. Talbot
2012Current Oncology Reports110 citations
Semantic Scholar
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
D. Temko, I. C. Van Gool, E. Rayner, M. Glaire +22 more
2018Journal of Pathology99 citations Open access
Semantic Scholar
Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy
J. Findlay, F. Castro-Giner, S. Makino, E. Rayner +16 more
2016Nature Communications93 citations Open access
Semantic Scholar
Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer
I. C. Van Gool, E. Stelloo, R. Nout, H. Nijman +9 more
2016Modern Pathology92 citations Open access
Semantic Scholar
Five endometrial cancer risk loci identified through genome-wide association analysis
Timothy H. T. Cheng, D. Thompson, T. O'Mara, J. Painter +84 more
2016Nature Genetics84 citations Open access
Semantic Scholar
Adjuvant Treatment for POLE Proofreading Domain–Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues
I. C. Van Gool, E. Rayner, E. M. Osse, R. Nout +7 more
2018Clinical Cancer Research76 citations Open access
Semantic Scholar
Practical guidance for mismatch repair-deficiency testing in endometrial cancer.
E. Stelloo, A. Jansen, E. M. Osse, R. Nout +7 more
201771 citations Open access
Semantic Scholar
Extended Survival in Women With Brain Metastases From HER2 Overexpressing Breast Cancer
D. Church, Ramayana Modgil, S. Guglani, A. Bahl +4 more
2008American Journal of Clinical Oncology71 citations
Semantic Scholar
Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series
E. Domingo, C. Camps, P. Kaisaki, Marie J Parsons +25 more
2018The Lancet Gastroenterology and Hepatology68 citations Open access
Semantic Scholar
A clinical decision support system optimising adjuvant chemotherapy for colorectal cancers by integrating deep learning and pathological staging markers: a development and validation study.
A. Kleppe, O. Skrede, S. de Raedt, T. Hveem +10 more
2022The Lancet Oncology67 citations Open access
Semantic Scholar
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
C. Taylor, R. Watson, O. Tong, W. Ye +21 more
2022Nature Medicine64 citations Open access
Semantic Scholar
Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer
N. Horeweg, M. de Bruyn, R. Nout, E. Stelloo +15 more
2020Cancer immunology research63 citations Open access
Semantic Scholar
Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
M. Glaire, E. Domingo, A. Sveen, J. Bruun +12 more
2019British Journal of Cancer51 citations Open access
Semantic Scholar
POLE proofreading mutation, immune response and prognosis in endometrial cancer
I. C. Van Gool, T. Bosse, D. Church
2015Oncoimmunology38 citations Open access
Semantic Scholar
'Toxgnostics': an unmet need in cancer medicine
D. Church, R. Kerr, E. Domingo, Dan Rosmarin +4 more
2014Nature Reviews. Cancer32 citations
Semantic Scholar
Biomarkers in Early-Stage Colorectal Cancer: Ready for Prime Time?
D. Church, R. Midgley, D. Kerr
2012Digestive Diseases31 citations
Semantic Scholar
Value of Supraregional Multidisciplinary Review for the Contemporary Management of Testicular Tumors
K. Purshouse, R. Watson, D. Church, C. Richardson +11 more
2017Clinical Genitourinary Cancer27 citations
Semantic Scholar
CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial
M. Saunders, J. Graham, Dennis Cunningham, R. Plummer +6 more
2022ESMO Open26 citations Open access
Semantic Scholar
The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer
P. Alexander, A. Roseweir, K. Pennel, H. V. van Wyk +15 more
2020British Journal of Cancer24 citations Open access
Semantic Scholar
Vaccination of chemotherapy patients—effect of guideline implementation
M. Toleman, K. Herbert, N. McCarthy, D. Church
2016Supportive Care in Cancer24 citations
Semantic Scholar
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape
M. Glaire, N. Ryan, M. Ijsselsteijn, Katarzyna Z. Kedzierska +6 more
2022Journal of Pathology23 citations Open access
Semantic Scholar
What is the extent of the advantage of video-assisted thoracoscopic surgical resection over thoracotomy in terms of delivery of adjuvant chemotherapy following non-small-cell lung cancer resection?
E. Teh, U. Abah, D. Church, W. Saka +3 more
2014Interactive Cardiovascular and Thoracic Surgery22 citations Open access
Semantic Scholar
Screening for Lynch syndrome and referral to clinical genetics by selective mismatch repair protein immunohistochemistry testing: an audit and cost analysis
R. Colling, D. Church, J. Carmichael, Lucinda Murphy +5 more
2015Journal of Clinical Pathology20 citations
Semantic Scholar
Igf2 ligand dependency of Pten+/− developmental and tumour phenotypes in the mouse
D. Church, B. Phillips, Daniel J Stuckey, D. J. Barnes +6 more
2011Oncogene20 citations Open access
Semantic Scholar
Stage II colon cancer.
D. Church, R. Midgley, D. Kerr
2013Chinese Clinical Oncology18 citations
Semantic Scholar
Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactions
A. Cornish, Andreas J. Gruber, B. Kinnersley, D. Chubb +30 more
2022bioRxiv16 citations Open access
Semantic Scholar
The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
H. Russell, Katarzyna Z. Kedzierska, D. Buchanan, R. Thomas +11 more
2020Clinical Epigenetics16 citations Open access
Semantic Scholar
Cancer predisposition syndromes: lessons for truly precision medicine
Mark A. Glaire, Matthew Brown, D. Church, I. Tomlinson
2017Journal of Pathology16 citations Open access
Semantic Scholar
Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer
Victoria Gray, S. Briggs, C. Palles, E. Jaeger +20 more
2019Journal of the National Cancer Institute11 citations Open access
Semantic Scholar
POLEM: Avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III dMMR or POLE exonuclease domain mutant colon cancer—A phase III randomized study.
David K. Lau, D. Cunningham, A. Gillbanks, R. Crux +11 more
2019Journal of Clinical Oncology11 citations
Semantic Scholar
Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies
N. Ryan, Thomas D. J. Walker, J. Bolton, N. T. ter Haar +6 more
2021Cancers10 citations Open access
Semantic Scholar

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