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A. Dai · SciRah

Researcher profile · Semantic Scholar

A. Dai

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A. Dai — researcher profile on SciRah

h-index: 29
Works: 76
Citations: 2,896

Most-cited papers

Common activation mechanism of class A GPCRs
Qingtong Zhou, De-Hua Yang, Meng Wu, Yu Guo +12 more
2019eLife483 citations Open access
Semantic Scholar
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators
Gaojie Song, De-Hua Yang, Yu-Xia Wang, C. de Graaf +18 more
2017Nature214 citations
Semantic Scholar
Structure of the full-length glucagon class B G protein-coupled receptor
Hao-Nan Zhang, Anna Qiao, De-Hua Yang, Lin-Lin Yang +29 more
2017Nature192 citations Open access
Semantic Scholar
Structural basis of Gs and Gi recognition by the human glucagon receptor
Anna Qiao, Shuo Han, Xinmei Li, Zhixin Li +16 more
2020Science141 citations
Semantic Scholar
Structure of the glucagon receptor in complex with a glucagon analogue
Hao-Nan Zhang, Anna Qiao, Lin-Lin Yang, N. Van Eps +18 more
2018Nature141 citations
Semantic Scholar
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors
Feng-Hui Zhao, Qingtong Zhou, Z. Cong, K. Hang +18 more
2022Nature Communications133 citations Open access
Semantic Scholar
Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
Shuling Lin, Shuo Han, Xiao-qing Cai, Q. Tan +16 more
2021Nature132 citations
Semantic Scholar
Structure and dynamics of the active human parathyroid hormone receptor-1
Li-Hua Zhao, Shanshan Ma, Ieva Sutkeviciute, D. Shen +20 more
2019Science104 citations Open access
Semantic Scholar
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Qiufeng Liu, De-Hua Yang, Y. Zhuang, T. Croll +12 more
2021Nature Chemical Biology94 citations Open access
Semantic Scholar
DeepCPI: A Deep Learning-based Framework for Large-scale in silico Drug Screening
Fangping Wan, Yue Zhu, Hailin Hu, A. Dai +7 more
2019Genomics, Proteomics & Bioinformatics88 citations Open access
Semantic Scholar
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist
W. Yin, X. E. Zhou, De-Hua Yang, P. de Waal +17 more
2018Cell Discovery79 citations Open access
Semantic Scholar
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor
Z. Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou +15 more
2021Nature Communications71 citations Open access
Semantic Scholar
Structural basis for activation of the growth hormone-releasing hormone receptor
Fu-Lai Zhou, Huibing Zhang, Z. Cong, Li-Hua Zhao +18 more
2020Nature Communications65 citations Open access
Semantic Scholar
Structural insights into ligand recognition and activation of the melanocortin-4 receptor
Huibing Zhang, Li-Nan Chen, De-Hua Yang, C. Mao +13 more
2021Cell Research54 citations Open access
Semantic Scholar
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors*
Li-Hua Zhao, Yan-Ting Yin, De-Hua Yang, Bo Liu +11 more
2016Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Dimerization and antidepressant recognition at noradrenaline transporter
Heng Zhang, Yu-Ling Yin, A. Dai, Tian-Wei Zhang +11 more
2024Nature52 citations
Semantic Scholar
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
Sai-Fei Lei, Lachlan Clydesdale, A. Dai, Xiao-qing Cai +10 more
2018Journal of Biological Chemistry51 citations Open access
Semantic Scholar
Structures of the human cholecystokinin receptors bound to agonists and antagonists
Xue-Feng Zhang, Cheng-Lin He, Mu Wang, Qingtong Zhou +18 more
2021Nature Chemical Biology50 citations
Semantic Scholar
Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor
Shan-Shan Ma, Yan Chen, A. Dai, W. Yin +6 more
2021Cell Research49 citations Open access
Semantic Scholar
Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)*
De-Hua Yang, C. de Graaf, Lin-Lin Yang, Gaojie Song +9 more
2016Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Pharmacological characterization of mono-, dual- and tri- peptidic agonists at GIP and GLP-1 receptors.
Elita Yuliantie, Sanaz Darbalaei, A. Dai, Pei-Shen Zhao +4 more
2020Biochemical Pharmacology44 citations
Semantic Scholar
Structural insights into ligand recognition and selectivity of somatostatin receptors
Wenli Zhao, Shuo Han, Na Qiu, Wenbo Feng +20 more
2022Cell Research42 citations Open access
Semantic Scholar
Structural analysis of the dual agonism at GLP-1R and GCGR
Yang Li, Qing-Tong Zhou, A. Dai, Feng-Hui Zhao +6 more
2023Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24
Z. Cong, Qingtong Zhou, Yang Li, Li-Nan Chen +10 more
2022bioRxiv34 citations Open access
Semantic Scholar
Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor
Yan Lu, Shanshan Qin, Bingjie Zhang, A. Dai +8 more
2019Analytical Chemistry34 citations Open access
Semantic Scholar
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
Feng-Hui Zhao, Chao Zhang, Qingtong Zhou, K. Hang +14 more
2021bioRxiv33 citations Open access
Semantic Scholar
High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening
Shanshan Qin, Mengmeng Meng, De-Hua Yang, Wenwen Bai +16 more
2018Chemical Science32 citations Open access
Semantic Scholar
Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1
Ping Luo, Wenbo Feng, Shan-Shan Ma, A. Dai +8 more
2023Cell Research30 citations Open access
Semantic Scholar
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
Li-Hua Zhao, Qing-Ning Yuan, A. Dai, Xin-Heng He +7 more
2022bioRxiv30 citations Open access
Semantic Scholar
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors.
Sanaz Darbalaei, Elita Yuliantie, A. Dai, Rulue Chang +5 more
2020Biochemical Pharmacology29 citations
Semantic Scholar
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
Xi Wang, Xi Cheng, Li-Hua Zhao, Yu-zhe Wang +11 more
2021Proceedings of the National Academy of Sciences of the United States of America26 citations Open access
Semantic Scholar
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
Rulue Chang, Xin Zhang, Anna Qiao, A. Dai +14 more
2020Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors
Wenbo Feng, Qingtong Zhou, Xianyue Chen, A. Dai +11 more
2023Cell Discovery21 citations Open access
Semantic Scholar
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs
Can-Rong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang +12 more
2025Cell Discovery20 citations Open access
Semantic Scholar
Structural and functional evidence that GPR30 is not a direct estrogen receptor
Heng Liu, Shimeng Guo, A. Dai, Peiyu Xu +8 more
2024Cell Research20 citations Open access
Semantic Scholar
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
Ying-Na Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang +12 more
2021Nature Communications18 citations Open access
Semantic Scholar
Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists.
Shuangjie Shu, Xiao-qing Cai, Jia Li, Yang Feng +5 more
2016Bioorganic & Medicinal Chemistry15 citations Open access
Semantic Scholar
Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site.
Jiang Wang, De-Hua Yang, Xi Cheng, Lin-Lin Yang +10 more
2021ACS Chemical Biology12 citations
Semantic Scholar
Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.
G. Lin, Qiao-Feng Liu, A. Dai, Xiao-qing Cai +7 more
2020Biochemical Journal12 citations Open access
Semantic Scholar
High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4
G. Lin, Lin Lin, Xiao-qing Cai, A. Dai +6 more
2020Acta Pharmacologica Sinica10 citations Open access
Semantic Scholar
A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities.
Shuangjie Shu, A. Dai, Jiang Wang, Bin Wang +7 more
2018Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
Qingtong Zhou, Wan-Jing Guo, A. Dai, Xiao-qing Cai +6 more
2021Biomolecules9 citations Open access
Semantic Scholar
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
Sanaz Darbalaei, Rulue Chang, Qingtong Zhou, Yan Chen +3 more
2022Acta Pharmacologica Sinica8 citations Open access
Semantic Scholar
Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor.
Elita Yuliantie, W. V. D. van der Velden, Viktorija Labroska, A. Dai +10 more
2021Biochemical Pharmacology8 citations Open access
Semantic Scholar
The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression
Yunjun Ge, De-Hua Yang, A. Dai, Cai-Hong Zhou +2 more
2014Bioscience Reports7 citations Open access
Semantic Scholar
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia
Yue Wang, Ping Luo, Hai-Yan Xu, Li Zhan +28 more
2026Science Advances6 citations Open access
Semantic Scholar
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling.
Sai-Fei Lei, Qian Meng, Yan-Yun Liu, Qiao-Feng Liu +6 more
2024European Journal of Pharmacology6 citations
Semantic Scholar
Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors
Feng-Hui Zhao, Qingtong Zhou, Z. Cong, K. Hang +18 more
2021bioRxiv6 citations Open access
Semantic Scholar
Identification of a carbohydrate recognition motif of purinergic receptors
Li-Fen Zhao, Fangyu Wei, Xin-Heng He, A. Dai +4 more
2023bioRxiv5 citations Open access
Semantic Scholar
Molecular characterization of G-protein-coupled receptor (GPCR) and protein kinase A (PKA) cDNA in Perinereis aibuhitensis and expression during benzo(a)pyrene exposure
Hua-He Yi, Jia Sun, P. Han, He-Lin Zhao +84 more
2019PeerJ4 citations Open access
Semantic Scholar

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