Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

K. Nacro · SciRah

Researcher profile · Semantic Scholar

K. Nacro

Share profile

K. Nacro — researcher profile on SciRah

h-index: 19
Works: 57
Citations: 1,633

Most-cited papers

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
I. Enyedy, Y. Ling, K. Nacro, Y. Tomita +10 more
2001Journal of Medicinal Chemistry319 citations Open access
Semantic Scholar
Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein*
Q. Wang, D. Bhattacharyya, S. Garfield, K. Nacro +2 more
1999Journal of Biological Chemistry189 citations Open access
Semantic Scholar
Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function
S. Lim, T. Y. Saw, Min Zhang, M. R. Janes +10 more
2013Proceedings of the National Academy of Sciences of the United States of America139 citations Open access
Semantic Scholar
Rescue of oxytocin response and social behavior in a rodent model of autism
Hanna Hörnberg, E. Pérez-Garci, D. Schreiner, Laetitia Hattstatt-Burklé +6 more
2020Nature107 citations Open access
Semantic Scholar
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.
M. J. Caloca, M. García-Bermejo, P. Blumberg, N. Lewin +7 more
1999Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.
Yan Li, Zhenzhen Zhang, W. W. Phoo, Y. R. Loh +8 more
2018Structure81 citations Open access
Semantic Scholar
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
K. Nacro, B. Bienfait, Jeewoo Lee, Kee-Chung Han +6 more
2000Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
Structure-guided fragment-based in silico drug design of dengue protease inhibitors
Tim Knehans, Andreas Schüller, D. N. Doan, K. Nacro +5 more
2011J. Comput. Aided Mol. Des.57 citations
Semantic Scholar
Role of Hydrophobic Residues in the C1b Domain of Protein Kinase C δ on Ligand and Phospholipid Interactions*
Q. Wang, T. Fang, K. Nacro, V. Márquez +2 more
2001Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.
Hai-Yan Yang, L. R. Chennamaneni, Melvyn Ho, Hua-Ang Shi +29 more
2018Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Update on the Development of MNK Inhibitors as Therapeutic Agents.
Weijun Xu, S. Kannan, C. Verma, K. Nacro
2021Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.
K. Nacro, Co Zha, P. Guzzo, R. Herr +2 more
2007Bioorganic & Medicinal Chemistry37 citations
Semantic Scholar
Topography of transcriptionally active chromatin in glioblastoma
Liang Xu, Ye Chen, Yu-Lun Huang, E. Sandanaraj +24 more
2021Science Advances29 citations Open access
Semantic Scholar
Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
D. M. Sigano, Megan L. Peach, K. Nacro, Yongseok Choi +4 more
2003Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Attempt to rationalize the diastereoselectivity in the addition of ester enolate to optically active α,β-epoxyaldehydes
K. Nacro, M. Baltas, Liliane Gorrichon
199928 citations
Semantic Scholar
Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.
S. Kannan, A. Poulsen, Hai-Yan Yang, Melvyn Ho +8 more
2015Biochemistry27 citations
Semantic Scholar
Identification of covalent active site inhibitors of dengue virus protease
Xiaoying Koh-stenta, J. Joy, Si-Fang Wang, P. Kwek +10 more
2015Drug Design, Development and Therapy27 citations Open access
Semantic Scholar
Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.
Jin Xu, An-Qi Chen, M. Go, K. Nacro +2 more
2011ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.
Hirokazu Tamamura, B. Bienfait, K. Nacro, N. Lewin +2 more
2000Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
MNK1 and MNK2 enforce expression of E2F1, FOXM1 and WEE1 to drive soft tissue sarcoma
Xinyu Ke, Ye Chen, V. Tham, R. Lin +12 more
2021Oncogene18 citations Open access
Semantic Scholar
Stereoselective synthesis of five and/or six membered ring hydroxylactones obtained by Lewis acid mediated reaction of γ,δ-epoxy-β-hydroxyesters; access to 5-methylated 2-deoxysugars.
K. Nacro, M. Baltas, J. Escudier, L. Gorrichon
199717 citations
Semantic Scholar
Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases
S. Kannan, Mohan R. Pradhan, J. Cherian, T. Joseph +7 more
2017ACS Omega16 citations Open access
Semantic Scholar
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
Shuang Liu, Congxiang Zha, K. Nacro, Min Hu +37 more
2014ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.
A. Henderson, P. Guzzo, Animesh Ghosh, Jagjit Kaur +9 more
2012Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).
S. Benzaria, B. Bienfait, K. Nacro, Shao-Meng Wang +4 more
1998Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Enhanced diastereoselectivity in the addition of ester enolate to optically active α,β-epoxyaldehydes obtained from nerol and geraniol
K. Nacro, M. Baltas, J. Escudier, L. Gorrichon
199615 citations
Semantic Scholar
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.
J. Cherian, K. Nacro, Zhi Ying Poh, Samantha Guo +21 more
2016Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
A facile synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines
Min Hu, P. Guzzo, Congxiang Zha, K. Nacro +3 more
201213 citations
Semantic Scholar
Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity
K. Nacro, Jeewoo Lee, J. Barchi, N. Lewin +2 more
200212 citations
Semantic Scholar
b 2-Chimaerin is a novel target for diacylglycerol : Binding properties and changes in subcellular localization mediated by ligand binding to its C 1 domain
M. J. Caloca, M. García-Bermejo, P. Blumberg, N. Lewin +7 more
199912 citations
Semantic Scholar
Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
J. Kwiatkowski, Boping Liu, Shermaine Pang, Nur Huda Binte Ahmad +22 more
2020Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Identification of small‐molecule binding sites of a ubiquitin‐conjugating enzyme‐UBE2T through fragment‐based screening
Yong Yao Loh, J. Anantharajan, Qiwei Huang, Wei-Jun Xu +13 more
2024Protein Science8 citations Open access
Semantic Scholar
Lactonisation and lactone ether formation of nerol geraniol compounds. Use of 13C to identify the cyclisation process
K. Nacro, M. Baltas, C. Zedde, Liliane Gorrichon +1 more
19998 citations
Semantic Scholar
Stereochemistry Control in the Lewis Acid Mediated Lactonization Reaction of γ,δ-Epoxy-β-silyloxy Esters
K. Nacro, L. Gorrichon, J. Escudier, M. Baltas
20016 citations
Semantic Scholar
An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist
Matthew L. Isherwood, P. Guzzo, A. Henderson, Ming-Min Hsia +10 more
20125 citations
Semantic Scholar
Effect of Ser392 phosphorylation on the structure and dynamics of the polybasic domain of ADP ribosylation factor nucleotide site opener protein: a molecular simulation study.
Kannan Srinivasaraghavan, K. Nacro, Gerhard Grüber, C. Verma
2013Biochemistry4 citations
Semantic Scholar
Enabling Synthesis of Triple Reuptake Inhibitor (+)-BMS-820836, a Potential Therapeutic Agent for the Treatment of Depression
Paul C. Lobben, Rasidul Amin, Bang-Chi Chen, Wen-Ge Cui +10 more
20163 citations
Semantic Scholar
Conformationally Constrained Analogues of Diacylglycerol (DAG). Part 17. Contrast Between sn-1 and sn-2 DAG Lactones in Binding to Protein Kinase C.
H. Tamamura, Bruno Bienfait, K. Nacro, N. Lewin +2 more
20003 citations
Semantic Scholar
Influence of the Nature and Substitution of Chiral 2,3-Epoxy Alcohol Derivatives on the Enantiomeric Elution Order on Chiralcel OD Column
K. Nacro, C. Zedde, J. Escudier, M. Baltas +2 more
19983 citations Open access
Semantic Scholar
ETC-501 is a Brain Penetrant MNK Kinase Inhibitor that Potentiates TMZ-Induced Senescence and Sensitizes Glioblastoma Cells to Senolytic Therapy.
G. Nah, Y. Chong, Fatin Nasha Sulaimi, K. Lee +12 more
2026Cancer Research2 citations
Semantic Scholar
Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations.
S. Kannan, A. Poulsen, Hai-Yan Yang, Melvyn Ho +8 more
2017Biochemistry2 citations
Semantic Scholar
Abstract 4726: ETC-501, a novel brain penetrant MNK kinase inhibitor, potentiates TMZ-induced senescence and sensitizes glioblastoma cells to senolytic therapy
G. Nah, Y. Chong, Fatin Nasha Sulaimi, K. Lee +8 more
2025Cancer Research1 citations
Semantic Scholar
Dual Specific Inhibitors Of The BCR-ABL and MNK Kinases As Potential Therapeutics For Blast Crisis Chronic Myeloid Leukemia
S. Lim, J. Cherian, K. Nacro, Yun-Shan Chew +22 more
20131 citations
Semantic Scholar
Abstract 6668: MNK2-dependent activation of de novo lipid synthesis drives breast cancer brain metastasis
Jessie Ling Ai Wong, Giselle Sek Suan Nah, Fatin Nasha Binte Sulaimi, K. Lee +5 more
2025Cancer Research0 citations
Semantic Scholar
Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities
Liang Xu, Ye Chen, Yu-Lun Huang, E. Sandanaraj +24 more
2021Molecular and Cellular Biology/Genetics0 citations
Semantic Scholar
Restoration of oxytocin receptor signaling and social recognition in a mouse model of autism
Hanna Hörnberg, E. Pérez-Garci, D. Schreiner, Laetitia Hattstatt-Burkle +7 more
20210 citations
Semantic Scholar
Backbone assignment of Zika Virus NS2B-NS3 Protease in complex with a covalent inhibitor
Yan Li, Zhenzhen Zhang, W. W. Phoo, Y. R. Loh +9 more
20180 citations
Semantic Scholar
Abstract 2134: Rational design of selective MNK 1 and 2 kinase inhibitors for the treatment of blast crisis chronic myeloid leukemia patients
K. Nacro, Hai-Yan Yang, Melvyn Ho, Y. Yeap +24 more
20160 citations
Semantic Scholar
Identification of covalent active site inhibitors of dengue virus protease
Xiaoying Koh-stenta, J. Joy, Si-Fang Wang, P. Kwek +8 more
20150 citations
Semantic Scholar
Abstract 948: Discovery of dual MNK 1 and 2 and BCR-ABL kinase inhibitors for the treatment of blast crisis chronic myeloid leukemia
J. Cherian, K. Nacro, Zhi Ying Poh, Samantha Guo +18 more
20140 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

J. Hill×15
Invite
J. Hill — researcher profile on SciRah
Hai-Yan Yang×11
Invite
Hai-Yan Yang — researcher profile on SciRah
A. Poulsen×10
Invite
A. Poulsen — researcher profile on SciRah
Boping Liu×9
Invite
Boping Liu — researcher profile on SciRah

×8

Invite

N. Lewin — researcher profile on SciRah

Invite

J. Joy — researcher profile on SciRah

Invite

V. Márquez — researcher profile on SciRah

Invite

P. Blumberg — researcher profile on SciRah

Invite

Melvyn Ho — researcher profile on SciRah

Invite

S. Lim — researcher profile on SciRah

Invite

A. Matter — researcher profile on SciRah

Invite

P. Kwek — researcher profile on SciRah