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T. Riera · SciRah

Researcher profile · Semantic Scholar

T. Riera

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T. Riera — researcher profile on SciRah

h-index: 22
Works: 45
Citations: 2,777

Most-cited papers

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
B. Hubbard, A. P. Gomes, H. Dai, Jun Li +26 more
2013Science623 citations Open access
Semantic Scholar
SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
Hongying Yang, Wei Zhang, H. Pan, H. G. Feldser +13 more
2012PLoS ONE380 citations Open access
Semantic Scholar
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
A. Fedoriw, Satyajit R. Rajapurkar, S. O'Brien, Sarah V. Gerhart +43 more
2019Cancer Cell290 citations Open access
Semantic Scholar
Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species
A. P. Gomes, H. Dai, Jun Li, Thomas Considine +20 more
245 citations
Semantic Scholar
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
H. Dai, A. Case, T. Riera, Thomas Considine +29 more
2014Nature Communications200 citations Open access
Semantic Scholar
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Allison E. Drew, O. Moradei, S. Jacques, N. Rioux +20 more
2017Scientific Reports122 citations Open access
Semantic Scholar
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
L. Mitchell, Allison E. Drew, S. Ribich, N. Rioux +14 more
2015ACS Medicinal Chemistry Letters121 citations Open access
Semantic Scholar
SIRT1 Activation by Small Molecules
H. Dai, Lauren Kustigian, David P. Carney, A. Case +7 more
2010Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
L. Mitchell, P. Boriack-Sjodin, Sherri A. Smith, M. Thomenius +17 more
2016ACS Medicinal Chemistry Letters79 citations Open access
Semantic Scholar
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis.
Nwakaso N Umejiego, D. Gollapalli, Lisa Sharling, Anna Volftsun +6 more
2008Chemistry and Biology79 citations Open access
Semantic Scholar
The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity
I. Macpherson, S. Kirubakaran, Suresh Kumar Gorla, T. Riera +4 more
2010Journal of the American Chemical Society68 citations Open access
Semantic Scholar
Cryptosporidium parvum IMP Dehydrogenase
Nwakaso N Umejiego, Catherine Li, T. Riera, L. Hedstrom +1 more
2004Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
M. Thomenius, Jennifer Totman, D. Harvey, L. Mitchell +30 more
2018PLoS ONE47 citations Open access
Semantic Scholar
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
S. Jacques, Katrina P. Aquino, J. Gureasko, P. Boriack-Sjodin +3 more
2016Biochemistry47 citations
Semantic Scholar
Cryptosporidium parvum IMP Dehydrogenase IDENTIFICATION OF FUNCTIONAL, STRUCTURAL, AND DYNAMIC PROPERTIES THAT CAN BE EXPLOITED FOR DRUG DESIGN*
Nwakaso N Umejiego, Catherine Li, T. Riera, L. Hedstrom +1 more
200435 citations
Semantic Scholar
Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies
Joshua S. Alford, J. Lampe, Dorothy Brach, R. Chesworth +10 more
2022ACS Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca.
Ya-Lin Zhang, Melissa H Heinsen, M. Kostic, Gina M. Pagani +5 more
2004Bioorganic & Medicinal Chemistry33 citations
Semantic Scholar
Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies
J. Lampe, Joshua S. Alford, P. Boriak-Sjodin, Dorothy Brach +13 more
2021ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
A Kinetic Alignment of Orthologous Inosine-5′-monophosphate Dehydrogenases
T. Riera, Wen Wang, H. R. Josephine, L. Hedstrom
2008Biochemistry28 citations Open access
Semantic Scholar
Substitution of the conserved Arg-Tyr dyad selectively disrupts the hydrolysis phase of the IMP dehydrogenase reaction.
Yollete V. Guillén Schlippe, T. Riera, M. Seyedsayamdost, L. Hedstrom
2004Biochemistry25 citations
Semantic Scholar
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.
A. Basavapathruni, J. Gureasko, Margaret Porter-Scott, W. Hermans +6 more
2016Biochemistry22 citations
Semantic Scholar
Allosteric activation via kinetic control: Potassium accelerates a conformational change in IMP dehydrogenase
T. Riera, Lian-Qing Zheng, H. R. Josephine, Donghong Min +2 more
2011Biochemistry22 citations Open access
Semantic Scholar
The Identification of the SIRT1 Activator SRT2104 as a Clinical Candidate
P. Ng, J. Bemis, J. Disch, C. Vu +20 more
201320 citations
Semantic Scholar
The synthetic phosphagen cyclocreatine phosphate inhibits the growth of a broad spectrum of solid tumors.
L. Schimmel, V. Khandekar, K. Martin, T. Riera +3 more
1996Anticancer Research10 citations
Semantic Scholar
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Allison E. Drew, O. Moradei, S. Jacques, N. Rioux +20 more
2017Scientific Reports7 citations Open access
Semantic Scholar
Quantitative Analysis of Receptor Tyrosine Kinase-Effector Coupling at Functionally Relevant Stimulus Levels*♦
Simin Li, Devayani P. Bhave, Jennifer M. Chow, T. Riera +5 more
2015Journal of Biological Chemistry6 citations Open access
Semantic Scholar
New ways to target old receptors.
A. Whitty, T. Riera
2008Current Opinion in Chemical Biology6 citations
Semantic Scholar
IMP dehydrogenase: the dynamics of drug selectivity.
L. Hedstrom, L. Gan, Yollete V. Guillén Schlippe, T. Riera +1 more
2003Nucleic acids research. Supplement6 citations
Semantic Scholar
Pharmacologic Inhibition of the Histone Methyltransferase SETD2 with EZM0414 As a Novel Therapeutic Strategy in Relapsed or Refractory Multiple Myeloma and Diffuse Large B-Cell Lymphoma
Jennifer Totman, Dorothy Brach, V. Motwani, Selene Howe +13 more
2021Blood4 citations Open access
Semantic Scholar
Identification of a First-in-Class SETD2 Inhibitor That Shows Potent and Selective Anti-Proliferative Activity in t(4;14) Multiple Myeloma: T(4;14) Multiple Myeloma Cells Are Dependent on Both H3K36 Di and Tri-Methylation
M. Thomenius, Jennifer Totman, Katherine Cosmopoulos, Dorothy Brach +8 more
2018Blood4 citations Open access
Semantic Scholar
Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor
Elayne Chan-Penebre, Veronica Gibaja, J. Campbell, Ogunbodede Olu +20 more
20174 citations
Semantic Scholar
Characterization of Inhibitor Binding Through Multiple Inhibitor Analysis: A Novel Local Fitting Method.
T. Riera, T. Wigle, R. Copeland
2016Methods in molecular biology4 citations
Semantic Scholar
Evidence for a Common Mechanism of SIRT 1 Regulation by Allosteric Activators Citation
C. Hubbard, A. P. Gomes, H. Dai, J. Li +3 more
20132 citations
Semantic Scholar
Abstract 2144: Kinetic mechanism of the lysine methyltransferase SMYD3 using MAP3K2 protein substrate
T. Riera, T. Wigle, J. Gureasko, P. Boriack-Sjodin +1 more
20151 citations
Semantic Scholar
Abstract C85: Identification of a novel potent selective SMYD3 inhibitor with oral bioavailability
L. Mitchell, Paula Ann Boriack-Sjodin, Sherri A. Smith, M. Thomenius +16 more
20151 citations
Semantic Scholar
Thermodynamic and kinetic consequences of conformational changes in IMP dehydrogenase catalysis: Characterization of flap mutants and potassium activation
T. Riera
20071 citations
Semantic Scholar
Abstract 104: ATF7IP does not alter the substrate specificity of the lysine methyltransferase SETDB1
A. Basavapathruni, J. Gureasko, M. Scott, P. Boriack-Sjodin +3 more
20150 citations
Semantic Scholar
Microsoft Word-Li et al (Revised) 1-21-15.docx
Simin Li, Devayani P. Bhave, Jennifer M. Chow, T. Riera +6 more
20150 citations
Semantic Scholar
Abstract B78: CRISPR pooled screening identifies differential dependencies on epigenetic pathways
A. Grassian, Julian Fowler, I. Feldman, T. Riera +7 more
20150 citations
Semantic Scholar
Abstract 97: CARM1 preferentially methylates H3R17 over H3R26 through a random kinetic mechanism
S. Jacques, Katrina P. Aquino, J. Gureasko, P. Boriack-Sjodin +2 more
20150 citations
Semantic Scholar
Abstract 5376: Identification of the first small molecule PRMT6 inhibitor tool compound
Allison E. Drew, L. Mitchell, N. Rioux, K. Swinger +7 more
20150 citations
Semantic Scholar
Quantitative Analysis of How RET Receptor Activation is Coupled to ERK and Akt Signaling
Simin Li, Javad Noorbaksh, T. Riera, P. Mehta +1 more
20130 citations
Semantic Scholar
Chapter 13:SIRT1 Activators in Development
R. Perni, V. Suri, T. Riera, Joseph C. Wu +3 more
20120 citations
Semantic Scholar
Quantitative Analysis of Growth Factor Receptor Signaling
A. Whitty, T. Riera, Stephen L. Sazinsky, James D. Wright +5 more
20100 citations Open access
Semantic Scholar
The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase
T. Riera, J. D'Aquino, J. Lu, G. Petsko +1 more
20090 citations
Semantic Scholar

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