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Katherine Cosmopoulos · SciRah

Researcher profile · Semantic Scholar

Katherine Cosmopoulos

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Katherine Cosmopoulos — researcher profile on SciRah

h-index: 11
Works: 19
Citations: 2,485

Most-cited papers

Functional delivery of viral miRNAs via exosomes
D. Pegtel, Katherine Cosmopoulos, D. Thorley-Lawson, M. van Eijndhoven +5 more
2010Proceedings of the National Academy of Sciences of the United States of America1,645 citations Open access
Semantic Scholar
Comprehensive Profiling of Epstein-Barr Virus MicroRNAs in Nasopharyngeal Carcinoma
Katherine Cosmopoulos, M. Pegtel, Jared B. Hawkins, H. Moffett +3 more
2008Journal of Virology191 citations Open access
Semantic Scholar
A Novel Persistence Associated EBV miRNA Expression Profile Is Disrupted in Neoplasia
Jin Qiu, Katherine Cosmopoulos, M. Pegtel, E. Hopmans +4 more
2011PLoS Pathogens143 citations Open access
Semantic Scholar
Initial Testing (Stage 1) of Tazemetostat (EPZ-6438), a Novel EZH2 Inhibitor, by the Pediatric Preclinical Testing Program
R. Kurmasheva, M. Sammons, Edward Favours, Jianwrong Wu +6 more
2016Pediatric Blood & Cancer111 citations Open access
Semantic Scholar
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
J. Blank, Xiao-Zhen Liu, Katherine Cosmopoulos, David C. Bouck +8 more
2013Cancer Research103 citations
Semantic Scholar
Overcoming Immune Checkpoint Blockade Resistance via EZH2 Inhibition.
Hye-Jung Kim, H. Cantor, Katherine Cosmopoulos
2020Trends in immunology76 citations Open access
Semantic Scholar
Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Khristofer Garcia, J. Blank, David C. Bouck, Xiao-Zhen Liu +10 more
2014Molecular Cancer Therapeutics50 citations
Semantic Scholar
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
M. Thomenius, Jennifer Totman, D. Harvey, L. Mitchell +30 more
2018PLoS ONE47 citations Open access
Semantic Scholar
Immunoglobulin Deficiencies and Susceptibility to Infection Among Homozygotes and Heterozygotes for C2 Deficiency
C. Alper, Jianhua Xu, Katherine Cosmopoulos, B. Dolinski +8 more
2003Journal of Clinical Immunology46 citations
Semantic Scholar
Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies
Joshua S. Alford, J. Lampe, Dorothy Brach, R. Chesworth +10 more
2022ACS Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies
J. Lampe, Joshua S. Alford, P. Boriak-Sjodin, Dorothy Brach +13 more
2021ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma
Jennifer Totman, Dorothy Brach, V. Motwani, Selene Howe +13 more
2021Blood4 citations Open access
Semantic Scholar
Identification of a First-in-Class SETD2 Inhibitor That Shows Potent and Selective Anti-Proliferative Activity in t(4;14) Multiple Myeloma: T(4;14) Multiple Myeloma Cells Are Dependent on Both H3K36 Di and Tri-Methylation
M. Thomenius, Jennifer Totman, Katherine Cosmopoulos, Dorothy Brach +8 more
2018Blood4 citations Open access
Semantic Scholar
Abstract 808: Opportunity for therapeutic expansion in mantle cell lymphoma: Tazemetostat combination synergy status in preclinical MCL models
T. Hood, Katherine Cosmopoulos, Allison E. Drew, Kelli A. Armstrong +3 more
2018Experimental and Molecular Therapeutics3 citations
Semantic Scholar
Abstract A137: Initial testing (Stage 1) of EPZ-6438 (tazemetostat), a novel EZH2 inhibitor, by the pediatric preclinical testing program (PPTP)
R. Kurmasheva, Katherine Cosmopoulos, M. Sammons, Edward Favours +3 more
20151 citations
Semantic Scholar
Abstract C233: Activation of p53 by the NEDD8 activating enzyme inhibitor MLN4924 is independent of Cdt1 and involves the cullin-RING ligase CRL4-DTL.
J. Blank, Xiao-Zhen Liu, Hugues Bernard, H. Liao +2 more
20130 citations
Semantic Scholar
Abstract B92: Nedd8-activating enzyme inhibitor MLN4924 provides synergy in nonclinical models with mitomycin C through interactions with ATR, BRCA1/BRCA2 and chromatin dynamics pathways.
E. Lightcap, Khristofer Garcia, J. Blank, David C. Bouck +10 more
20130 citations
Semantic Scholar
Abstract 3104: Genome-wide screen for modulators of cell death induced by the NEDD8-activating enzyme inhibitor MLN4924
Katherine Cosmopoulos, J. Blank, Xiao-Zhen Liu, David C. Bouck +7 more
20120 citations
Semantic Scholar
Epstein-Barr virus non -coding RNA: Micro-managing viral infection, persistence and pathogenesis
Katherine Cosmopoulos
20090 citations
Semantic Scholar

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