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Massimiliano Runfola · SciRah

Researcher profile · Semantic Scholar

Massimiliano Runfola

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Massimiliano Runfola — researcher profile on SciRah

h-index: 10
Works: 23
Citations: 452

Most-cited papers

Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders
F. Saponaro, S. Sestito, Massimiliano Runfola, S. Rapposelli +1 more
2020Frontiers in Medicine111 citations Open access
Semantic Scholar
Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?
S. Sestito, L. Pruccoli, Massimiliano Runfola, V. Citi +5 more
2019European journal of medicinal chemistry55 citations
Semantic Scholar
TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD
A. Caddeo, M. Kowalik, M. Serra, Massimiliano Runfola +4 more
2021International Journal of Molecular Sciences49 citations Open access
Semantic Scholar
New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective
S. Sestito, Massimiliano Runfola, M. Tonelli, G. Chiellini +1 more
2018Frontiers in Pharmacology40 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis.
Massimiliano Runfola, S. Sestito, Lorenza Bellusci, V. La Pietra +9 more
2019European journal of medicinal chemistry32 citations Open access
Semantic Scholar
Potential role of two novel agonists of thyroid hormone receptor‐β on liver regeneration
A. Perra, M. Kowalik, L. Cabras, Massimiliano Runfola +6 more
2020Cell Proliferation26 citations Open access
Semantic Scholar
Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.
G. Chiellini, Giulia Nesi, S. Sestito, S. Chiarugi +11 more
2016Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Beyond Antioxidant Effects: Nature-Based Templates Unveil New Strategies for Neurodegenerative Diseases
A. Bacci, Massimiliano Runfola, S. Sestito, S. Rapposelli
2021Antioxidants22 citations Open access
Semantic Scholar
Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6
Lorenza Bellusci, Massimiliano Runfola, V. Carnicelli, S. Sestito +8 more
2020Molecules22 citations Open access
Semantic Scholar
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer’s Disease
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese +15 more
2021Pharmaceuticals12 citations Open access
Semantic Scholar
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics
Massimiliano Runfola, S. Sestito, S. Gul, G. Chiellini +1 more
2020Data in Brief10 citations Open access
Semantic Scholar
Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.
S. Sestito, A. Bacci, S. Chiarugi, Massimiliano Runfola +10 more
2021European journal of medicinal chemistry9 citations Open access
Semantic Scholar
Diphenyl-Methane Based Thyromimetic Inhibitors for Transthyretin Amyloidosis
Bokyung Kim, Y. Ko, Massimiliano Runfola, S. Rapposelli +3 more
2021International Journal of Molecular Sciences8 citations Open access
Semantic Scholar
Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids
A. Bacci, F. Corsi, Massimiliano Runfola, S. Sestito +5 more
2022Pharmaceuticals7 citations Open access
Semantic Scholar
Optimization of a dispersive liquid-liquid microextraction method followed by UHPLC analysis for fluoxetine quantification in environmental water resources.
Massimiliano Runfola, Diana L. D. Lima, A. P. Fonseca, Z. Barbosa
2018Journal of Separation Science6 citations Open access
Semantic Scholar
Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity
Beatrice Polini, Caterina Ricardi, Francesca Di Lupo, Massimiliano Runfola +6 more
2025Cells5 citations Open access
Semantic Scholar
Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges
V. A. Baldassarro, C. Quadalti, Massimiliano Runfola, C. Manera +2 more
2023Pharmaceuticals5 citations Open access
Semantic Scholar
Synthesis of aryl-fused bicyclo[3.1.1]heptanes and validation as naphthyl bioisosteres
Aidan Kerckhoffs, M. Tregear, Pol Hernández-Lladó, Massimiliano Runfola +9 more
2026Nature Chemistry3 citations Open access
Semantic Scholar
Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation
S. Sestito, S. Chiarugi, E. Margheritis, Massimiliano Runfola +3 more
2019Proceedings2 citations Open access
Semantic Scholar
SUN-717 SG-2 a Novel Multi-Target Directed Ligand (MTDL) for the Treatment of Neurodegenerative Diseases (NDDS)
S. Sestito, Massimiliano Runfola, Lavinia Bandini, Filippo Santucci +3 more
2020Journal of the Endocrine Society1 citations Open access
Semantic Scholar
SG-2: A promising lipolytic and pro-autophagic hit-compound to treat Alzheimer’s disease
Massimiliano Runfola, Michele Perni, S. Sestito, G. Chiellini +2 more
20201 citations Open access
Semantic Scholar
Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues
Massimiliano Runfola, Beatrice Polini, Anna Mazzierli, L. Raffellini +11 more
2026Molecules0 citations Open access
Semantic Scholar
The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays
Massimiliano Runfola, S. Gul
20190 citations
Semantic Scholar

Frequent co-authors

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S. Rapposelli×18
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S. Rapposelli — researcher profile on SciRah
S. Sestito×14
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S. Sestito — researcher profile on SciRah
G. Chiellini×11
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G. Chiellini — researcher profile on SciRah
A. Bacci×6
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A. Bacci — researcher profile on SciRah

×5

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S. Gul — researcher profile on SciRah

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C. Manera — researcher profile on SciRah

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M. Kowalik — researcher profile on SciRah

A. Columbano×3

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A. Columbano — researcher profile on SciRah

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A. Perra — researcher profile on SciRah

Lorenza Bellusci×3

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Lorenza Bellusci — researcher profile on SciRah

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S. Chiarugi — researcher profile on SciRah

G. Saccomanni×2

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G. Saccomanni — researcher profile on SciRah