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A. Watt · SciRah

Researcher profile · Semantic Scholar

A. Watt

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A. Watt — researcher profile on SciRah

h-index: 20
Works: 53
Citations: 2,002

Most-cited papers

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.
David C. Evans, A. Watt, D. Nicoll-Griffith, T. Baillie
2004Chemical Research in Toxicology624 citations
Semantic Scholar
Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering
B. Moore, Lorna Stevenson, A. Watt, S. Flitsch +3 more
2004Nature Biotechnology168 citations
Semantic Scholar
Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS.
A. Watt, Denise Morrison, Karen L. Locker, David C. Evans
2000Analytical Chemistry111 citations
Semantic Scholar
Total Synthesis and Determination of the Absolute Configuration of Epibatidine
S. Fletcher, R. Baker, M. Chambers, R. Herbert +5 more
1994102 citations
Semantic Scholar
In Vitro and In Vivo Inhibition of Inositol Monophosphatase by the Bisphosphonate L‐690,330
J. Atack, Susan M. Cook, A. Watt, S. Fletcher +1 more
1993Journal of Neurochemistry90 citations
Semantic Scholar
Chiral Base-Mediated Asymmetric Synthesis of Tricarbonyl(.eta.6-arene)chromium Complexes
R. Ewin, A. Macleod, D. Price, N. Simpkins +1 more
199487 citations
Semantic Scholar
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
L. J. Street, R. Baker, W. Davey, A. R. Guiblin +6 more
1995Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
An Increased Throughput Method for the Determination of Partition Coefficients
L. Hitzel, A. Watt, Karen L. Locker
2000Pharmaceutical Research61 citations
Semantic Scholar
Determination of dissolved aluminium by the micelle-enhanced fluorescence of its lumogallion complex
A. Howard, A. Coxhead, I. Potter, A. Watt
198655 citations
Semantic Scholar
A proteomic investigation of drug-induced steatosis in rat liver.
G. Meneses-Lorente, P. Guest, J. Lawrence, N. Muniappa +7 more
2004Chemical Research in Toxicology54 citations
Semantic Scholar
Metabolite identification in drug discovery.
A. Watt, R. Mortishire-Smith, U. Gerhard, Steven R. Thomas
2003Current opinion in drug discovery & development54 citations
Semantic Scholar
High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.
G. Showell, S. Bourrain, J. G. Neduvelil, S. Fletcher +6 more
1994Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
A quantitative high-throughput trapping assay as a measurement of potential for bioactivation.
G. Meneses-Lorente, M. Sakatis, T. Schulz-Utermoehl, C. De Nardi +1 more
2006Analytical Biochemistry48 citations
Semantic Scholar
Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery.
A. Watt, Denise Morrison, David C. Evans
2000Drug Discovery Today47 citations
Semantic Scholar
A study of the synthesis and racemisation of a chiral lithiated tricarbonyl(η6-anisole)chromium complex
P. Anthony, N. Simpkins, A. Macleod, A. Watt
199446 citations
Semantic Scholar
An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis.
Denise Morrison, Amy Davies, A. Watt
2002Analytical Chemistry27 citations
Semantic Scholar
Discovery of a Series of Ester-substituted NLRP3 Inflammasome Inhibitors.
David Harrison, N. Boutard, K. Brzózka, M. Bugaj +17 more
2020Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Utility of Long-Term Cultured Human Hepatocytes as an in Vitro Model for Cytochrome P450 Induction
G. Meneses-Lorente, C. Pattison, C. Guyomard, C. Chesné +3 more
2007Drug Metabolism And Disposition23 citations
Semantic Scholar
Determination of drug concentrations in plasma by a highly automated, generic and flexible protein precipitation and liquid chromatography/tandem mass spectrometry method applicable to the drug discovery environment.
D. O'Connor, Dawn E Clarke, Denise Morrison, A. Watt
2002Rapid Communications in Mass Spectrometry23 citations
Semantic Scholar
Measurement of Lithium‐Induced Changes in Mouse Inositol(1)Phosphate Levels In Vivo
J. Atack, Susan M. Cook, A. Watt, C. Ragan
1992Journal of Neurochemistry20 citations
Semantic Scholar
Potent, selective, water-soluble benzodiazepine-based CCKB receptor antagonists that contain lipophilic carboxylate surrogates
M. Chambers, S. C. Hobbs, M. I. Graham, A. Watt +6 more
199519 citations
Semantic Scholar
Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.
David Harrison, M. Bock, J. Doedens, C. Gabel +8 more
2022ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a−/− and mdr1a+/+ mice
N. M. J. Rupniak, A. Fisher, S. Boyce, D. Clarke +3 more
2003Behavioural Pharmacology17 citations
Semantic Scholar
L-708,474: The C5-cyclohexyl analogue of L-365,260, a selective high affinity ligand for the CCKB/gastrin receptor
M. Chambers, S. C. Hobbs, S. Fletcher, V. Matassa +6 more
199316 citations
Semantic Scholar
3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution
C. Swain, B. Williams, Robert K. Baker, M. Cascieri +12 more
199715 citations
Semantic Scholar
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.
Andrew D Cansfield, T. Ladduwahetty, M. Sunose, Katie Ellard +11 more
2016ACS Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Development of BT1718, a Bicycle Drug Conjugate® (BDC) targeting MT1-MMP for treatment of solid tumours
G. Bennett, H. Harrison, S. Campbell, D. Teufel +3 more
201614 citations
Semantic Scholar
Determination of the collisionally activated dissociation of a substituted indole by orthogonal acceleration quadrupole time-of-flight mass spectrometry
A. Watt, A. Pike, Denise Morrison
2001Journal of the American Society for Mass Spectrometry13 citations
Semantic Scholar
Mast cells and peptide induced histamine release
A. Watt
2001InflammoPharmacology13 citations
Semantic Scholar
Parallel synthesis of 3-aryloxy-2-propanolamines and evaluation as dual affinity 5-HT(1A) and 5-HT re-uptake ligands.
M. B. Van Niel, M. Beer, J. L. Castro, Susan K. F. Cheng +8 more
1999Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Determination of the in vitro metabolism of (+)- and (-)-epibatidine.
A. Watt, Laure Hitzel, Denise Morrison, Karen L. Locker
2000Journal of Chromatography A10 citations
Semantic Scholar
Resolution of Synthetic (+)- and (-)-Epibatidine by Chiral High Performance Liquid Chromatography and Identification of the Natural Enantiomer
A. Watt, H. Verrier, D. O'Connor
199410 citations
Semantic Scholar
Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.
C. Hop, Yan-Feng Wang, Sanjeev Kumar, M. Elipe +15 more
2002Drug Metabolism And Disposition9 citations
Semantic Scholar
Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry.
Karen L. Locker, Denise Morrison, A. Watt
2001Journal of Chromatography B: Biomedical Sciences and Applications8 citations
Semantic Scholar
Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function
Alexandre Bignon, A. Watt, M. Linterman
2017Frontiers in Immunology7 citations Open access
Semantic Scholar
A Randomized, Double-Blind, Crossover Comparison of MK-0929 and Placebo in the Treatment of Adults With ADHD
Anna Rivkin, R. Alexander, J. Knighton, P. Hutson +6 more
2012Journal of Attention Disorders6 citations
Semantic Scholar
Use of chiral liquid chromatography-tandem mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists.
A. Watt, Laure Hitzel, Denise Morrison, Karen L. Locker
2000Journal of Chromatography A5 citations
Semantic Scholar
Strategic and technical challenges for drug discovery.
A. Watt, Denise Morrison
2001Drug Discovery Today4 citations
Semantic Scholar
Analytical and Preparative Enantiomeric Separation of a Series of C5-Cycloalkylamine-L,4-Benzodiazepin-2-one CCKB Receptor Antagonists by Chiral HPLC
A. Watt, H. Verrier, D. Rathbone
19973 citations
Semantic Scholar
Enantiomeric separation of substituted 2-arylindoles on derivatised polysaccharide chiral stationary phases.
A. Watt, L. Hitzel, R. Mortishire-Smith
2002Journal of Biochemical and Biophysical Methods2 citations
Semantic Scholar
ENANTIOMERIC SEPARATION OF A SERIES OF 1,4-BENZODIAZEPIN-2-ONE CCK B RECEPTOR ANTAGONISTS BEARING ACIDIC SUBSTITUENTS BY CHIRAL HPLC
A. Watt, D. Rathbone, H. Verrier, M. Chambers +1 more
19992 citations
Semantic Scholar
Total Synthesis and Determination of the Absolute Configuration of Epibatidine.
S. Fletcher, R. Baker, M. Chambers, R. Herbert +5 more
19942 citations
Semantic Scholar
Enantiomeric Separation of Substituted Quinuclidinyl-Pyrazines by HPLC Using an Acetylated β-Cyclodextrin Chiral Stationary Phase
A. Watt, D. Rathbone
19932 citations
Semantic Scholar
Perkin 1 Abstracts: Biocatalysis in Organic Synthesis
G. Grogan, Alexis Carstairs, I. J. Jackson, D. McIntyre +3 more
20021 citations
Semantic Scholar
CHIRAL SEPARATION OF 4,4-DISUBSTITUTED PIPERIDINYL SUBSTANCE P ANTAGONISTS
A. Watt, L. Hitzel
20001 citations
Semantic Scholar
In Vitro Studies of the Oxidative Metabolism of L-737,415, A C5-Cycloalkylamine-1,4-Benzodiazepin-2-One CCKB Receptor Antagonist
A. Watt, D. O'Connor, Steve Thomas, R. Herbert +1 more
19951 citations
Semantic Scholar
Photocatalyst evaluation for solar-based aqueous organic oxidation
K. Magrini, A. Watt, B. Rinehart
19951 citations
Semantic Scholar
Drug Metabolism and Reactive Metabolites
A. Watt
20090 citations
Semantic Scholar
Synthesis of novel benzotriazole substrates suitable for screening hydrolytic enzymes
A. Watt
20020 citations
Semantic Scholar
Perkin 1 Astracts: Biocatalysis in Organic Synthesis
G. Grogan, Alexis Carstairs, I. J. Jackson, D. McIntyre +3 more
20010 citations
Semantic Scholar

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Karen L. Locker×6
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S. Fletcher×6
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R. Baker×5
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M. Chambers — researcher profile on SciRah

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S. C. Hobbs — researcher profile on SciRah

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L. Hitzel — researcher profile on SciRah

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