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E. Lightcap · SciRah

Researcher profile · Semantic Scholar

E. Lightcap

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E. Lightcap — researcher profile on SciRah

h-index: 18
Works: 49
Citations: 2,077

Most-cited papers

Proteasome inhibition measurements: clinical application.
E. Lightcap, T. McCormack, C. Pien, V. Chau +2 more
2000Clinical Chemistry296 citations
Semantic Scholar
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.
V. Podust, J. Brownell, T. Gladysheva, Rong S. Luo +5 more
2000Proceedings of the National Academy of Sciences of the United States of America265 citations Open access
Semantic Scholar
Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.
Xingyue He, Jessica Riceberg, Teresa A. Soucy, Erik Koenig +25 more
2017Nature Chemical Biology207 citations
Semantic Scholar
Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341
J. Fleming, E. Lightcap, S. Sadis, Vala Thoroddsen +2 more
2002Proceedings of the National Academy of Sciences of the United States of America200 citations Open access
Semantic Scholar
MYC regulation of a “poor-prognosis” metastatic cancer cell state
A. Wolfer, B. Wittner, D. Irimia, R. Flavin +13 more
2010Proceedings of the National Academy of Sciences of the United States of America178 citations Open access
Semantic Scholar
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis
T. Schmelzle, A. Mailleux, Michael Overholtzer, J. Carroll +4 more
2007Proceedings of the National Academy of Sciences of the United States of America155 citations Open access
Semantic Scholar
A small molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
E. Lightcap, Pengfei Yu, S. Grossman, K. Song +26 more
2021Science Translational Medicine123 citations Open access
Semantic Scholar
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
J. Blank, Xiao-Zhen Liu, Katherine Cosmopoulos, David C. Bouck +8 more
2013Cancer Research103 citations
Semantic Scholar
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
Siquan Chen, J. Blank, Theodore W Peters, Xiao-Zhen Liu +18 more
2010Cancer Research102 citations Open access
Semantic Scholar
Akt and ERK Control the Proliferative Response of Mammary Epithelial cells to the Growth Factors IGF-1 and EGF through the Cell Cycle Inhibitor p57Kip2
Devin T. Worster, T. Schmelzle, Nicole L. Solimini, E. Lightcap +4 more
2012Science Signaling85 citations Open access
Semantic Scholar
Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924
H. Liao, Xiao-Zhen Liu, J. Blank, David C. Bouck +3 more
2011Molecular & Cellular Proteomics68 citations Open access
Semantic Scholar
Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD
Hong Liu, S. Dasgupta, Yu Fu, Brandi Bailey +3 more
2019BMC Immunology61 citations Open access
Semantic Scholar
Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Khristofer Garcia, J. Blank, David C. Bouck, Xiao-Zhen Liu +10 more
2014Molecular Cancer Therapeutics50 citations
Semantic Scholar
Edge‐count probabilities for the identification of local protein communities and their organization
V. Farutin, K. Robison, E. Lightcap, Vlado Dancík +3 more
2005Proteins: Structure, Function, and Bioinformatics38 citations
Semantic Scholar
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
Michael E. Stokes, Veronica Calvo, Sho Fujisawa, C. Dudgeon +12 more
2023Clinical Cancer Research33 citations Open access
Semantic Scholar
Slow-Binding Inhibition of γ-Aminobutyric Acid Aminotransferase by Hydrazine Analogues†,‡
E. Lightcap, R. Silverman
199626 citations Open access
Semantic Scholar
Assays for proteasome inhibition.
P. Elliott, Teresa A. Soucy, C. Pien, J. Adams +1 more
2003Methods in Molecular Medicine21 citations
Semantic Scholar
Discrete monomeric metaphosphate anion as an intermediate in the hydrolysis of .mu.-monothiopyrophosphate
E. Lightcap, P. Frey
199220 citations
Semantic Scholar
Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.
D. Nandi, E. Lightcap, Y. Koo, Xing-Liang Lu +2 more
2003International Journal of Biochemistry and Cell Biology9 citations
Semantic Scholar
Evidence for monomeric metaphosphate as an intermediate in the hydrolysis of .mu.-monothiopyrophosphate
E. Lightcap, P. Frey
19916 citations
Semantic Scholar
Cancer Biology and Signal Transduction Nedd 8-Activating Enzyme Inhibitor MLN 4924 Provides Synergy with Mitomycin C through Interactions with ATR , BRCA 1 / BRCA 2 , and Chromatin Dynamics Pathways
Khristofer Garcia, J. Blank, David C. Bouck, Xiao-Zhen Liu +10 more
20145 citations
Semantic Scholar
Abstract 3079: Pharmacodynamic evaluation of the novel SUMOylation inhibitor TAK-981 in a mouse tumor model
A. Berger, S. Friedlander, O. Ghasemi, S. Grossman +10 more
2019Experimental and Molecular Therapeutics4 citations
Semantic Scholar
Acoustic Liquid Handling for Rapid siRNA Transfection Optimization
Andrew S. Xiao, E. Lightcap, David C. Bouck
2015Journal of biomolecular screening4 citations Open access
Semantic Scholar
Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues.
E. Lightcap, R. Silverman
1996Journal of Medicinal Chemistry4 citations
Semantic Scholar
Abstract 6231: Activation of GCN2 by HC-7366 results in significant antitumor efficacy as monotherapy and in combination with multiple standard of care agents in various solid cancer models
Feven Tameire, P. Wojnarowicz, C. Dudgeon, Sho Fujisawa +21 more
2023Cancer Research3 citations
Semantic Scholar
Time-dependent inhibition of γ-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine
E. Lightcap, M. H. Hopkins, G. T. Olson, R. Silverman
19953 citations
Semantic Scholar
884 PERK inhibitor HC-5404 demonstrates immune-activation and anti-tumor efficacy in combination with anti-PD1 immune checkpoint inhibitor antibody
Anissa S. H. Chan, J. Drees, Yun-Fang Li, Takashi O. Kangas +13 more
2022Regular and Young Investigator Award Abstracts2 citations Open access
Semantic Scholar
Abstract A164: The small molecule UAE inhibitor TAK-243 (MLN7243) prevents DNA damage repair and reduces cell viability/tumor growth when combined with radiation, carboplatin and docetaxel
M. Milhollen, Junfeng Shi, T. Traore, J. Huck +8 more
20152 citations
Semantic Scholar
Abstract C55: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer
David C. Bouck, Khristofer Garcia, J. Blank, Xiao-Zhen Liu +5 more
20151 citations
Semantic Scholar
Cellular and biochemical characterization of an inhibitor of the Ubiquitin Activating Enzyme (UAE)
D. Sappal, N. Bence, P. Fleming, M. Milhollen +13 more
20111 citations
Semantic Scholar
Abstract A196: Development, validation, and clinical implementation of a peripheral blood RT-PCR pharmacodynamic assay for MLN4924, an investigational small molecule inhibitor of NEDD8-activating enzyme (NAE).
R. Walker, Erik Koenig, G. Mulligan, E. Lightcap +8 more
20111 citations
Semantic Scholar
Abstract A70: A genome‐wide siRNA screen for modulators of cell death induced by the proteasome inhibitor bortezomib
Siquan Chen, J. Blank, Theodore W Peters, Jane X. Liu +18 more
20091 citations
Semantic Scholar
Enzymatic and chemical reactivities of sym-monothiopyrophosphate
C. J. Halkides, E. Lightcap, P. Frey
19911 citations
Semantic Scholar
Abstract A30: Activation of GCN2 by HC-7366 results in significant anti-tumor efficacy as monotherapy and in combination with Venetoclax in AML models
Feven Tameire, P. Wojnarowicz, Sho Fujisawa, Sharon Huang +20 more
2023Blood Cancer Discovery0 citations
Semantic Scholar
Abstract P029: CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors
T. Y. Morita, Jie Yu, Y. Kashima, Kosuke Tanaka +7 more
2021Poster Presentations - Proffered Abstracts0 citations
Semantic Scholar
Immune Landscape in the Inflamed Colonic Mucosa of Patients with IBD
Hong Liu, S. Dasgupta, Yu Fu, Brandi Bailey +3 more
2020Prime Archives in Immunology0 citations Open access
Semantic Scholar
Abstract 1423: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer
Xiao-Zhen Liu, David C. Bouck, Khristofer Garcia, J. Blank +5 more
2017Molecular and Cellular Biology, Genetics0 citations
Semantic Scholar
Abstract 1147: Probing the roles of SUMOylation in cancer cell biology using a selective SUMO activating enzyme inhibitor
Sai M. Pulukuri, Xingyue He, S. Grossman, Jessica Riceberg +12 more
20170 citations
Semantic Scholar
Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation
M. Milhollen, J. Shi, T. Traore, J. Huck +11 more
20160 citations
Semantic Scholar
Abstract B156: Regulation of tumor metabolism by the investigational proteasome inhibitor ixazomib in KRAS wild-type and KRAS mutant xenograft tumors.
N. Chattopadhyay, A. Berger, J. Garnsey, Hugues Bernard +3 more
2013Metabolism0 citations
Semantic Scholar
Abstract C233: Activation of p53 by the NEDD8 activating enzyme inhibitor MLN4924 is independent of Cdt1 and involves the cullin-RING ligase CRL4-DTL.
J. Blank, Xiao-Zhen Liu, Hugues Bernard, H. Liao +2 more
20130 citations
Semantic Scholar
Abstract B92: Nedd8-activating enzyme inhibitor MLN4924 provides synergy in nonclinical models with mitomycin C through interactions with ATR, BRCA1/BRCA2 and chromatin dynamics pathways.
E. Lightcap, Khristofer Garcia, J. Blank, David C. Bouck +10 more
20130 citations
Semantic Scholar
373 A Quantitative Proteomic Analysis Identifies Neddylated Proteins Regulated by the Investigational NEDD8-activating Enzyme Inhibitor MLN4924
X. Liu, J. Blank, H. Liao, E. Lightcap
20120 citations
Semantic Scholar
Abstract 3104: Genome-wide screen for modulators of cell death induced by the NEDD8-activating enzyme inhibitor MLN4924
Katherine Cosmopoulos, J. Blank, Xiao-Zhen Liu, David C. Bouck +7 more
20120 citations
Semantic Scholar
Abstract A45: Investigation of efficacy of the NAE inhibitor MLN4924 across large-scale cell line panels reveals potentially sensitive cancer indications and candidate predictive biomarkers.
Bin Li, M. Schu, S. Blakemore, W. Trepicchio +6 more
20110 citations
Semantic Scholar
Abstract 3300: MYC regulation of a “poor prognosis” metastatic cancer cell state
A. Wolfer, B. Wittner, D. Irimia, R. Flavin +13 more
20100 citations
Semantic Scholar
Abstract B40: Development of a pharmacodynamic assay for the second‐generation proteasome inhibitor MLN9708 in clinical trials of multiple myeloma
Y. Jie, Yu Yang, B. Stringer, Trisha Babcock +9 more
20090 citations
Semantic Scholar
Phosphorylation of vimentin by Aurora A kinase: implications for the use of intermediate filaments as pharmacodynamic markers of Aurora A activity
Neil Rollins, J. Weiner, E. Lightcap, H. Liao +4 more
20080 citations
Semantic Scholar
Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine.
E. Lightcap, M. H. Hopkins, G. T. Olson, R. Silverman
1995Bioorganic & Medicinal Chemistry0 citations
Semantic Scholar

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