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Jake E. Delmore · SciRah

Researcher profile · Semantic Scholar

Jake E. Delmore

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Jake E. Delmore — researcher profile on SciRah

h-index: 18
Works: 56
Citations: 4,415

Most-cited papers

BET bromodomain inhibition as a therapeutic strategy to target c-Myc
Jake E. Delmore, Ghayas C. Issa, M. Lemieux, P. Rahl +20 more
2011Cell2,827 citations Open access
Semantic Scholar
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anti-cancer drug activity
Douglas W. McMillin, Jake E. Delmore, E. Weisberg, J. Negri +10 more
2010Nature Medicine305 citations Open access
Semantic Scholar
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
E. Cokorinos, Jake E. Delmore, A. Reyes, Bina Albuquerque +26 more
2017Cell Metabolism268 citations Open access
Semantic Scholar
Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications.
J. Jakubikova, Sophia Adamia, M. Kost-Alimova, Steffen Klippel +13 more
2011Blood160 citations Open access
Semantic Scholar
Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.
Douglas W. McMillin, M. Ooi, Jake E. Delmore, J. Negri +10 more
2009Cancer Research149 citations Open access
Semantic Scholar
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models
Ryan M. Esquejo, Christopher T. Salatto, Jake E. Delmore, Bina Albuquerque +24 more
2018EBioMedicine142 citations Open access
Semantic Scholar
Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma
J. Jakubikova, D. Cervi, M. Ooi, Kihyun Kim +14 more
2011Haematologica76 citations Open access
Semantic Scholar
The interaction of bortezomib with multidrug transporters: implications for therapeutic applications in advanced multiple myeloma and other neoplasias
R. O'Connor, M. Ooi, J. Meiller, J. Jakubikova +7 more
2013Cancer Chemotherapy and Pharmacology75 citations Open access
Semantic Scholar
Molecular and cellular effects of NEDD8 activating enzyme (NAE) inhibition in myeloma
Douglas W. McMillin, H. Jacobs, Jake E. Delmore, Leutz Buon +9 more
2012Molecular Cancer Therapeutics49 citations Open access
Semantic Scholar
Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp.
Shu-Geng Cao, Douglas W. McMillin, G. Tamayo, Jake E. Delmore +2 more
2012Journal of Natural Products40 citations Open access
Semantic Scholar
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels
Rachel J. Roth Flach, Eliza Bollinger, A. Reyes, Brigitte Laforest +29 more
2023Nature Communications38 citations Open access
Semantic Scholar
Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies.
R. Rickles, Laura T. Pierce, T. Giordano, Winnie F. Tam +6 more
2010Blood38 citations Open access
Semantic Scholar
Compartment-Specific Bioluminescence Imaging platform for the high-throughput evaluation of antitumor immune function.
Douglas W. McMillin, Jake E. Delmore, J. Negri, Matthew Vanneman +8 more
2012Blood33 citations Open access
Semantic Scholar
Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition.
C. Mitsiades, P. Hayden, V. Kotoula, Douglas W. McMillin +5 more
2007Journal of Clinical Endocrinology and Metabolism31 citations Open access
Semantic Scholar
Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation
Douglas W. McMillin, Jake E. Delmore, J. Negri, M. Ooi +7 more
2011PLoS ONE30 citations Open access
Semantic Scholar
Methyljasmonate Displays In Vitro and In Vivo Activity against Multiple Myeloma Cells
Steffen Klippel, J. Jakubikova, Jake E. Delmore, M. Ooi +6 more
2012British Journal of Haematology28 citations Open access
Semantic Scholar
In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465
J. Negri, Douglas W. McMillin, Jake E. Delmore, N. Mitsiades +10 more
2009British Journal of Haematology27 citations Open access
Semantic Scholar
Molecular and cellular effects of multi-targeted CDK inhibition in myeloma: Biological and clinical implications
Douglas W. McMillin, Jake E. Delmore, J. Negri, Leutz Buon +11 more
2011British Journal of Haematology24 citations Open access
Semantic Scholar
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Tim F. Ryder, M. F. Calabrese, G. Walker, K. O. Cameron +12 more
2018Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism
Ryan M. Esquejo, Bina Albuquerque, Anna Sher, M. Blatnik +8 more
2022Heliyon13 citations Open access
Semantic Scholar
Activity of New Heat Shock Protein 90 (hsp90) Inhibitor NVP-AUY922 Against Myeloma Cells Sensitive and Resistant to Conventional Agents.
Douglas W. McMillin, J. Negri, Jake E. Delmore, P. Hayden +12 more
200710 citations
Semantic Scholar
Adenosine A 2 A receptor agonists and PDE inhibitors : a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies
R. Rickles, Laura T. Pierce, T. Giordano, Winnie F. Tam +6 more
20107 citations
Semantic Scholar
MLN4924, a Novel Investigational NEDD8 Activating Enzyme Inhibitor, Exhibits Preclinical Activity In Multiple Myeloma and Waldenström's Macroglobulinemia through Mechanism Distinct From Existing Proteasome Inhibitors
Douglas W. McMillin, Z. Hunter, Jake E. Delmore, V. Monrose +7 more
20105 citations
Semantic Scholar
The Antidiabetic Biguanide Metformin Induces Growth Arrest in Multiple Myeloma Cells in Vitro, overcoming the Effect of Stromal Cells
M. Ooi, Douglas W. McMillin, J. Negri, Jake E. Delmore +7 more
20084 citations
Semantic Scholar
The Interaction of Bortezomib with P-Gp, MRP-1 and BCRP Drug Transporters: Implications for Therapeutic Applications of Bortezomib in Advanced Multiple Myeloma and Other Neoplasias.
M. Ooi, R. O'Connor, J. Jakubikova, J. Meiller +9 more
20093 citations
Semantic Scholar
Anti-Myeloma Activity of Selective PI-3K/PDK/mTOR Inhibitor BEZ235.
Douglas W. McMillin, J. Negri, Jake E. Delmore, P. Hayden +8 more
20073 citations
Semantic Scholar
Preclinical Studies of Salinomycin In Multiple Myeloma (MM) Models: Targeting of Side Population (SP) Cells In the Context of Tumor – Microenvironment Interactions.
E. Kastritis, J. Jakubikova, Jake E. Delmore, Steffen Klippel +8 more
20102 citations
Semantic Scholar
Compartment-Specific Bioluminescence Imaging (CS-BLI) High- Throughput Assays Provide Comparative Insights into the Impact of Osteoclasts Vs. Stromal Cells on Activity of Anti-Myeloma Therapeutics
M. Ooi, Douglas W. McMillin, J. Negri, Jake E. Delmore +5 more
20082 citations
Semantic Scholar
Anti-Myeloma Activity of the Dual Akt/p70 S6K Inhibitor EXEL-6075.
Douglas W. McMillin, J. Negri, Jake E. Delmore, M. Ooi +6 more
20072 citations
Semantic Scholar
Activity of CDK1/2 Inhibitor LCQ195 Against Multiple Myeloma Cells.
Douglas W. McMillin, Jake E. Delmore, J. Negri, P. Hayden +6 more
20072 citations
Semantic Scholar
Author Correction: Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity
Douglas W. McMillin, Jake E. Delmore, E. Weisberg, J. Negri +10 more
2024Nature Medicine1 citations Open access
Semantic Scholar
Proteasome Inhibitors Sensitize Myeloma Cells to T Cell-Mediated Killing
N. V. van de Donk, H. Lokhorst, M. Emmelot, T. Aarts-Riemens +13 more
20111 citations
Semantic Scholar
Activity of the NEDD8-specific inhibitor MLN 4924 in multiple myeloma and Waldenström's macroglobulinemia, and effect on miRNA expression.
Douglas W. McMillin, Z. Hunter, Jake E. Delmore, Peter G. Smith +5 more
20101 citations
Semantic Scholar
The Transcriptional Signature of Kinases Inhibited by the Multi-Targeted Kinase Inhibitor AS703569 Is Associated with Clinical Outcome in Multiple Myeloma (MM): Anti-MM Activity of AS703569 in Preclinical Studies.
Jake E. Delmore, D. Cervi, Douglas W. McMillin, E. Kastritis +12 more
20091 citations
Semantic Scholar
Targeting the Clonogenic Side Population of Multiple Myeloma by Immunomodulatory Drugs (IMiDs) in the Context of Stromal Cell Microenvironment: Pathophysiologic and Clinical Implications.
J. Jakubikova, D. Cervi, J. Daley, D. Cholujová +12 more
20091 citations
Semantic Scholar
Interactions of the Mdm2/p53 and Proteasome Pathways: Implications for Combination Strategies to Enhance the Anti-Myeloma Activity of Bortezomib
M. Ooi, P. Hayden, Douglas W. McMillin, J. Negri +9 more
20081 citations
Semantic Scholar
Abstract 566: Branched Chain Ketoacid Dehydrogenase Kinase Inhibition Alters Substrate Utilization and Gene Expression in Myocytes
Parker Siddall, Eliza Bollinger, Matthew J. Peloquin, Bina Albuquerque +13 more
2019Circulation Research0 citations
Semantic Scholar
Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications
Eugen Dhimolea, E. King, E. Kastritis, Douglas W. McMillin +11 more
20140 citations
Semantic Scholar
Cell Non-Autonomous Modulation Of Tumor Cell Responses To Pharmacological Inhibition Of The Proteasome
R. Groen, C. Hayes, J. Jakubikova, B.M. Megan +9 more
20130 citations
Semantic Scholar
Tumor Cell-Dependent Differences in Stroma-Induced Changes to Bortezomib Sensitivity.
Eugen Dhimolea, J. Jakubikova, R. Groen, Jake E. Delmore +6 more
20120 citations
Semantic Scholar
Cells of the Osteoblast Lineage Confer Myeloma Cell Resistance to Established and Investigational Therapeutic Agents
C. Hayes, P. Dowling, R. Groen, Douglas W. McMillin +9 more
20120 citations
Semantic Scholar
Preclinical Development Molecular and Cellular Effects of NEDD 8-Activating Enzyme Inhibition in Myeloma
Douglas W. McMillin, H. Jacobs, Jake E. Delmore, Leutz Buon +9 more
20120 citations
Semantic Scholar
In Vitro Anti-Myeloma Activity of the Multitargeted Kinase Inhibitor Midostaurin in the Context of Heterotypic Cocultures of Myeloma Cells with Nonmalignant Microenvironmental Accessory Cells
P. Lawasut, H. Jacobs, Jake E. Delmore, J. Negri +6 more
20110 citations
Semantic Scholar
Inhibition of c-Myc Expression and Function in Hematologic Malignancies
Ghayas C. Issa, Jake E. Delmore, M. McKeown, M. Lemieux +19 more
20110 citations
Semantic Scholar
Proteomic Characterization of An Isogenic Multiple Myeloma Cell Line Model of Bortezomib Resistance
C. Hayes, P. Dowling, J. Negri, M. Henry +14 more
20110 citations
Semantic Scholar
Compartment-Specific Bioluminescence Imaging Platform for the Open-Ended Identification of Novel Immunomodulatory Agents and High-Throughput Evaluation of Anti-Tumor Immune Function
Douglas W. McMillin, Jake E. Delmore, Matthew Vanneman, R. Schlossman +7 more
20100 citations
Semantic Scholar
Development of New Treatment Strategies Targeting Clonogenic and Tumorigenic Myeloma Side Population.
J. Jakubikova, Steffen Klippel, E. Kastritis, J. Daley +7 more
20100 citations
Semantic Scholar
Synergistic Enhancement of Conventional Anti-MM Drugs Efficacy with Plant Isothiocyanates: Therapeutic Implications
J. Jakubikova, M. Ooi, Steffen Klippel, Jake E. Delmore +5 more
20100 citations
Semantic Scholar
Effects of Tanespimycin On Glucocorticoid Receptor Translocation.
C. Mitsiades, M. Agler, Yingjie Zhu, M. Ooi +3 more
20090 citations
Semantic Scholar
Methyljasmonate, An Inhibitor of Glycolytic Energy Production, Displays Pre-Clinical Activity against Multiple Myeloma Cells.
Steffen Klippel, J. Jakubikova, Jake E. Delmore, M. Ooi +6 more
20090 citations
Semantic Scholar

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C. Mitsiades×42
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Douglas W. McMillin×36
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Douglas W. McMillin — researcher profile on SciRah
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J. Negri — researcher profile on SciRah

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M. Ooi — researcher profile on SciRah

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J. Jakubikova×17

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J. Laubach — researcher profile on SciRah

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H. Jacobs — researcher profile on SciRah

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E. Kastritis — researcher profile on SciRah