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F. Pflumio · SciRah

Researcher profile · Semantic Scholar

F. Pflumio

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F. Pflumio — researcher profile on SciRah

h-index: 41
Works: 119
Citations: 6,315

Most-cited papers

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
S. Amsellem, F. Pflumio, D. Bardinet, B. Izac +4 more
2003Nature Medicine326 citations
Semantic Scholar
Genetic Inactivation of the PRC2 Complex in T-Cell Acute Lymphoblastic Leukemia
P. Ntziachristos, A. Tsirigos, P. Van Vlierberghe, Jelena Nedjic +25 more
2012Nature Medicine286 citations Open access
Semantic Scholar
The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells.
A. Sirven, F. Pflumio, Véronique Zennou, M. Titeux +4 more
2000Blood235 citations
Semantic Scholar
Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse
E. Clappier, B. Gerby, F. Sigaux, M. Delord +6 more
2011Journal of Experimental Medicine209 citations Open access
Semantic Scholar
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.
A. Gutierrez, L. Pan, R. Groen, F. Baleydier +21 more
2014Journal of Clinical Investigation196 citations Open access
Semantic Scholar
Heterogeneity of human lympho-myeloid progenitors at the single cell level
D. Karamitros, B. Stoilova, Zahra Aboukhalil, F. Hamey +16 more
2017Nature Immunology193 citations Open access
Semantic Scholar
NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.
F. Armstrong, P. B. de la Grange, B. Gerby, M. Rouyez +9 more
2009Blood178 citations Open access
Semantic Scholar
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
H. Medyouf, Samuel Gusscott, Hongfang Wang, Jen-Chieh Tseng +11 more
2011Journal of Experimental Medicine175 citations Open access
Semantic Scholar
Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein.
Muriel Asheuer, F. Pflumio, S. Benhamida, A. Dubart-Kupperschmitt +4 more
2004Proceedings of the National Academy of Sciences of the United States of America165 citations Open access
Semantic Scholar
Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood.
R. Haddad, P. Guardiola, B. Izac, C. Thibault +7 more
2004Blood163 citations
Semantic Scholar
Integrative screening approach identifies regulators of polyploidization and targets for acute megakaryocytic leukemia
Q. Wen, B. Goldenson, S. Silver, Monica Schenone +44 more
2012Cell149 citations Open access
Semantic Scholar
Dynamics of thymus-colonizing cells during human development.
R. Haddad, F. Guimiot, E. Six, Frederic Jourquin +10 more
2006Immunity124 citations Open access
Semantic Scholar
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
C. Thiollier, Cécile K. Lopez, B. Gerby, C. Ignacimouttou +26 more
2012Journal of Experimental Medicine119 citations Open access
Semantic Scholar
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia.
D. Sánchez-Martínez, M. L. Baroni, F. Gutiérrez-Agüera, H. Roca-Ho +16 more
2019Blood118 citations Open access
Semantic Scholar
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia
Aissa Benyoucef, C. Palii, Chao-Chen Wang, Christopher J Porter +13 more
2016Genes & Development115 citations Open access
Semantic Scholar
Lentivirus-mediated gene transfer in primary T cells is enhanced by a central DNA flap
V. Dardalhon, B. Herpers, N. Noraz, F. Pflumio +5 more
2001Gene Therapy105 citations
Semantic Scholar
Ultra-high dose rate FLASH and conventional dose rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis.
Sara Chabi, Thi Hong Van To, R. Leavitt, S. Poglio +8 more
2020International Journal of Radiation Oncology, Biology, Physics104 citations Open access
Semantic Scholar
PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.
C. Naudin, Aurore Hattabi, F. Michelet, A. Miri-Nezhad +7 more
2017Blood102 citations Open access
Semantic Scholar
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
H. Medyouf, Xiuhua Gao, F. Armstrong, Samuel Gusscott +7 more
2009Blood95 citations Open access
Semantic Scholar
Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates.
N. Debili, C. Robin, V. Schiavon, R. Letestu +4 more
2001Blood90 citations
Semantic Scholar
Identification of Lymphomyeloid Primitive Progenitor Cells in Fresh Human Cord Blood and in the Marrow of Nonobese Diabetic–Severe Combined Immunodeficient (NOD-SCID) Mice Transplanted with Human CD34+ Cord Blood Cells
C. Robin, F. Pflumio, W. Vainchenker, L. Coulombel
1999Journal of Experimental Medicine85 citations Open access
Semantic Scholar
CD133+ Cell Selection Is an Alternative to CD34+ Cell Selection for Ex Vivo Expansion of Hematopoietic Stem Cells
L. Kobari, M. Giarratana, F. Pflumio, B. Izac +2 more
2001Journal of Hematotherapy & Stem Cell Research83 citations
Semantic Scholar
ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.
C. Thirant, C. Ignacimouttou, Cécile K. Lopez, M. Diop +26 more
2017Cancer Cell80 citations Open access
Semantic Scholar
Alternative Lengthening of Telomeres in Human Glioma Stem Cells
David C. Silvestre, J. R. Pineda, F. Hoffschir, J. Studler +5 more
2011Stem Cells72 citations Open access
Semantic Scholar
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia
Sophie Kusy, B. Gerby, N. Goardon, N. Gault +8 more
2010Journal of Experimental Medicine72 citations Open access
Semantic Scholar
Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells.
P. Brunet de la Grange, F. Armstrong, V. Duval, M. Rouyez +3 more
2006Blood69 citations Open access
Semantic Scholar
Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors
C. Thirant, B. Bessette, P. Varlet, S. Puget +19 more
2011PLoS ONE68 citations Open access
Semantic Scholar
A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche.
P. Charbord, C. Pouget, H. Binder, F. Dumont +13 more
2014Cell Stem Cell66 citations Open access
Semantic Scholar
SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.
D. Reynaud, E. Ravet, M. Titeux, F. Mazurier +4 more
2005Blood64 citations
Semantic Scholar
Transduced CD34+ cells from adrenoleukodystrophy patients with HIV-derived vector mediate long-term engraftment of NOD/SCID mice.
S. Benhamida, F. Pflumio, A. Dubart-Kupperschmitt, J. C. Zhao-Emonet +6 more
2003Molecular Therapy61 citations Open access
Semantic Scholar
Human Adipose-Derived Stromal Cells Efficiently Support Hematopoiesis In Vitro and In Vivo: A Key Step for Therapeutic Studies
F. de Toni, S. Poglio, Aissa Benyoucef, B. Cousin +4 more
2011Stem Cells and Development60 citations
Semantic Scholar
Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis.
E. Ravet, D. Reynaud, M. Titeux, B. Izac +4 more
2004Blood56 citations
Semantic Scholar
Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia.
X. Cahu, J. Calvo, S. Poglio, N. Prade +13 more
2017Blood Advances55 citations Open access
Semantic Scholar
Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia
Ya-Lu Zhou, Cui-Juan Han, Eric Wang, Adam H Lorch +40 more
2020Cancer Discovery54 citations Open access
Semantic Scholar
SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia
É. Pasmant, B. Gilbert-Dussardier, Arnaud Petit, B. de Laval +17 more
2014Oncogene52 citations Open access
Semantic Scholar
Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene-driven myeloid leukemia.
Cécile K. Lopez, Esteve Noguera, V. Stavropoulou, E. Robert +32 more
2019Cancer Discovery49 citations Open access
Semantic Scholar
Maximal lentivirus-mediated gene transfer and sustained transgene expression in human hematopoietic primitive cells and their progeny.
S. Amsellem, E. Ravet, S. Fichelson, F. Pflumio +1 more
2002Molecular Therapy42 citations Open access
Semantic Scholar
HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4
Céline Auvray, A. Delahaye, F. Pflumio, R. Haddad +7 more
2012Haematologica38 citations Open access
Semantic Scholar
Lymphoid-affiliated genes are associated with active histone modifications in human hematopoietic stem cells.
J. Maes, Marta Maleszewska, C. Guillemin, F. Pflumio +6 more
2008Blood38 citations
Semantic Scholar
SCID mice as an in vivo model of human cord blood hematopoiesis.
J. Vormoor, T. Lapidot, F. Pflumio, G. Risdon +3 more
1994Blood cells38 citations
Semantic Scholar
Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations
Elia Henry, Inès Souissi-Sahraoui, Margaux Deynoux, Andréas Lefevre +6 more
2019Haematologica36 citations Open access
Semantic Scholar
Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression
B. Uzan, S. Poglio, B. Gerby, Ching-Lein Wu +17 more
2014EMBO Molecular Medicine35 citations Open access
Semantic Scholar
Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL
A. Touzart, E. Lengliné, Mehdi Latiri, M. Belhocine +16 more
2019Clinical Cancer Research34 citations Open access
Semantic Scholar
Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.
Laurent Renou, P. Boelle, C. Deswarte, S. Spicuglia +11 more
2017Blood Advances34 citations Open access
Semantic Scholar
Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.
A. Trinquand, N. dos Santos, Christine Tran Quang, F. Rocchetti +18 more
2016Cancer Discovery34 citations Open access
Semantic Scholar
Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors.
Sara Chabi, B. Uzan, I. Naguibneva, J. Rucci +6 more
2019Cell Reports32 citations Open access
Semantic Scholar
Impaired functionality and homing of Fancg-deficient hematopoietic stem cells.
V. Barroca, M. Mouthon, D. Lewandowski, P. Brunet de la Grange +8 more
2012Human Molecular Genetics31 citations Open access
Semantic Scholar
Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop.
Lucine Fahy, J. Calvo, Sara Chabi, Laurent Renou +12 more
2021Blood Advances30 citations Open access
Semantic Scholar
Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia
T. Nguyen, M. Nokin, Silvia Terés, M. Tomé +21 more
2020Molecular Oncology30 citations Open access
Semantic Scholar
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.
Damien Roos-Weil, C. Decaudin, M. Armand, V. Della-Valle +32 more
2019Cancer Discovery29 citations Open access
Semantic Scholar

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