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S. Fletcher · SciRah

Researcher profile · Semantic Scholar

S. Fletcher

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S. Fletcher — researcher profile on SciRah

h-index: 20
Works: 59
Citations: 1,764

Most-cited papers

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases
L. van Rompaey, R. Galien, E. M. van der Aar, P. Clément-Lacroix +13 more
2013Journal of Immunology225 citations Open access
Semantic Scholar
[ 3 H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABA A Receptors which Contain the α5 Subunit
K. Quirk, P. Blurton, S. Fletcher, P. Leeson +4 more
1996173 citations
Semantic Scholar
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
Edward C. Taylor, P. J. Harrington, S. Fletcher, G. Beardsley +1 more
1985Journal of Medicinal Chemistry127 citations Open access
Semantic Scholar
Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
C. Menet, S. Fletcher, G. V. Van Lommen, Raphaël Geney +15 more
2014Journal of Medicinal Chemistry108 citations Open access
Semantic Scholar
Total Synthesis and Determination of the Absolute Configuration of Epibatidine
S. Fletcher, R. Baker, M. Chambers, R. Herbert +5 more
1994102 citations
Semantic Scholar
Mechanism of inositol monophosphatase, the putative target of lithium therapy.
S. Pollack, J. Atack, Michael R. Knowles, G. Mcallister +5 more
1994Proceedings of the National Academy of Sciences of the United States of America100 citations Open access
Semantic Scholar
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
Mathieu Pizzonero, S. Dupont, Marielle Babel, Stéphane Beaumont +27 more
2014Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
In Vitro and In Vivo Inhibition of Inositol Monophosphatase by the Bisphosphonate L‐690,330
J. Atack, Susan M. Cook, A. Watt, S. Fletcher +1 more
1993Journal of Neurochemistry90 citations
Semantic Scholar
Antinociceptive and toxic effects of (+)‐epibatidine oxalate attributable to nicotinic agonist activity
N. Rupniak, Shil Patel, R. Marwood, J. Webb +5 more
1994British Journal of Pharmacology56 citations Open access
Semantic Scholar
The search for novel TRPV1-antagonists: from carboxamides to benzimidazoles and indazolones.
S. Fletcher, Edward G. Mciver, S. Lewis, Frank Burkamp +7 more
2006Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Synthesis and biological activity of L-5-deazafolic acid and L-5-deazaaminopterin: synthetic strategies to 5-deazapteridines
E. C. Taylor, D. Palmer, T. George, S. Fletcher +6 more
198350 citations
Semantic Scholar
Discovery of 9-cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Frédéric Labéguère, S. Dupont, Luke J. Alvey, F. Soulas +27 more
2020Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.
G. Showell, S. Bourrain, J. G. Neduvelil, S. Fletcher +6 more
1994Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
S. Fletcher, Frank Burkamp, P. Blurton, Susan K. F. Cheng +15 more
2002Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Intramolecular Dipolar Cycloaddition Reactions to Give Substituted Indoles – A Formal Synthesis of Deethylibophyllidine
I. Coldham, Benjamin C. Dobson, S. Fletcher, Andrew I. Franklin
200743 citations
Semantic Scholar
Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator.
F. Nique, Séverine Hebbe, N. Triballeau, C. Peixoto +16 more
2012Journal of Medicinal Chemistry40 citations
Semantic Scholar
Synthesis and nicotinic acetylcholine-binding properties of epibatidinehomologues: homoepibatidine and dihomoepibatidine
J. Malpass, David A. Hemmings, A. L. Wallis, S. Fletcher +1 more
200140 citations
Semantic Scholar
The synthesis of (+)- and (–)-epibatidine
S. Fletcher, R. Baker, M. Chambers, S. C. Hobbs +1 more
199339 citations
Semantic Scholar
Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers.
J. Atack, A. Prior, S. Fletcher, K. Quirk +2 more
1994Journal of Pharmacology and Experimental Therapeutics34 citations
Semantic Scholar
SYNTHESIS AND BIOLOGICAL ACTIVITY OF L-5-DEAZAFOLIC ACID AND L-DEAZAAMINOPTERIN: SYNTHETIC STRATEGIES TO 5-DEAZAPTERIDINES
E. C. Taylor, D. Palmer, T. George, S. Fletcher +3 more
198423 citations
Semantic Scholar
Potent, selective, water-soluble benzodiazepine-based CCKB receptor antagonists that contain lipophilic carboxylate surrogates
M. Chambers, S. C. Hobbs, M. I. Graham, A. Watt +6 more
199519 citations
Semantic Scholar
Synthesis of tetracyclic indole-containing ring systems by intramolecular cycloadditions of azomethine ylides
I. Coldham, Benjamin C. Dobson, Andrew I. Franklin, S. Fletcher
200717 citations
Semantic Scholar
Synthesis of 4-amino-4-deoxy-7,10-methano-5-deazapteroic acid and 7,10-methano-5-deazapteroic acid
E. C. Taylor, S. Fletcher, S. Fitzjohn
198517 citations
Semantic Scholar
L-708,474: The C5-cyclohexyl analogue of L-365,260, a selective high affinity ligand for the CCKB/gastrin receptor
M. Chambers, S. C. Hobbs, S. Fletcher, V. Matassa +6 more
199316 citations
Semantic Scholar
Sarcosine based indandione hGlyT1 inhibitors.
C. Thomson, K. Duncan, S. Fletcher, I. Huscroft +4 more
2006Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Synthesis of D,L-7,10-ethano-5-deazaaminopterin and L-7,10-ethano-5-deazafolic acid
E. C. Taylor, J. Skotnicki, S. Fletcher
198514 citations
Semantic Scholar
Inhibitors of inositol monophosphatase
J. Atack, S. Fletcher
199413 citations
Semantic Scholar
Synthesis of α-methylene-β-lactams
S. Fletcher, I. Kay
197813 citations
Semantic Scholar
The proconvulsant effects of the GABAA α5 subtype-selective compound RY-080 may not be α5-mediated
J. Atack, P. Bayley, S. Fletcher, R. Mckernan +2 more
200612 citations
Semantic Scholar
A New Pyridazine Series of GABAA α5 Ligands
M. B. Van Niel, Kevin J. Wilson, Charles H. Adkins, J. Atack +13 more
200512 citations Open access
Semantic Scholar
Inhibitors of myo-inositol monophosphatase containing methylenebisphosphonic acid as a replacement for a phosphate group
J. J. Kulagowski, R. Baker, S. Fletcher
199112 citations
Semantic Scholar
Preparation of 3‐aminoalkylbenzo[b]thiophenes
Frank Burkamp, S. Fletcher
20027 citations
Semantic Scholar
CCK-B antagonists in the control of anxiety and gastric acid secretion.
M. Chambers, S. Fletcher
2000Progress in Medicinal Chemistry7 citations
Semantic Scholar
Synthesis of a novel tetrahydrothieno[2,3-b]pyrrole
E. C. Taylor, S. Fletcher, Claire E. McCarthy, V. Cody +1 more
19887 citations
Semantic Scholar
A Convenient Synthesis of t-butyl p-Aminobenzoate
E. C. Taylor, S. Fletcher, A. Sabb
19847 citations
Semantic Scholar
The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.
J. Atack, P. Bayley, S. Fletcher, R. Mckernan +2 more
2006European Journal of Pharmacology5 citations
Semantic Scholar
C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists
G. Showell, S. Bourrain, S. Fletcher, J. G. Neduvelil +8 more
19955 citations
Semantic Scholar
Condensation of 2,4-diamino-6(1H)-pyrimidinone with 2-(aminomethylene)cyclopentanone
E. C. Taylor, S. Fletcher
19845 citations
Semantic Scholar
A new pyridazine series of GABAA alpha5 ligands.
M. B. Van Niel, Kevin J. Wilson, Charles H. Adkins, J. Atack +13 more
2005Journal of Medicinal Chemistry4 citations
Semantic Scholar
4-hydroxyphenoxymethylene bisphosphonic acid derivatives: potent, non-hydrolysable inhibitors of MYO-inositol monophosphatase
S. Fletcher, R. Baker, T. Ladduwahetty, Andrew Sharpe +2 more
19934 citations
Semantic Scholar
Inhibitors of myo-inositol monophosphatase unrelated to the enzyme substrate
S. Fletcher, Robert K. Baker, P. Leeson, M. Teall +2 more
19924 citations
Semantic Scholar
Total Synthesis and Determination of the Absolute Configuration of Epibatidine.
S. Fletcher, R. Baker, M. Chambers, R. Herbert +5 more
19942 citations
Semantic Scholar
Synthesis of 5,10-Dideaza-5,6,7,8-Tetrahydrofolic Acid (DDATHF) and Analogs
E. C. Taylor, G. S. Wong, S. Fletcher, P. J. Harrington +2 more
19862 citations
Semantic Scholar
Synthesis and Nicotinic Acetylcholine-Binding Properties of Epibatidine Homologues: Homoepibatidine and Dihomoepibatidine.
J. Malpass, David A. Hemmings, A. L. Wallis, S. Fletcher +1 more
20101 citations
Semantic Scholar
AbstractBenzodiazepine amidines: Novel, water-soluble 5-amino-1,4-benzodiazepin-2-one derivatives as potent CCKB receptor antagonists
Victor G. Matassa, G. Showell, Sylvie Bourrain, J. G. Neduvelil +8 more
19941 citations
Semantic Scholar
Novel compounds which are useful for the treatment of degenerative and inflammatory diseases
Nolwenn Jouannigot, C. Menet, Rompaey Luc Juliaan Corina Van, S. Fletcher +3 more
20090 citations
Semantic Scholar
Synthesis of Tetracyclic Indole-Containing Ring Systems by Intramolecular Cycloadditions of Azomethine Ylides.
I. Coldham, Benjamin C. Dobson, Andrew I. Franklin, S. Fletcher
20070 citations
Semantic Scholar
Preparation of 3‐Aminoalkylbenzo[b]thiophenes.
Frank Burkamp, S. Fletcher
20030 citations
Semantic Scholar
Amino-heterocyclic compounds as vr-1 antagonists for treatment of pain
P. Blurton, Frank Burkamp, S. Fletcher, G. Hollingworth +4 more
20030 citations
Semantic Scholar
Potent, Selective, Water-Soluble Benzodiazepine-Based CCKB Receptor Antagonists that Contain Lipophilic Carboxylate Surrogates.
M. Chambers, S. C. Hobbs, M. I. Graham, A. Watt +6 more
19960 citations
Semantic Scholar

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