Madeleine M. Fletcher

Most-cited papers

1. Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

   C. de Graaf, D. Donnelly, D. Wootten, J. Lau +10 more

   2016Pharmacological Reviews370 citations Open access

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2. Activation of the GLP-1 receptor by a non-peptidic agonist

   Pei-Shen Zhao, Yi-Lynn Liang, M. Belousoff, Giuseppe Deganutti +16 more

   2020Nature148 citations Open access

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3. Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.

   Yi-Lynn Liang, M. Belousoff, Pei-Shen Zhao, C. Koole +11 more

   2020Molecules and Cells103 citations Open access

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4. Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.

   Yi-Lynn Liang, M. Belousoff, Madeleine M. Fletcher, Xin Zhang +11 more

   2020ACS Pharmacology & Translational Science88 citations Open access

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5. A structural basis for amylin receptor phenotype

   Jianjun Cao, M. Belousoff, Yi-Lynn Liang, Rachel M. Johnson +7 more

   2022Science78 citations

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6. AM833 Is a Novel Agonist of Calcitonin Family G Protein–Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists

   Madeleine M. Fletcher, Peter Keov, Tin T. Truong, G. Mennen +7 more

   2021Journal of Pharmacology and Experimental Therapeutics58 citations Open access

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7. Glucagon‐like peptide‐1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

   Madeleine M. Fletcher, M. Halls, Pei-Shen Zhao, Lachlan Clydesdale +3 more

   2018Biochemical Pharmacology50 citations

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8. The complexity of signalling mediated by the glucagon-like peptide-1 receptor.

   Madeleine M. Fletcher, M. Halls, A. Christopoulos, P. Sexton +1 more

   2016Biochemical Society Transactions39 citations

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9. Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism.

   Renata Kowalczyk, M. Brimble, Yusuke Tomabechi, A. Fairbanks +2 more

   2014Organic and biomolecular chemistry37 citations

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10. Structural insight into selectivity of amylin and calcitonin receptor agonists

    Jianjun Cao, M. Belousoff, Elliot J. Gerrard, R. Danev +11 more

    2023Nature Chemical Biology20 citations Open access

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11. Understanding VPAC receptor family peptide binding and selectivity

    S. Piper, Giuseppe Deganutti, Jessica Lu, Pei-Shen Zhao +9 more

    2022Nature Communications20 citations Open access

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12. Molecular insights into peptide agonist engagement with the PTH receptor.

    B. P. Cary, Elliot J. Gerrard, M. Belousoff, Madeleine M. Fletcher +5 more

    2023Structure16 citations Open access

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13. Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors.

    G. Mennen, Z. Ying, Madeleine M. Fletcher, M. A. Razzak +5 more

    2025Biochemistry3 citations

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14. Molecular insights into peptide agonist engagement with the PTH1 receptor

    B. P. Cary, Elliot J. Gerrard, M. Belousoff, Madeleine M. Fletcher +5 more

    2022bioRxiv1 citations Open access

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15. The spatiotemporal control of signalling and trafficking of the GLP-1R

    Madeleine M. Fletcher

    20191 citations

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16. The Effect of Glycosylation on the Potency of Pramlintide, An Anti-Diabetic Drug

    Madeleine M. Fletcher, Renata Kowalczyk, A. Fairbanks, M. Brimble +1 more

    20130 citations

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