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K. Sedelies · SciRah

Researcher profile · Semantic Scholar

K. Sedelies

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K. Sedelies — researcher profile on SciRah

h-index: 17
Works: 20
Citations: 1,609

Most-cited papers

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation
V. Sutton, Joanne E. Davis, M. Cancilla, R. Johnstone +4 more
2000Journal of Experimental Medicine404 citations Open access
Semantic Scholar
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.
M. Peart, K. Tainton, A. Ruefli, A. Dear +5 more
2003Cancer Research247 citations
Semantic Scholar
A Central Role for Bid in Granzyme B-induced Apoptosis*
N. Waterhouse, K. Sedelies, K. Browne, M. Wowk +8 more
2005Journal of Biological Chemistry146 citations Open access
Semantic Scholar
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
Lukas E. Dow, Anthony M. Brumby, R. Muratore, M. Coombe +5 more
2003Oncogene133 citations Open access
Semantic Scholar
Cytotoxic T lymphocyte–induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
N. Waterhouse, V. Sutton, K. Sedelies, A. Ciccone +4 more
2006Journal of Cell Biology101 citations Open access
Semantic Scholar
Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes*
K. Sedelies, T. Sayers, Kirsten M. Edwards, Weisan Chen +3 more
2004Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis
V. Sutton, N. Waterhouse, K. Browne, K. Sedelies +5 more
2007Journal of Cell Biology69 citations Open access
Semantic Scholar
Functional dissociation of ΔΨm and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
N. Waterhouse, K. Sedelies, V. Sutton, M. Pinkoski +5 more
2006Cell Death and Differentiation63 citations Open access
Semantic Scholar
Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
O. Susanto, S. Stewart, I. Voskoboinik, D. Brasacchio +7 more
2013Cell Death and Differentiation61 citations Open access
Semantic Scholar
Role of Bid‐induced mitochondrial outer membrane permeabilization in granzyme B‐induced apoptosis
N. Waterhouse, K. Sedelies, J. Trapani
2006Immunology and Cell Biology61 citations
Semantic Scholar
The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress
C. Bird, M. Christensen, M. Mangan, Monica D. Prakash +5 more
2014Cell Death and Differentiation44 citations Open access
Semantic Scholar
Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
K. Sedelies, A. Ciccone, C. Clarke, J. Oliaro +9 more
2008Cell Death and Differentiation39 citations Open access
Semantic Scholar
Cytotoxic lymphocytes; instigators of dramatic target cell death.
N. Waterhouse, C. Clarke, K. Sedelies, M. Teng +1 more
2004Biochemical Pharmacology37 citations
Semantic Scholar
Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer
B. Gabrielli, F. Bokhari, Max V. Ranall, Z. Oo +16 more
2015Molecular Cancer Therapeutics35 citations Open access
Semantic Scholar
A Critical Role for Granzymes in Antigen Cross-Presentation through Regulating Phagocytosis of Killed Tumor Cells
S. Hoves, V. Sutton, N. Haynes, E. Hawkins +8 more
2011Journal of Immunology32 citations
Semantic Scholar
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737
VR Sutton, K. Sedelies, G. Dewson, M. Christensen +5 more
2012Cell Death and Disease22 citations Open access
Semantic Scholar
Granzyme B; the chalk-mark of a cytotoxic lymphocyte
N. Waterhouse, K. Sedelies, C. Clarke
2004Journal of Translational Medicine17 citations Open access
Semantic Scholar
Immunity, Granzymes and Cell Killing
N. Waterhouse, O. Susanto, K. Sedelies, J. Trapani
20092 citations
Semantic Scholar
This information is current as Phagocytosis of Killed Tumor Cells Cross-Presentation through Regulating A Critical Role for Granzymes in Antigen
S. Hoves, V. Sutton, N. Haynes, E. Hawkins +8 more
20110 citations
Semantic Scholar
Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells.
O. Susanto, K. Sedelies, J. Trapani, N. Waterhouse
2009Blood0 citations
Semantic Scholar

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