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A. Newbold · SciRah

Researcher profile · Semantic Scholar

A. Newbold

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A. Newbold — researcher profile on SciRah

h-index: 20
Works: 58
Citations: 2,043

Most-cited papers

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
J. Baell, D. Leaver, S. Hermans, Gemma L. Kelly +48 more
2018Nature279 citations Open access
Semantic Scholar
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma
R. Lindemann, A. Newbold, K. Whitecross, L. Cluse +13 more
2007Proceedings of the National Academy of Sciences of the United States of America224 citations Open access
Semantic Scholar
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
S. Vervoort, S. A. Welsh, J. Devlin, E. Barbieri +29 more
2021Cell181 citations Open access
Semantic Scholar
A Central Role for Bid in Granzyme B-induced Apoptosis*
N. Waterhouse, K. Sedelies, K. Browne, M. Wowk +8 more
2005Journal of Biological Chemistry146 citations Open access
Semantic Scholar
The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy.
L. Ellis, M. Bots, R. Lindemann, Jessica E. Bolden +7 more
2009Blood120 citations Open access
Semantic Scholar
Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity.
G. Matthews, A. Newbold, R. Johnstone
2012Advances in Cancer Research116 citations
Semantic Scholar
How do tumor cells respond to HDAC inhibition?
A. Newbold, K. Falkenberg, H. Prince, Ricky W. Johnstone
2016The FEBS Journal107 citations Open access
Semantic Scholar
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
K. Whitecross, A. E. Alsop, L. Cluse, A. Wiegmans +6 more
2009Blood88 citations Open access
Semantic Scholar
Suppression of behavioural and physiological oestrus in the mare by vaccination against GnRH.
M. Elhay, A. Newbold, A. Britton, P. Turley +2 more
2007Australian Veterinary Journal78 citations Open access
Semantic Scholar
Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas.
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
2013Blood73 citations Open access
Semantic Scholar
Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
A. Newbold, R. Lindemann, L. Cluse, K. Whitecross +2 more
2008Molecular Cancer Therapeutics66 citations Open access
Semantic Scholar
PIDDosome-independent tumor suppression by Caspase-2
C. Manzl, Lukas Peintner, G. Krumschnabel, Florian J. Bock +5 more
2012Cell Death and Differentiation64 citations Open access
Semantic Scholar
BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members
S. Hogg, A. Newbold, S. Vervoort, L. Cluse +8 more
2016Molecular Cancer Therapeutics61 citations
Semantic Scholar
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
Srividya B. Balachander, Steven W. Criscione, Kate F. Byth, Justin Cidado +34 more
2020Clinical Cancer Research57 citations Open access
Semantic Scholar
Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukaemia.
Stefan Bjelosevic, Emily Gruber, A. Newbold, Carolyn Shembrey +12 more
2021Cancer Discovery55 citations Open access
Semantic Scholar
The role of p21waf1/cip1 and p27Kip1 in HDACi-mediated tumor cell death and cell cycle arrest in the Eμ-myc model of B-cell lymphoma
A. Newbold, J. Salmon, B. Martin, K. Stanley +1 more
2014Oncogene45 citations
Semantic Scholar
Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities
A. Newbold, G. Matthews, M. Bots, L. Cluse +16 more
2013Molecular Cancer Therapeutics43 citations Open access
Semantic Scholar
Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.
John M. Walker, Souravi Ghosh, Joanne Pagnon, C. Colantoni +3 more
2007Vaccine40 citations
Semantic Scholar
Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.
L. J. Valente, B. Aubrey, M. Herold, Gemma L. Kelly +7 more
2016Cell Reports37 citations Open access
Semantic Scholar
Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia.
M. Ghisi, L. Kats, F. Masson, Jason Li +15 more
2016Cancer Cell34 citations Open access
Semantic Scholar
Detection of apoptotic cells using propidium iodide staining.
A. Newbold, B. Martin, C. Cullinane, M. Bots
2014Cold Spring Harbor Protocols18 citations
Semantic Scholar
The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression
Lin Xiao, M. Karsa, Emma Ronca, A. Bongers +18 more
2022Frontiers in Oncology14 citations Open access
Semantic Scholar
A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity
KJ Falkenberg, A. Newbold, CM Gould, J. Luu +4 more
2016Cell Death and Differentiation14 citations Open access
Semantic Scholar
Scribble acts as an oncogene in Eμ-myc-driven lymphoma
E. Hawkins, J. Oliaro, KM Ramsbottom, A. Newbold +3 more
2016Oncogene14 citations
Semantic Scholar
Detection of apoptotic cells using immunohistochemistry.
A. Newbold, B. Martin, C. Cullinane, M. Bots
2014Cold Spring Harbor Protocols10 citations Open access
Semantic Scholar
A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation.
J. Devlin, B. Martin, Nenad Bartonicek, Keziah E. Ting +16 more
2025Molecules and Cells9 citations Open access
Semantic Scholar
mTORC1 induces apoptosis in MYC-driven B-cell lymphomas Combined inhibition of PI3K-related DNA damage response kinases and
M. Wall, R. Hannan, R. Pearson, G. McArthur +12 more
20139 citations
Semantic Scholar
Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors
A. Newbold, Sj Vervoort, Bp Martin, M. Bots +1 more
2012Cell Death and Disease9 citations Open access
Semantic Scholar
Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma
Danielle H Oh, Xiao Ma, S. Hogg, Jackson He +13 more
2023Proceedings of the National Academy of Sciences of the United States of America8 citations Open access
Semantic Scholar
Cloning and characterisation of Ifi206: A new murine HIN‐200 family member
Louise E. Ludlow, Linda L. Hii, J. Thorpe, A. Newbold +4 more
2008Journal of Cellular Biochemistry8 citations
Semantic Scholar
Stepwise progression of β-selection during T cell development involves histone deacetylation
Anchi S Chann, M. Charnley, Lucas M. Newton, A. Newbold +5 more
2022Life Science Alliance3 citations Open access
Semantic Scholar
Corrigendum: Detection of Apoptotic Cells Using Propidium Iodide Staining.
A. Newbold, B. Martin, C. Cullinane, M. Bots
2018Cold Spring Harbor Protocols3 citations Open access
Semantic Scholar
Measuring apoptosis in mammals in vivo.
A. Newbold, B. Martin, C. Cullinane, M. Bots
2014Cold Spring Harbor Protocols3 citations
Semantic Scholar
Dual Bcl-2/Bcl-xl inhibition via AZD0466 combines with immune checkpoint blockade to enhance anti-tumour activity
Dane M. Newman, Courtney L. Andersen, L. Cluse, A. Newbold +5 more
2026Cell Death and Disease2 citations Open access
Semantic Scholar
Reprogramming of serine metabolism is an actionable vulnerability in FLT3-ITD driven acute myeloid leukaemia
Stefan Bjelosevic, Emily Gruber, A. Newbold, L. Kats +9 more
2020bioRxiv2 citations Open access
Semantic Scholar
A PP2A-Integrator complex fine-tunes transcription by opposing CDK9
S. Vervoort, S. A. Welsh, J. Devlin, E. Barbieri +24 more
2020bioRxiv2 citations Open access
Semantic Scholar
Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in solid tumors.
A. Newbold, B. Martin, C. Cullinane, M. Bots
2014Cold Spring Harbor Protocols2 citations
Semantic Scholar
THE THERAPY OF SYPHILIS
P. Mulzer, A. Newbold
19132 citations
Semantic Scholar
P1212: RATIONALLY DESIGNED CHIMERIC PI3K-BET BROMODOMAIN INHIBITORS ELICIT CURATIVE RESPONSES IN MYC-DRIVEN LYMPHOMA
Danielle H Oh, Xiao Ma, Jackson He, Conor J. Kearney +13 more
2023HemaSphere0 citations Open access
Semantic Scholar
Stepwise progression of β-selection during T cell development as revealed by histone deacetylation inhibition
Anchi S Chann, M. Charnley, Lucas M. Newton, A. Newbold +5 more
2021bioRxiv0 citations Open access
Semantic Scholar
3002 – REPROGRAMMING OF SERINE METABOLISM IS A METABOLIC VULNERABILITY IN FMS-LIKE TYROSINE KINASE 3 (FLT3) MUTANT ACUTE MYELOID LEUKAEMIA
Stefan Bjelosevic, Emily Gruber, A. Newbold, Carolyn Shembrey +8 more
20200 citations Open access
Semantic Scholar
Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in hematological tumors.
A. Newbold, B. Martin, C. Cullinane, M. Bots
2014Cold Spring Harbor Protocols0 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar
LYMPHOID NEOPLASIA Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
J. Shortt, B. Martin, A. Newbold, K. Hannan +12 more
20130 citations
Semantic Scholar

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