Researcher profile · Semantic Scholar

L. Mitchell

h-index: 12
Works: 39
Citations: 1,000

Most-cited papers

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
A. Fedoriw, Satyajit R. Rajapurkar, S. O'Brien, Sarah V. Gerhart +43 more
2019Cancer Cell290 citations Open access
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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Allison E. Drew, O. Moradei, S. Jacques, N. Rioux +20 more
2017Scientific Reports122 citations Open access
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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
L. Mitchell, Allison E. Drew, S. Ribich, N. Rioux +14 more
2015ACS Medicinal Chemistry Letters121 citations Open access
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4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.
B. Palmer, A. M. Thompson, R. J. Booth, E. Dobrusin +8 more
2006Journal of Medicinal Chemistry102 citations Open access
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Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
L. Mitchell, P. Boriack-Sjodin, Sherri A. Smith, M. Thomenius +17 more
2016ACS Medicinal Chemistry Letters79 citations Open access
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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
M. Thomenius, Jennifer Totman, D. Harvey, L. Mitchell +30 more
2018PLoS ONE47 citations Open access
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An enantioselective total synthesis of (+)- and (-)-saudin. Determination of the absolute configuration.
R. K. Boeckman, Maria del Rosario Rico Ferreira, L. Mitchell, P. Shao
2002Journal of the American Chemical Society32 citations
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Identification of a peptide inhibitor for the histone methyltransferase WHSC1
M. Morrison, P. Boriack-Sjodin, Kerren K. Swinger, T. Wigle +10 more
2018PLoS ONE31 citations Open access
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A homologous enolate Truce–Smiles rearrangement
L. Mitchell, N. Barvian
200430 citations
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A practical Buchwald-Hartwig amination of 2-bromopyridines with volatile amines.
J. Li, Z. Wang, L. Mitchell
2007Journal of Organic Chemistry28 citations
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Thyroid receptor agonists for the treatment of androgenetic alopecia.
J. Li, L. Mitchell, R. Dow
2010Bioorganic & Medicinal Chemistry Letters23 citations Open access
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Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.
L. Mitchell, Theodore R. Johnson, Guang-Wei Lu, D. Du +13 more
2010Journal of Medicinal Chemistry12 citations Open access
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(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.
Lain‐Yen Hu, D. Du, Jennifer K. Hoffman, Y. Smith +27 more
2007Bioorganic & Medicinal Chemistry Letters12 citations Open access
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4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.
L. Mitchell, Zhi Wang, Lain‐Yen Hu, C. Kostlan +5 more
2009Bioorganic & Medicinal Chemistry Letters11 citations Open access
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Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.
Jennifer A. Van Camp, Lain‐Yen Hu, C. Kostlan, B. Lefker +9 more
2007Bioorganic & Medicinal Chemistry Letters9 citations Open access
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Studies Culminating in the Total Synthesis and Determination of the Absolute Configuration of (-)-Saudin
R. K. Boeckman, M. del Rosario Ferreira, L. Mitchell, P. Shao +2 more
2011Tetrahedron8 citations Open access
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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Allison E. Drew, O. Moradei, S. Jacques, N. Rioux +20 more
2017Scientific Reports7 citations Open access
Semantic Scholar
Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.
L. Mitchell, Lain‐Yen Hu, Maria N Nguyen, S. Fakhoury +9 more
2009Bioorganic & Medicinal Chemistry Letters7 citations Open access
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Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652
N. Rioux, L. Mitchell, P. Tiller, Katie Plant +7 more
2015Drug Metabolism And Disposition6 citations Open access
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Acid-Promoted Fries Rearrangements of Benzannulated Lactones
R. C. Cambie, L. Mitchell, P. Rutledge
19986 citations
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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer
Peter C. Smith, X. Puyang, Craig Furman, Zheng-Guo Zhu +31 more
20174 citations
Semantic Scholar
Modifications of Rings B and C of Podocarpic Acid: Towards the Synthesis of Quassinoids Richard
C. Cambié, W. Denny, M. Hay, L. Mitchell +2 more
19994 citations
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Unique 11b‐Substituted Indeno[2,1‐c]quinolin‐6‐one Ring System
L. Mitchell, Brian Samas
20053 citations
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Documentation of a rare example of an intramolecular 1,2-addition of a trialkylborane to a carbonyl group
R. K. Boeckman, L. Mitchell, P. Shao, R. Lachicotte
20003 citations
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Oxidative Decarboxylation of Podocarpic Acid Derivatives
R. C. Cambie, P. Davy, L. Mitchell, C. E. F. Rickard +1 more
19983 citations
Semantic Scholar
A Homologous Enolate Truce—Smiles Rearrangement.
L. Mitchell, Barvian Nicole Chantel
20042 citations
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A Synthesis of Triptoquinones D, E, and F from Podocarpic Acid
R. C. Cambie, L. Mitchell, P. Rutledge
19982 citations
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Abstract C85: Identification of a novel potent selective SMYD3 inhibitor with oral bioavailability
L. Mitchell, Paula Ann Boriack-Sjodin, Sherri A. Smith, M. Thomenius +16 more
20151 citations
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12,12-Ethylenedioxy-8α, 9α-epoxypodocarpan-19-oic acid
R. C. Cambie, L. Mitchell, C. E. F. Rickard, P. Rutledge
19981 citations
Semantic Scholar
Abstract P1-10-08: Development of a first-in-class oral selective ERα covalent antagonist (SERCA) for the treatment of ERαWT and ERαMUT breast cancer
M. Korpal, X. Puyang, Craig Furman, Zheng-Guo Zhu +44 more
20180 citations
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Abstract 5376: Identification of the first small molecule PRMT6 inhibitor tool compound
Allison E. Drew, L. Mitchell, N. Rioux, K. Swinger +7 more
20150 citations
Semantic Scholar
Acid-Promoted Fries Rearrangements of Benzannulated Lactones.
R. C. Cambie, L. Mitchell, P. Rutledge
20100 citations
Semantic Scholar
A Practical Buchwald—Hartwig Amination of 2‐Bromopyridines with Volatile Amines.
J. Li, Z. Wang, L. Mitchell
20070 citations
Semantic Scholar
The First Report of Selective Small Molecule Melanocortin-5 Receptor Antagonists
L. Mitchell, J. Li
20070 citations
Semantic Scholar
Unique 11b-Substituted Indeno[2,1-c]quinolin-6-one Ring System.
L. Mitchell, Brian Samas
20050 citations
Semantic Scholar
Inhibiteurs de checkpoint kinases (wee1 et chk1)
R. J. Booth, W. Denny, E. Dobrusin, A. Kraker +6 more
20030 citations
Semantic Scholar
An Enantioselective Total Synthesis of (+)‐ and (‐)‐Saudin. Determination of the Absolute Configuration.
R. K. Boeckman, Maria del Rosario Rico Ferreira, L. Mitchell, P. Shao
20020 citations
Semantic Scholar
A Synthesis of Triptoquinones D, E, and F from Podocarpic Acid.
R. C. Cambie, L. Mitchell, P. Rutledge
19990 citations
Semantic Scholar
Oxidative Decarboxylation of Podocarpic Acid Derivatives.
R. C. Cambie, P. Davy, L. Mitchell, C. E. F. Rickard +1 more
19980 citations
Semantic Scholar

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