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S. Silver · SciRah

Researcher profile · Semantic Scholar

S. Silver

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S. Silver — researcher profile on SciRah

h-index: 27
Works: 44
Citations: 15K

Most-cited papers

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
D. Barbie, P. Tamayo, J. Boehm, S. Kim +31 more
2009Nature3,493 citations Open access
Semantic Scholar
A Next Generation Connectivity Map: L1000 platform and the first 1,000,000 profiles
A. Subramanian, R. Narayan, Steven M. Corsello, David Peck +52 more
2017bioRxiv3,160 citations Open access
Semantic Scholar
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
Lauren L C Marotta, Vanessa Almendro, Andriy Marusyk, M. Shipitsin +24 more
2011Journal of Clinical Investigation897 citations Open access
Semantic Scholar
Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
J. Barretina, B. Taylor, S. Banerji, A. Ramos +42 more
2010Nature Genetics729 citations Open access
Semantic Scholar
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
R. Firestein, A. Bass, S. Kim, I. Dunn +24 more
2008Nature707 citations Open access
Semantic Scholar
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
S. Shapira, I. Gat-Viks, Bennett O. V. Shum, A. Dricot +9 more
2009Cell689 citations Open access
Semantic Scholar
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.
E. Mcdonald, Antoine de Weck, M. Schlabach, E. Billy +96 more
2017Cell617 citations Open access
Semantic Scholar
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
C. Scholl, S. Fröhling, Ian F. Dunn, A. Schinzel +14 more
2009Cell574 citations Open access
Semantic Scholar
A public genome-scale lentiviral expression library of human ORFs
Xiao-Ping Yang, J. Boehm, Xin-Ping Yang, K. Salehi-Ashtiani +20 more
2011Nature Methods567 citations Open access
Semantic Scholar
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
K. Vasudevan, D. Barbie, M. Davies, Rosalia Rabinovsky +30 more
2009Cancer Cell548 citations Open access
Semantic Scholar
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
T. Jones, Anne E Carpenter, Michael R. Lamprecht, J. Moffat +7 more
2009Proceedings of the National Academy of Sciences of the United States of America398 citations Open access
Semantic Scholar
An epigenetic mechanism of resistance to targeted therapy in T-cell acute lymphoblastic leukemia
Birgit Knoechel, J. Roderick, K. Williamson, Jiang Zhu +23 more
2014Nature Genetics346 citations Open access
Semantic Scholar
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
Meghana M. Kulkarni, M. Booker, S. Silver, Adam A. Friedman +3 more
2006Nature Methods306 citations
Semantic Scholar
The transcription factor Eyes absent is a protein tyrosine phosphatase
Tina L. Tootle, S. Silver, Erin L. Davies, V. Newman +5 more
2003Nature266 citations
Semantic Scholar
Signaling circuitries in development: insights from the retinal determination gene network
S. Silver, Ilaria Rebay
2004Development206 citations Open access
Semantic Scholar
Proteomic and Genetic Approaches Identify Syk as an AML Target
C. Hahn, J. Berchuck, K. Ross, Rose M. Kakoza +15 more
2009Cancer Cell174 citations Open access
Semantic Scholar
Integrative screening approach identifies regulators of polyploidization and targets for acute megakaryocytic leukemia
Q. Wen, B. Goldenson, S. Silver, Monica Schenone +44 more
2012Cell149 citations Open access
Semantic Scholar
Functional Dissection of Eyes absent Reveals New Modes of Regulation within the Retinal Determination Gene Network
S. Silver, Erin L. Davies, Laura Doyon, Ilaria Rebay
2003Molecular and Cellular Biology139 citations Open access
Semantic Scholar
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor initiating cell state
Yakov Chudnovsky, Dohoon Kim, Si-Yuan Zheng, Warren A. Whyte +25 more
2014Cell Reports127 citations Open access
Semantic Scholar
New vision from Eyes absent: transcription factors as enzymes.
Ilaria Rebay, S. Silver, Tina L. Tootle
2005Trends in Genetics93 citations
Semantic Scholar
Functional screening identifies miR-315 as a potent activator of Wingless signaling
S. Silver, Joshua W. Hagen, Katsutomo Okamura, N. Perrimon +1 more
2007Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK 1
D. Barbie, P. Tamayo, Jesse S. Boehm, So Young Kim +31 more
201273 citations
Semantic Scholar
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer
R. Witwicki, Muhammad B. Ekram, X. Qiu, M. Janiszewska +29 more
2018Cell Reports63 citations Open access
Semantic Scholar
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms
Ye Wang, Morvarid Mohseni, Angelo L Grauel, Javier Estrada Diez +44 more
2021Scientific Reports61 citations Open access
Semantic Scholar
Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers
Huai-Xiang Hao, Hong-Yun Wang, Chen Liu, S. Kovats +21 more
2019Molecular Cancer Therapeutics42 citations Open access
Semantic Scholar
CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity
S. Kim, I. Dunn, R. Firestein, Piyush B. Gupta +10 more
2010PLoS ONE41 citations Open access
Semantic Scholar
Using Drosophila to Decipher How Mutations Associated With Human Branchio-Oto-Renal Syndrome and Optical Defects Compromise the Protein Tyrosine Phosphatase and Transcriptional Functions of Eyes Absent
M. Mutsuddi, B. W. Chaffee, Justin J. Cassidy, S. Silver +2 more
2005Genetics40 citations
Semantic Scholar
CK 1 e Is Required for Breast Cancers Dependent on b-Catenin Activity
S. Kim, I. Dunn, R. Firestein, Piyush B. Gupta +10 more
201027 citations
Semantic Scholar
Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening.
L. Griner, Kalyani Gampa, Toan T. Do, H. Nguyen +4 more
2018Journal of Visualized Experiments11 citations Open access
Semantic Scholar
In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling
Zainab Jagani, Gregg Chenail, K. Xiang, Geoffrey Bushold +65 more
2019bioRxiv8 citations Open access
Semantic Scholar
Ftx-6058 Induces Fetal Hemoglobin Production and Ameliorates Disease Pathology in Sickle Cell Mice
David Matson, Ke-Qiang Xie, Mark Roth, B. Stuart +5 more
2021Blood6 citations
Semantic Scholar
Peer Review #1 of "Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold (v0.1)"
M. Al-Sanea, A. Abdelazem, M. Al-Sanea, B. Park +186 more
20205 citations Open access
Semantic Scholar
New class of Son‐of‐sevenless (Sos) alleles highlights the complexities of Sos function
S. Silver, Fangli Chen, Laura Doyon, A. Zink +1 more
2004Genesis5 citations
Semantic Scholar
FEM: mining biological meaning from cell level in single-cell RNA sequencing data
Yun-Qing Liu, Na Lu, Chang-Wei Bi, Ting-Yu Han +247 more
2021PeerJ3 citations Open access
Semantic Scholar
In Vivo Characterization of Ftx-6058, a Novel Small Molecular Fetal Hemoglobin Inducer for Sickle Cell Disease
Ke-Qiang Xie, Mark Roth, I. Efremov, S. Silver +5 more
2020Blood3 citations
Semantic Scholar
A Kinome shRNA Screen to Identify Pathways That Regulate Megakaryocyte Polyploidization and New Targets for Differentiation Therapy
Q. Wen, S. Silver, T. Lewis, Sridevi Ponduru +9 more
20102 citations
Semantic Scholar
Abstract 4782: Epigenetic resistance to Notch inhibition in T cell acute lymphoblastic leukemia
Birgit Knoechel, J. Roderick, K. Williamson, Jiang Zhu +26 more
20141 citations
Semantic Scholar
Abstract #3822: PDK1-SGK3 signaling in the absence of AKT activation in PIK3CA- mutant cancers
K. Vasudevan, D. Barbie, M. Davies, Rosalia Rabinovsky +25 more
20091 citations
Semantic Scholar
Abstract 5448: PTK7 as a potential therapeutic target in ovarian cancer
Z. Ding, Amanda Lennon, Keli Perron, David P. Harper +22 more
20140 citations
Semantic Scholar
Abstract 3135:In vitroandin vivosynthetic lethal screens to identify novel targets in the context of PTEN deficiency.
Jingxin Zhang, J. Murtie, O. Iartchouk, Hui Cao +20 more
20130 citations
Semantic Scholar
a public genome-scale lentiviral expression library of human orfs
Xiao-Ping Yang, Jesse S. Boehm, Xin-Ping Yang, K. Salehi-Ashtiani +19 more
20110 citations
Semantic Scholar
Abstract #5608: Synthetic lethal interaction between oncogenic KRAS dependency and suppression of STK33 in human cancer cells
C. Scholl, S. Fröhling, I. Dunn, A. Schinzel +14 more
20090 citations
Semantic Scholar
High-Throughput RNA Interference Screening Identifies Synthetic Lethality Between Oncogenic KRAS Dependency and Suppression of STK33
C. Scholl, S. Fröhling, I. Dunn, D. Barbie +10 more
20080 citations
Semantic Scholar
A feed and livestock model of the United States with application to the possible effects on U.S. agriculture of large-scale corn alcohol production.
S. Silver
19840 citations
Semantic Scholar

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