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M. Birnbaum · SciRah

Researcher profile · Semantic Scholar

M. Birnbaum

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M. Birnbaum — researcher profile on SciRah

h-index: 105
Works: 241
Citations: 47K

Most-cited papers

Essential Regulation of Cell Bioenergetics By Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
C. Cárdenas, Russell A. Miller, Ian Smith, Thi V. Bui +10 more
2010Cell1,035 citations Open access
Semantic Scholar
The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity
W. Holland, Russell A. Miller, Zhao V. Wang, K. Sun +14 more
2010Nature Medicine752 citations Open access
Semantic Scholar
Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development
David O’Sullivan, G. V. D. van der Windt, S. Huang, Jonathan D. Curtis +10 more
2014Immunity708 citations Open access
Semantic Scholar
Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
Rachel J. Perry, J. Camporez, R. Kursawe, Paul M. Titchenell +16 more
2015Cell678 citations Open access
Semantic Scholar
MICU1 is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake That Regulates Cell Survival
Karthik Mallilankaraman, Patrick J. Doonan, C. Cárdenas, H. Chandramoorthy +10 more
2012Cell676 citations Open access
Semantic Scholar
The aetiology and molecular landscape of insulin resistance
D. E. James, J. Stöckli, M. Birnbaum
2021Nature reviews. Molecular cell biology573 citations
Semantic Scholar
The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids
Cholsoon Jang, Sheng Hui, Wen-Yun Lu, Alexis Cowan +6 more
2018Cell Metabolism558 citations Open access
Semantic Scholar
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
Ming-Jian Lu, Min Wan, Karla F. Leavens, Q. Chu +6 more
2012Nature Medicine387 citations Open access
Semantic Scholar
Unraveling the Regulation of Hepatic Metabolism by Insulin
Paul M. Titchenell, M. Lazar, M. Birnbaum
2017Trends in endocrinology and metabolism372 citations Open access
Semantic Scholar
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
Zheng Sun, Russell A. Miller, Rajesh T. Patel, Jie Chen +11 more
2012Nature Medicine339 citations Open access
Semantic Scholar
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
M. Juntilla, V. Patil, Marco Calamito, Rohan P. Joshi +2 more
2010Blood287 citations Open access
Semantic Scholar
Molecular Aspects of Fructose Metabolism and Metabolic Disease
M. Herman, M. Birnbaum
2021Cell Metabolism271 citations Open access
Semantic Scholar
Hepatocyte Insulin Signaling is Required for Feeding-Induced Lipogenesis but Dispensable for the Suppression of Glucose Production
Paul M. Titchenell, W. Quinn, Ming-Jian Lu, Q. Chu +7 more
2016Cell Metabolism246 citations Open access
Semantic Scholar
Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway
Sarah M Choi, David F. Tucker, Danielle N. Gross, R. Easton +4 more
2010Molecular and Cellular Biology227 citations Open access
Semantic Scholar
Metabolic drivers of non-alcoholic fatty liver disease
K. Bence, M. Birnbaum
2020Molecular Metabolism188 citations Open access
Semantic Scholar
An energetic tale of AMPK-independent effects of metformin.
Russell A. Miller, M. Birnbaum
2010Journal of Clinical Investigation174 citations Open access
Semantic Scholar
Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling.
Russell A. Miller, Q. Chu, John E. Le Lay, P. Scherer +5 more
2011Journal of Clinical Investigation168 citations Open access
Semantic Scholar
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates.
Danna M. Breen, Hanna Kim, Donald Bennett, R. Calle +14 more
2020Cell Metabolism166 citations Open access
Semantic Scholar
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
Kashyap A. Patel, M. Foretz, A. Marion, D. Campbell +14 more
2014Nature Communications163 citations Open access
Semantic Scholar
Insulin signaling to hepatic lipid metabolism in health and disease
Karla F. Leavens, M. Birnbaum
2011Critical reviews in biochemistry and molecular biology162 citations
Semantic Scholar
Hepatic Insulin Signaling is Dispensable for Suppression of Glucose Output by Insulin in Vivo
Paul M. Titchenell, Q. Chu, B. Monks, M. Birnbaum
2015Nature Communications161 citations Open access
Semantic Scholar
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt
A. Weljie, P. Meerlo, Namni Goel, Arjun Sengupta +5 more
2015Proceedings of the National Academy of Sciences of the United States of America156 citations Open access
Semantic Scholar
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
Ryan M. Esquejo, Christopher T. Salatto, Jake E. Delmore, Bina Albuquerque +24 more
2018EBioMedicine142 citations Open access
Semantic Scholar
PPARγ contributes to PKM2 and HK2 expression in fatty liver
G. Panasyuk, C. Espeillac, C. Chauvin, Ludivine A. Pradelli +12 more
2012Nature Communications142 citations Open access
Semantic Scholar
Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.
S. Chatterjee, E. Browning, Nan-Kang Hong, K. Debolt +4 more
2012American Journal of Physiology. Heart and Circulatory Physiology139 citations Open access
Semantic Scholar
Postprandial Hepatic Lipid Metabolism Requires Signaling though Akt2 Independent of the Transcription Factors FoxA2, FoxO1 and SREBP1c
Min Wan, Karla F. Leavens, D. Saleh, R. Easton +5 more
2011Cell Metabolism137 citations Open access
Semantic Scholar
TLR4-mediated AKT Activation is MyD88/TRIF-dependent and Critical for Induction of OxPhos and Mitochondrial Transcription Factor A in Murine Macrophages
C. Bauerfeld, R. Rastogi, Gaila Pirockinaite, Icksoo Lee +6 more
2012Journal of Immunology120 citations Open access
Semantic Scholar
Spontaneous hepatocellular carcinoma after the combined deletion of Akt isoforms
Qi Wang, Wan-Ni Yu, Xinyu Chen, Xiao-Ding Peng +4 more
2016Cancer Cell117 citations Open access
Semantic Scholar
Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes
A. Saxena, J. Frias, Lisa S. Brown, Donal N. Gorman +3 more
2023JAMA Network Open110 citations Open access
Semantic Scholar
Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
David O’Sullivan, G. V. D. van der Windt, S. Huang, Jonathan D. Curtis +10 more
2018Immunity109 citations Open access
Semantic Scholar
The critical role of AKT2 in hepatic steatosis induced by PTEN loss.
Li-Na He, X. Hou, G. Kanel, Ni Zeng +6 more
2010American Journal of Pathology105 citations Open access
Semantic Scholar
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2
Vivian A. Galicia, Li-Na He, Hien Dang, G. Kanel +10 more
2010Gastroenterology102 citations Open access
Semantic Scholar
Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Marco Calamito, M. Juntilla, Matthew D Thomas, Daniel L. Northrup +4 more
2010Blood99 citations Open access
Semantic Scholar
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
Lisa M. DiPilato, Faiyaz Ahmad, M. Harms, P. Seale +2 more
2015Molecular and Cellular Biology95 citations Open access
Semantic Scholar
Akt1 Deficiency in Schizophrenia and Impairment of Hippocampal Plasticity and Function
D. Balu, G. Carlson, K. Talbot, H. Kazi +4 more
2010Hippocampus94 citations Open access
Semantic Scholar
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
Hagoon Jang, G. Lee, C. Selby, Gung Lee +8 more
2016Nature Communications92 citations Open access
Semantic Scholar
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
J. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing +21 more
2021Molecular Metabolism86 citations Open access
Semantic Scholar
mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion
W. Quinn, Min Wan, Swapnil V. Shewale, R. Gelfer +3 more
2017Journal of Clinical Investigation85 citations Open access
Semantic Scholar
A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition
Min Wan, Karla F. Leavens, Roger W. Hunter, S. Koren +7 more
2013Cell Metabolism85 citations Open access
Semantic Scholar
Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy
Christopher T. Salatto, Russell A. Miller, K. O. Cameron, E. Cokorinos +24 more
2017Journal of Pharmacology and Experimental Therapeutics81 citations
Semantic Scholar
Akt-mediated FoxO1 inhibition is required for liver regeneration
M. Pauta, N. Rotllan, Ana Fernández-Hernando, Cédric Langhi +11 more
2015Hepatology73 citations Open access
Semantic Scholar
Control of gluconeogenesis by metformin: Does redox trump energy charge?
Joseph A. Baur, M. Birnbaum
2014Cell Metabolism73 citations Open access
Semantic Scholar
Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity
Min Wan, R. Easton, C. Gleason, B. Monks +3 more
2011Molecular and Cellular Biology73 citations Open access
Semantic Scholar
Inhibition of ketohexokinase in adults with NAFLD reduces liver fat and inflammatory markers: A randomized phase 2 trial.
David J. Kazierad, Kristin Chidsey, V. Somayaji, A. Bergman +2 more
2021i Medicina72 citations Open access
Semantic Scholar
Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition
M. Goncalves, E. Pistilli, A. Balduzzi, M. Birnbaum +3 more
2010PLoS ONE72 citations Open access
Semantic Scholar
A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.
S. Tokuda, C. Mahaffey, B. Monks, Christian R Faulkner +3 more
2011Human Molecular Genetics67 citations Open access
Semantic Scholar
Activation of Akt Is Essential for the Propagation of Mitochondrial Respiratory Stress Signaling and Activation of the Transcriptional Coactivator Heterogeneous Ribonucleoprotein A2
Manti Guha, Ji-Kang Fang, R. Monks, M. Birnbaum +1 more
2010Molecular Biology of the Cell66 citations Open access
Semantic Scholar
Lack of AKT in adipocytes causes severe lipodystrophy
Abigail L. Shearin, B. Monks, P. Seale, M. Birnbaum
2016Molecular Metabolism65 citations Open access
Semantic Scholar
Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Russell A. Miller, Yu-Ji Shi, Wen-Yun Lu, David A. Pirman +11 more
2018Nature Medicine63 citations Open access
Semantic Scholar
Akt and mTOR pathways differentially regulate the development of natural and inducible TH17 cells
Jiyeon Kim, Tammarah Sklarz, Lauren B. Banks, M. Gohil +12 more
2013Nature Immunology61 citations Open access
Semantic Scholar

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Russell A. Miller×9
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B. Monks×8
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Paul M. Titchenell×7
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Min Wan×7
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Ming-Jian Lu×4

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Karla F. Leavens×4

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C. Cárdenas×3

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