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Q. Wen · SciRah

Researcher profile · Semantic Scholar

Q. Wen

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Q. Wen — researcher profile on SciRah

h-index: 24
Works: 48
Citations: 1,695

Most-cited papers

Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.
Haitao Wang, Qishan Zhang, Q. Wen, Yongxin Zheng +4 more
2012Cellular Signalling160 citations
Semantic Scholar
Integrative screening approach identifies regulators of polyploidization and targets for acute megakaryocytic leukemia
Q. Wen, B. Goldenson, S. Silver, Monica Schenone +44 more
2012Cell149 citations Open access
Semantic Scholar
Targeting megakaryocytic induced fibrosis by AURKA inhibition in the myeloproliferative neoplasms
Q. Wen, Qiong Yang, B. Goldenson, Sébastien Malinge +14 more
2015Nature Medicine137 citations Open access
Semantic Scholar
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
C. Thiollier, Cécile K. Lopez, B. Gerby, C. Ignacimouttou +26 more
2012Journal of Experimental Medicine119 citations Open access
Semantic Scholar
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3 and BCR-ABL
R. Mali, Baskar Ramdas, Peilin Ma, Jian-Jian Shi +16 more
2011Cancer Cell103 citations Open access
Semantic Scholar
AKT is a therapeutic target in myeloproliferative neoplasms
Irum Khan, Zan Huang, Q. Wen, Monika J. Stankiewicz +14 more
2013Leukemia93 citations Open access
Semantic Scholar
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.
R. Bhansali, Malini Rammohan, Paul Lee, Anouchka P. Laurent +19 more
2021Journal of Clinical Investigation75 citations Open access
Semantic Scholar
Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis
Laure Gilles, A. Arslan, C. Marinaccio, Q. Wen +17 more
2017Journal of Clinical Investigation73 citations Open access
Semantic Scholar
Aurora Kinase A Inhibition Provides Clinical Benefit, Normalizes Megakaryocytes, and Reduces Bone Marrow Fibrosis in Patients with Myelofibrosis: A Phase I Trial
N. Gangat, C. Marinaccio, R. Swords, J. Watts +30 more
2019Clinical Cancer Research71 citations Open access
Semantic Scholar
Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo
Brittany Woods, Wei Chen, Sophia Chiu, C. Marinaccio +11 more
2019Clinical Cancer Research64 citations Open access
Semantic Scholar
The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells
Haitao Wang, Xuanhe Zhou, Jian-Chun Huang, N. Mu +6 more
2013Psychopharmacology59 citations
Semantic Scholar
Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation
I. Nitulescu, S. Meyer, Q. Wen, J. Crispino +4 more
2017EBioMedicine52 citations Open access
Semantic Scholar
An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia
Alok Swaroop, Jon Oyer, C. Will, Xiaoxiao Huang +10 more
2018Oncogene51 citations Open access
Semantic Scholar
LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms
C. Marinaccio, P. Suraneni, Hamza Celik, Andrew G. Volk +21 more
2021Cancer Discovery40 citations Open access
Semantic Scholar
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms
Baobing Zhao, Y. Mei, Lan Cao, Jingxin Zhang +13 more
2017Journal of Clinical Investigation39 citations Open access
Semantic Scholar
ANP32A regulates histone H3 acetylation and promotes leukemogenesis
Xue-Jing Yang, Bin Lu, Xue-Qing Sun, Cui-Juan Han +10 more
2018Leukemia38 citations
Semantic Scholar
Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome.
A. Norton, C. Fisher, Hui Liu, Q. Wen +11 more
2007Blood38 citations Open access
Semantic Scholar
Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells.
Q. Wen, Xiaolu Duan, Rifang Liao, P. Little +5 more
2011Neuroscience Letters32 citations
Semantic Scholar
Long non-coding RNA MALAT1 modulate cell migration, proliferation and apoptosis by sponging microRNA-146a to regulate CXCR4 expression in acute myeloid leukemia
Xian-Fu Sheng, Li-Li Hong, Hui Li, Fei Huang +2 more
2020Hematology30 citations Open access
Semantic Scholar
Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.
B. Goldenson, Gina T. Kirsammer, Monika J. Stankiewicz, Q. Wen +1 more
2015Blood30 citations Open access
Semantic Scholar
Forkhead family transcription factor FoxO and neural differentiation
Q. Wen, Haitao Wang, P. Little, R. Quirion +1 more
2012Neurogenetics30 citations
Semantic Scholar
Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways
Haitao Wang, Xiaoying Su, Jiankang Fang, Xin Xin +6 more
2018International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21
Dandan Yu, Z. Zhao, Li Wang, Shishi Qiao +3 more
2022Journal of Translational Medicine26 citations Open access
Semantic Scholar
Survivin is not required for the endomitotic cell cycle of megakaryocytes.
Q. Wen, C. Leung, Zan Huang, S. Small +3 more
2009Blood25 citations Open access
Semantic Scholar
Tumor-Promoting ATAD2 and Its Preclinical Challenges
Hai-Cheng Liu, Q. Wen, Sheng Yan, Wei-Kun Zeng +5 more
2022Biomolecules22 citations Open access
Semantic Scholar
PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN
Li-bo Liu, Q. Wen, R. Gong, Laure Gilles +7 more
2014Cell Death and Disease22 citations Open access
Semantic Scholar
Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer
Donghai Yang, Xin Fan, Ping Yin, Q. Wen +5 more
2012BMC Immunology20 citations Open access
Semantic Scholar
Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice.
D. Mccrann, T. Yezefski, Hao G. Nguyen, Nicholas Papadantonakis +4 more
2008Blood15 citations Open access
Semantic Scholar
Genomic Features of Organ-Specific Metastases in Lung Adenocarcinoma
Alei Feng, Yanjun Li, Guang-Xu Li, Yu Wang +8 more
2022Frontiers in Oncology13 citations Open access
Semantic Scholar
ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia
Xue-Qing Sun, Bin Lu, Cui-Juan Han, Wanlin Qiu +9 more
2017Blood Cancer Journal13 citations Open access
Semantic Scholar
Kinase signaling and targeted therapy for primary myelofibrosis
Qiong Yang, J. Crispino, Q. Wen
2016Experimental Hematology10 citations Open access
Semantic Scholar
AKT activation is a feature of CALR mutant Myeloproliferative Neoplasms
Chun-Ling Fu, Q. Wen, C. Marinaccio, Te Ling +6 more
2018Leukemia8 citations Open access
Semantic Scholar
Corrigendum to “Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway” [Cell. Signal. 2012; 24:17–24]
Haitao Wang, Qishan Zhang, Q. Wen, Yongxin Zheng +4 more
20126 citations Open access
Semantic Scholar
Aurora A Kinase Is a Novel Therapeutic Target In The Myeloproliferative Neoplasms
Q. Wen, B. Goldenson, Sébastien Malinge, B. Stein +14 more
20134 citations
Semantic Scholar
Adaptive diversity of innate immune receptor family short pentraxins in Murinae
Yan Li, J. Robins, Jianping Ye, Zhi-Yong Huang +2 more
2012FEBS Letters4 citations
Semantic Scholar
Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms
Chunjie Yu, Qiong Yang, Yu-Hong Chen, De-Min Wang +4 more
2016Cell & Bioscience2 citations Open access
Semantic Scholar
Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo
Q. Wen, Brittany Woods, Qiong Yang, Chiu Sophia +4 more
20162 citations
Semantic Scholar
Induction of Megakaryocyte Polyploidization in Combination with JAK Inhibition As a Novel Therapeutic Strategy for Myeloproliferative Neoplasms
Q. Wen, B. Goldenson, Sébastien Malinge, Priya Koppikar +3 more
20112 citations
Semantic Scholar
A Kinome shRNA Screen to Identify Pathways That Regulate Megakaryocyte Polyploidization and New Targets for Differentiation Therapy
Q. Wen, S. Silver, T. Lewis, Sridevi Ponduru +9 more
20102 citations
Semantic Scholar
Aurora A Kinase Is Required For Hematopoiesis and Couples Polyploidization With Terminal Differentiation In Megakaryocytes Through Phosphorylation Of NF-E2
B. Goldenson, Q. Wen, J. Crispino
20131 citations
Semantic Scholar
Dysregulation of PSTPIP2 Due to Loss of GATA-1 Contributes to Aberrant Megakaryopoiesis
Lu Liu, Shangqin Liu, Q. Wen, J. Crispino +1 more
20121 citations
Semantic Scholar
Aryl Hydrocarbon Receptor (AhR) Antagonist Stemregenin 1 (SR1) Enhances in Vitro- and in Vivo-Derived Platelets (PLTs) From Human Megakaryocytes (MKs)
Yuhuan Wang, V. Hayes, Lin Lu, Xiao-Ji Chen +8 more
20121 citations
Semantic Scholar
Inhibition of AKT Signaling Potently Inhibits the Growth of JAK and MPL-Mutant Cells in the Myeloproliferative Neoplasms In Vitro and In Vivo,
Irum Khan, Zan Huang, Q. Wen, Priya Koppikar +3 more
20111 citations
Semantic Scholar
MicroRNA-200c-3p Functions as a Tumor Suppressor in Kidney Renal Clear Cell Carcinoma by Targeting Vascular Endothelial Growth Factor A
Yan-Min Li, Hui Xu, Q. Wen, Xiao-Qing Yan +1 more
20210 citations Open access
Semantic Scholar
PAK1 Inhibition Slows Growth and Partially Promotes Differentiation of AMKL Cells
Chun-Ling Fu, Chun-Qin Wang, Xue-Ting Hu, K. Qi +8 more
20210 citations Open access
Semantic Scholar
PS1562 IDENTIFYING RELATIONSHIP BETWEEN HEREDITARY PREDISPOSITION GENE AND COMPLICATIONS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION IN ACUTE LEUKEMIA
Z. Li, T. Wu, X. Wen, Y. Zhao +4 more
2019HemaSphere0 citations Open access
Semantic Scholar
Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms
Chunjie Yu, Qiong Yang, Yu-Hong Chen, De-Min Wang +4 more
2016Cell & Bioscience0 citations Open access
Semantic Scholar
Tyrosine 599 Plays an Essential Role and Cooperates with Tyrosine 604 in MPL W515L-Indiced Myeloproliferative Neoplasms
Zan Huang, Chunjie Yu, Q. Wen, Qiong Yang +3 more
20140 citations
Semantic Scholar

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