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Khristofer Garcia · SciRah

Researcher profile · Semantic Scholar

Khristofer Garcia

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Khristofer Garcia — researcher profile on SciRah

h-index: 10
Works: 24
Citations: 961

Most-cited papers

Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
E. Kupperman, Edmund C. Lee, Yueying Cao, Bret Bannerman +16 more
2010Cancer Research462 citations Open access
Semantic Scholar
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
J. Blank, Xiao-Zhen Liu, Katherine Cosmopoulos, David C. Bouck +8 more
2013Cancer Research103 citations
Semantic Scholar
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib.
Siquan Chen, J. Blank, Theodore W Peters, Xiao-Zhen Liu +18 more
2010Cancer Research102 citations Open access
Semantic Scholar
Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924
H. Liao, Xiao-Zhen Liu, J. Blank, David C. Bouck +3 more
2011Molecular & Cellular Proteomics68 citations Open access
Semantic Scholar
Nedd8-Activating Enzyme Inhibitor MLN4924 Provides Synergy with Mitomycin C through Interactions with ATR, BRCA1/BRCA2, and Chromatin Dynamics Pathways
Khristofer Garcia, J. Blank, David C. Bouck, Xiao-Zhen Liu +10 more
2014Molecular Cancer Therapeutics50 citations
Semantic Scholar
Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
C. Blackburn, C. Barrett, J. Blank, F. Bruzzese +12 more
2010Bioorganic & Medicinal Chemistry Letters39 citations
Semantic Scholar
Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.
A. Gould, Ruth Adams, S. Adhikari, K. Aertgeerts +44 more
2011Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit
C. Blackburn, K. Gigstad, P. Hales, Khristofer Garcia +13 more
2010Biochemical Journal28 citations Open access
Semantic Scholar
Development of a bioassay to detect T-cell-activating impurities for T-cell-dependent bispecific antibodies
Ho-Young Lee, E. Contreras, A. Register, Qiang Wu +4 more
2019Scientific Reports17 citations Open access
Semantic Scholar
Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.
Matthew O. Duffey, Ruth Adams, C. Blackburn, Ryan W. Chau +20 more
2010Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome
C. Blackburn, C. Barrett, J. Blank, F. Bruzzese +14 more
201210 citations
Semantic Scholar
Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20 S β 5-subunit
C. Blackburn, K. Gigstad, P. Hales, Khristofer Garcia +13 more
201010 citations
Semantic Scholar
Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen.
Zhong-Hua Yan, A. Burkhardt, H. Loke, Jesse J. Chen +7 more
2013Analytical Biochemistry7 citations
Semantic Scholar
Cancer Biology and Signal Transduction Nedd 8-Activating Enzyme Inhibitor MLN 4924 Provides Synergy with Mitomycin C through Interactions with ATR , BRCA 1 / BRCA 2 , and Chromatin Dynamics Pathways
Khristofer Garcia, J. Blank, David C. Bouck, Xiao-Zhen Liu +10 more
20145 citations
Semantic Scholar
Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of melanoma and CRC.
E. Cunniff, Julie Zhang, J. Chouitar, J. Mettetal +16 more
20134 citations
Semantic Scholar
Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC.
E. Cunniff, Julie Zhang, J. Chouitar, J. Mettetal +16 more
20132 citations
Semantic Scholar
Abstract C55: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer
David C. Bouck, Khristofer Garcia, J. Blank, Xiao-Zhen Liu +5 more
20151 citations
Semantic Scholar
Preclinical Combination Of The Oral Investigational Agents ACY-1215, a Selective HDAC6 Inhibitor, and Ixazomib, a Proteasome Inhibitor, Demonstrates Combination Benefit In Multiple Myeloma Cell Lines and Xenograft Models
Bret Bannerman, S. Quayle, Jie Yu, Khristofer Garcia +4 more
20131 citations
Semantic Scholar
Abstract C99: Beyond bortezomib: Development of Millennium's next-generation proteasome inhibitors.
C. Tsu, J. Blank, Khristofer Garcia, Jane X. Liu +15 more
20111 citations
Semantic Scholar
In-Vitro and in-Vivo Evaluation of the Orally Active Proteasome Inhibitor MLN9708 in Hematological Models of Human Cancer.
E. Kupperman, Edmund C. Lee, Yueying Cao, Bret Bannerman +16 more
20091 citations
Semantic Scholar
Abstract A70: A genome‐wide siRNA screen for modulators of cell death induced by the proteasome inhibitor bortezomib
Siquan Chen, J. Blank, Theodore W Peters, Jane X. Liu +18 more
20091 citations
Semantic Scholar
Abstract 1423: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer
Xiao-Zhen Liu, David C. Bouck, Khristofer Garcia, J. Blank +5 more
2017Molecular and Cellular Biology, Genetics0 citations
Semantic Scholar
Abstract B92: Nedd8-activating enzyme inhibitor MLN4924 provides synergy in nonclinical models with mitomycin C through interactions with ATR, BRCA1/BRCA2 and chromatin dynamics pathways.
E. Lightcap, Khristofer Garcia, J. Blank, David C. Bouck +10 more
20130 citations
Semantic Scholar
Abstract 3104: Genome-wide screen for modulators of cell death induced by the NEDD8-activating enzyme inhibitor MLN4924
Katherine Cosmopoulos, J. Blank, Xiao-Zhen Liu, David C. Bouck +7 more
20120 citations
Semantic Scholar

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