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K. Bence · SciRah

Researcher profile · Semantic Scholar

K. Bence

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K. Bence — researcher profile on SciRah

h-index: 39
Works: 74
Citations: 5,115

Most-cited papers

Neuronal PTP1B regulates body weight, adiposity and leptin action
K. Bence, M. Delibegović, Bingzhong Xue, Cem Z. Gorgun +3 more
2006Nature Medicine642 citations Open access
Semantic Scholar
Leptin and insulin act on POMC neurons to promote the browning of white fat
G. Dodd, Stephanie Decherf, Kim Loh, Stephanie E. Simonds +11 more
2015Cell382 citations Open access
Semantic Scholar
Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress
M. Delibegović, Derek J. Zimmer, Caitlin Kauffman, Kimberly Rak +6 more
2009Diabetes276 citations Open access
Semantic Scholar
PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice.
Ryoichi Banno, Derek J. Zimmer, B. D. De Jonghe, M. Atienza +3 more
2010Journal of Clinical Investigation198 citations Open access
Semantic Scholar
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
Kim Loh, Atsushi Fukushima, Xin-Mei Zhang, S. Galic +15 more
2011Cell Metabolism195 citations Open access
Semantic Scholar
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials
R. Calle, Neeta B. Amin, S. Carvajal-Gonzalez, Trenton T. Ross +17 more
2021Nature Medicine191 citations
Semantic Scholar
Metabolic drivers of non-alcoholic fatty liver disease
K. Bence, M. Birnbaum
2020Molecular Metabolism188 citations Open access
Semantic Scholar
Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit
K. Bence, Wei Ma, T. Kozasa, Xin-Yun Huang
1997Nature183 citations
Semantic Scholar
Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B
M. Delibegović, K. Bence, N. Mody, Eun-Gyoung Hong +4 more
2007Molecular and Cellular Biology179 citations Open access
Semantic Scholar
Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation.
M. Hayes, Theresa M. Leichner, Shi-ru Zhao, Grace S. Lee +6 more
2016Cell Metabolism154 citations Open access
Semantic Scholar
Metabolic Targets in Nonalcoholic Fatty Liver Disease
W. Esler, K. Bence
2019Cellular and Molecular Gastroenterology and Hepatology135 citations Open access
Semantic Scholar
Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance
David J. Reiner, Elizabeth G. Mietlicki-Baase, Lauren E. McGrath, Derek J. Zimmer +9 more
2016Journal of Neuroscience126 citations Open access
Semantic Scholar
Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation
M. Hayes, K. Skibicka, Theresa M. Leichner, Douglas J. Guarnieri +3 more
2010Cell Metabolism118 citations Open access
Semantic Scholar
Liver-Specific Deletion of Protein Tyrosine Phosphatase (PTP) 1B Improves Obesity- and Pharmacologically-Induced Endoplasmic Reticulum Stress
A. Agouni, N. Mody, C. Owen, A. Czopek +4 more
2011Biochemical Journal100 citations Open access
Semantic Scholar
Activation of the hypothalamic–pituitary–adrenal axis by exogenous and endogenous GDF15
I. Cimino, Hanna Kim, Y. L. Loraine Tung, Kent Pedersen +24 more
2021Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
J. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing +21 more
2021Molecular Metabolism86 citations Open access
Semantic Scholar
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Trenton T. Ross, Collin Crowley, K. Kelly, Anthony Rinaldi +12 more
2020Cellular and Molecular Gastroenterology and Hepatology86 citations Open access
Semantic Scholar
Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways
Maria I. Kontaridis, Wentian Yang, K. Bence, Darragh Cullen +7 more
2008Circulation86 citations Open access
Semantic Scholar
Interactions between Conserved Residues in Transmembrane Helices 1, 2, and 7 of the Thyrotropin-releasing Hormone Receptor*
Jeffrey H. Perlman, A. Colson, Wei Wang, K. Bence +2 more
1997Journal of Biological Chemistry84 citations Open access
Semantic Scholar
Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance.
M. Hayes, K. Skibicka, K. Bence, H. Grill
2009Endocrinology83 citations Open access
Semantic Scholar
Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues
Bingzhong Xue, T. Pulinilkunnil, I. Murano, K. Bence +12 more
2009Molecular and Cellular Biology81 citations Open access
Semantic Scholar
Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation.
M. Hayes, K. Skibicka, Theresa M. Leichner, Douglas J. Guarnieri +3 more
2016Cell Metabolism78 citations Open access
Semantic Scholar
Intracellular signals mediating the food intake suppressive effects of hindbrain glucagon-like-peptide-1 receptor activation
M. Hayes, Theresa M. Leichner, Shi-ru Zhao, Grace S. Lee +6 more
2011Cell Metabolism75 citations Open access
Semantic Scholar
Central Regulation of Metabolism by Protein Tyrosine Phosphatases
R. Tsou, K. Bence
2012Frontiers in Neuroscience71 citations Open access
Semantic Scholar
Genetic Evidence for a Tyrosine Kinase Cascade Preceding the Mitogen-activated Protein Kinase Cascade in Vertebrate G Protein Signaling*
Y. Wan, K. Bence, A. Hata, T. Kurosaki +2 more
1997Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis
C. Owen, A. Czopek, A. Agouni, L. Grant +10 more
2012PLoS ONE68 citations Open access
Semantic Scholar
Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.
R. Tsou, Derek J. Zimmer, B. D. De Jonghe, K. Bence
2012Endocrinology66 citations Open access
Semantic Scholar
Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice
C. Owen, E. Lees, L. Grant, Derek J. Zimmer +3 more
2013Diabetologia62 citations Open access
Semantic Scholar
Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) Signaling*
Ceren Ozek, S. Kanoski, Zhon-Yin Zhang, H. Grill +1 more
2014Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning
Federico Fuentes, Derek J. Zimmer, M. Atienza, Jamie Schottenfeld +4 more
2012PLoS ONE61 citations Open access
Semantic Scholar
The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency
R. Tsou, K. Bence
2012Journal of Obesity52 citations Open access
Semantic Scholar
Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit.
K. Bence, W. Ma, T. Kozasa, X.-Y. Huang
1997Nature52 citations
Semantic Scholar
Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice
Lei Wang, Sai P. Pydi, Ying-Hong Cui, Lu Zhu +7 more
2019Molecular Metabolism51 citations Open access
Semantic Scholar
Melanocortin Control of Energy Balance: Evidence from Rodent Models
B. D. De Jonghe, M. Hayes, K. Bence
2011Cellular and Molecular Life Sciences50 citations Open access
Semantic Scholar
Epithelial Protein-Tyrosine Phosphatase 1B (PTP1B) Contributes to the Induction of Mammary Tumors by HER2/Neu but is not Essential for Tumor Maintenance
K. Balavenkatraman, N. Aceto, A. Britschgi, U. Mueller +3 more
2011Molecular Cancer Research50 citations Open access
Semantic Scholar
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals.
S. Kanoski, Shi-ru Zhao, Douglas J. Guarnieri, R. DiLeone +5 more
2012American Journal of Physiology. Endocrinology and Metabolism49 citations Open access
Semantic Scholar
Deficiency in protein tyrosine phosphatase PTP1B shortens lifespan and leads to development of acute leukemia
Samantha Le Sommer, N. Morrice, Martina Pesaresi, Dawn Thompson +7 more
2017Cancer Research45 citations Open access
Semantic Scholar
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies
C. Carbone, Hui Zheng, S. Bhattacharya, J. R. Lewis +7 more
2012Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor
R. Tsou, Kimberly Rak, Derek J. Zimmer, K. Bence
2014Molecular Metabolism43 citations Open access
Semantic Scholar
Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes +7 more
2023Molecular Metabolism37 citations Open access
Semantic Scholar
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
B. D. De Jonghe, M. Hayes, Derek J. Zimmer, S. Kanoski +2 more
2012American Journal of Physiology. Endocrinology and Metabolism37 citations Open access
Semantic Scholar
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
B. D. De Jonghe, M. Hayes, Ryoichi Banno, K. Skibicka +9 more
2011American Journal of Physiology. Endocrinology and Metabolism36 citations Open access
Semantic Scholar
Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity
Lei Wang, Sai P. Pydi, Lu Zhu, L. F. Barella +5 more
2020Nature Communications33 citations Open access
Semantic Scholar
Cannabinoid receptor-1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.
Simeng Wang, Qingzhang Zhu, G. Liang, Tania Franks +8 more
2021Journal of Clinical Investigation32 citations Open access
Semantic Scholar
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.
M. A. Lim, K. Bence, Ishani Sandesara, P. Andreux +4 more
2014Human Molecular Genetics32 citations Open access
Semantic Scholar
Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.
T. Bruder-Nascimento, B. Butler, D. Herren, M. Brands +2 more
2015Pharmacological Research29 citations Open access
Semantic Scholar
Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance
Ceren Ozek, Derek J. Zimmer, B. D. De Jonghe, R. Kalb +1 more
2015Molecular Metabolism28 citations Open access
Semantic Scholar
Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B.
D. Koss, G. Riedel, K. Bence, B. Platt
2013Cell Calcium25 citations
Semantic Scholar
Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome?
K. Bence
2010Journal of clinical metabolism & diabetes24 citations
Semantic Scholar
Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1 B ( PTP 1 B ) Improves Metabolic Syndrome and Attenuates Diet-Induced ER Stress
M. Delibegović, Derek J. Zimmer, Caitlin Kauffman, Kimberly Rak +6 more
200817 citations
Semantic Scholar

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Derek J. Zimmer×14
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B. Neel×11
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M. Delibegović×9
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B. D. De Jonghe

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H. Grill — researcher profile on SciRah

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S. Kanoski — researcher profile on SciRah

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W. Esler — researcher profile on SciRah