Researcher profile · Semantic Scholar

J. Mobbs

h-index: 10
Works: 39
Citations: 447

Most-cited papers

Structural and regulatory diversity shape HLA-C protein expression levels
Gurman Kaur, S. Gras, J. Mobbs, J. Vivian +11 more
2017Nature Communications104 citations Open access
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Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
J. Mobbs, M. Belousoff, K. Harikumar, S. Piper +9 more
2021PLoS Biology67 citations Open access
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The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule
J. Mobbs, P. Illing, Nadine L. Dudek, A. Brooks +4 more
2017Journal of Biological Chemistry41 citations Open access
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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, A. Powers +13 more
2023Nature Communications35 citations Open access
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The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors.
Liu-Di Zhang, J. Mobbs, Lauren T. May, A. Glukhova +1 more
2023Current Opinion in Structural Biology31 citations Open access
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Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase.
J. Mobbs, A. Koay, Alex Di Paolo, M. Bieri +7 more
2015Biochemical Journal28 citations
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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Ziva Vuckovic, Jinan Wang, Vi Pham, J. Mobbs +20 more
2023eLife24 citations Open access
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AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding.
M. Bieri, J. Mobbs, A. Koay, Gavin Louey +7 more
2012Biophysical Journal20 citations Open access
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Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors
J. Mobbs, K. A. Black, M. Tran, Wessel A. C. Burger +5 more
2023bioRxiv18 citations Open access
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The P2X1 receptor as a therapeutic target
Felix M. Bennetts, J. Mobbs, S. Ventura, D. Thal
2022Purinergic Signalling Purinergic Signalling18 citations Open access
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Structural insights into the human P2X1 receptor and ligand interactions
Felix M. Bennetts, Hariprasad Venugopal, A. Glukhova, J. Mobbs +2 more
2024bioRxiv10 citations Open access
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Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor
Liu Zhang, J. Mobbs, Felix M. Bennetts, Hariprasad Venugopal +7 more
2025bioRxiv9 citations Open access
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Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02
Sushma Anand, D. Littler, J. Mobbs, Asolina Braun +5 more
2023Journal of Biological Chemistry9 citations Open access
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High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub–200-keV direct electron detector
Hariprasad Venugopal, J. Mobbs, Cyntia Taveneau, Daniel R. Fox +8 more
2025Science Advances7 citations Open access
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Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR
Wessel A. C. Burger, J. Mobbs, Bhavika Rana, Jinan Wang +10 more
2025Nature Communications6 citations Open access
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Structural basis for Porcupine inhibition
Katrina A Black, J. Mobbs, Hariprasad Venugopal, Toby A. Dite +5 more
2025bioRxiv3 citations Open access
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Structure-guided allosteric modulation of the delta opioid receptor
J. Mobbs, M. D. Nguyen, Owindeep Deo, Damian Bartuzi +14 more
2025bioRxiv3 citations Open access
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Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
K. Harikumar, Pei-Shen Zhao, B. P. Cary, Xiaomeng Xu +10 more
2024PLoS Biology3 citations Open access
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Unravelling the Carbohydrate‐Binding Preferences of the Carbohydrate‐Binding Modules of AMP‐Activated Protein Kinase
J. Mobbs, Alex Di Paolo, R. D. Metcalfe, Emily E. Selig +3 more
2018ChemBioChem3 citations Open access
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Cryo-EM reveals a new allosteric binding site at the M5 mAChR
Wessel A. C. Burger, J. Mobbs, Bhavika Rana, Jinan Wang +10 more
2025bioRxiv2 citations Open access
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A transgenic mouse allows characterisation of the HLA-C*06:02 immunopeptidome in a model of psoriasis.
Asolina Braun, J. Mobbs, Shanzou Chung, Johanna E. Tuomisto +16 more
2025Journal of Investigative Dermatology2 citations
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A transgenic mouse allows to capture the HLA-C*06:02 immunopeptidome in a model of psoriasis
Asolina Braun, J. Mobbs, Shanzou Chung, Johanna E. Tuomisto +16 more
2025bioRxiv1 citations
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Obtaining high-resolution cryo-EM structures using a common LaB6, 120-keV electron microscope equipped with a sub 200-keV optimised direct electron detector
Hariprasad Venugopal, J. Mobbs, Cyntia Taveneau, Daniel R. Fox +7 more
2024bioRxiv1 citations Open access
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Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine Receptor
Ziva Vuckovic, Jinan Wang, Vi Pham, J. Mobbs +20 more
2022Social Science Research Network1 citations Open access
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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Ziva Vuckovic, Jinan Wang, Vi Pham, J. Mobbs +19 more
2022bioRxiv1 citations Open access
Semantic Scholar
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity
J. Mobbs, M. Belousoff, K. Harikumar, S. Piper +9 more
2021bioRxiv1 citations Open access
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Applications of NMR and ITC for the Study of the Kinetics of Carbohydrate Binding by AMPK β-Subunit Carbohydrate-Binding Modules.
P. Gooley, A. Koay, J. Mobbs
2018Methods in molecular biology1 citations
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Structure-guided allosteric modulation of the delta opioid receptor
J. Mobbs, M. D. Nguyen, Owindeep Deo, Damian Bartuzi +14 more
2026Nature Communications0 citations Open access
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Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent
Steven O. Devenish, Sahil D. Patel, Laura V. Ussingkær, L. F. Almeida Silva +6 more
2026Signal Transduction and Targeted Therapy0 citations Open access
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Structural basis of MK-97 positive allosteric modulation at the M4 mAChR
Michaela G. Kaoullas, J. Mobbs, Ziva Vuckovic, M. Belousoff +19 more
2026bioRxiv0 citations Open access
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Sub 3Å cryoEM structure using a standard LaB6 120kV TEM upgraded with direct electron detector
H. Venugopal, J. Mobbs, Cyntia Taveneau, Daniel R. Fox +4 more
2024BIO Web of Conferences0 citations Open access
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013 Uncovering antigen triggers in genetically predisposed psoriasis patients
A. Braun, J. Ye, J. Mobbs, S. Anand +15 more
2023Journal of Investigative Dermatology0 citations
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Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
J. Mobbs, M. Belousoff, R. Danev, D. Thal +1 more
20210 citations
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Human Cholecystokinin 1 receptor (CCK1R) Gs complex
J. Mobbs, M. Belousoff, R. Danev, D. Thal +1 more
20210 citations
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HLA-C*06:02 presenting ARFNDLRFV
J. Mobbs, J. Vivian, J. Rossjohn
20170 citations
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HLA-C*06:02 presenting ARTELYRSL
J. Mobbs, J. Vivian, J. Rossjohn
20170 citations
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Molecular characterisation of the carbohydrate binding modules of AMPK
J. Mobbs
20160 citations
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beta1 carbohydrate binding module (CBM) of AMP-activated protein kinase (AMPK) in complex with glucosyl-beta-cyclododextrin
J. Mobbs, M. Gorman, M. Parker, P. Gooley +1 more
20150 citations
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beta2 carbohydrate binding module (CBM) of AMP-activated protein kinase (AMPK)
J. Mobbs, M. Gorman, M. Parker, P. Gooley +1 more
20150 citations
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C. Valant

×9

Hariprasad Venugopal×9

J. Vivian×8

D. Wootten×8

P. Sexton×7

Wessel A. C. Burger×7

Vi Pham×7

A. Glukhova×7