I. Coldham

Most-cited papers

1. Intramolecular dipolar cycloaddition reactions of azomethine ylides.

   I. Coldham, R. Hufton

   2005Chemical Reviews812 citations

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2. Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

   A. Jayavelu, T. Schnöder, F. Perner, Carolin Herzog +28 more

   2020Nature138 citations

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3. Asymmetric deprotonation of N-boc piperidine: react IR monitoring and mechanistic aspects.

   D. Stead, G. Carbone, P. O’Brien, Kevin R. Campos +2 more

   2010Journal of the American Chemical Society136 citations

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4. An experimental and in situ IR spectroscopic study of the lithiation-substitution of N-Boc-2-phenylpyrrolidine and -piperidine: controlling the formation of quaternary stereocenters.

   Nadeem S. Sheikh, D. Leonori, G. Barker, James D. Firth +4 more

   2012Journal of the American Chemical Society85 citations

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5. Highly efficient synthesis of tricyclic amines by a cyclization/cycloaddition cascade: total syntheses of aspidospermine, aspidospermidine, and quebrachamine.

   I. Coldham, Adam J. M. Burrell, L. White, H. Adams +1 more

   2007Angewandte Chemie84 citations

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6. Cascade cyclization, dipolar cycloaddition to bridged tricyclic amines related to the Daphniphyllum alkaloids.

   I. Coldham, Adam J. M. Burrell, Hélène D. S. Guerrand, N. Oram

   2011Organic Letters64 citations

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7. Stereoselective formation of fused tricyclic amines from acyclic aldehydes by a cascade process involving condensation, cyclization, and dipolar cycloaddition.

   Adam J. M. Burrell, I. Coldham, L. Watson, N. Oram +2 more

   2009Journal of Organic Chemistry61 citations

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8. Regioselective and stereoselective copper(I)-promoted allylation and conjugate addition of N-Boc-2-lithiopyrrolidine and N-Boc-2-lithiopiperidine.

   I. Coldham, D. Leonori

   2010Journal of Organic Chemistry56 citations

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9. Dynamic thermodynamic and dynamic kinetic resolution of 2-lithiopyrrolidines.

   I. Coldham, S. Dufour, T. Haxell, Jignesh J. Patel +1 more

   2006Journal of the American Chemical Society54 citations

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10. Synthesis of 2-arylpiperidines by palladium couplings of aryl bromides with organozinc species derived from deprotonation of N-boc-piperidine.

    I. Coldham, D. Leonori

    2008Organic Letters51 citations

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11. Synthesis of 1,1-disubstituted tetrahydroisoquinolines by lithiation and substitution, with in situ IR spectroscopy and configurational stability studies.

    Xia-Bing Li, I. Coldham

    2014Journal of the American Chemical Society49 citations Open access

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12. Asymmetric substitutions of 2-lithiated N-boc-piperidine and N-Boc-azepine by dynamic resolution.

    I. Coldham, Sophie Raimbault, D. Whittaker, P. Chovatia +3 more

    2010Chemistry47 citations

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13. Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (+/-)-crispine A.

    I. Coldham, S. Jana, L. Watson, Nathaniel G. Martin

    2009Organic and biomolecular chemistry45 citations

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14. Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

    Adam J. M. Burrell, I. Coldham

    201044 citations

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15. Intramolecular Dipolar Cycloaddition Reactions to Give Substituted Indoles – A Formal Synthesis of Deethylibophyllidine

    I. Coldham, Benjamin C. Dobson, S. Fletcher, Andrew I. Franklin

    200743 citations

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16. Synthesis of fused tricyclic amines from enolizable acyclic aldehydes by cyclization then dipolar cycloaddition cascade: synthesis of myrioxazine A.

    Adam J. M. Burrell, I. Coldham, N. Oram

    2009Organic Letters42 citations

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17. Asymmetric deprotonation of N-Boc-piperidines

    I. Coldham, P. O’Brien, Jignesh J. Patel, Sophie Raimbault +3 more

    200737 citations

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18. Barrier to enantiomerization of unstabilized, chelated, and dipole-stabilized 2-lithiopyrrolidines.

    Neil J. Ashweek, P. Brandt, I. Coldham, S. Dufour +4 more

    2005Journal of the American Chemical Society36 citations

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19. Synthesis and Evaluation of 1‐Amino‐6‐halo‐β‐carbolines as Antimalarial and Antiprion Agents

    M. J. Thompson, Jennifer C. Louth, S. Little, Matthew P. Jackson +3 more

    2012ChemMedChem31 citations

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20. Unfolded protein response is an early, non-critical event during hepatic stellate cell activation

    I. Mannaerts, Lien F. R. Thoen, N. Eysackers, F. Cubero +5 more

    2019Cell Death and Disease30 citations Open access

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21. Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine.

    Xia-Bing Li, D. Leonori, Nadeem S. Sheikh, I. Coldham

    2013Chemistry30 citations

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22. Asymmetric lithiation-substitution of amines involving rearrangement of borates.

    I. Coldham, Jignesh J. Patel, Sophie Raimbault, D. Whittaker +3 more

    2008Organic Letters29 citations

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23. Cascade cyclization intermolecular dipolar cycloaddition by multi-component couplings—synthesis of indolizidines and pyrrolizidines

    I. Coldham, S. Jana, L. Watson, Christopher D. Pilgram

    200828 citations

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24. Dynamic resolution of N-Boc-2-lithiopiperidine.

    I. Coldham, Sophie Raimbault, P. Chovatia, Jignesh J. Patel +3 more

    2008Chemical Communications27 citations

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25. Dynamic thermodynamic resolution of lithiated N-Boc-N'-alkylpiperazines

    Steven P. Robinson, Nadeem S. Sheikh, C. A. Baxter, I. Coldham

    201024 citations

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26. The Barrier to Enantiomerization and Dynamic Resolution of N-Boc-2-lithiopiperidine and the Effect of TMEDA

    I. Coldham, D. Leonori, T. Beng, R. E. Gawley

    2009Chemical Communications23 citations Open access

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27. Synthesis and kinetic resolution of N-Boc-2-arylpiperidines.

    Edward J. Cochrane, D. Leonori, L. Hassall, I. Coldham

    2014Chemical Communications22 citations Open access

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28. Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular cycloaddition.

    Adam J. M. Burrell, L. Watson, Nathaniel G. Martin, N. Oram +1 more

    2010Organic and biomolecular chemistry22 citations

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29. The barrier to enantiomerization of N-Boc-2-lithiopyrrolidine: the effect of chiral and achiral diamines.

    T. Yousaf, Rodger L. Williams, I. Coldham, R. E. Gawley

    2008Chemical Communications22 citations Open access

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30. Remarkable configurational stability of magnesiated nitriles.

    G. Barker, Madeha R. Alshawish, M. C. Skilbeck, I. Coldham

    2013Angewandte Chemie20 citations

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31. Dipolar cycloaddition and ring-closing metathesis in the synthesis of the tetracyclic ABCE ring system of manzamine A

    I. Coldham, Steven M. Pih, Rémi Rabot

    200520 citations

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32. Preparation of 1-Substituted Tetrahydro-β-carbolines by Lithiation-Substitution.

    Edward J. Cochrane, L. Hassall, I. Coldham

    2015Journal of Organic Chemistry19 citations Open access

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33. Cascade cyclization, dipolar cycloaddition of azomethine imines for the synthesis of pyrazolidines.

    Hélène D. S. Guerrand, H. Adams, I. Coldham

    2011Organic and biomolecular chemistry19 citations

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34. Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine

    T. Beng, T. Yousaf, I. Coldham, R. E. Gawley

    2009Journal of the American Chemical Society19 citations Open access

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35. Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones.

    Rungroj Saruengkhanphasit, D. Collier, I. Coldham

    2017Journal of Organic Chemistry18 citations Open access

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36. Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids.

    Andrew I. Franklin, David Bensa, H. Adams, I. Coldham

    2011Organic and biomolecular chemistry18 citations

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37. Dynamic Resolutions of Chiral Organolithiums

    I. Coldham, Nadeem S. Sheikh

    201018 citations

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38. Synthesis of tetracyclic indole-containing ring systems by intramolecular cycloadditions of azomethine ylides

    I. Coldham, Benjamin C. Dobson, Andrew I. Franklin, S. Fletcher

    200717 citations

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39. Dynamic kinetic resolution of N-Boc-2-lithiopyrrolidine.

    I. Coldham, Jignesh J. Patel, Graciela Sanchez-Jimenez

    2005Chemical Communications17 citations

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40. Main group organometallics in synthesis

    I. Coldham

    201016 citations

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41. Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine.

    I. Coldham, Jignesh J. Patel, Sophie Raimbault, D. Whittaker

    2007Chemical Communications16 citations

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42. Asymmetric synthesis of 3-hydroxy-pyrrolidines via tin-lithium exchange and cyclization.

    G. Christoph, Christian Stratmann, I. Coldham, D. Hoppe

    2006Organic Letters16 citations

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43. Arylthio-metal exchange of α-arylthioalkanenitriles.

    Dinesh Nath, M. C. Skilbeck, I. Coldham, F. Fleming

    2014Organic Letters14 citations

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44. Synthesis of carboxylic amides by ring-opening of oxazolidinones with Grignard reagents.

    David Bensa, I. Coldham, Pia Feinäugle, R. Pathak +1 more

    2008Organic and biomolecular chemistry14 citations

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45. Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts

    Anthony Choi, R. Morley, I. Coldham

    2019Beilstein Journal of Organic Chemistry13 citations Open access

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46. Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench

    Nicholas Carter, Xia-Bing Li, Lewis Reavey, A. Meijer +1 more

    2017Chemical Science13 citations Open access

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47. Synthesis of 2-hydroxy-3-indolinones and 3-hydroxy-2-indolinones by anionic cyclization, in situ oxidation and rearrangement

    I. Coldham, H. Adams, Neil J. Ashweek, Thomas A. Barker +2 more

    201013 citations

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48. Structural studies of {6Li} 2-lithiopyrrolidines using NMR spectroscopy

    R. E. Gawley, Rosalyn Klein, Neil J. Ashweek, I. Coldham

    200513 citations

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49. Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench.

    Ruaa A. Talk, Alexia Duperray, Xia-Bing Li, I. Coldham

    2016Organic and biomolecular chemistry12 citations

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50. Synthesis of an azabicyclic framework towards (±)-actinophyllic acid

    D. Mortimer, M. Whiting, J. Harrity, Simon Jones +1 more

    201412 citations Open access

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