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D. Wootten · SciRah

Researcher profile · Semantic Scholar

D. Wootten

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D. Wootten — researcher profile on SciRah

h-index: 49
Works: 166
Citations: 7,819

Most-cited papers

Differential GLP-1R binding and activation by peptide and non-peptide agonists
Xin Zhang, M. Belousoff, Pei-Shen Zhao, A. Kooistra +18 more
2020bioRxiv188 citations Open access
Semantic Scholar
Activation of the GLP-1 receptor by a non-peptidic agonist
Pei-Shen Zhao, Yi-Lynn Liang, M. Belousoff, Giuseppe Deganutti +16 more
2020Nature148 citations Open access
Semantic Scholar
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
C. Draper-Joyce, Rebecca F. Bhola, Jinan Wang, Apurba Bhattarai +20 more
2021Nature143 citations Open access
Semantic Scholar
Structural basis of Gs and Gi recognition by the human glucagon receptor
Anna Qiao, Shuo Han, Xinmei Li, Zhixin Li +16 more
2020Science141 citations
Semantic Scholar
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
V. Lagou, Long-Da Jiang, A. Ulrich, L. Zudina +92 more
2023Nature Genetics118 citations Open access
Semantic Scholar
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Yi-Lynn Liang, M. Belousoff, Madeleine M. Fletcher, Xin Zhang +11 more
2020ACS Pharmacology & Translational Science88 citations Open access
Semantic Scholar
Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.
Shanshan Ma, Q. Shen, Li-Hua Zhao, C. Mao +12 more
2020Molecules and Cells80 citations Open access
Semantic Scholar
Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
T. M. Josephs, M. Belousoff, Yi-Lynn Liang, S. Piper +9 more
2021Science79 citations
Semantic Scholar
A structural basis for amylin receptor phenotype
Jianjun Cao, M. Belousoff, Yi-Lynn Liang, Rachel M. Johnson +7 more
2022Science78 citations
Semantic Scholar
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, M. Khoshouei +14 more
2021bioRxiv77 citations Open access
Semantic Scholar
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35
Cheng-Xue Qin, L. Norling, E. A. Vecchio, E. Brennan +5 more
2022British Journal of Pharmacology75 citations Open access
Semantic Scholar
Glucose-dependent insulinotropic polypeptide (GIP)
T. Müller, Alice E. Adriaenssens, Ah-Ren Bo, M. Blüher +35 more
2025Molecular Metabolism71 citations Open access
Semantic Scholar
Structure and dynamics of semaglutide and taspoglutide bound GLP-1R-Gs complexes
Xin Zhang, M. Belousoff, Yi-Lynn Liang, R. Danev +2 more
2021bioRxiv71 citations Open access
Semantic Scholar
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
J. Mobbs, M. Belousoff, K. Harikumar, S. Piper +9 more
2021PLoS Biology67 citations Open access
Semantic Scholar
New Insights into the Structure and Function of Class B1 GPCRs
B. P. Cary, Xin Zhang, Jianjun Cao, Rachel M. Johnson +4 more
2022Endocrine reviews60 citations Open access
Semantic Scholar
Evolving cryo-EM structural approaches for GPCR drug discovery
Xin Zhang, Rachel M. Johnson, I. Drulyte, Lingbo Yu +5 more
2021bioRxiv60 citations Open access
Semantic Scholar
AM833 Is a Novel Agonist of Calcitonin Family G Protein–Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists
Madeleine M. Fletcher, Peter Keov, Tin T. Truong, G. Mennen +7 more
2021Journal of Pharmacology and Experimental Therapeutics58 citations Open access
Semantic Scholar
Structural and Functional Diversity among Agonist-Bound States of the GLP-1 Receptor
B. P. Cary, Giuseppe Deganutti, Pei-Shen Zhao, Tin T. Truong +7 more
2021bioRxiv53 citations Open access
Semantic Scholar
Routine sub-2.5 Å cryo-EM structure determination of GPCRs
R. Danev, M. Belousoff, Yi-Lynn Liang, Xin Zhang +3 more
2021Nature Communications49 citations Open access
Semantic Scholar
Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM
S. Piper, Rachel M. Johnson, D. Wootten, P. Sexton
2022Chemical Reviews47 citations Open access
Semantic Scholar
Pharmacological characterization of mono-, dual- and tri- peptidic agonists at GIP and GLP-1 receptors.
Elita Yuliantie, Sanaz Darbalaei, A. Dai, Pei-Shen Zhao +4 more
2020Biochemical Pharmacology44 citations
Semantic Scholar
Structure and dynamics of the active Gs-coupled human secretin receptor
M. Dong, Giuseppe Deganutti, S. Piper, Yi-Lynn Liang +11 more
2020Nature Communications43 citations Open access
Semantic Scholar
The Molecular Control of Calcitonin Receptor Signaling.
E. dal Maso, A. Glukhova, Yue Zhu, J. García-Nafría +14 more
2019ACS Pharmacology & Translational Science39 citations Open access
Semantic Scholar
Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors.
Michael L. Garelja, M. Au, M. Brimble, Joseph J Gingell +12 more
2020ACS Pharmacology & Translational Science37 citations Open access
Semantic Scholar
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity
Paul M. Levine, Aaron T. Balana, E. Sturchler, C. Koole +10 more
2019Journal of the American Chemical Society36 citations Open access
Semantic Scholar
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, A. Powers +13 more
2023Nature Communications35 citations Open access
Semantic Scholar
The role of G protein-coupled receptor kinases in GLP-1R β-arrestin recruitment and internalisation.
Samantha M. McNeill, Jessica Lu, Carlo Marion C. Carino, A. Inoue +3 more
2024Biochemical Pharmacology33 citations Open access
Semantic Scholar
Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors
Jessica Lu, S. Piper, Pei-Shen Zhao, L. Miller +2 more
2022International Journal of Molecular Sciences33 citations Open access
Semantic Scholar
Structural basis for allosteric modulation of class B GPCRs
D. Wootten, L. Miller
2019Annual Review of Pharmacology and Toxicology33 citations Open access
Semantic Scholar
Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics
L. Miller, K. Harikumar, D. Wootten, P. Sexton
2021Frontiers in Endocrinology29 citations Open access
Semantic Scholar
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors.
Sanaz Darbalaei, Elita Yuliantie, A. Dai, Rulue Chang +5 more
2020Biochemical Pharmacology29 citations
Semantic Scholar
Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.
Rachel M. Johnson, Xin Zhang, S. Piper, Theodore J. Nettleton +5 more
2021Biochemical and Biophysical Research Communications - BBRC28 citations Open access
Semantic Scholar
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
Rulue Chang, Xin Zhang, Anna Qiao, A. Dai +14 more
2020Journal of Biological Chemistry26 citations Open access
Semantic Scholar
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Edin Muratspahić, David Feldman, David E. Kim, Xian-Ming Qu +42 more
2025bioRxiv24 citations Open access
Semantic Scholar
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Ziva Vuckovic, Jinan Wang, Vi Pham, J. Mobbs +20 more
2023eLife24 citations Open access
Semantic Scholar
Structural insight into selectivity of amylin and calcitonin receptor agonists
Jianjun Cao, M. Belousoff, Elliot J. Gerrard, R. Danev +11 more
2023Nature Chemical Biology20 citations Open access
Semantic Scholar
Understanding VPAC receptor family peptide binding and selectivity
S. Piper, Giuseppe Deganutti, Jessica Lu, Pei-Shen Zhao +9 more
2022Nature Communications20 citations Open access
Semantic Scholar
RAMPs regulate signalling bias and internalisation of the GIPR
Matthew Harris, Duncan I. Mackie, J. B. Pawlak, Sabrina Carvalho +17 more
2021bioRxiv19 citations Open access
Semantic Scholar
The metabolic effects of mirabegron are mediated primarily by β3‐adrenoceptors
Nodi Dehvari, Masaaki Sato, M. Bokhari, A. Kalinovich +12 more
2020Pharmacology Research & Perspectives19 citations Open access
Semantic Scholar
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
A. Ostrovskaya, C. Hick, D. S. Hutchinson, B. Stringer +4 more
2019BMC Cancer18 citations Open access
Semantic Scholar
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3
Isabella C. Russell, Xin Zhang, Fabian Bumbak, Samantha M. McNeill +8 more
2024Biochemistry17 citations Open access
Semantic Scholar
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors
Jianjun Cao, M. Belousoff, R. Johnson, Peter Keov +11 more
2025Nature Communications16 citations Open access
Semantic Scholar
Molecular insights into peptide agonist engagement with the PTH receptor.
B. P. Cary, Elliot J. Gerrard, M. Belousoff, Madeleine M. Fletcher +5 more
2023Structure16 citations Open access
Semantic Scholar
Development of a Novel Assay for Direct Assessment of Selective Amylin Receptor Activation Reveals Novel Differences in Behavior of Selective and Nonselective Peptide Agonists
Peter Keov, G. Christopoulos, C. Hick, Tine Glendorf +3 more
2024Molecular Pharmacology13 citations Open access
Semantic Scholar
Implications of ligand-receptor binding kinetics on GLP-1R signalling.
Pei-Shen Zhao, Tin T. Truong, Jon Merlin, P. Sexton +1 more
2022Biochemical Pharmacology13 citations Open access
Semantic Scholar
Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors
Giuseppe Deganutti, S. Atanasio, Roxana-Maria Rujan, P. Sexton +2 more
2021Frontiers in Molecular Biosciences13 citations Open access
Semantic Scholar
De novo design of miniproteins targeting GPCRs
Edin Muratspahić, David Feldman, David E. Kim, Xian-Ming Qu +68 more
2026Nature12 citations
Semantic Scholar
Engineering of a Biologically Active Glycosylated Glucagon-Like Peptide-1 Analogue.
C. Chandrashekar, Feng Lin, Yuji Nishiuchi, Sam F Mohammed +12 more
2024Journal of Medicinal Chemistry12 citations
Semantic Scholar
Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor.
Vi Pham, Yue Zhu, E. dal Maso, C. A. Reynolds +10 more
2019ACS Pharmacology & Translational Science12 citations Open access
Semantic Scholar
Glycosylation Improves the Proteolytic Stability of Exenatide.
C. Chandrashekar, Y. Nishiuchi, Barbara F White, Yanni Arsenakis +10 more
2023Bioconjugate chemistry10 citations
Semantic Scholar

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P. Sexton×38
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P. Sexton — researcher profile on SciRah
M. Belousoff×20
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M. Belousoff — researcher profile on SciRah
R. Danev×19
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R. Danev — researcher profile on SciRah
Pei-Shen Zhao×15
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Pei-Shen Zhao — researcher profile on SciRah

A. Christopoulos

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A. Christopoulos — researcher profile on SciRah

Yi-Lynn Liang×13

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Yi-Lynn Liang — researcher profile on SciRah

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Xin Zhang — researcher profile on SciRah

Giuseppe Deganutti×10

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Giuseppe Deganutti — researcher profile on SciRah

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S. Piper — researcher profile on SciRah

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L. Miller — researcher profile on SciRah

Tin T. Truong×8

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Tin T. Truong — researcher profile on SciRah

C. A. Reynolds×8

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C. A. Reynolds — researcher profile on SciRah