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S. Dupont · SciRah

Researcher profile · Semantic Scholar

S. Dupont

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S. Dupont — researcher profile on SciRah

h-index: 21
Works: 39
Citations: 4,874

Most-cited papers

Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes.
S. Dupont, A. Krust, A. Gansmuller, A. Dierich +2 more
2000Development1,048 citations
Semantic Scholar
Estrogen Receptor-&agr; Mediates the Protective Effects of Estrogen Against Vascular Injury
G. Pare, A. Krust, R. Karas, S. Dupont +3 more
2002Circulation Research407 citations Open access
Semantic Scholar
Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
E. Vegeto, Silvia Belcredito, Sabrina Etteri, S. Ghisletti +7 more
2003Proceedings of the National Academy of Sciences of the United States of America401 citations Open access
Semantic Scholar
Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males.
N. Sims, S. Dupont, A. Krust, P. Clément-Lacroix +4 more
2002Bone362 citations
Semantic Scholar
Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes
S. Dupont, A. Krust, A. Gansmuller, A. Dierich +2 more
2000324 citations
Semantic Scholar
Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo.
B. Vayssiere, S. Dupont, Agnès Choquart, F. Petit +4 more
1997Molecular Endocrinology320 citations Open access
Semantic Scholar
Estradiol enhances primary antigen‐specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor α expression in hematopoietic cells
A. Maret, J. D. Coudert, L. Garidou, G. Foucras +7 more
2003European Journal of Immunology318 citations Open access
Semantic Scholar
Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice
W. Krężel, S. Dupont, A. Krust, P. Chambon +1 more
2001Proceedings of the National Academy of Sciences of the United States of America282 citations Open access
Semantic Scholar
Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β
L. Brouchet, A. Krust, S. Dupont, P. Chambon +2 more
2001263 citations Open access
Semantic Scholar
Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the α-, but not β-, Estrogen Receptor
B. Darblade, C. Pendaries, A. Krust, S. Dupont +5 more
2002201 citations Open access
Semantic Scholar
Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial.
Toby M. Maher, E. M. van der Aar, O. Van de Steen, Lisa Allamassey +6 more
2018The Lancet Respiratory Medicine194 citations Open access
Semantic Scholar
Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-&agr; but Not Estrogen Receptor-&bgr;
L. Brouchet, A. Krust, S. Dupont, P. Chambon +2 more
2001Circulation131 citations
Semantic Scholar
Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor.
B. Darblade, C. Pendaries, A. Krust, S. Dupont +5 more
2002Circulation Research119 citations
Semantic Scholar
Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
N. Vandeghinste, J. Klattig, C. Jagerschmidt, S. Lavazais +15 more
2018Journal of Investigative Dermatology112 citations Open access
Semantic Scholar
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
Mathieu Pizzonero, S. Dupont, Marielle Babel, Stéphane Beaumont +27 more
2014Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Discovery of 9-cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Frédéric Labéguère, S. Dupont, Luke J. Alvey, F. Soulas +27 more
2020Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERα and ERβ
S. Dupont, C. Dennefeld, A. Krust, P. Chambon +1 more
200342 citations
Semantic Scholar
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases
S. Lavazais, M. Jargosch, S. Dupont, Frédéric Labéguère +16 more
2023Science Translational Medicine39 citations
Semantic Scholar
Safety, Pharmacokinetics, and Pharmacodynamics of the Autotaxin Inhibitor GLPG1690 in Healthy Subjects: Phase 1 Randomized Trials
E. M. van der Aar, J. Desrivot, S. Dupont, B. Heckmann +5 more
2019Journal of clinical pharmacology39 citations Open access
Semantic Scholar
Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta.
S. Dupont, C. Dennefeld, A. Krust, P. Chambon +1 more
2003Developmental Dynamics24 citations
Semantic Scholar
Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip
E. M. van der Aar, H. Deckx, S. Dupont, A. Fieuw +8 more
2021Clinical pharmacology in drug development21 citations Open access
Semantic Scholar
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases
C. Peixoto, A. Joncour, Taouès Temal-Laib, Amynata Tirera +22 more
2024Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
ADAMTS-5 inhibitor GLPG1972, a potential new treatment in osteoarthritis, shows favorable safety, pharmacokinetics and pharmacodynamics in healthy subjects
E. V. D. Aar, J. Desrivot, Liesbeth Fagard, D. Amantini +5 more
201812 citations Open access
Semantic Scholar
Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor GLPG1690 in a mouse model for IPF
M. Ongenaert, S. Dupont, R. Blanqué, R. Brys +2 more
20169 citations
Semantic Scholar
GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
H. Timmis, T. Van Kaem, J. Desrivot, S. Dupont +5 more
2021Clinical pharmacology in drug development8 citations Open access
Semantic Scholar
OP0161 The JAK1 selective inhibitor filgotinib regulates both enthesis and colon inflammation in a mouse model of psoriatic arthritis
C. Robin-Jagerschmidt, Stéphanie Lavazais, F. Marsais, Alain Monjardet +11 more
20178 citations Open access
Semantic Scholar
Favorable human safety, pharmacokinetics and pharmacodynamics of the autotaxin inhibitor GLPG1690, a potential new treatment in COPD
E. V. D. Aar, Liesbeth Fagard, J. Desrivot, S. Dupont +5 more
20156 citations
Semantic Scholar
Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment
R. Blanqué, N. Desroy, S. Dupont, C. Cottereaux +7 more
20154 citations
Semantic Scholar
GPR84 inhibition as a novel therapeutic approach in IBD: mechanistic and translational studies
S. Dupont, I. Arijs, R. Blanqué, D. Laukens +14 more
20154 citations Open access
Semantic Scholar
FRI0539 A safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) study with increasing oral doses of glpg1972 administered daily for 29 days shows a strong biomarker effect in patients with KNEE and/or HIP OA
H. Deckx, S. Hatch, M. Robberechts, S. Dupont +6 more
2018Osteoarthritis3 citations Open access
Semantic Scholar
Estradiol Alters Nitric Oxide Production in the Mouse Aorta Through the &agr;-, but not &bgr;-, Estrogen Receptor
B. Darblade, C. Pendaries, A. Krust, S. Dupont +5 more
20023 citations
Semantic Scholar
FRI0428 The JAK1-selective inhibitor, filgotinib, inhibits inflammation pathways observed in an IL23-induced psoriatic arthritis mouse model
R. Blanqué, Maté Ongenaert, C. David, C. Robin-Jagerschmidt +5 more
20171 citations Open access
Semantic Scholar
437 IL-17C inhibition reduces skin inflammation in IL23-induced psoriasis mouse model
F. Marsais, M. Auberval, S. Lavazais, L. Lepescheux +6 more
20171 citations Open access
Semantic Scholar
Sa1844 The JAK1-Selective Inhibitor, Filgotinib, Reverses the Disease Signature of Colon Mucosa in Experimental Colitis
M. Ongenaert, S. Dupont, B. Vayssiere, R. Brys +1 more
20161 citations
Semantic Scholar
DOP070 The FFA2 antagonist GLPG0974: opportunity to treat neutrophil-driven inflammation
F. Vanhoutte, F. Namour, S. Dupont, W. Haazen +4 more
20141 citations Open access
Semantic Scholar
THU0116 Biological Effects of the JAK1 Selective Inhibitor GLPG0634 on Inflammation Markers in Arthritic Mice
Béatrice Vayssière, S. de Vos, D. Merciris, M. Auberval +8 more
20131 citations
Semantic Scholar
AB0506 Identification of a Gene Signature and Response Biomarkers in Circulating Leukocytes of RA Patients After Treatment with the JAK1-Selective Inhibitor Filgotinib (GLPG0634)
Maté Ongenaert, S. Dupont, Béatrice Vayssière, L. Meuleners +2 more
20150 citations
Semantic Scholar
Mo1234 The FFA2 Antagonist GLPG0974: A Promising Approach to Treat Neutrophil-Driven Inflammation
F. Vanhoutte, F. Namour, S. Dupont, Mathieu Pizzonero +5 more
20140 citations Open access
Semantic Scholar
THU0138 Glpg0634m1, A Major Metabolite of the Jak1-Selective Inhibitor Glpg0634, is Also Jak1-Selective and Efficient in the Rat CIA Model
C. Belleville-Da-Costa, D. Merciris, Béatrice Vayssière, N. Houvenaghel +10 more
20140 citations
Semantic Scholar

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