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K. Harikumar · SciRah

Researcher profile · Semantic Scholar

K. Harikumar

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K. Harikumar — researcher profile on SciRah

h-index: 31
Works: 108
Citations: 2,829

Most-cited papers

Single-molecule FRET imaging of GPCR dimers in living cells
Wesley B. Asher, P. Geggier, Michael D. Holsey, G. Gilmore +14 more
2021Nature Methods164 citations Open access
Semantic Scholar
Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex
J. Ke, K. Harikumar, Clara Erice, Chen Chen +9 more
2013Genes & Development141 citations Open access
Semantic Scholar
Transmembrane Segment IV Contributes a Functionally Important Interface for Oligomerization of the Class II G Protein-coupled Secretin Receptor*
K. Harikumar, D. Pinon, L. Miller
2007Journal of Biological Chemistry111 citations Open access
Semantic Scholar
Crystal structure of the Frizzled 4 receptor in a ligand-free state
Shifan Yang, Yi-Ran Wu, Ting-Hai Xu, P. de Waal +21 more
2018Nature107 citations
Semantic Scholar
Structure of an AMPK complex in an inactive, ATP-bound state
Yan Yan, S. Mukherjee, K. Harikumar, Timothy S. Strutzenberg +16 more
2021Science96 citations Open access
Semantic Scholar
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
K. Harikumar, D. Wootten, D. Pinon, C. Koole +7 more
2012Proceedings of the National Academy of Sciences of the United States of America82 citations Open access
Semantic Scholar
Differential Effects of Modification of Membrane Cholesterol and Sphingolipids on the Conformation, Function, and Trafficking of the G Protein-coupled Cholecystokinin Receptor*
K. Harikumar, Vishwajeet Puri, R. Singh, K. Hanada +2 more
2005Journal of Biological Chemistry78 citations Open access
Semantic Scholar
G-protein-dependent cell surface dynamics of the human serotonin1A receptor tagged to yellow fluorescent protein.
T. Pucadyil, Shanti Kalipatnapu, K. Harikumar, N. Rangaraj +2 more
2004Biochemistry78 citations
Semantic Scholar
Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors
K. Harikumar, M. Morfis, Cayle S. Lisenbee, P. Sexton +1 more
2006Molecular Pharmacology75 citations
Semantic Scholar
Heterodimerization of Type A and B Cholecystokinin Receptors Enhance Signaling and Promote Cell Growth*
Zhi-Jie Cheng, K. Harikumar, E. Holicky, L. Miller
2003Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
J. Mobbs, M. Belousoff, K. Harikumar, S. Piper +9 more
2021PLoS Biology67 citations Open access
Semantic Scholar
Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization
Z. DeBruine, J. Ke, K. Harikumar, Xin Gu +6 more
2017Genes & Development65 citations Open access
Semantic Scholar
Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation*
A. Pioszak, K. Harikumar, N. Parker, L. Miller +1 more
2010Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands
Ya-Guo Zheng, E. Akgün, K. Harikumar, Jessika A Hopson +4 more
2009Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross‐class GPCR heterocomplex
L. O. Lee, Stephanie Y. L. Ng, Jessica Y. S. Chu, Revathi Sekar +3 more
2014The FASEB Journal54 citations Open access
Semantic Scholar
Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor
Fan Gao, K. Harikumar, M. Dong, Po-Lo C. H. Lam +5 more
2009Molecular Pharmacology54 citations Open access
Semantic Scholar
Pattern of Intra-Family Hetero-Oligomerization Involving the G-Protein-Coupled Secretin Receptor
K. Harikumar, M. Morfis, P. Sexton, L. Miller
2008Journal of Molecular Neuroscience54 citations Open access
Semantic Scholar
Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol
Ross M. Potter, K. Harikumar, S.Vincent Wu, L. Miller
2012Journal of Lipid Research52 citations Open access
Semantic Scholar
THE MOLECULAR BASIS OF ASSOCIATION OF RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 WITH THE FAMILY B G PROTEIN-COUPLED SECRETIN RECEPTOR
K. Harikumar, J. Simms, G. Christopoulos, P. Sexton +1 more
2009Biochemistry50 citations Open access
Semantic Scholar
Dimerization in the Absence of Higher Order Oligomerization of the G Protein-Coupled Secretin Receptor
K. Harikumar, R. Happs, L. Miller
2008Biochimica et Biophysica Acta50 citations Open access
Semantic Scholar
Environment and Mobility of a Series of Fluorescent Reporters at the Amino Terminus of Structurally Related Peptide Agonists and Antagonists Bound to the Cholecystokinin Receptor*
K. Harikumar, D. Pinon, William S. Wessels, F. G. Prendergast +1 more
2002Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Ligand Binding Characteristics of the Human Serotonin1A Receptor Heterologously Expressed in CHO Cells
Shanti Kalipatnapu, T. Pucadyil, K. Harikumar, A. Chattopadhyay
2004Bioscience Reports47 citations
Semantic Scholar
Structure and dynamics of the active Gs-coupled human secretin receptor
M. Dong, Giuseppe Deganutti, S. Piper, Yi-Lynn Liang +11 more
2020Nature Communications43 citations Open access
Semantic Scholar
Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus.
A. Chattopadhyay, Md. Jafurulla, Shanti Kalipatnapu, T. Pucadyil +1 more
2005Biochemical and Biophysical Research Communications - BBRC43 citations
Semantic Scholar
Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerization
K. Harikumar, Alicja M. Ball, P. Sexton, L. Miller
2010Regulatory Peptides37 citations Open access
Semantic Scholar
Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function.
K. Harikumar, M. Dong, Zhi-Jie Cheng, D. Pinon +2 more
2006Biochemistry37 citations Open access
Semantic Scholar
Distinct Molecular Mechanisms for Agonist Peptide Binding to Types A and B Cholecystokinin Receptors Demonstrated Using Fluorescence Spectroscopy*
K. Harikumar, Jeremy M. Clain, D. Pinon, M. Dong +1 more
2005Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.
L. J. Miller, M. Dong, K. Harikumar, Fan Gao
2007Biochemical Society Transactions32 citations
Semantic Scholar
Membrane Cholesterol Affects Stimulus-Activity Coupling in Type 1, but not Type 2, CCK Receptors: Use of Cell Lines with Elevated Cholesterol
K. Harikumar, Ross M. Potter, Achyut Patil, Valerie Echeveste +1 more
2013Lipids30 citations Open access
Semantic Scholar
Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and 2 cholecystokinin receptors
E. Akgün, M. Körner, Fan Gao, K. Harikumar +4 more
2009Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics
L. Miller, K. Harikumar, D. Wootten, P. Sexton
2021Frontiers in Endocrinology29 citations Open access
Semantic Scholar
Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor
R. Ward, J. Pediani, K. Harikumar, L. Miller +1 more
2017Biochemical Journal29 citations Open access
Semantic Scholar
Fluorescent Indicators Distributed throughout the Pharmacophore of Cholecystokinin Provide Insights into Distinct Modes of Binding and Activation of Type A and B Cholecystokinin Receptors*
K. Harikumar, D. Pinon, L. Miller
2006Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
Yan Yan, Ting-Hai Xu, K. Harikumar, L. Miller +2 more
2017Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Measurement of intermolecular distances for the natural agonist Peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer.
K. Harikumar, D. Pinon, William S. Wessels, Eric S. Dawson +3 more
2004Molecular Pharmacology24 citations
Semantic Scholar
Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor*
Erin E. Cawston, Po-Lo C. H. Lam, K. Harikumar, M. Dong +8 more
2012Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Use of Probes with Fluorescence Indicator Distributed throughout the Pharmacophore to Examine the Peptide Agonist-binding Environment of the Family B G Protein-coupled Secretin Receptor*
K. Harikumar, K. Hosohata, D. Pinon, L. Miller
2006Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Role of Disulfides and Sulfhydryl Groups in Agonist and Antagonist Binding in Serotonin1A Receptors from Bovine Hippocampus
K. Harikumar, P. John, A. Chattopadhyay
2004Cellular and molecular neurobiology22 citations
Semantic Scholar
A Type 1 Cholecystokinin Receptor Mutant That Mimics the Dysfunction Observed for Wild Type Receptor in a High Cholesterol Environment*
Aditya J. Desai, K. Harikumar, L. Miller
2014Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Ligand binding and activation of the secretin receptor, a prototypic family B G protein‐coupled receptor
Laurence J. Miller, M. Dong, K. Harikumar
2012British Journal of Pharmacology21 citations Open access
Semantic Scholar
Cholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptor.
Aditya J. Desai, M. Dong, K. Harikumar, L. J. Miller
2016International Journal of Obesity Supplements20 citations Open access
Semantic Scholar
Modulation of β-Catenin Signaling by Glucagon Receptor Activation
J. Ke, Cheng-Hai Zhang, K. Harikumar, C. Zylstra-Diegel +5 more
2012PLoS ONE20 citations Open access
Semantic Scholar
Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors
J. Geiger, Rick Sexton, Zina Al-Sahouri, Ming-Yue Lee +5 more
2021Biochimica et Biophysica Acta - Biomembranes19 citations Open access
Semantic Scholar
Molecular Basis for Benzodiazepine Agonist Action at the Type 1 Cholecystokinin Receptor*
K. Harikumar, Erin E. Cawston, Po-Lo C. H. Lam, Achyut Patil +6 more
2013Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation.
S. Wu, K. Harikumar, R. Burgess, J. Reeve +1 more
2008American Journal of Physiology - Gastrointestinal and Liver Physiology19 citations Open access
Semantic Scholar
Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization
K. Harikumar, E. Akgün, P. Portoghese, L. Miller
2010Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Fluorescence Resonance Energy Transfer Analysis of Secretin Docking to Its Receptor
K. Harikumar, Po-Lo C. H. Lam, M. Dong, P. Sexton +2 more
2007Journal of Biological Chemistry17 citations Open access
Semantic Scholar
The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus.
L. J. Miller, P. Sexton, M. Dong, K. Harikumar
2014International Journal of Obesity Supplements16 citations Open access
Semantic Scholar
Fluorescence Resonance Energy Transfer Analysis of the Antagonist- and Partial Agonist-occupied States of the Cholecystokinin Receptor*
K. Harikumar, L. Miller
2005Journal of Biological Chemistry15 citations Open access
Semantic Scholar
Analysis of the cellular and molecular mechanisms of trophic action of a misspliced form of the type B cholecystokinin receptor present in colon and pancreatic cancer.
Zhi-Jie Cheng, K. Harikumar, Wei-Qun Ding, E. Holicky +1 more
2005Cancer Letters14 citations
Semantic Scholar

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